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Items: 16

1.

Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes.

Tran C, Heng B, Teo JD, Humphrey SJ, Qi Y, Couttas TA, Stefen H, Brettle M, Fath T, Guillemin GJ, Don AS.

J Neurochem. 2019 Nov 19:e14917. doi: 10.1111/jnc.14917. [Epub ahead of print]

PMID:
31742704
2.

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS.

J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22.

PMID:
31641049
3.

High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.

Lemay AM, Courtemanche O, Couttas TA, Jamsari G, Gagné A, Bossé Y, Joubert P, Don AS, Marsolais D.

J Lipid Res. 2019 Oct;60(10):1776-1786. doi: 10.1194/jlr.M093955. Epub 2019 Aug 13.

PMID:
31409741
4.

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.

Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS.

Nat Commun. 2018 Aug 21;9(1):3165. doi: 10.1038/s41467-018-05613-7.

5.

Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration.

Couttas TA, Kain N, Tran C, Chatterton Z, Kwok JB, Don AS.

J Alzheimers Dis. 2018;63(2):503-514. doi: 10.3233/JAD-171054.

PMID:
29660940
6.

Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.

Chen J, Qi Y, Zhao Y, Kaczorowski D, Couttas TA, Coleman PR, Don AS, Bertolino P, Gamble JR, Vadas MA, Xia P, McCaughan GW.

Oncotarget. 2018 Feb 26;9(21):15635-15649. doi: 10.18632/oncotarget.24583. eCollection 2018 Mar 20.

7.

Contextual fear conditioning is enhanced in mice lacking functional sphingosine kinase 2.

Lei M, Shafique A, Shang K, Couttas TA, Zhao H, Don AS, Karl T.

Behav Brain Res. 2017 Aug 30;333:9-16. doi: 10.1016/j.bbr.2017.06.019. Epub 2017 Jun 15.

PMID:
28625547
8.

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease.

Couttas TA, Kain N, Suchowerska AK, Quek LE, Turner N, Fath T, Garner B, Don AS.

Neurobiol Aging. 2016 Jul;43:89-100. doi: 10.1016/j.neurobiolaging.2016.03.027. Epub 2016 Apr 4.

PMID:
27255818
9.

Fluorescent Assays for Ceramide Synthase Activity.

Couttas TA, Don AS.

Methods Mol Biol. 2016;1376:23-33. doi: 10.1007/978-1-4939-3170-5_3.

PMID:
26552672
10.

A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC.

Couttas TA, Lim XY, Don AS.

Lipids. 2015 Jan;50(1):101-9. doi: 10.1007/s11745-014-3969-5. Epub 2014 Nov 18.

PMID:
25403920
11.

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy.

Don AS, Hsiao JH, Bleasel JM, Couttas TA, Halliday GM, Kim WS.

Acta Neuropathol Commun. 2014 Oct 29;2:150. doi: 10.1186/s40478-014-0150-6.

12.

Re-configuration of sphingolipid metabolism by oncogenic transformation.

Don AS, Lim XY, Couttas TA.

Biomolecules. 2014 Mar 14;4(1):315-53. doi: 10.3390/biom4010315. Review.

13.

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis.

Couttas TA, Kain N, Daniels B, Lim XY, Shepherd C, Kril J, Pickford R, Li H, Garner B, Don AS.

Acta Neuropathol Commun. 2014 Jan 23;2:9. doi: 10.1186/2051-5960-2-9.

14.

Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases.

Couttas TA, Raftery MJ, Padula MP, Herbert BR, Wilkins MR.

Proteomics. 2012 Apr;12(7):960-72. doi: 10.1002/pmic.201100570.

PMID:
22522802
15.

Monitoring cytoplasmic protein complexes with blue native gel electrophoresis and stable isotope labelling with amino acids in cell culture: analysis of changes in the 20S proteasome.

Couttas TA, Raftery MJ, Erce MA, Wilkins MR.

Electrophoresis. 2011 Jul;32(14):1819-23. doi: 10.1002/elps.201100122. Epub 2011 Jun 24.

PMID:
21710547
16.

Immonium ion scanning for the discovery of post-translational modifications and its application to histones.

Couttas TA, Raftery MJ, Bernardini G, Wilkins MR.

J Proteome Res. 2008 Jul;7(7):2632-41. doi: 10.1021/pr700644t. Epub 2008 Jun 3.

PMID:
18517236

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