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Items: 1 to 50 of 58

1.

Molecular cloning of an ester-forming triterpenoid: UDP-glucose 28-O-glucosyltransferase involved in saponin biosynthesis from the medicinal plant Centella asiatica.

de Costa F, Barber CJS, Kim YB, Reed DW, Zhang H, Fett-Neto AG, Covello PS.

Plant Sci. 2017 Sep;262:9-17. doi: 10.1016/j.plantsci.2017.05.009. Epub 2017 May 23.

PMID:
28716424
2.

Genetically engineered hairy root cultures of Hyoscyamus senecionis and H. muticus: ploidy as a promising parameter in the metabolic engineering of tropane alkaloids.

Dehghan E, Reed DW, Covello PS, Hasanpour Z, Palazon J, Oksman-Caldentey KM, Ahmadi FS.

Plant Cell Rep. 2017 Oct;36(10):1615-1626. doi: 10.1007/s00299-017-2178-0. Epub 2017 Jul 13.

PMID:
28707113
3.

Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.

Chekan JR, Estrada P, Covello PS, Nair SK.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6551-6556. doi: 10.1073/pnas.1620499114. Epub 2017 Jun 5.

4.

Purification of a Recombinant Polyhistidine-Tagged Glucosyltransferase Using Immobilized Metal-Affinity Chromatography (IMAC).

de Costa F, Barber CJ, Pujara PT, Reed DW, Covello PS.

Methods Mol Biol. 2016;1405:91-7. doi: 10.1007/978-1-4939-3393-8_9.

PMID:
26843168
5.

From Plant Extract to a cDNA Encoding a Glucosyltransferase Candidate: Proteomics and Transcriptomics as Tools to Help Elucidate Saponin Biosynthesis in Centella asiatica.

de Costa F, Barber CJ, Reed DW, Covello PS.

Methods Mol Biol. 2016;1405:43-8. doi: 10.1007/978-1-4939-3393-8_5.

PMID:
26843164
6.

Production of Triterpenoid Sapogenins in Hairy Root Cultures of Silene vulgaris.

Kim YB, Reed DW, Covello PS.

Nat Prod Commun. 2015 Nov;10(11):1919-22.

PMID:
26749827
7.

An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis.

Dehghan E, Shahriari Ahmadi F, Ghotbi Ravandi E, Reed DW, Covello PS, Bahrami AR.

Plant Physiol Biochem. 2013 Sep;70:188-94. doi: 10.1016/j.plaphy.2013.05.007. Epub 2013 May 18.

PMID:
23786817
8.

Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest.

Xiao M, Zhang Y, Chen X, Lee EJ, Barber CJ, Chakrabarty R, Desgagné-Penix I, Haslam TM, Kim YB, Liu E, MacNevin G, Masada-Atsumi S, Reed DW, Stout JM, Zerbe P, Zhang Y, Bohlmann J, Covello PS, De Luca V, Page JE, Ro DK, Martin VJ, Facchini PJ, Sensen CW.

J Biotechnol. 2013 Jul 10;166(3):122-34. doi: 10.1016/j.jbiotec.2013.04.004. Epub 2013 Apr 16.

9.

High-level semi-synthetic production of the potent antimalarial artemisinin.

Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD.

Nature. 2013 Apr 25;496(7446):528-32. doi: 10.1038/nature12051. Epub 2013 Apr 10.

PMID:
23575629
10.

The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzyme.

Barber CJ, Pujara PT, Reed DW, Chiwocha S, Zhang H, Covello PS.

J Biol Chem. 2013 May 3;288(18):12500-10. doi: 10.1074/jbc.M112.437947. Epub 2013 Mar 13.

11.

Identification and quantification of cyclolinopeptides in five flaxseed cultivars.

Gui B, Shim YY, Datla RS, Covello PS, Stone SL, Reaney MJ.

J Agric Food Chem. 2012 Sep 5;60(35):8571-9. doi: 10.1021/jf301847u. Epub 2012 Aug 24.

PMID:
22897677
12.

Topological study of mechanistic diversity in conjugated fatty acid biosynthesis.

Bhar P, Reed DW, Covello PS, Buist PH.

Angew Chem Int Ed Engl. 2012 Jul 2;51(27):6686-90. doi: 10.1002/anie.201202080. Epub 2012 May 23. No abstract available.

PMID:
22623346
13.

Synthetic biosystems for the production of high-value plant metabolites.

Facchini PJ, Bohlmann J, Covello PS, De Luca V, Mahadevan R, Page JE, Ro DK, Sensen CW, Storms R, Martin VJ.

Trends Biotechnol. 2012 Mar;30(3):127-31. doi: 10.1016/j.tibtech.2011.10.001. Epub 2011 Dec 29.

PMID:
22209518
14.

Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases.

Weathers PJ, Arsenault PR, Covello PS, McMickle A, Teoh KH, Reed DW.

Phytochem Rev. 2011 Jun;10(2):173-183.

15.

The biosynthesis of Caryophyllaceae-like cyclic peptides in Saponaria vaccaria L. from DNA-encoded precursors.

Condie JA, Nowak G, Reed DW, Balsevich JJ, Reaney MJ, Arnison PG, Covello PS.

Plant J. 2011 Aug;67(4):682-90. doi: 10.1111/j.1365-313X.2011.04626.x. Epub 2011 Jun 10.

16.

Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants.

Maes L, Van Nieuwerburgh FC, Zhang Y, Reed DW, Pollier J, Vande Casteele SR, Inzé D, Covello PS, Deforce DL, Goossens A.

New Phytol. 2011 Jan;189(1):176-89. doi: 10.1111/j.1469-8137.2010.03466.x. Epub 2010 Sep 27.

17.

The production of artemisinin precursors in tobacco.

Zhang Y, Nowak G, Reed DW, Covello PS.

Plant Biotechnol J. 2011 May;9(4):445-54. doi: 10.1111/j.1467-7652.2010.00556.x. Epub 2010 Aug 18.

18.

A glandular trichome-specific monoterpene alcohol dehydrogenase from Artemisia annua.

Polichuk DR, Zhang Y, Reed DW, Schmidt JF, Covello PS.

Phytochemistry. 2010 Aug;71(11-12):1264-9. doi: 10.1016/j.phytochem.2010.04.026. Epub 2010 Jun 4.

PMID:
20621795
19.

Structural control of chemoselectivity, stereoselectivity, and substrate specificity in membrane-bound fatty acid acetylenases and desaturases.

Gagné SJ, Reed DW, Gray GR, Covello PS.

Biochemistry. 2009 Dec 29;48(51):12298-304. doi: 10.1021/bi901605d.

PMID:
19950909
20.

Mechanistic insights into the cytochrome P450-mediated oxidation and rearrangement of littorine in tropane alkaloid biosynthesis.

Nasomjai P, Reed DW, Tozer DJ, Peach MJ, Slawin AM, Covello PS, O'Hagan D.

Chembiochem. 2009 Sep 21;10(14):2382-93. doi: 10.1002/cbic.200900318.

PMID:
19693762
21.

Making artemisinin.

Covello PS.

Phytochemistry. 2008 Dec;69(17):2881-5. doi: 10.1016/j.phytochem.2008.10.001. Epub 2008 Nov 1.

PMID:
18977499
22.

Systemic acquired resistance in canola is linked with pathogenesis-related gene expression and requires salicylic Acid.

Potlakayala SD, Reed DW, Covello PS, Fobert PR.

Phytopathology. 2007 Jul;97(7):794-802. doi: 10.1094/PHYTO-97-7-0794.

23.

The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.

Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS.

J Biol Chem. 2008 Aug 1;283(31):21501-8. doi: 10.1074/jbc.M803090200. Epub 2008 May 21.

24.

High efficiency Agrobacterium rhizogenes-mediated transformation of Saponaria vaccaria L. (Caryophyllaceae) using fluorescence selection.

Schmidt JF, Moore MD, Pelcher LE, Covello PS.

Plant Cell Rep. 2007 Sep;26(9):1547-54. Epub 2007 May 22.

PMID:
17516073
25.

Primary structure, regioselectivity, and evolution of the membrane-bound fatty acid desaturases of Claviceps purpurea.

Meesapyodsuk D, Reed DW, Covello PS, Qiu X.

J Biol Chem. 2007 Jul 13;282(28):20191-9. Epub 2007 May 17.

26.

Functional genomics and the biosynthesis of artemisinin.

Covello PS, Teoh KH, Polichuk DR, Reed DW, Nowak G.

Phytochemistry. 2007 Jul;68(14):1864-71. Epub 2007 Mar 30.

PMID:
17399751
27.

Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase.

Meesapyodsuk D, Balsevich J, Reed DW, Covello PS.

Plant Physiol. 2007 Feb;143(2):959-69. Epub 2006 Dec 15.

28.

Expression of the Arabidopsis ADS1 gene in Brassica juncea results in a decreased level of total saturated fatty acids.

Yao K, Bacchetto RG, Lockhart KM, Friesen LJ, Potts DA, Covello PS, Taylor DC.

Plant Biotechnol J. 2003 May;1(3):221-9.

29.

Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement.

Li R, Reed DW, Liu E, Nowak J, Pelcher LE, Page JE, Covello PS.

Chem Biol. 2006 May;13(5):513-20.

30.
31.

Domain swapping localizes the structural determinants of regioselectivity in membrane-bound fatty acid desaturases of Caenorhabditis elegans.

Sasata RJ, Reed DW, Loewen MC, Covello PS.

J Biol Chem. 2004 Sep 17;279(38):39296-302. Epub 2004 Jun 29. Erratum in: J Biol Chem. 2006 Jun 23;281(25):17540.

32.

Mechanistic study of an improbable reaction: alkene dehydrogenation by the delta12 acetylenase of Crepis alpina.

Reed DW, Polichuk DR, Buist PH, Ambrose SJ, Sasata RJ, Savile CK, Ross AR, Covello PS.

J Am Chem Soc. 2003 Sep 3;125(35):10635-40.

PMID:
12940747
33.

Mechanistic characterization of omega-3 desaturation in the green alga Chlorella vulgaris.

Daligault F, Reed DW, Savile CK, Nugier-Chauvin C, Patin H, Covello PS, Buist PH.

Phytochemistry. 2003 Aug;63(7):739-44.

PMID:
12877913
34.

Mechanism of 1,4-dehydrogenation catalyzed by a fatty acid (1,4)-desaturase of Calendula officinalis.

Reed DW, Savile CK, Qiu X, Buist PH, Covello PS.

Eur J Biochem. 2002 Oct;269(20):5024-9.

35.

A desaturase-like protein from white spruce is a Delta(9) desaturase.

Marillia EF, Giblin EM, Covello PS, Taylor DC.

FEBS Lett. 2002 Aug 28;526(1-3):49-52.

36.

High-level production of gamma-linolenic acid in Brassica juncea using a delta6 desaturase from Pythium irregulare.

Hong H, Datla N, Reed DW, Covello PS, MacKenzie SL, Qiu X.

Plant Physiol. 2002 May;129(1):354-62.

37.

Probing the mechanism of a cyanobacterial Delta9 fatty acid desaturase from Spirulina platensis C1 (Arthrospira sp. PCC 9438).

Meesapyodsuk D, Reed DW, Cheevadhanarak S, Deshnium P, Covello PS.

Comp Biochem Physiol B Biochem Mol Biol. 2001 Jul;129(4):831-5.

PMID:
11435137
38.

Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight.

Jako C, Kumar A, Wei Y, Zou J, Barton DL, Giblin EM, Covello PS, Taylor DC.

Plant Physiol. 2001 Jun;126(2):861-74.

39.

Substrate specificity, regioselectivity and cryptoregiochemistry of plant and animal omega-3 fatty acid desaturases.

Meesapyodsuk D, Reed DW, Savile CK, Buist PH, Schäfer UA, Ambrose SJ, Covello PS.

Biochem Soc Trans. 2000 Dec;28(6):632-5.

PMID:
11171151
40.

Identification and analysis of a gene from Calendula officinalis encoding a fatty acid conjugase.

Qiu X, Reed DW, Hong H, MacKenzie SL, Covello PS.

Plant Physiol. 2001 Feb;125(2):847-55.

41.

Characterization of the regiochemistry and cryptoregiochemistry of a Caenorhabditis elegans fatty acid desaturase (FAT-1) expressed in Saccharomyces cerevisiae.

Meesapyodsuk D, Reed DW, Savile CK, Buist PH, Ambrose SJ, Covello PS.

Biochemistry. 2000 Oct 3;39(39):11948-54.

PMID:
11009608
42.
43.

An example of intron junctional sliding in the gene families encoding squalene monooxygenase homologues in Arabidopsis thaliana and Brassica napus.

Schäfer UA, Reed DW, Hunter DG, Yao K, Weninger AM, Tsang EW, Reaney MJ, MacKenzie SL, Covello PS.

Plant Mol Biol. 1999 Mar;39(4):721-8.

PMID:
10350086
44.
46.

Alteration of seed fatty acid composition by an ethyl methanesulfonate-induced mutation in Arabidopsis thaliana affecting diacylglycerol acyltransferase activity.

Katavic V, Reed DW, Taylor DC, Giblin EM, Barton DL, Zou J, Mackenzie SL, Covello PS, Kunst L.

Plant Physiol. 1995 May;108(1):399-409.

47.

On the evolution of RNA editing.

Covello PS, Gray MW.

Trends Genet. 1993 Aug;9(8):265-8. Review.

PMID:
8379005
48.

RNA editing in plant mitochondria and chloroplasts.

Gray MW, Covello PS.

FASEB J. 1993 Jan;7(1):64-71. Review.

PMID:
8422976
50.

Characterization of transcription initiation sites on the soybean mitochondrial genome allows identification of a transcription-associated sequence motif.

Brown GG, Auchincloss AH, Covello PS, Gray MW, Menassa R, Singh M.

Mol Gen Genet. 1991 Sep;228(3):345-55.

PMID:
1716724

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