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Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients.

Labriet A, Lévesque É, Mattia E, Cecchin E, Jonker D, Couture F, Simonyan D, Buonadonna A, D'Andrea M, Villeneuve L, Toffoli G, Guillemette C.

Pharmacogenomics. 2019 Nov 8. doi: 10.2217/pgs-2019-0091. [Epub ahead of print]


Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.

Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad É, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm BT, Cellot S.

Blood Adv. 2019 Nov 12;3(21):3307-3321. doi: 10.1182/bloodadvances.2019030981.


Cryptic recurrent ACIN1-NUTM1 fusions in non-KMT2A-rearranged infant acute lymphoblastic leukemia.

Pincez T, Landry JR, Roussy M, Jouan L, Bilodeau M, Laramée L, Couture F, Sinnett D, Gendron P, Hébert J, Oligny L, Rouette A, Tran TH, Wilhelm BT, Bittencourt H, Cellot S.

Genes Chromosomes Cancer. 2019 Sep 12. doi: 10.1002/gcc.22808. [Epub ahead of print]


Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients.

Labriet A, Lévesque É, Cecchin E, De Mattia E, Villeneuve L, Rouleau M, Jonker D, Couture F, Simonyan D, Allain EP, Buonadonna A, D'Andrea M, Toffoli G, Guillemette C.

Sci Rep. 2019 Sep 10;9(1):13008. doi: 10.1038/s41598-019-49477-3.


Oncological and functional outcomes of a large Canadian robotic-assisted radical prostatectomy database with 10 years of surgical experience.

Tholomier C, Couture F, Ajib K, Preisser F, Bondarenko HD, Negrean C, Karakiewicz P, El-Hakim A, Zorn KC.

Can J Urol. 2019 Aug;26(4):9843-9851.


V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss.

Mohammad AH, Assadian S, Couture F, Lefebvre KJ, El-Assaad W, Barrès V, Ouellet V, Boulay PL, Yang J, Latour M, Furic L, Muller W, Sonenberg N, Mes-Masson AM, Saad F, Day R, Teodoro JG.

Oncotarget. 2019 Aug 13;10(48):4923-4936. doi: 10.18632/oncotarget.27075. eCollection 2019 Aug 13.


Malignant solitary fibrous tumour of the kidney with an extensive thrombus: A case report and review of the literature.

Couture F, Legault B, Ekindi N, Noel-Lamy M, Pavic M, Richard PO.

Urol Case Rep. 2019 Jul 29;26:100974. doi: 10.1016/j.eucr.2019.100974. eCollection 2019 Sep.


Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma.

Ascierto PA, Ferrucci PF, Fisher R, Del Vecchio M, Atkinson V, Schmidt H, Schachter J, Queirolo P, Long GV, Di Giacomo AM, Svane IM, Lotem M, Bar-Sela G, Couture F, Mookerjee B, Ghori R, Ibrahim N, Moreno BH, Ribas A.

Nat Med. 2019 Jun;25(6):941-946. doi: 10.1038/s41591-019-0448-9. Epub 2019 Jun 6.


Safety, Efficacy, and Patient-Reported Health-Related Quality of Life and Symptom Burden with Nivolumab in Patients with Advanced Non-Small Cell Lung Cancer, Including Patients Aged 70 Years or Older or with Poor Performance Status (CheckMate 153).

Spigel DR, McCleod M, Jotte RM, Einhorn L, Horn L, Waterhouse DM, Creelan B, Babu S, Leighl NB, Chandler JC, Couture F, Keogh G, Goss G, Daniel DB, Garon EB, Schwartzberg LS, Sen R, Korytowsky B, Li A, Aanur N, Hussein MA.

J Thorac Oncol. 2019 Sep;14(9):1628-1639. doi: 10.1016/j.jtho.2019.05.010. Epub 2019 May 20.


The AFMC electives diversification policy: Potential drawbacks and benefits for medical students applying to urology.

Nguyen DD, Lee JY, Couture F, Richard PO, Fahmy N, Perrotte P, Domes T, Bhojani N.

Can Urol Assoc J. 2019 Apr 26. doi: 10.5489/cuaj.6000. [Epub ahead of print] No abstract available.


Perceptions and intentions toward medical assistance in dying among Canadian medical students.

Falconer J, Couture F, Demir KK, Lang M, Shefman Z, Woo M.

BMC Med Ethics. 2019 Apr 2;20(1):22. doi: 10.1186/s12910-019-0356-z.


Predictors of deviation in neurovascular bundle preservation during robotic prostatectomy.

Couture F, Polesello S, Tholomier C, Bondarenko HD, Karakiewicz PI, Nazzani S, Preisser F, El-Hakim A, Zorn KC.

Can J Urol. 2019 Feb;26(1):9644-9653.


Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug.

Kwiatkowska A, Couture F, Ait-Mohand S, Desjardins R, Dory YL, Guérin B, Day R.

Sci Rep. 2019 Feb 14;9(1):2118. doi: 10.1038/s41598-018-37568-6.


Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue.

Dianati V, Navals P, Couture F, Desjardins R, Dame A, Kwiatkowska A, Day R, Dory YL.

J Med Chem. 2018 Dec 27;61(24):11250-11260. doi: 10.1021/acs.jmedchem.8b01381. Epub 2018 Dec 13.


Evaluation of PACE4 isoforms as biomarkers in thyroid cancer.

Fradet L, Temmar R, Couture F, Belzile M, Fortier PH, Day R.

J Otolaryngol Head Neck Surg. 2018 Oct 19;47(1):63. doi: 10.1186/s40463-018-0311-x.


Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.

Dianati V, Kwiatkowska A, Couture F, Desjardins R, Dory YL, Day R.

J Med Chem. 2018 Sep 27;61(18):8457-8467. doi: 10.1021/acs.jmedchem.8b01144. Epub 2018 Sep 17.


Isolated peritoneal carcinomatosis from metastatic castration-resistant prostate cancer and associated biliary obstruction: A case report.

Couture F, Chin J, Chong J, Tanguay S.

Urol Case Rep. 2018 Aug 12;21:10-11. doi: 10.1016/j.eucr.2018.08.007. eCollection 2018 Nov. No abstract available.


Use of the AccuVein AV400 during RARP: an infrared augmented reality device to help reduce abdominal wall hematoma.

Law KW, Ajib K, Couture F, Tholomier C, Bondarenko HD, Preisser F, Karakiewicz PI, Zorn KC.

Can J Urol. 2018 Aug;25(4):9384-9388.


Real-world patient- and caregiver-reported outcomes in advanced breast cancer.

Lambert-Obry V, Gouault-Laliberté A, Castonguay A, Zanotti G, Tran T, Mates M, Lemieux J, Chabot P, Prady C, Couture F, Lachaine J.

Curr Oncol. 2018 Aug;25(4):e282-e290. doi: 10.3747/co.25.3765. Epub 2018 Aug 14.


Association of STAT-3 rs1053004 and VDR rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients.

De Mattia E, Cecchin E, Montico M, Labriet A, Guillemette C, Dreussi E, Roncato R, Bignucolo A, Buonadonna A, D'Andrea M, Coppola L, Lonardi S, Lévesque E, Jonker D, Couture F, Toffoli G.

Front Pharmacol. 2018 Apr 13;9:367. doi: 10.3389/fphar.2018.00367. eCollection 2018.


Prostate cancer biochemical recurrence after salvage radiotherapy: first look into risk stratification and prognosis.

Couture F, Tholomier C, Zorn KC.

BJU Int. 2018 Mar;121(3):320-321. doi: 10.1111/bju.13978. No abstract available.


NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy.

Roussy M, Bilodeau M, Jouan L, Tibout P, Laramée L, Lemyre E, Léveillé F, Tihy F, Cardin S, Sauvageau C, Couture F, Louis I, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hébert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot S.

Genes Chromosomes Cancer. 2018 Jun;57(6):311-319. doi: 10.1002/gcc.22532. Epub 2018 Mar 28.


Assessment of urology postgraduate trainees' competencies in flexible ureteroscopic stone extraction.

Aloosh M, Couture F, Fahmy N, Elhilali MM, Andonian S.

Can Urol Assoc J. 2018 Feb;12(2):52-58. doi: 10.5489/cuaj.4570. Epub 2017 Dec 1.


WITHDRAWN: PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity.

Okada K, Moon HJ, Finney J, Couture F, Day R, Mure M.

J Biol Chem. 2017 Nov 28. pii: jbc.C117.810978. doi: 10.1074/jbc.C117.810978. [Epub ahead of print]


Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L.

Labriet A, De Mattia E, Cecchin E, Lévesque É, Jonker D, Couture F, Buonadonna A, D'Andrea M, Villeneuve L, Toffoli G, Guillemette C.

Front Pharmacol. 2017 Oct 10;8:712. doi: 10.3389/fphar.2017.00712. eCollection 2017.


PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer.

Couture F, Sabbagh R, Kwiatkowska A, Desjardins R, Guay SP, Bouchard L, Day R.

Cancer Res. 2017 Dec 15;77(24):6863-6879. doi: 10.1158/0008-5472.CAN-17-1397. Epub 2017 Oct 9.


EJCB - Molecular basis of protein fates in the secretory and endocytic pathways, and beyond.

Couture F, Jansen AM, Taghert P, Brix K.

Eur J Cell Biol. 2017 Aug;96(5):369-371. doi: 10.1016/j.ejcb.2017.06.006. Epub 2017 Jun 15. No abstract available.


Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations.

Łepek T, Kwiatkowska A, Couture F, Ly K, Desjardins R, Dory Y, Prahl A, Day R.

Eur J Cell Biol. 2017 Aug;96(5):476-485. doi: 10.1016/j.ejcb.2017.04.001. Epub 2017 Apr 23.


PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.

Panet F, Couture F, Kwiatkowska A, Desjardins R, Guérin B, Day R.

Eur J Cell Biol. 2017 Aug;96(5):469-475. doi: 10.1016/j.ejcb.2017.03.006. Epub 2017 Mar 21.


Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.

Małuch I, Levesque C, Kwiatkowska A, Couture F, Ly K, Desjardins R, Neugebauer WA, Prahl A, Day R.

J Med Chem. 2017 Apr 13;60(7):2732-2744. doi: 10.1021/acs.jmedchem.6b01499. Epub 2017 Mar 24.


Erratum to: nab-Paclitaxel Plus Gemcitabine Versus Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma: Canadian Subgroup Analysis of the Phase 3 MPACT Trial.

Tehfe M, Dowden S, Kennecke H, El-Maraghi R, Lesperance B, Couture F, Letourneau R, Liu H, Romano A.

Adv Ther. 2017 Jan;34(1):277-279. doi: 10.1007/s12325-016-0442-2. No abstract available.


nab-Paclitaxel Plus Gemcitabine Versus Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma: Canadian Subgroup Analysis of the Phase 3 MPACT Trial.

Tehfe M, Dowden S, Kennecke H, El-Maraghi R, Lesperance B, Couture F, Letourneau R, Liu H, Romano A.

Adv Ther. 2016 May;33(5):747-59. doi: 10.1007/s12325-016-0327-4. Epub 2016 Apr 16. Erratum in: Adv Ther. 2016 Nov 24;:.


Novel Insights into Structure-Activity Relationships of N-Terminally Modified PACE4 Inhibitors.

Kwiatkowska A, Couture F, Levesque C, Ly K, Beauchemin S, Desjardins R, Neugebauer W, Dory YL, Day R.

ChemMedChem. 2016 Feb 4;11(3):289-301. doi: 10.1002/cmdc.201500532. Epub 2016 Jan 11.


Pretreatment with anti-thymocyte globulin versus no anti-thymocyte globulin in patients with haematological malignancies undergoing haemopoietic cell transplantation from unrelated donors: a randomised, controlled, open-label, phase 3, multicentre trial.

Walker I, Panzarella T, Couban S, Couture F, Devins G, Elemary M, Gallagher G, Kerr H, Kuruvilla J, Lee SJ, Moore J, Nevill T, Popradi G, Roy J, Schultz KR, Szwajcer D, Toze C, Foley R; Canadian Blood and Marrow Transplant Group.

Lancet Oncol. 2016 Feb;17(2):164-173. doi: 10.1016/S1470-2045(15)00462-3. Epub 2015 Dec 24. Erratum in: Lancet Oncol. 2018 Nov;19(11):e581.


ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients.

Chen S, Villeneuve L, Jonker D, Couture F, Laverdière I, Cecchin E, Innocenti F, Toffoli G, Lévesque E, Guillemette C.

Pharmacogenet Genomics. 2015 Dec;25(12):573-83. doi: 10.1097/FPC.0000000000000168.


Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity.

Couture F, Ly K, Levesque C, Kwiatkowska A, Ait-Mohand S, Desjardins R, Guérin B, Day R.

Biomed Res Int. 2015;2015:824014. doi: 10.1155/2015/824014. Epub 2015 May 31.


Reversal of Severe and Refractory Humoral Hypercalcemia With 177Lu-Octreotate Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumor of the Pancreas.

Iliuta IA, Beauregard JM, Couture F, Douville P, Mac-Way F.

Clin Nucl Med. 2015 Sep;40(9):e448-50. doi: 10.1097/RLU.0000000000000862.


A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients.

Chen S, Laverdiere I, Tourancheau A, Jonker D, Couture F, Cecchin E, Villeneuve L, Harvey M, Court MH, Innocenti F, Toffoli G, Lévesque E, Guillemette C.

Pharmacogenomics J. 2015 Dec;15(6):513-20. doi: 10.1038/tpj.2015.12. Epub 2015 Mar 17.


PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation.

Levesque C, Couture F, Kwiatkowska A, Desjardins R, Guérin B, Neugebauer WA, Day R.

Oncotarget. 2015 Feb 28;6(6):3680-93.


Therapeutic uses of furin and its inhibitors: a patent review.

Couture F, Kwiatkowska A, Dory YL, Day R.

Expert Opin Ther Pat. 2015 Apr;25(4):379-96. doi: 10.1517/13543776.2014.1000303. Epub 2015 Jan 7. Review.


Cyclosporine and methotrexate-related pharmacogenomic predictors of acute graft-versus-host disease.

Laverdière I, Guillemette C, Tamouza R, Loiseau P, Peffault de Latour R, Robin M, Couture F, Filion A, Lalancette M, Tourancheau A, Charron D, Socié G, Lévesque É.

Haematologica. 2015 Feb;100(2):275-83. doi: 10.3324/haematol.2014.109884. Epub 2014 Nov 25.


A homozygous loss-of-function variant in MYH11 in a case with megacystis-microcolon-intestinal hypoperistalsis syndrome.

Gauthier J, Ouled Amar Bencheikh B, Hamdan FF, Harrison SM, Baker LA, Couture F, Thiffault I, Ouazzani R, Samuels ME, Mitchell GA, Rouleau GA, Michaud JL, Soucy JF.

Eur J Hum Genet. 2015 Sep;23(9):1266-8. doi: 10.1038/ejhg.2014.256. Epub 2014 Nov 19.


PACE4-based molecular targeting of prostate cancer using an engineered ⁶⁴Cu-radiolabeled peptide inhibitor.

Couture F, Levesque C, Dumulon-Perreault V, Ait-Mohand S, D'Anjou F, Day R, Guérin B.

Neoplasia. 2014 Aug;16(8):634-43. doi: 10.1016/j.neo.2014.07.010.


Favorable outcomes from allogeneic and autologous stem cell transplantation for patients with transformed nonfollicular indolent lymphoma.

Villa D, George A, Seymour JF, Toze CL, Crump M, Lee C, Buckstein R, Stewart DA, MacDonald D, Foley R, Xenocostas A, Sabloff M, Chua N, Couture F, Larouche JF, Cohen S, Savage KJ, Connors JM, Panzarella T, Carney DA, Dickinson M, Kuruvilla J.

Biol Blood Marrow Transplant. 2014 Nov;20(11):1813-8. doi: 10.1016/j.bbmt.2014.07.015. Epub 2014 Jul 18.


Transarterial embolization therapies for the treatment of hepatocellular carcinoma: CEPO review and clinical recommendations.

Boily G, Villeneuve JP, Lacoursière L, Chaudhury P, Couture F, Ouellet JF, Lapointe R, Goulet S, Gervais N; Comité de l'évolution des pratiques en oncologie.

HPB (Oxford). 2015 Jan;17(1):52-65. doi: 10.1111/hpb.12273. Epub 2014 Jun 24. Review.


Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.

Longuespée R, Couture F, Levesque C, Kwiatkowska A, Desjardins R, Gagnon S, Vergara D, Maffia M, Fournier I, Salzet M, Day R.

Transl Oncol. 2014 May 9. pii: S1936-5233(14)00043-6. doi: 10.1016/j.tranon.2014.04.008. [Epub ahead of print]


Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin.

Gagnon H, Beauchemin S, Kwiatkowska A, Couture F, D'Anjou F, Levesque C, Dufour F, Desbiens AR, Vaillancourt R, Bernard S, Desjardins R, Malouin F, Dory YL, Day R.

J Med Chem. 2014 Jan 9;57(1):29-41. doi: 10.1021/jm400633d. Epub 2013 Dec 23.


Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor.

Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL, Day R.

J Med Chem. 2014 Jan 9;57(1):98-109. doi: 10.1021/jm401457n. Epub 2013 Dec 18.


Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells.

D'Anjou F, Couture F, Desjardins R, Day R.

Methods Mol Biol. 2014;1103:67-82. doi: 10.1007/978-1-62703-730-3_6.


Adjuvant treatment for endometrial cancer: literature review and recommendations by the Comité de l'évolution des pratiques en oncologie (CEPO).

Morneau M, Foster W, Lalancette M, Van Nguyen-Huynh T, Renaud MC, Samouëlian V, Letarte N; Comité de l'évolution des pratiques en oncologie; Comité de l'évolution des pratiques en oncologie, Almanric K, Boily G, Bouchard P, Boulanger J, Cournoyer G, Couture F, Gervais N, Goulet S, Guay MP, Kavanagh M, Lemieux J, Lespérance B, Letarte N, Morneau M, Ouellet JF, Pineau G, Rajan R, Roy I, Samson B, Sidéris L, Vincent F.

Gynecol Oncol. 2013 Oct;131(1):231-40. doi: 10.1016/j.ygyno.2013.07.084. Epub 2013 Jul 19. Review.


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