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A-Type KV Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction.

Zemel BM, Ritter DM, Covarrubias M, Muqeem T.

Front Mol Neurosci. 2018 Aug 6;11:253. doi: 10.3389/fnmol.2018.00253. eCollection 2018. Review.


Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites.

Wang Y, Yang E, Wells MM, Bondarenko V, Woll K, Carnevale V, Granata D, Klein ML, Eckenhoff RG, Dailey WP, Covarrubias M, Tang P, Xu Y.

J Gen Physiol. 2018 Sep 3;150(9):1317-1331. doi: 10.1085/jgp.201811993. Epub 2018 Jul 17.


Propofol inhibits prokaryotic voltage-gated Na+ channels by promoting activation-coupled inactivation.

Yang E, Granata D, Eckenhoff RG, Carnevale V, Covarrubias M.

J Gen Physiol. 2018 Sep 3;150(9):1299-1316. doi: 10.1085/jgp.201711924. Epub 2018 Jul 17.


Identification of a type II cystatin in Fragaria chiloensis: A proteinase inhibitor differentially regulated during achene development and in response to biotic stress-related stimuli.

Aceituno-Valenzuela U, Covarrubias MP, Aguayo MF, Valenzuela-Riffo F, Espinoza A, Gaete-Eastman C, Herrera R, Handford M, Norambuena L.

Plant Physiol Biochem. 2018 Aug;129:158-167. doi: 10.1016/j.plaphy.2018.05.021. Epub 2018 May 19.


Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration.

Cheng L, Al-Owais M, Covarrubias ML, Koch WJ, Manning DR, Peers C, Riobo-Del Galdo NA.

J Biol Chem. 2018 Jul 13;293(28):11022-11032. doi: 10.1074/jbc.RA118.001989. Epub 2018 May 25.


Changes in cell wall pectins and their relation to postharvest mesocarp softening of "Hass" avocados (Persea americana Mill.).

Defilippi BG, Ejsmentewicz T, Covarrubias MP, Gudenschwager O, Campos-Vargas R.

Plant Physiol Biochem. 2018 Jul;128:142-151. doi: 10.1016/j.plaphy.2018.05.018. Epub 2018 May 17.


Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics.

Yang E, Zhi L, Liang Q, Covarrubias M.

Methods Enzymol. 2018;602:339-368. doi: 10.1016/bs.mie.2018.01.013. Epub 2018 Mar 15.


Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn.

Muqeem T, Ghosh B, Pinto V, Lepore AC, Covarrubias M.

J Neurosci. 2018 Apr 11;38(15):3729-3740. doi: 10.1523/JNEUROSCI.3212-17.2018. Epub 2018 Mar 14.


Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.

Woll KA, Zhou X, Bhanu NV, Garcia BA, Covarrubias M, Miller KW, Eckenhoff RG.

FASEB J. 2018 Aug;32(8):4172-4189. doi: 10.1096/fj.201701347R. Epub 2018 Mar 5.


Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons.

Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M.

J Neurosci. 2017 Aug 23;37(34):8256-8272. doi: 10.1523/JNEUROSCI.0434-17.2017. Epub 2017 Jul 27.


Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation.

Woll KA, Peng W, Liang Q, Zhi L, Jacobs JA, Maciunas L, Bhanu N, Garcia BA, Covarrubias M, Loll PJ, Dailey WP, Eckenhoff RG.

ACS Chem Biol. 2017 May 19;12(5):1353-1362. doi: 10.1021/acschembio.7b00222. Epub 2017 Apr 3.


Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels.

Bu W, Liang Q, Zhi L, Maciunas L, Loll PJ, Eckenhoff RG, Covarrubias M.

Mol Neurobiol. 2018 Feb;55(2):1692-1702. doi: 10.1007/s12035-017-0437-2. Epub 2017 Feb 15.


Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions.

Fineberg JD, Szanto TG, Panyi G, Covarrubias M.

Sci Rep. 2016 Aug 9;6:31131. doi: 10.1038/srep31131.


A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.

Woll KA, Murlidaran S, Pinch BJ, Hénin J, Wang X, Salari R, Covarrubias M, Dailey WP, Brannigan G, Garcia BA, Eckenhoff RG.

J Biol Chem. 2016 Sep 23;291(39):20473-86. doi: 10.1074/jbc.M116.736975. Epub 2016 Jul 26.


Positive Allosteric Modulation of Kv Channels by Sevoflurane: Insights into the Structural Basis of Inhaled Anesthetic Action.

Liang Q, Anderson WD, Jones ST, Souza CS, Hosoume JM, Treptow W, Covarrubias M.

PLoS One. 2015 Nov 24;10(11):e0143363. doi: 10.1371/journal.pone.0143363. eCollection 2015.


Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics.

Covarrubias M, Barber AF, Carnevale V, Treptow W, Eckenhoff RG.

Biophys J. 2015 Nov 17;109(10):2003-11. doi: 10.1016/j.bpj.2015.09.032. Review.


Kv3.4 channel function and dysfunction in nociceptors.

Ritter DM, Zemel BM, Lepore AC, Covarrubias M.

Channels (Austin). 2015;9(4):209-17. doi: 10.1080/19336950.2015.1056949. Epub 2015 Jun 3.


Role for the propofol hydroxyl in anesthetic protein target molecular recognition.

Woll KA, Weiser BP, Liang Q, Meng T, McKinstry-Wu A, Pinch B, Dailey WP, Gao WD, Covarrubias M, Eckenhoff RG.

ACS Chem Neurosci. 2015 Jun 17;6(6):927-35. doi: 10.1021/acschemneuro.5b00078. Epub 2015 Mar 30.


Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury.

Ritter DM, Zemel BM, Hala TJ, O'Leary ME, Lepore AC, Covarrubias M.

J Neurosci. 2015 Jan 21;35(3):1260-73. doi: 10.1523/JNEUROSCI.1594-14.2015.


Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms.

Barber AF, Carnevale V, Klein ML, Eckenhoff RG, Covarrubias M.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6726-31. doi: 10.1073/pnas.1405768111. Epub 2014 Apr 21.


Force sensitive handles and capacitive touch sensor for driving a flexible haptic-based immersive system.

Covarrubias M, Bordegoni M, Cugini U.

Sensors (Basel). 2013 Oct 9;13(10):13487-508. doi: 10.3390/s131013487.


Improving manual skills in persons with disabilities (PWD) through a multimodal assistance system.

Covarrubias M, Gatti E, Bordegoni M, Cugini U, Mansutti A.

Disabil Rehabil Assist Technol. 2014 Jul;9(4):335-43. doi: 10.3109/17483107.2013.799238. Epub 2013 May 21.


Dipeptidyl-peptidase-like proteins cast in a new role: enabling scorpion toxin block of A-type K+ channels.

Covarrubias M.

J Physiol. 2013 May 15;591(10):2373-4. doi: 10.1113/jphysiol.2013.254441. No abstract available.


[Prognostic role of NT-proBNP in emergency department in the elderly with acute heart failure].

Martín Sánchez FJ, Covarrubias M, Terán C, Llorens P, Herrero P, Jacob J, Gil V, Fernández C, Miró O; grupo ICA-SEMES.

Rev Esp Geriatr Gerontol. 2013 Jul-Aug;48(4):155-60. doi: 10.1016/j.regg.2012.11.010. Epub 2013 Mar 23. Spanish.


Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels.

Fineberg JD, Ritter DM, Covarrubias M.

J Gen Physiol. 2012 Nov;140(5):513-27. doi: 10.1085/jgp.201210869.


Novel activation of voltage-gated K(+) channels by sevoflurane.

Barber AF, Liang Q, Covarrubias M.

J Biol Chem. 2012 Nov 23;287(48):40425-32. doi: 10.1074/jbc.M112.405787. Epub 2012 Oct 4.


Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR.

Zhang J, Qu X, Covarrubias M, Germann MW.

Biochim Biophys Acta. 2013 Feb;1828(2):595-601. doi: 10.1016/j.bbamem.2012.09.025. Epub 2012 Sep 29.


TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production.

Li S, Kendall SE, Raices R, Finlay J, Covarrubias M, Liu Z, Lowe G, Lin YH, Teh YH, Leigh V, Dhillon S, Flanagan S, Aboody KS, Glackin CA.

BMC Biol. 2012 Aug 14;10:73. doi: 10.1186/1741-7007-10-73.


Identification of a 4-microRNA signature for clear cell renal cell carcinoma metastasis and prognosis.

Wu X, Weng L, Li X, Guo C, Pal SK, Jin JM, Li Y, Nelson RA, Mu B, Onami SH, Wu JJ, Ruel NH, Wilczynski SP, Gao H, Covarrubias M, Figlin RA, Weiss LM, Wu H.

PLoS One. 2012;7(5):e35661. doi: 10.1371/journal.pone.0035661. Epub 2012 May 18.


Interplay between HIV-1 infection and host microRNAs.

Sun G, Li H, Wu X, Covarrubias M, Scherer L, Meinking K, Luk B, Chomchan P, Alluin J, Gombart AF, Rossi JJ.

Nucleic Acids Res. 2012 Mar;40(5):2181-96. doi: 10.1093/nar/gkr961. Epub 2011 Nov 10.


Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons.

Ritter DM, Ho C, O'Leary ME, Covarrubias M.

J Physiol. 2012 Jan 1;590(1):145-61. doi: 10.1113/jphysiol.2011.218560. Epub 2011 Nov 7.


Molecular mapping of general anesthetic sites in a voltage-gated ion channel.

Barber AF, Liang Q, Amaral C, Treptow W, Covarrubias M.

Biophys J. 2011 Oct 5;101(7):1613-22. doi: 10.1016/j.bpj.2011.08.026.


Targeting apoptosis for optical imaging of infection.

Thakur ML, Zhang K, Paudyal B, Devakumar D, Covarrubias MY, Chen CP, Gray BD, Wickstrom E, Pak KY.

Mol Imaging Biol. 2012 Apr;14(2):163-71. doi: 10.1007/s11307-011-0490-6. Erratum in: Mol Imaging Biol. 2012 Apr;14(2):172. Cheng, Changpo [corrected to Chen, Chang-po].


Cortactin is required for N-cadherin regulation of Kv1.5 channel function.

Cheng L, Yung A, Covarrubias M, Radice GL.

J Biol Chem. 2011 Jun 10;286(23):20478-89. doi: 10.1074/jbc.M111.218560. Epub 2011 Apr 20.


Geodesic Spline Interface for Haptic Curve Rendering.

Bordegoni M, Ferrise F, Covarrubias M, Antolini M.

IEEE Trans Haptics. 2011 Mar-Apr;4(2):111-21. doi: 10.1109/TOH.2011.1.


Mechanisms of closed-state inactivation in voltage-gated ion channels.

Bähring R, Covarrubias M.

J Physiol. 2011 Feb 1;589(Pt 3):461-79. doi: 10.1113/jphysiol.2010.191965. Epub 2010 Nov 22. Review.


Simulating complex ion channel kinetics with IonChannelLab.

Santiago-Castillo JA, Covarrubias M, Sánchez-Rodríguez JE, Perez-Cornejo P, Arreola J.

Channels (Austin). 2010 Sep-Oct;4(5):422-8. doi: 10.4161/chan.4.5.13404. Epub 2010 Sep 1.


MicroRNA profiling of clear cell renal cell carcinoma by whole-genome small RNA deep sequencing of paired frozen and formalin-fixed, paraffin-embedded tissue specimens.

Weng L, Wu X, Gao H, Mu B, Li X, Wang JH, Guo C, Jin JM, Chen Z, Covarrubias M, Yuan YC, Weiss LM, Wu H.

J Pathol. 2010 Sep;222(1):41-51. doi: 10.1002/path.2736.


Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane.

Eckenhoff RG, Xi J, Shimaoka M, Bhattacharji A, Covarrubias M, Dailey WP.

ACS Chem Neurosci. 2010 Feb 17;1(2):139-145. Epub 2009 Oct 12.


Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel.

Bhattacharji A, Klett N, Go RC, Covarrubias M.

Br J Pharmacol. 2010 Apr;159(7):1475-85. doi: 10.1111/j.1476-5381.2010.00642.x. Epub 2010 Feb 5.


A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism.

Jerng HH, Dougherty K, Covarrubias M, Pfaffinger PJ.

Channels (Austin). 2009 Nov;3(6):448-61. Epub 2009 Nov 30.


Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons.

Phuket TR, Covarrubias M.

Front Mol Neurosci. 2009 Jul 7;2:3. doi: 10.3389/neuro.02.003.2009. eCollection 2009.


The dipeptidyl-aminopeptidase-like protein 6 is an integral voltage sensor-interacting beta-subunit of neuronal K(V)4.2 channels.

Dougherty K, Tu L, Deutsch C, Covarrubias M.

Channels (Austin). 2009 Mar-Apr;3(2):122-8. Epub 2009 Mar 3.


The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels.

Kaulin YA, De Santiago-Castillo JA, Rocha CA, Nadal MS, Rudy B, Covarrubias M.

J Neurosci. 2009 Mar 11;29(10):3242-51. doi: 10.1523/JNEUROSCI.4767-08.2009.


NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes.

Schwenk J, Zolles G, Kandias NG, Neubauer I, Kalbacher H, Covarrubias M, Fakler B, Bentrop D.

J Biol Chem. 2008 Jul 4;283(27):18937-46. doi: 10.1074/jbc.M800976200. Epub 2008 May 5.


The neuronal Kv4 channel complex.

Covarrubias M, Bhattacharji A, De Santiago-Castillo JA, Dougherty K, Kaulin YA, Na-Phuket TR, Wang G.

Neurochem Res. 2008 Aug;33(8):1558-67. doi: 10.1007/s11064-008-9650-8. Epub 2008 Mar 21. Review.


Gating charge immobilization in Kv4.2 channels: the basis of closed-state inactivation.

Dougherty K, De Santiago-Castillo JA, Covarrubias M.

J Gen Physiol. 2008 Mar;131(3):257-73. doi: 10.1085/jgp.200709938.


Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons.

Amarillo Y, De Santiago-Castillo JA, Dougherty K, Maffie J, Kwon E, Covarrubias M, Rudy B.

J Physiol. 2008 Apr 15;586(8):2093-106. doi: 10.1113/jphysiol.2007.150540. Epub 2008 Feb 14.


Cumulative activation of voltage-dependent KVS-1 potassium channels.

Rojas P, Garst-Orozco J, Baban B, de Santiago-Castillo JA, Covarrubias M, Salkoff L.

J Neurosci. 2008 Jan 16;28(3):757-65. doi: 10.1523/JNEUROSCI.3825-07.2008.


Mechanism of the modulation of Kv4:KChIP-1 channels by external K+.

Kaulin YA, De Santiago-Castillo JA, Rocha CA, Covarrubias M.

Biophys J. 2008 Feb 15;94(4):1241-51. Epub 2007 Oct 19.

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