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Formative assessment scores in tutorial sessions correlates with OSCE and progress testing scores in a PBL medical curriculum.

Couto LB, Durand MT, Wolff ACD, Restini CBA, Faria M Jr, Romão GS, Bestetti RB.

Med Educ Online. 2019 Dec;24(1):1560862. doi: 10.1080/10872981.2018.1560862.


Comment on: Ten key features of the future medical school - not an impossible dream.

Romão GS, Couto LB, Durand MT, Bestetti RB.

Med Teach. 2019 Mar 1:1. doi: 10.1080/0142159X.2019.1566598. [Epub ahead of print] No abstract available.


Comments on Etiological Classification of Stroke in Patients with Chagas Disease Using TOAST, Causative Classification System TOAST, and ASCOD Phenotyping.

Bestetti RB, Dellalibera-Joviliano R, Couto LB.

J Stroke Cerebrovasc Dis. 2018 May;27(5):1434. doi: 10.1016/j.jstrokecerebrovasdis.2017.12.049. Epub 2018 Feb 21. No abstract available.


Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27.

Silva G, Teixeira Lima F, Seba V, Mendes Lourenço AL, Lucas TG, de Andrade BV, Torrezan GS, Polaquini CR, Garcia ME, Couto LB, Bestetti RB, de Castro França S, Fachin AL, Regasini LO, Marins M.

Molecules. 2018 Jan 30;23(2). pii: E279. doi: 10.3390/molecules23020279.


Problem-based learning in primary care at University of Ribeirão Preto (UNAERP) in Brazil.

Romão GS, Bestetti RB, Couto LB.

Adv Med Educ Pract. 2018 Jan 3;9:27-30. doi: 10.2147/AMEP.S157071. eCollection 2018. No abstract available.


Letter by Bestetti et al Regarding Article, "Inflammatory Cardiomyopathic Syndromes".

Bestetti RB, Dellalibera-Joviliano R, Couto LB.

Circ Res. 2018 Jan 5;122(1):e1. doi: 10.1161/CIRCRESAHA.117.312304. No abstract available.


Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.

George LA, Sullivan SK, Giermasz A, Rasko JEJ, Samelson-Jones BJ, Ducore J, Cuker A, Sullivan LM, Majumdar S, Teitel J, McGuinn CE, Ragni MV, Luk AY, Hui D, Wright JF, Chen Y, Liu Y, Wachtel K, Winters A, Tiefenbacher S, Arruda VR, van der Loo JCM, Zelenaia O, Takefman D, Carr ME, Couto LB, Anguela XM, High KA.

N Engl J Med. 2017 Dec 7;377(23):2215-2227. doi: 10.1056/NEJMoa1708538.


Assessment test before the reporting phase of tutorial session in problem-based learning.

Bestetti RB, Couto LB, Restini CB, Faria M Jr, Romão GS.

Adv Med Educ Pract. 2017 Feb 27;8:181-187. doi: 10.2147/AMEP.S125247. eCollection 2017.


Good teacher, good tutor.

Couto LB, Romão GS, Bestetti RB.

Adv Med Educ Pract. 2016 Jul 11;7:377-80. doi: 10.2147/AMEP.S110449. eCollection 2016. No abstract available.


Carlos Chagas Discoveries as a Drop Back to Scientific Construction of Chronic Chagas Heart Disease.

Bestetti RB, Restini CB, Couto LB.

Arq Bras Cardiol. 2016 Jul;107(1):63-70. doi: 10.5935/abc.20160079. Epub 2016 May 24. Review. English, Portuguese.


Could Carlos Chagas' assumption on the relationship between goiter and chronic Chagas heart disease be correct? A historical reappraisal.

Bestetti RB, Cardinalli-Neto A, Restini CB, Couto LB.

Int J Cardiol. 2016 Jan 1;202:410-2. doi: 10.1016/j.ijcard.2015.09.052. Epub 2015 Sep 25. Review.


Brazilian medical students' perceptions of expert versus non-expert facilitators in a (non) problem-based learning environment.

Couto LB, Bestetti RB, Restini CB, Faria M Jr, Romão GS.

Med Educ Online. 2015 Apr 15;20:26893. doi: 10.3402/meo.v20.26893. eCollection 2015.


Development of anatomophysiologic knowledge regarding the cardiovascular system: from Egyptians to Harvey.

Bestetti RB, Restini CB, Couto LB.

Arq Bras Cardiol. 2014 Dec;103(6):538-45. doi: 10.5935/abc.20140148. Epub 2014 Oct 10. Review. English, Portuguese.


Contextual considerations in implementing problem-based learning approaches in a Brazilian medical curriculum: the UNAERP experience.

Bestetti RB, Couto LB, Romão GS, Araújo GT, Restini CB.

Med Educ Online. 2014 Jun 13;19:24366. doi: 10.3402/meo.v19.24366. eCollection 2014.


When a misperception favors a tragedy: Carlos Chagas and the Nobel Prize of 1921.

Bestetti RB, Couto LB, Cardinalli-Neto A.

Int J Cardiol. 2013 Nov 20;169(5):327-30. doi: 10.1016/j.ijcard.2013.08.137. Epub 2013 Sep 7.


Evaluation of the Hypoglycemic Properties of Anacardium humile Aqueous Extract.

Urzêda MA, Marcussi S, Silva Pereira LL, França SC, Pereira AM, Pereira PS, da Silva SL, Guimarães CL, Calderon LA, Stábeli RG, Soares AM, Couto LB.

Evid Based Complement Alternat Med. 2013;2013:191080. doi: 10.1155/2013/191080. Epub 2013 May 2.


Preclinical evaluation of an anti-HCV miRNA cluster for treatment of HCV infection.

Yang X, Marcucci K, Anguela X, Couto LB.

Mol Ther. 2013 Mar;21(3):588-601. doi: 10.1038/mt.2012.247. Epub 2013 Jan 8.


Effects of the serjania erecta and zeyheria montana ethanol extracts in experimental pulpitis in rats: a histological study.

Nossa PM, Guenka LC, Couto LB, da-Cruz-Perez DE.

Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18(2):e337-42.


Animal Models for HCV Study.

Couto LB, Kolykhalov AA.

In: Tan SL, editor. Hepatitis C Viruses: Genomes and Molecular Biology. Norfolk (UK): Horizon Bioscience; 2006. Chapter 12.


Inhibition of hepatitis C virus replication using adeno-associated virus vector delivery of an exogenous anti-hepatitis C virus microRNA cluster.

Yang X, Haurigot V, Zhou S, Luo G, Couto LB.

Hepatology. 2010 Dec;52(6):1877-87. doi: 10.1002/hep.23908. Epub 2010 Oct 7.


Viral vector-mediated RNA interference.

Couto LB, High KA.

Curr Opin Pharmacol. 2010 Oct;10(5):534-42. doi: 10.1016/j.coph.2010.06.007. Epub 2010 Jul 9. Review.


Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B.

Arruda VR, Stedman HH, Haurigot V, Buchlis G, Baila S, Favaro P, Chen Y, Franck HG, Zhou S, Wright JF, Couto LB, Jiang H, Pierce GF, Bellinger DA, Mingozzi F, Nichols TC, High KA.

Blood. 2010 Jun 10;115(23):4678-88. doi: 10.1182/blood-2009-12-261156. Epub 2010 Mar 24.


Anti-inflammatory and anti-nociceptive effects of Zeyheria montana (Bignoniaceae) ethanol extract.

Guenka LC, Gomes RC, Melo VL, Kitanishi CR, Pereira PS, França SC, Couto LB, Beleboni RO.

Mem Inst Oswaldo Cruz. 2008 Dec;103(8):768-72.


Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy.

Jiang H, Couto LB, Patarroyo-White S, Liu T, Nagy D, Vargas JA, Zhou S, Scallan CD, Sommer J, Vijay S, Mingozzi F, High KA, Pierce GF.

Blood. 2006 Nov 15;108(10):3321-8. Epub 2006 Jul 25.


Descriptive and functional neuroanatomy of locus coeruleus-noradrenaline-containing neurons involvement in bradykinin-induced antinociception on principal sensory trigeminal nucleus.

Couto LB, Moroni CR, dos Reis Ferreira CM, Elias-Filho DH, Parada CA, Pelá IR, Coimbra NC.

J Chem Neuroanat. 2006 Aug;32(1):28-45. Epub 2006 May 5.


Inadvertent germline transmission of AAV2 vector: findings in a rabbit model correlate with those in a human clinical trial.

Schuettrumpf J, Liu JH, Couto LB, Addya K, Leonard DG, Zhen Z, Sommer J, Arruda VR.

Mol Ther. 2006 Jun;13(6):1064-73. Epub 2006 May 2. Erratum in: Mol Ther. 2006 Dec;14(6):893. Summer, Jürg [corrected to Sommer, Jürg].


Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs.

Jiang H, Lillicrap D, Patarroyo-White S, Liu T, Qian X, Scallan CD, Powell S, Keller T, McMurray M, Labelle A, Nagy D, Vargas JA, Zhou S, Couto LB, Pierce GF.

Blood. 2006 Jul 1;108(1):107-15. Epub 2006 Mar 7.


Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice.

Scallan CD, Jiang H, Liu T, Patarroyo-White S, Sommer JM, Zhou S, Couto LB, Pierce GF.

Blood. 2006 Mar 1;107(5):1810-7. Epub 2005 Oct 25.


Antiophidian properties of the aqueous extract of Mikania glomerata.

Maiorano VA, Marcussi S, Daher MA, Oliveira CZ, Couto LB, Gomes OA, França SC, Soares AM, Pereira PS.

J Ethnopharmacol. 2005 Dec 1;102(3):364-70. Epub 2005 Aug 3.


Modified infusion procedures affect recombinant adeno-associated virus vector type 2 transduction in the liver.

Ohashi K, Nakai H, Couto LB, Kay MA.

Hum Gene Ther. 2005 Mar;16(3):299-306.


Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model.

Arruda VR, Stedman HH, Nichols TC, Haskins ME, Nicholson M, Herzog RW, Couto LB, High KA.

Blood. 2005 May 1;105(9):3458-64. Epub 2004 Oct 12.


Preclinical gene therapy studies for hemophilia using adeno-associated virus (AAV) vectors.

Couto LB.

Semin Thromb Hemost. 2004 Apr;30(2):161-71. Review.


AAV-mediated gene therapy for hemophilia.

Couto LB, Pierce GF.

Curr Opin Mol Ther. 2003 Oct;5(5):517-23. Review.


Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1.

Arruda VR, Schuettrumpf J, Herzog RW, Nichols TC, Robinson N, Lotfi Y, Mingozzi F, Xiao W, Couto LB, High KA.

Blood. 2004 Jan 1;103(1):85-92. Epub 2003 Sep 11.


Phenotypic correction of a mouse model of hemophilia A using AAV2 vectors encoding the heavy and light chains of FVIII.

Scallan CD, Liu T, Parker AE, Patarroyo-White SL, Chen H, Jiang H, Vargas J, Nagy D, Powell SK, Wright JF, Sarkar R, Kazazian HH, McClelland A, Couto LB.

Blood. 2003 Dec 1;102(12):3919-26. Epub 2003 Jul 31.


Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector.

Scallan CD, Lillicrap D, Jiang H, Qian X, Patarroyo-White SL, Parker AE, Liu T, Vargas J, Nagy D, Powell SK, Wright JF, Turner PV, Tinlin SJ, Webster SE, McClelland A, Couto LB.

Blood. 2003 Sep 15;102(6):2031-7. Epub 2003 May 8.


AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

Manno CS, Chew AJ, Hutchison S, Larson PJ, Herzog RW, Arruda VR, Tai SJ, Ragni MV, Thompson A, Ozelo M, Couto LB, Leonard DG, Johnson FA, McClelland A, Scallan C, Skarsgard E, Flake AW, Kay MA, High KA, Glader B.

Blood. 2003 Apr 15;101(8):2963-72. Epub 2002 Dec 19.


Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy.

Herzog RW, Fields PA, Arruda VR, Brubaker JO, Armstrong E, McClintock D, Bellinger DA, Couto LB, Nichols TC, High KA.

Hum Gene Ther. 2002 Jul 20;13(11):1281-91.


Improved muscle-derived expression of human coagulation factor IX from a skeletal actin/CMV hybrid enhancer/promoter.

Hagstrom JN, Couto LB, Scallan C, Burton M, McCleland ML, Fields PA, Arruda VR, Herzog RW, High KA.

Blood. 2000 Apr 15;95(8):2536-42.


Posttranslational modifications of recombinant myotube-synthesized human factor IX.

Arruda VR, Hagstrom JN, Deitch J, Heiman-Patterson T, Camire RM, Chu K, Fields PA, Herzog RW, Couto LB, Larson PJ, High KA.

Blood. 2001 Jan 1;97(1):130-8.


Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.

Kay MA, Manno CS, Ragni MV, Larson PJ, Couto LB, McClelland A, Glader B, Chew AJ, Tai SJ, Herzog RW, Arruda V, Johnson F, Scallan C, Skarsgard E, Flake AW, High KA.

Nat Genet. 2000 Mar;24(3):257-61.


Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector.

Herzog RW, Yang EY, Couto LB, Hagstrom JN, Elwell D, Fields PA, Burton M, Bellinger DA, Read MS, Brinkhous KM, Podsakoff GM, Nichols TC, Kurtzman GJ, High KA.

Nat Med. 1999 Jan;5(1):56-63.


Brain sites involved in the antinociceptive effect of bradykinin in rats.

Couto LB, Corrêa FM, Pelá IR.

Br J Pharmacol. 1998 Dec;125(7):1578-84.


Adeno-associated viral vector-mediated gene transfer of human blood coagulation factor IX into mouse liver.

Nakai H, Herzog RW, Hagstrom JN, Walter J, Kung SH, Yang EY, Tai SJ, Iwaki Y, Kurtzman GJ, Fisher KJ, Colosi P, Couto LB, High KA.

Blood. 1998 Jun 15;91(12):4600-7.


A method for the preparative isolation and concentration of intact yeast artificial chromosomes.

Couto LB, Spangler EA, Rubin EM.

Nucleic Acids Res. 1989 Oct 11;17(19):8010. No abstract available.


Separation of the SOS-dependent and SOS-independent components of alkylating-agent mutagenesis.

Couto LB, Chaudhuri I, Donahue BA, Demple B, Essigmann JM.

J Bacteriol. 1989 Aug;171(8):4170-7.


A yeast DNA repair gene partially complements defective excision repair in mammalian cells.

Lambert C, Couto LB, Weiss WA, Schultz RA, Thompson LH, Friedberg EC.

EMBO J. 1988 Oct;7(10):3245-53.


Cellular responses to DNA damage in the yeast Saccharomyces cerevisiae.

Burtscher HJ, Cooper AJ, Couto LB.

Mutat Res. 1988 Jul;194(1):1-8. Review. No abstract available.


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