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Items: 1 to 50 of 109

1.

Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics.

Friesen M, Cowan CA.

Trends Endocrinol Metab. 2019 Jun;30(6):396-406. doi: 10.1016/j.tem.2019.03.002. Epub 2019 May 6. Review.

PMID:
31072658
2.

Generation of hypoimmunogenic human pluripotent stem cells.

Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10441-10446. doi: 10.1073/pnas.1902566116. Epub 2019 Apr 30.

3.

FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism.

Friesen M, Cowan CA.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):254-260. doi: 10.1016/j.bbrc.2017.11.008. Epub 2017 Nov 3.

PMID:
29108996
4.

Exome-wide association study of plasma lipids in >300,000 individuals.

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC, Boehnke M, Boerwinkle E, Bork-Jensen J, Bottinger EP, Brandslund I, Brown M, Busonero F, Caulfield MJ, Chambers JC, Chasman DI, Chen YE, Chen YI, Chowdhury R, Christensen C, Chu AY, Connell JM, Cucca F, Cupples LA, Damrauer SM, Davies G, Deary IJ, Dedoussis G, Denny JC, Dominiczak A, Dubé MP, Ebeling T, Eiriksdottir G, Esko T, Farmaki AE, Feitosa MF, Ferrario M, Ferrieres J, Ford I, Fornage M, Franks PW, Frayling TM, Frikke-Schmidt R, Fritsche LG, Frossard P, Fuster V, Ganesh SK, Gao W, Garcia ME, Gieger C, Giulianini F, Goodarzi MO, Grallert H, Grarup N, Groop L, Grove ML, Gudnason V, Hansen T, Harris TB, Hayward C, Hirschhorn JN, Holmen OL, Huffman J, Huo Y, Hveem K, Jabeen S, Jackson AU, Jakobsdottir J, Jarvelin MR, Jensen GB, Jørgensen ME, Jukema JW, Justesen JM, Kamstrup PR, Kanoni S, Karpe F, Kee F, Khera AV, Klarin D, Koistinen HA, Kooner JS, Kooperberg C, Kuulasmaa K, Kuusisto J, Laakso M, Lakka T, Langenberg C, Langsted A, Launer LJ, Lauritzen T, Liewald DCM, Lin LA, Linneberg A, Loos RJF, Lu Y, Lu X, Mägi R, Malarstig A, Manichaikul A, Manning AK, Mäntyselkä P, Marouli E, Masca NGD, Maschio A, Meigs JB, Melander O, Metspalu A, Morris AP, Morrison AC, Mulas A, Müller-Nurasyid M, Munroe PB, Neville MJ, Nielsen JB, Nielsen SF, Nordestgaard BG, Ordovas JM, Mehran R, O'Donnell CJ, Orho-Melander M, Molony CM, Muntendam P, Padmanabhan S, Palmer CNA, Pasko D, Patel AP, Pedersen O, Perola M, Peters A, Pisinger C, Pistis G, Polasek O, Poulter N, Psaty BM, Rader DJ, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Rich SS, Ridker PM, Rioux JD, Robertson NR, Roden DM, Rotter JI, Rudan I, Salomaa V, Samani NJ, Sanna S, Sattar N, Schmidt EM, Scott RA, Sever P, Sevilla RS, Shaffer CM, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith BH, Somayajula S, Southam L, Spector TD, Speliotes EK, Starr JM, Stirrups KE, Stitziel N, Strauch K, Stringham HM, Surendran P, Tada H, Tall AR, Tang H, Tardif JC, Taylor KD, Trompet S, Tsao PS, Tuomilehto J, Tybjaerg-Hansen A, van Zuydam NR, Varbo A, Varga TV, Virtamo J, Waldenberger M, Wang N, Wareham NJ, Warren HR, Weeke PE, Weinstock J, Wessel J, Wilson JG, Wilson PWF, Xu M, Yaghootkar H, Young R, Zeggini E, Zhang H, Zheng NS, Zhang W, Zhang Y, Zhou W, Zhou Y, Zoledziewska M; Charge Diabetes Working Group; EPIC-InterAct Consortium; EPIC-CVD Consortium; GOLD Consortium; VA Million Veteran Program, Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S.

Nat Genet. 2017 Dec;49(12):1758-1766. doi: 10.1038/ng.3977. Epub 2017 Oct 30.

5.

Humanity in a Dish: Population Genetics with iPSCs.

Warren CR, Cowan CA.

Trends Cell Biol. 2018 Jan;28(1):46-57. doi: 10.1016/j.tcb.2017.09.006. Epub 2017 Nov 23. Review.

PMID:
29054332
6.

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J.

Cell Stem Cell. 2017 Sep 7;21(3):305-318.e8. doi: 10.1016/j.stem.2017.07.008. Epub 2017 Aug 10.

7.

Utility of CRISPR/Cas9 systems in hematology research.

Lucas D, O'Leary HA, Ebert BL, Cowan CA, Tremblay CS.

Exp Hematol. 2017 Oct;54:1-3. doi: 10.1016/j.exphem.2017.06.006. Epub 2017 Jun 28. Review.

8.

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.

Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo RC, Cowan CA.

Stem Cell Reports. 2017 May 9;8(5):1164-1173. doi: 10.1016/j.stemcr.2017.03.014. Epub 2017 Apr 13.

9.

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA.

Cell Stem Cell. 2017 Apr 6;20(4):547-557.e7. doi: 10.1016/j.stem.2017.01.010.

10.

The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics.

Warren CR, Jaquish CE, Cowan CA.

Cell Stem Cell. 2017 Apr 6;20(4):431-433. doi: 10.1016/j.stem.2017.03.021.

11.

Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells.

Naylor RW, McGhee CN, Cowan CA, Davidson AJ, Holm TM, Sherwin T.

PLoS One. 2016 Oct 28;11(10):e0165464. doi: 10.1371/journal.pone.0165464. eCollection 2016.

12.

Microenvironmental Control of Adipocyte Fate and Function.

Pope BD, Warren CR, Parker KK, Cowan CA.

Trends Cell Biol. 2016 Oct;26(10):745-755. doi: 10.1016/j.tcb.2016.05.005. Epub 2016 Jun 4. Review.

13.

Adipocyte insulin receptor activity maintains adipose tissue mass and lifespan.

Friesen M, Hudak CS, Warren CR, Xia F, Cowan CA.

Biochem Biophys Res Commun. 2016 Aug 5;476(4):487-492. doi: 10.1016/j.bbrc.2016.05.151. Epub 2016 May 28.

PMID:
27246738
14.

Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells.

Peters DT, Henderson CA, Warren CR, Friesen M, Xia F, Becker CE, Musunuru K, Cowan CA.

Development. 2016 May 1;143(9):1475-81. doi: 10.1242/dev.132209.

15.

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.

Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O'Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5364-9. doi: 10.1073/pnas.1602886113. Epub 2016 Apr 13.

16.

Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease.

Yu H, Cowan CA.

Mol Endocrinol. 2016 Jun;30(6):575-86. doi: 10.1210/me.2015-1290. Epub 2016 Apr 13. Review.

17.

Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions.

Hendriks WT, Warren CR, Cowan CA.

Cell Stem Cell. 2016 Jan 7;18(1):53-65. doi: 10.1016/j.stem.2015.12.002. Review.

18.

Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report.

Gupta RM, Meissner TB, Cowan CA, Musunuru K.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):15-8. doi: 10.1161/ATVBAHA.115.305956. Epub 2015 Nov 5.

19.

Type 1 Diabetes and MicroRNA: It's Complicated.

Warren CR, Cowan CA.

Cell Metab. 2015 Aug 4;22(2):202-3. doi: 10.1016/j.cmet.2015.07.018.

20.

TALEN- and CRISPR/Cas9-Mediated Gene Editing in Human Pluripotent Stem Cells Using Lipid-Based Transfection.

Hendriks WT, Jiang X, Daheron L, Cowan CA.

Curr Protoc Stem Cell Biol. 2015 Aug 3;34:5B.3.1-25. doi: 10.1002/9780470151808.sc05b03s34.

PMID:
26237572
21.

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.

Patsch C, Challet-Meylan L, Thoma EC, Urich E, Heckel T, O'Sullivan JF, Grainger SJ, Kapp FG, Sun L, Christensen K, Xia Y, Florido MH, He W, Pan W, Prummer M, Warren CR, Jakob-Roetne R, Certa U, Jagasia R, Freskgård PO, Adatto I, Kling D, Huang P, Zon LI, Chaikof EL, Gerszten RE, Graf M, Iacone R, Cowan CA.

Nat Cell Biol. 2015 Aug;17(8):994-1003. doi: 10.1038/ncb3205. Epub 2015 Jul 27.

22.

Out-of-pocket health care expenditures, by insurance status, 2007-10.

Catlin MK, Poisal JA, Cowan CA.

Health Aff (Millwood). 2015 Jan;34(1):111-6. doi: 10.1377/hlthaff.2014.0422. Erratum in: Health Aff (Millwood). 2015 Feb;34(2):359. Health Aff (Millwood). 2015 Mar 1;34(3):540.

PMID:
25561651
23.

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, Rossi DJ, Cowan CA.

Cell Stem Cell. 2014 Nov 6;15(5):643-52. doi: 10.1016/j.stem.2014.10.004. Epub 2014 Nov 6.

24.

White-to-brown metabolic conversion of human adipocytes by JAK inhibition.

Moisan A, Lee YK, Zhang JD, Hudak CS, Meyer CA, Prummer M, Zoffmann S, Truong HH, Ebeling M, Kiialainen A, Gérard R, Xia F, Schinzel RT, Amrein KE, Cowan CA.

Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.

25.

A comparison of non-integrating reprogramming methods.

Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ.

Nat Biotechnol. 2015 Jan;33(1):58-63. doi: 10.1038/nbt.3070. Epub 2014 Dec 1.

26.

Genome editing for human gene therapy.

Meissner TB, Mandal PK, Ferreira LM, Rossi DJ, Cowan CA.

Methods Enzymol. 2014;546:273-95. doi: 10.1016/B978-0-12-801185-0.00013-1.

PMID:
25398345
27.

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

Veres A, Gosis BS, Ding Q, Collins R, Ragavendran A, Brand H, Erdin S, Cowan CA, Talkowski ME, Musunuru K.

Cell Stem Cell. 2014 Jul 3;15(1):27-30. doi: 10.1016/j.stem.2014.04.020. Erratum in: Cell Stem Cell. 2014 Aug 7;15(2):254. Cowan, Chad A [added].

28.

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing.

Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K.

Circ Res. 2014 Aug 15;115(5):488-92. doi: 10.1161/CIRCRESAHA.115.304351. Epub 2014 Jun 10.

29.

Differentiation of white and brown adipocytes from human pluripotent stem cells.

Lee YK, Cowan CA.

Methods Enzymol. 2014;538:35-47. doi: 10.1016/B978-0-12-800280-3.00003-7.

PMID:
24529432
30.

β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE.

Cell Metab. 2014 Jan 7;19(1):96-108. doi: 10.1016/j.cmet.2013.12.003.

31.

Liver in a dish.

Ding Q, Cowan CA.

Cell Res. 2013 Nov;23(11):1242-3. doi: 10.1038/cr.2013.117. Epub 2013 Aug 27.

32.

Genome editing in human pluripotent stem cells.

Peters DT, Cowan CA, Musunuru K.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2013 Apr 29.

33.

White to brite adipocyte transition and back again.

Lee YK, Cowan CA.

Nat Cell Biol. 2013 Jun;15(6):568-9. doi: 10.1038/ncb2776.

PMID:
23728463
34.

Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs.

Ding Q, Regan SN, Xia Y, Oostrom LA, Cowan CA, Musunuru K.

Cell Stem Cell. 2013 Apr 4;12(4):393-4. doi: 10.1016/j.stem.2013.03.006. No abstract available.

35.

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.

Mae SI, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K.

Nat Commun. 2013;4:1367. doi: 10.1038/ncomms2378.

36.

Genome-wide chromatin state transitions associated with developmental and environmental cues.

Zhu J, Adli M, Zou JY, Verstappen G, Coyne M, Zhang X, Durham T, Miri M, Deshpande V, De Jager PL, Bennett DA, Houmard JA, Muoio DM, Onder TT, Camahort R, Cowan CA, Meissner A, Epstein CB, Shoresh N, Bernstein BE.

Cell. 2013 Jan 31;152(3):642-54. doi: 10.1016/j.cell.2012.12.033. Epub 2013 Jan 17.

37.

A TALEN genome-editing system for generating human stem cell-based disease models.

Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA.

Cell Stem Cell. 2013 Feb 7;12(2):238-51. doi: 10.1016/j.stem.2012.11.011. Epub 2012 Dec 13.

38.

Expression analysis of macrodactyly identifies pleiotrophin upregulation.

Lau FH, Xia F, Kaplan A, Cerrato F, Greene AK, Taghinia A, Cowan CA, Labow BI.

PLoS One. 2012;7(7):e40423. doi: 10.1371/journal.pone.0040423. Epub 2012 Jul 27.

39.

Programming human pluripotent stem cells into white and brown adipocytes.

Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA.

Nat Cell Biol. 2012 Jan 15;14(2):209-19. doi: 10.1038/ncb2411.

40.

Cbx proteins help ESCs walk the line between self-renewal and differentiation.

Camahort R, Cowan CA.

Cell Stem Cell. 2012 Jan 6;10(1):4-6. doi: 10.1016/j.stem.2011.12.011.

41.

Efficient culturing and genetic manipulation of human pluripotent stem cells.

Schinzel RT, Ahfeldt T, Lau FH, Lee YK, Cowley A, Shen T, Peters D, Lum DH, Cowan CA.

PLoS One. 2011;6(12):e27495. doi: 10.1371/journal.pone.0027495. Epub 2011 Dec 15.

42.

Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue.

Lau FH, Deo RC, Mowrer G, Caplin J, Ahfeldt T, Kaplan A, Ptaszek L, Walker JD, Rosengard BR, Cowan CA.

PLoS One. 2011;6(10):e26092. doi: 10.1371/journal.pone.0026092. Epub 2011 Oct 11.

43.

Rapid cellular turnover in adipose tissue.

Rigamonti A, Brennand K, Lau F, Cowan CA.

PLoS One. 2011 Mar 2;6(3):e17637. doi: 10.1371/journal.pone.0017637.

44.

Identification of adult nephron progenitors capable of kidney regeneration in zebrafish.

Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ.

Nature. 2011 Feb 3;470(7332):95-100. doi: 10.1038/nature09669. Epub 2011 Jan 26.

45.

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.

Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ.

Nature. 2010 Aug 5;466(7307):714-9. doi: 10.1038/nature09266.

46.

Injection volumes of dextranomer/hyaluronic acid are increasing in the endoscopic management of vesicoureteral reflux.

Sorensen MD, Koyle MA, Cowan CA, Zamilpa I, Shnorhavorian M, Lendvay TS.

Pediatr Surg Int. 2010 May;26(5):509-13. doi: 10.1007/s00383-010-2558-9. Epub 2010 Feb 7.

PMID:
20140734
47.

Genome modification in human embryonic stem cells.

Tenzen T, Zembowicz F, Cowan CA.

J Cell Physiol. 2010 Feb;222(2):278-81. doi: 10.1002/jcp.21948. Review.

PMID:
19877154
48.

Photovoice as community-based participatory research: a qualitative review.

Hergenrather KC, Rhodes SD, Cowan CA, Bardhoshi G, Pula S.

Am J Health Behav. 2009 Nov-Dec;33(6):686-98. Review.

PMID:
19320617
49.

Induced pluripotent stem (iPS) cells: an up-to-the-minute review.

Lau F, Ahfeldt T, Osafune K, Akustsu H, Cowan CA.

F1000 Biol Rep. 2009 Nov 16;1:84. doi: 10.3410/B1-84.

50.

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.

Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H, Bernstein BE.

PLoS Genet. 2008 Oct;4(10):e1000242. doi: 10.1371/journal.pgen.1000242. Epub 2008 Oct 31.

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