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Phosphorus Consumption Within 1 Hour Prior to Blood Work and Associated Serum Levels of Phosphate, Calcium, and PTH in Adult Patients Receiving Hemodialysis Treatment.

Mazzetti T, Hopman WM, Couture L, Christilaw E, Munroe J, Babiolakis CS, Adams MA, Holden RM.

Can J Kidney Health Dis. 2019 Jun 27;6:2054358119856891. doi: 10.1177/2054358119856891. eCollection 2019.


Persistent metabolic youth in the aging female brain.

Goyal MS, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME, Vlassenko AG.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3251-3255. doi: 10.1073/pnas.1815917116. Epub 2019 Feb 4. Erratum in: Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5198.


The Heart and Kidney: Abnormal Phosphate Homeostasis Is Associated With Atherosclerosis.

Holden RM, Hétu MF, Li TY, Ward E, Couture LE, Herr JE, Christilaw E, Adams MA, Johri AM.

J Endocr Soc. 2018 Nov 28;3(1):159-170. doi: 10.1210/js.2018-00311. eCollection 2019 Jan 1.


Circulating Gas6 is associated with reduced human carotid atherosclerotic plaque burden in high risk cardiac patients.

Holden RM, Hétu MF, Li TY, Ward EC, Couture LE, Herr JE, Christilaw E, Adams MA, Johri AM.

Clin Biochem. 2019 Feb;64:6-11. doi: 10.1016/j.clinbiochem.2018.11.018. Epub 2018 Dec 1.


Erratum: Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates.

Liu YW, Chen B, Yang X, Fugate JA, Kalucki FA, Futakuchi-Tsuchida A, Couture L, Vogel KW, Astley CA, Baldessari A, Ogle J, Don CW, Steinberg ZL, Seslar SP, Tuck SA, Tsuchida H, Naumova AV, Dupras SK, Lyu MS, Lee J, Hailey DW, Reinecke H, Pabon L, Fryer BH, MacLellan WR, Thies RS, Murry CE.

Nat Biotechnol. 2018 Sep 6;36(9):899. doi: 10.1038/nbt0918-899a. No abstract available.


Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates.

Liu YW, Chen B, Yang X, Fugate JA, Kalucki FA, Futakuchi-Tsuchida A, Couture L, Vogel KW, Astley CA, Baldessari A, Ogle J, Don CW, Steinberg ZL, Seslar SP, Tuck SA, Tsuchida H, Naumova AV, Dupras SK, Lyu MS, Lee J, Hailey DW, Reinecke H, Pabon L, Fryer BH, MacLellan WR, Thies RS, Murry CE.

Nat Biotechnol. 2018 Aug;36(7):597-605. doi: 10.1038/nbt.4162. Epub 2018 Jul 2. Erratum in: Nat Biotechnol. 2018 Sep 6;36(9):899.


Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease.

Vlassenko AG, Gordon BA, Goyal MS, Su Y, Blazey TM, Durbin TJ, Couture LE, Christensen JJ, Jafri H, Morris JC, Raichle ME, Benzinger TL.

Neurobiol Aging. 2018 Jul;67:95-98. doi: 10.1016/j.neurobiolaging.2018.03.014. Epub 2018 Mar 20.


Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling.

Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, Kuhl E, Bernstein D, Couture LA, Gold JD, Zimmermann WH, Wu JC.

Stem Cells. 2018 Feb;36(2):265-277. doi: 10.1002/stem.2732. Epub 2017 Nov 13.


Loss of Brain Aerobic Glycolysis in Normal Human Aging.

Goyal MS, Vlassenko AG, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME.

Cell Metab. 2017 Aug 1;26(2):353-360.e3. doi: 10.1016/j.cmet.2017.07.010.


Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH.

Circulation. 2017 May 9;135(19):1832-1847. doi: 10.1161/CIRCULATIONAHA.116.024145. Epub 2017 Feb 6.


Social emotional information processing in adults: Development and psychometrics of a computerized video assessment in healthy controls and aggressive individuals.

Coccaro EF, Fanning JR, Fisher E, Couture L, Lee RJ.

Psychiatry Res. 2017 Feb;248:40-47. doi: 10.1016/j.psychres.2016.11.004. Epub 2016 Nov 8.


Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner.

Su Y, Vlassenko AG, Couture LE, Benzinger TL, Snyder AZ, Derdeyn CP, Raichle ME.

J Cereb Blood Flow Metab. 2017 Apr;37(4):1435-1446. doi: 10.1177/0271678X16656200. Epub 2016 Jan 1.


Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation "Memories".

Tompkins JD, Jung M, Chen CY, Lin Z, Ye J, Godatha S, Lizhar E, Wu X, Hsu D, Couture LA, Riggs AD.

EBioMedicine. 2016 Jan 19;4:74-85. doi: 10.1016/j.ebiom.2016.01.021. eCollection 2016 Feb.


Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors.

Vlassenko AG, McConathy J, Couture LE, Su Y, Massoumzadeh P, Leeds HS, Chicoine MR, Tran DD, Huang J, Dahiya S, Marcus DS, Fouke SJ, Rich KM, Raichle ME, Benzinger TL.

Dis Markers. 2015;2015:874904. doi: 10.1155/2015/874904. Epub 2015 Sep 3.


Perceptions and Barriers to Universal Gloving for Infection Prevention: A Survey of Healthcare Workers and Patients.

Masroor N, Donovan SD, Sanogo K, Couture L, Ober J, Stevens MP, Bearman G.

Infect Control Hosp Epidemiol. 2015 Dec;36(12):1471-2. doi: 10.1017/ice.2015.194. Epub 2015 Sep 4. No abstract available.


Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells.

Chen VC, Ye J, Shukla P, Hua G, Chen D, Lin Z, Liu JC, Chai J, Gold J, Wu J, Hsu D, Couture LA.

Stem Cell Res. 2015 Sep;15(2):365-75. doi: 10.1016/j.scr.2015.08.002. Epub 2015 Aug 13.


Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model.

Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen VC, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC.

Circ Res. 2015 Sep 25;117(8):720-30. doi: 10.1161/CIRCRESAHA.115.306985. Epub 2015 Aug 19.


2005 Donor Eligibility Requirements: Unintended Consequences for Stem Cell Development.

Couture LA, Carpenter MK.

Stem Cells Transl Med. 2015 Oct;4(10):1097-100. doi: 10.5966/sctm.2015-0045. Epub 2015 Aug 18.


Hurdles to clinical translation of human induced pluripotent stem cells.

Neofytou E, O'Brien CG, Couture LA, Wu JC.

J Clin Invest. 2015 Jul 1;125(7):2551-7. doi: 10.1172/JCI80575. Epub 2015 Jul 1. Review.


The suspension culture of undifferentiated human pluripotent stem cells using spinner flasks.

Chen VC, Couture LA.

Methods Mol Biol. 2015;1283:13-21. doi: 10.1007/7651_2014_118.


Cell therapy product administration and safety: data capture and analysis from the Production Assistance for Cellular Therapies (PACT) program.

Lindblad RW, Ibenana L, Wagner JE, McKenna DH Jr, Hei DJ, Hematti P, Couture LA, Silberstein LE, Armant M, Rooney CM, Gee AP, Welniak LA, Heath Mondoro T, Wood DA, Styers D.

Transfusion. 2015 Mar;55(3):674-9. doi: 10.1111/trf.12881. Epub 2014 Oct 14. Review. No abstract available.


Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.

Gingras J, Smith S, Matson DJ, Johnson D, Nye K, Couture L, Feric E, Yin R, Moyer BD, Peterson ML, Rottman JB, Beiler RJ, Malmberg AB, McDonough SI.

PLoS One. 2014 Sep 4;9(9):e105895. doi: 10.1371/journal.pone.0105895. eCollection 2014.


Surveying the best in translation.

Grunseth M, Chen C, Kelly R, Cook SB, Megaw G, Couture L.

Nat Biotechnol. 2014 May;32(5):415-8. doi: 10.1038/nbt.2887. No abstract available.


An update from the United States National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) program: a decade of cell therapy.

Wood D, Wesselschmidt R, Hematti P, Gee AP, Rooney C, Silberstein L, Armant M, Couture L, Wagner JE, McKenna DH Jr, Hei D, Mondoro TH, Welniak L, Lindblad R.

Clin Transl Sci. 2014 Apr;7(2):93-9. doi: 10.1111/cts.12148. Epub 2014 Mar 21. No abstract available.


Optimizing the production of suspension cells using the G-Rex "M" series.

Bajgain P, Mucharla R, Wilson J, Welch D, Anurathapan U, Liang B, Lu X, Ripple K, Centanni JM, Hall C, Hsu D, Couture LA, Gupta S, Gee AP, Heslop HE, Leen AM, Rooney CM, Vera JF.

Mol Ther Methods Clin Dev. 2014 May 14;1:14015. doi: 10.1038/mtm.2014.15. eCollection 2014.


Pluripotent stem cells for Parkinson's disease: progress and challenges.

Zeng X, Couture LA.

Stem Cell Res Ther. 2013 Apr 15;4(2):25. doi: 10.1186/scrt173. Review.


Optimizing dopaminergic differentiation of pluripotent stem cells for the manufacture of dopaminergic neurons for transplantation.

Liu Q, Pedersen OZ, Peng J, Couture LA, Rao MS, Zeng X.

Cytotherapy. 2013 Aug;15(8):999-1010. doi: 10.1016/j.jcyt.2013.03.006. Epub 2013 May 7.


Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies.

Aboody KS, Najbauer J, Metz MZ, D'Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Brown CE, Kim SU, Badie B, Portnow J.

Sci Transl Med. 2013 May 8;5(184):184ra59. doi: 10.1126/scitranslmed.3005365.


Troubleshooting the rabbit ferric chloride-induced arterial model of thrombosis to assess in vivo efficacy of antithrombotic drugs.

Couture L, Richer LP, Mercier M, Hélie C, Lehoux D, Hossain SM.

J Pharmacol Toxicol Methods. 2013 Mar-Apr;67(2):91-7. doi: 10.1016/j.vascn.2012.11.003. Epub 2012 Dec 8.


Epigenetic stability, adaptability, and reversibility in human embryonic stem cells.

Tompkins JD, Hall C, Chen VC, Li AX, Wu X, Hsu D, Couture LA, Riggs AD.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12544-9. doi: 10.1073/pnas.1209620109. Epub 2012 Jul 16.


Production of CGMP-Grade Lentiviral Vectors.

Ausubel LJ, Hall C, Sharma A, Shakeley R, Lopez P, Quezada V, Couture S, Laderman K, McMahon R, Huang P, Hsu D, Couture L.

Bioprocess Int. 2012 Feb;10(2):32-43. No abstract available.


Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptides.

Couture LA, Piao W, Ru LW, Vogel SN, Toshchakov VY.

J Biol Chem. 2012 Jul 13;287(29):24641-8. doi: 10.1074/jbc.M112.360925. Epub 2012 May 30.


Scalable GMP compliant suspension culture system for human ES cells.

Chen VC, Couture SM, Ye J, Lin Z, Hua G, Huang HI, Wu J, Hsu D, Carpenter MK, Couture LA.

Stem Cell Res. 2012 May;8(3):388-402. doi: 10.1016/j.scr.2012.02.001. Epub 2012 Feb 22.


Clinical evaluation of safety and immunogenicity of PADRE-cytomegalovirus (CMV) and tetanus-CMV fusion peptide vaccines with or without PF03512676 adjuvant.

La Rosa C, Longmate J, Lacey SF, Kaltcheva T, Sharan R, Marsano D, Kwon P, Drake J, Williams B, Denison S, Broyer S, Couture L, Nakamura R, Dadwal S, Kelsey MI, Krieg AM, Diamond DJ, Zaia JA.

J Infect Dis. 2012 Apr 15;205(8):1294-304. doi: 10.1093/infdis/jis107. Epub 2012 Mar 7. Erratum in: J Infect Dis. 2013 Sep;208(6):1038. Dadwal, Sanjeet [added].


An optimized method to assess in vivo efficacy of antithrombotic drugs using optical coherence tomography and a modified Doppler flow system.

Couture L, Richer LP, Cadieux C, Thomson CM, Hossain SM.

J Pharmacol Toxicol Methods. 2011 Nov-Dec;64(3):264-8. doi: 10.1016/j.vascn.2011.09.001. Epub 2011 Sep 25.


GMP scale-up and banking of pluripotent stem cells for cellular therapy applications.

Ausubel LJ, Lopez PM, Couture LA.

Methods Mol Biol. 2011;767:147-59. doi: 10.1007/978-1-61779-201-4_11.


Targeting TLR4 signaling by TLR4 Toll/IL-1 receptor domain-derived decoy peptides: identification of the TLR4 Toll/IL-1 receptor domain dimerization interface.

Toshchakov VY, Szmacinski H, Couture LA, Lakowicz JR, Vogel SN.

J Immunol. 2011 Apr 15;186(8):4819-27. doi: 10.4049/jimmunol.1002424. Epub 2011 Mar 14.


Replication-competent lentivirus analysis of clinical grade vector products.

Cornetta K, Yao J, Jasti A, Koop S, Douglas M, Hsu D, Couture LA, Hawkins T, Duffy L.

Mol Ther. 2011 Mar;19(3):557-66. doi: 10.1038/mt.2010.278. Epub 2010 Dec 21.


Current good manufacturing practice production of an oncolytic recombinant vesicular stomatitis viral vector for cancer treatment.

Ausubel LJ, Meseck M, Derecho I, Lopez P, Knoblauch C, McMahon R, Anderson J, Dunphy N, Quezada V, Khan R, Huang P, Dang W, Luo M, Hsu D, Woo SL, Couture L.

Hum Gene Ther. 2011 Apr;22(4):489-97. doi: 10.1089/hum.2010.159. Epub 2011 Mar 8.


Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition.

Vlassenko AG, Vaishnavi SN, Couture L, Sacco D, Shannon BJ, Mach RH, Morris JC, Raichle ME, Mintun MA.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17763-7. doi: 10.1073/pnas.1010461107. Epub 2010 Sep 13.


Saddle pulmonary embolism visualized by transthoracic echocardiography.

Kanjanauthai S, Couture LA, Fissha M, Gentry M, Sharma GK.

J Am Coll Cardiol. 2010 Sep 7;56(11):e21. doi: 10.1016/j.jacc.2009.10.097. No abstract available.


Regulatory considerations for the development of autologous induced pluripotent stem cell therapies.

Carpenter MK, Couture LA.

Regen Med. 2010 Jul;5(4):569-79. doi: 10.2217/rme.10.55.


RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.

DiGiusto DL, Krishnan A, Li L, Li H, Li S, Rao A, Mi S, Yam P, Stinson S, Kalos M, Alvarnas J, Lacey SF, Yee JK, Li M, Couture L, Hsu D, Forman SJ, Rossi JJ, Zaia JA.

Sci Transl Med. 2010 Jun 16;2(36):36ra43. doi: 10.1126/scitranslmed.3000931.


Scalable pluripotent stem cell culture.

Couture LA.

Nat Biotechnol. 2010 Jun;28(6):562-3. doi: 10.1038/nbt0610-562. No abstract available.


Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms.

Lai SY, Koppikar P, Thomas SM, Childs EE, Egloff AM, Seethala RR, Branstetter BF, Gooding WE, Muthukrishnan A, Mountz JM, Lui VW, Shin DM, Agarwala SS, Johnson R, Couture LA, Myers EN, Johnson JT, Mills G, Argiris A, Grandis JR.

J Clin Oncol. 2009 Mar 10;27(8):1235-42. doi: 10.1200/JCO.2008.17.8251. Epub 2009 Feb 9.


Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination.

Fenneteau F, Turgeon J, Couture L, Michaud V, Li J, Nekka F.

Theor Biol Med Model. 2009 Jan 15;6:2. doi: 10.1186/1742-4682-6-2.


Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors.

Sheline YI, Price JL, Vaishnavi SN, Mintun MA, Barch DM, Epstein AA, Wilkins CH, Snyder AZ, Couture L, Schechtman K, McKinstry RC.

Am J Psychiatry. 2008 Apr;165(4):524-32. doi: 10.1176/appi.ajp.2007.07010175. Epub 2008 Feb 15.


The ATP-binding cassette transporters and their implication in drug disposition: a special look at the heart.

Couture L, Nash JA, Turgeon J.

Pharmacol Rev. 2006 Jun;58(2):244-58. Review.


Safety and immunological efficacy of a prostate cancer plasmid DNA vaccine encoding prostatic acid phosphatase (PAP).

Johnson LE, Frye TP, Arnot AR, Marquette C, Couture LA, Gendron-Fitzpatrick A, McNeel DG.

Vaccine. 2006 Jan 16;24(3):293-303. Epub 2005 Aug 9.


Induction of infertility in adult male bonnet monkeys by immunization with phage-expressed peptides of the extracellular domain of FSH receptor.

Rao AJ, Ramachandra SG, Ramesh V, Couture L, Abdennebi L, Salesse R, Remy JJ.

Reprod Biomed Online. 2004 Apr;8(4):385-91.


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