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Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans.

Jüttner J, Szabo A, Gross-Scherf B, Morikawa RK, Rompani SB, Hantz P, Szikra T, Esposti F, Cowan CS, Bharioke A, Patino-Alvarez CP, Keles Ö, Kusnyerik A, Azoulay T, Hartl D, Krebs AR, Schübeler D, Hajdu RI, Lukats A, Nemeth J, Nagy ZZ, Wu KC, Wu RH, Xiang L, Fang XL, Jin ZB, Goldblum D, Hasler PW, Scholl HPN, Krol J, Roska B.

Nat Neurosci. 2019 Aug;22(8):1345-1356. doi: 10.1038/s41593-019-0431-2. Epub 2019 Jul 8.


Emerging roles for MEF2 in brain development and mental disorders.

Assali A, Harrington AJ, Cowan CW.

Curr Opin Neurobiol. 2019 May 23;59:49-58. doi: 10.1016/j.conb.2019.04.008. [Epub ahead of print] Review.


Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics.

Friesen M, Cowan CA.

Trends Endocrinol Metab. 2019 Jun;30(6):396-406. doi: 10.1016/j.tem.2019.03.002. Epub 2019 May 6. Review.


Generation of hypoimmunogenic human pluripotent stem cells.

Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10441-10446. doi: 10.1073/pnas.1902566116. Epub 2019 Apr 30.


Early-life stress, microbiota, and brain development: probiotics reverse the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant rats.

Cowan CSM, Stylianakis AA, Richardson R.

Dev Cogn Neurosci. 2019 Jun;37:100627. doi: 10.1016/j.dcn.2019.100627. Epub 2019 Apr 3.


Fathers' and mothers' attachment styles, couple conflict, parenting quality, and children's behavior problems: an intervention test of mediation.

Cowan PA, Cowan CP, Pruett MK, Pruett K.

Attach Hum Dev. 2019 Oct;21(5):532-550. doi: 10.1080/14616734.2019.1582600. Epub 2019 Mar 1.


Introduction: bringing dads back into the family.

Cowan PA, Cowan CP.

Attach Hum Dev. 2019 Oct;21(5):419-425. doi: 10.1080/14616734.2019.1582594. Epub 2019 Feb 22. No abstract available.


Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) regulates anxiety- and novelty-related behaviors.

Penrod RD, Kumar J, Smith LN, McCalley D, Nentwig TB, Hughes BW, Barry GM, Glover K, Taniguchi M, Cowan CW.

Genes Brain Behav. 2019 Feb 13:e12561. doi: 10.1111/gbb.12561. [Epub ahead of print]


Differential gene expression in the mesocorticolimbic system of innately high- and low-impulsive rats.

Moloney GM, van Oeffelen WEPA, Ryan FJ, van de Wouw M, Cowan C, Claesson MJ, Schellekens H, Dinan TG, Cryan JF.

Behav Brain Res. 2019 May 17;364:193-204. doi: 10.1016/j.bbr.2019.01.022. Epub 2019 Feb 6.


CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.

Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, Cowan CM, Ban Y, Stacey RG, Grad LI, McAlary L, Mackenzie IR, Foster LJ, Cashman NR.

J Biol Chem. 2019 Mar 8;294(10):3744-3759. doi: 10.1074/jbc.RA118.004825. Epub 2019 Jan 11.


What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review.

Kan JM, Cowan CSM, Ooi CY, Kasparian NA.

Dev Psychobiol. 2019 Jul;61(5):700-713. doi: 10.1002/dev.21819. Epub 2019 Jan 8.


Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety.

Anderson EM, Sun H, Guzman D, Taniguchi M, Cowan CW, Maze I, Nestler EJ, Self DW.

Neuropsychopharmacology. 2019 Jul;44(8):1370-1376. doi: 10.1038/s41386-018-0305-4. Epub 2018 Dec 26.


Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration.

Macé É, Montaldo G, Trenholm S, Cowan C, Brignall A, Urban A, Roska B.

Neuron. 2018 Dec 5;100(5):1241-1251.e7. doi: 10.1016/j.neuron.2018.11.031.


Feeding melancholic microbes: MyNewGut recommendations on diet and mood.

Dinan TG, Stanton C, Long-Smith C, Kennedy P, Cryan JF, Cowan CSM, Cenit MC, van der Kamp JW, Sanz Y.

Clin Nutr. 2018 Nov 17. pii: S0261-5614(18)32543-3. doi: 10.1016/j.clnu.2018.11.010. [Epub ahead of print] Review.


The diagnosis conundrum: Comparison of crowdsourced and expert assessments of toddlers with high and low risk of autism spectrum disorder.

Myers E, Stone WL, Bernier R, Lendvay T, Comstock B, Cowan C.

Autism Res. 2018 Dec;11(12):1629-1634. doi: 10.1002/aur.2030. Epub 2018 Nov 26.


Psychosocial aspects of the lived experience of multiple sclerosis: personal perspectives.

Cowan CK, Pierson JM, Leggat SG.

Disabil Rehabil. 2018 Sep 27:1-11. doi: 10.1080/09638288.2018.1498545. [Epub ahead of print]


It is a complex issue: emerging connections between epigenetic regulators in drug addiction.

Anderson EM, Penrod RD, Barry SM, Hughes BW, Taniguchi M, Cowan CW.

Eur J Neurosci. 2018 Sep 25. doi: 10.1111/ejn.14170. [Epub ahead of print] Review.


A precision medicine approach to pharmacological adjuncts to extinction: a call to broaden research.

King G, Baker KD, Bisby MA, Chan D, Cowan CSM, Stylianakis AA, Zimmermann KS, Richardson R.

Psychopharmacology (Berl). 2019 Jan;236(1):143-161. doi: 10.1007/s00213-018-4999-0. Epub 2018 Aug 16. Review.


Making Sense of … the Microbiome in Psychiatry.

Bastiaanssen TFS, Cowan CSM, Claesson MJ, Dinan TG, Cryan JF.

Int J Neuropsychopharmacol. 2019 Jan 1;22(1):37-52. doi: 10.1093/ijnp/pyy067.


Early-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation.

Cowan CSM, Richardson R.

Dev Psychobiol. 2019 Jul;61(5):679-687. doi: 10.1002/dev.21765. Epub 2018 Jul 24.


A Brief Guide to Studying Fear in Developing Rodents: Important Considerations and Common Pitfalls.

Cowan CSM, Richardson R.

Curr Protoc Neurosci. 2018 Apr;83(1):e44. doi: 10.1002/cpns.44. Review.


An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection.

Lang J, Cheng Y, Rolfe A, Hammack C, Vera D, Kyle K, Wang J, Meissner TB, Ren Y, Cowan C, Tang H.

Stem Cell Reports. 2018 Aug 14;11(2):348-362. doi: 10.1016/j.stemcr.2018.06.006. Epub 2018 Jul 5.


Any Way You Splice It: New Molecular Mechanisms of Cocaine-Induced Alternative Gene Expression.

Penrod RD, Anderson EM, Cowan CW.

Biol Psychiatry. 2018 Aug 1;84(3):162-164. doi: 10.1016/j.biopsych.2018.06.004. Epub 2018 Jun 22. No abstract available.


Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A.

Transplantation. 2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217. Review.


A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers.

Silverman JM, Gibbs E, Peng X, Martens KM, Balducci C, Wang J, Yousefi M, Cowan CM, Lamour G, Louadi S, Ban Y, Robert J, Stukas S, Forloni G, Hsiung GR, Plotkin SS, Wellington CL, Cashman NR.

ACS Chem Neurosci. 2018 Jul 18;9(7):1591-1606. doi: 10.1021/acschemneuro.7b00469. Epub 2018 Apr 16.


Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving.

Li X, Carreria MB, Witonsky KR, Zeric T, Lofaro OM, Bossert JM, Zhang J, Surjono F, Richie CT, Harvey BK, Son H, Cowan CW, Nestler EJ, Shaham Y.

Biol Psychiatry. 2018 Aug 1;84(3):213-222. doi: 10.1016/j.biopsych.2017.12.008. Epub 2017 Dec 29.


High-impact workflow changes for value-based care success.

Saunders C, Alcorn C, Cowan C, Fabbiano M.

Am J Manag Care. 2017 Dec;23(13 Spec No.):SP514-SP516. No abstract available.


Improving the Consent Process in Foot and Ankle Surgery With the Use of Personalized Patient Literature.

Howard N, Cowan C, Ahluwalia R, Wright A, Hennessy M, Jackson G, Platt S.

J Foot Ankle Surg. 2018 Jan - Feb;57(1):81-85. doi: 10.1053/j.jfas.2017.08.011.


Virus stamping for targeted single-cell infection in vitro and in vivo.

Schubert R, Trenholm S, Balint K, Kosche G, Cowan CS, Mohr MA, Munz M, Martinez-Martin D, Fläschner G, Newton R, Krol J, Scherf BG, Yonehara K, Wertz A, Ponti A, Ghanem A, Hillier D, Conzelmann KK, Müller DJ, Roska B.

Nat Biotechnol. 2018 Jan;36(1):81-88. doi: 10.1038/nbt.4034. Epub 2017 Dec 18.


Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior.

Guzman D, Carreira MB, Friedman AK, Adachi M, Neve RL, Monteggia LM, Han MH, Cowan CW, Self DW.

J Neurosci. 2018 Jan 17;38(3):575-585. doi: 10.1523/JNEUROSCI.2828-16.2017. Epub 2017 Dec 1.


Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.

Xu YX, Redon V, Yu H, Querbes W, Pirruccello J, Liebow A, Deik A, Trindade K, Wang X, Musunuru K, Clish CB, Cowan C, Fizgerald K, Rader D, Kathiresan S.

Atherosclerosis. 2018 Jan;268:196-206. doi: 10.1016/j.atherosclerosis.2017.08.031. Epub 2017 Sep 21.


Rethinking the Role of Thought Suppression in Psychological Models and Treatment.

Cowan CSM, Wong SF, Le L.

J Neurosci. 2017 Nov 22;37(47):11293-11295. doi: 10.1523/JNEUROSCI.2511-17.2017. No abstract available.


Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling.

Cowan CSM, Hoban AE, Ventura-Silva AP, Dinan TG, Clarke G, Cryan JF.

Bioessays. 2018 Jan;40(1). doi: 10.1002/bies.201700172. Epub 2017 Nov 17. Review.


FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism.

Friesen M, Cowan CA.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):254-260. doi: 10.1016/j.bbrc.2017.11.008. Epub 2017 Nov 3.


Exome-wide association study of plasma lipids in >300,000 individuals.

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC, Boehnke M, Boerwinkle E, Bork-Jensen J, Bottinger EP, Brandslund I, Brown M, Busonero F, Caulfield MJ, Chambers JC, Chasman DI, Chen YE, Chen YI, Chowdhury R, Christensen C, Chu AY, Connell JM, Cucca F, Cupples LA, Damrauer SM, Davies G, Deary IJ, Dedoussis G, Denny JC, Dominiczak A, Dubé MP, Ebeling T, Eiriksdottir G, Esko T, Farmaki AE, Feitosa MF, Ferrario M, Ferrieres J, Ford I, Fornage M, Franks PW, Frayling TM, Frikke-Schmidt R, Fritsche LG, Frossard P, Fuster V, Ganesh SK, Gao W, Garcia ME, Gieger C, Giulianini F, Goodarzi MO, Grallert H, Grarup N, Groop L, Grove ML, Gudnason V, Hansen T, Harris TB, Hayward C, Hirschhorn JN, Holmen OL, Huffman J, Huo Y, Hveem K, Jabeen S, Jackson AU, Jakobsdottir J, Jarvelin MR, Jensen GB, Jørgensen ME, Jukema JW, Justesen JM, Kamstrup PR, Kanoni S, Karpe F, Kee F, Khera AV, Klarin D, Koistinen HA, Kooner JS, Kooperberg C, Kuulasmaa K, Kuusisto J, Laakso M, Lakka T, Langenberg C, Langsted A, Launer LJ, Lauritzen T, Liewald DCM, Lin LA, Linneberg A, Loos RJF, Lu Y, Lu X, Mägi R, Malarstig A, Manichaikul A, Manning AK, Mäntyselkä P, Marouli E, Masca NGD, Maschio A, Meigs JB, Melander O, Metspalu A, Morris AP, Morrison AC, Mulas A, Müller-Nurasyid M, Munroe PB, Neville MJ, Nielsen JB, Nielsen SF, Nordestgaard BG, Ordovas JM, Mehran R, O'Donnell CJ, Orho-Melander M, Molony CM, Muntendam P, Padmanabhan S, Palmer CNA, Pasko D, Patel AP, Pedersen O, Perola M, Peters A, Pisinger C, Pistis G, Polasek O, Poulter N, Psaty BM, Rader DJ, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Rich SS, Ridker PM, Rioux JD, Robertson NR, Roden DM, Rotter JI, Rudan I, Salomaa V, Samani NJ, Sanna S, Sattar N, Schmidt EM, Scott RA, Sever P, Sevilla RS, Shaffer CM, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith BH, Somayajula S, Southam L, Spector TD, Speliotes EK, Starr JM, Stirrups KE, Stitziel N, Strauch K, Stringham HM, Surendran P, Tada H, Tall AR, Tang H, Tardif JC, Taylor KD, Trompet S, Tsao PS, Tuomilehto J, Tybjaerg-Hansen A, van Zuydam NR, Varbo A, Varga TV, Virtamo J, Waldenberger M, Wang N, Wareham NJ, Warren HR, Weeke PE, Weinstock J, Wessel J, Wilson JG, Wilson PWF, Xu M, Yaghootkar H, Young R, Zeggini E, Zhang H, Zheng NS, Zhang W, Zhang Y, Zhou W, Zhou Y, Zoledziewska M; Charge Diabetes Working Group; EPIC-InterAct Consortium; EPIC-CVD Consortium; GOLD Consortium; VA Million Veteran Program, Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S.

Nat Genet. 2017 Dec;49(12):1758-1766. doi: 10.1038/ng.3977. Epub 2017 Oct 30.


Humanity in a Dish: Population Genetics with iPSCs.

Warren CR, Cowan CA.

Trends Cell Biol. 2018 Jan;28(1):46-57. doi: 10.1016/j.tcb.2017.09.006. Epub 2017 Nov 23. Review.


HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.

Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Kalivas PW, Self DW, Lin Y, Cowan CW.

Neuron. 2017 Sep 27;96(1):130-144.e6. doi: 10.1016/j.neuron.2017.09.015.


High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture.

Robert J, Button EB, Stukas S, Boyce GK, Gibbs E, Cowan CM, Gilmour M, Cheng WH, Soo SK, Yuen B, Bahrabadi A, Kang K, Kulic I, Francis G, Cashman N, Wellington CL.

Mol Neurodegener. 2017 Aug 22;12(1):60. doi: 10.1186/s13024-017-0201-0.


BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors.

Anderson EM, Wissman AM, Chemplanikal J, Buzin N, Guzman D, Larson EB, Neve RL, Nestler EJ, Cowan CW, Self DW.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9469-9474. doi: 10.1073/pnas.1702441114. Epub 2017 Aug 14.


Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J.

Cell Stem Cell. 2017 Sep 7;21(3):305-318.e8. doi: 10.1016/j.stem.2017.07.008. Epub 2017 Aug 10.


Elevated IOP alters the space-time profiles in the center and surround of both ON and OFF RGCs in mouse.

Sabharwal J, Seilheimer RL, Tao X, Cowan CS, Frankfort BJ, Wu SM.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8859-8864. doi: 10.1073/pnas.1706994114. Epub 2017 Jul 31.


Utility of CRISPR/Cas9 systems in hematology research.

Lucas D, O'Leary HA, Ebert BL, Cowan CA, Tremblay CS.

Exp Hematol. 2017 Oct;54:1-3. doi: 10.1016/j.exphem.2017.06.006. Epub 2017 Jun 28. Review.


Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice.

Edwards MR, Dai R, Heid B, Cecere TE, Khan D, Mu Q, Cowan C, Luo XM, Ahmed SA.

Int Immunol. 2017 Jun 1;29(6):263-276. doi: 10.1093/intimm/dxx033.


Novel role and regulation of HDAC4 in cocaine-related behaviors.

Penrod RD, Carreira MB, Taniguchi M, Kumar J, Maddox SA, Cowan CW.

Addict Biol. 2018 Mar;23(2):653-664. doi: 10.1111/adb.12522. Epub 2017 Jun 21.


TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration.

Koblish M, Carr R 3rd, Siuda ER, Rominger DH, Gowen-MacDonald W, Cowan CL, Crombie AL, Violin JD, Lark MW.

J Pharmacol Exp Ther. 2017 Aug;362(2):254-262. doi: 10.1124/jpet.117.241117. Epub 2017 May 22.


Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy.

Sealey MA, Vourkou E, Cowan CM, Bossing T, Quraishe S, Grammenoudi S, Skoulakis EMC, Mudher A.

Neurobiol Dis. 2017 Sep;105:74-83. doi: 10.1016/j.nbd.2017.05.003. Epub 2017 May 11.


Parents as Partners: A U.K. Trial of a U.S. Couples-Based Parenting Intervention For At-Risk Low-Income Families.

Casey P, Cowan PA, Cowan CP, Draper L, Mwamba N, Hewison D.

Fam Process. 2017 Sep;56(3):589-606. doi: 10.1111/famp.12289. Epub 2017 Apr 24.


Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.

Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo RC, Cowan CA.

Stem Cell Reports. 2017 May 9;8(5):1164-1173. doi: 10.1016/j.stemcr.2017.03.014. Epub 2017 Apr 13.


Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA.

Cell Stem Cell. 2017 Apr 6;20(4):547-557.e7. doi: 10.1016/j.stem.2017.01.010.


The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics.

Warren CR, Jaquish CE, Cowan CA.

Cell Stem Cell. 2017 Apr 6;20(4):431-433. doi: 10.1016/j.stem.2017.03.021.

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