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Using genomics to understand the origin and dispersion of multidrug and extensively drug resistant tuberculosis in Portugal.

Perdigão J, Gomes P, Miranda A, Maltez F, Machado D, Silva C, Phelan JE, Brum L, Campino S, Couto I, Viveiros M, Clark TG, Portugal I.

Sci Rep. 2020 Feb 13;10(1):2600. doi: 10.1038/s41598-020-59558-3.


Life satisfaction mediates the association between childhood maltreatment and depressive symptoms: a study in a sample of Brazilian adolescents.

de Vasconcelos NM, Ribeiro M, Reis D, Couto I, Sena C, Botelho AC, Bonavides D, Hemanny C, Seixas C, Zeni CP, de Oliveira IR.

Braz J Psychiatry. 2020 Jan 24. pii: S1516-44462020005001201. doi: 10.1590/1516-4446-2019-0535. [Epub ahead of print]


In vitro antimicrobial efficacy of two medical grade honey formulations against common high-risk meticillin-resistant staphylococci and Pseudomonas spp. pathogens.

Cremers N, Belas A, Santos Costa S, Couto I, de Rooster H, Pomba C.

Vet Dermatol. 2020 Apr;31(2):90-96. doi: 10.1111/vde.12811. Epub 2019 Dec 5.


Heterogeneity of clinical management of low-grade gastric lymphoma of mucosa-associated lymphoid tissue. An audit of 198 patients in Spain.

Puig I, Sanabria E, Feu F, Couto I, Blanco M, Alonso P, Gisbert JP, McNicholl AG, Seoane A, Bory F, Polo F, Orivé V, Ponce J, Borda F, Hervás A, Pérez-Aisa Á, Rivera R, Quintero E, Nicolás-Pérez D, Bujanda L, Rodrigo L, Calvet X; Spanish Gastroenterological Association Gastroduodenal Diseases Study Group.

Gastroenterol Hepatol. 2020 Feb;43(2):79-86. doi: 10.1016/j.gastrohep.2019.08.012. Epub 2019 Nov 29. English, Spanish.


Genetic Diversity of norA, Coding for a Main Efflux Pump of Staphylococcus aureus.

Costa SS, Sobkowiak B, Parreira R, Edgeworth JD, Viveiros M, Clark TG, Couto I.

Front Genet. 2019 Jan 9;9:710. doi: 10.3389/fgene.2018.00710. eCollection 2018.


Advances in the molecular diagnosis of tuberculosis: From probes to genomes.

Machado D, Couto I, Viveiros M.

Infect Genet Evol. 2019 Aug;72:93-112. doi: 10.1016/j.meegid.2018.11.021. Epub 2018 Nov 30. Review.


Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics.

Machado D, Azzali E, Couto I, Costantino G, Pieroni M, Viveiros M.

Future Microbiol. 2018 Sep;13:1383-1402. doi: 10.2217/fmb-2018-0110. Epub 2018 Sep 27.


Participatory implementation of an antibiotic stewardship programme supported by an innovative surveillance and clinical decision-support system.

Simões AS, Maia MR, Gregório J, Couto I, Asfeldt AM, Simonsen GS, Póvoa P, Viveiros M, Lapão LV.

J Hosp Infect. 2018 Nov;100(3):257-264. doi: 10.1016/j.jhin.2018.07.034. Epub 2018 Jul 30.


Contribution of efflux to colistin heteroresistance in a multidrug resistant Acinetobacter baumannii clinical isolate.

Machado D, Antunes J, Simões A, Perdigão J, Couto I, McCusker M, Martins M, Portugal I, Pacheco T, Batista J, Toscano C, Viveiros M.

J Med Microbiol. 2018 Jun;67(6):740-749. doi: 10.1099/jmm.0.000741. Epub 2018 May 2.


Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries.

Perdigão J, Silva C, Diniz J, Pereira C, Machado D, Ramos J, Silva H, Abilleira F, Brum C, Reis AJ, Macedo M, Scaini JL, Silva AB, Esteves L, Macedo R, Maltez F, Clemente S, Coelho E, Viegas S, Rabna P, Rodrigues A, Taveira N, Jordao L, Kritski A, Lapa E Silva JR, Mokrousov I, Couvin D, Rastogi N, Couto I, Pain A, McNerney R, Clark TG, von Groll A, Dalla-Costa ER, Rossetti ML, Silva PEA, Viveiros M, Portugal I.

Infect Genet Evol. 2019 Aug;72:44-58. doi: 10.1016/j.meegid.2018.03.011. Epub 2018 Mar 17.


Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains.

Machado D, Perdigão J, Portugal I, Pieroni M, Silva PA, Couto I, Viveiros M.

Antibiotics (Basel). 2018 Mar 3;7(1). pii: E18. doi: 10.3390/antibiotics7010018.


First report on antimicrobial resistance and molecular characterisation of Salmonella enterica serotype Typhi isolated from human specimens in Luanda, Angola.

Francisco M, Costa SS, Belas A, Ramos J, Couto I, Pomba C, Viveiros M.

J Glob Antimicrob Resist. 2018 Jun;13:246-249. doi: 10.1016/j.jgar.2018.02.001. Epub 2018 Feb 9.


Fighting antibiotic resistance in Portuguese hospitals: Understanding antibiotic prescription behaviours to better design antibiotic stewardship programmes.

Simões AS, Alves DA, Gregório J, Couto I, Dias S, Póvoa P, Viveiros M, Gonçalves L, Lapão LV.

J Glob Antimicrob Resist. 2018 Jun;13:226-230. doi: 10.1016/j.jgar.2018.01.013. Epub 2018 Jan 31.


Chemical Compounds and Bioactivity of Aqueous Extracts of Alibertia spp. in the Control of Plutella xylostella L. (Lepidoptera: Plutellidae).

Peres LLS, Sobreiro AI, Couto IFS, Silva RM, Pereira FF, Heredia-Vieira SC, Cardoso CAL, Mauad M, Scalon SPQ, Verza SS, Mussury RM.

Insects. 2017 Nov 22;8(4). pii: E125. doi: 10.3390/insects8040125.


Active antimicrobial efflux in Staphylococcus epidermidis: building up of resistance to fluoroquinolones and biocides in a major opportunistic pathogen.

Costa SS, Viveiros M, Pomba C, Couto I.

J Antimicrob Chemother. 2018 Feb 1;73(2):320-324. doi: 10.1093/jac/dkx400.


Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium.

Cannalire R, Machado D, Felicetti T, Santos Costa S, Massari S, Manfroni G, Barreca ML, Tabarrini O, Couto I, Viveiros M, Sabatini S, Cecchetti V.

Eur J Med Chem. 2017 Nov 10;140:321-330. doi: 10.1016/j.ejmech.2017.09.014. Epub 2017 Sep 12.


HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality.

Tavares AM, Fronteira I, Couto I, Machado D, Viveiros M, Abecasis AB, Dias S.

PLoS One. 2017 Sep 28;12(9):e0185526. doi: 10.1371/journal.pone.0185526. eCollection 2017. Review.


Subcutaneous emphysema related to air-powder tooth polishing: a report of three cases.

Alonso V, García-Caballero L, Couto I, Diniz M, Diz P, Limeres J.

Aust Dent J. 2017 Dec;62(4):510-515. doi: 10.1111/adj.12537. Epub 2017 Jul 16.


Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli.

Machado D, Fernandes L, Costa SS, Cannalire R, Manfroni G, Tabarrini O, Couto I, Sabatini S, Viveiros M.

PeerJ. 2017 Apr 26;5:e3168. doi: 10.7717/peerj.3168. eCollection 2017.


Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis.

Machado D, Coelho TS, Perdigão J, Pereira C, Couto I, Portugal I, Maschmann RA, Ramos DF, von Groll A, Rossetti MLR, Silva PA, Viveiros M.

Front Microbiol. 2017 Apr 27;8:711. doi: 10.3389/fmicb.2017.00711. eCollection 2017.


Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection.

Couto I, Victoria M, Veloso VG, Rodrigues L, Grinsztejn B, Lacerda M, Victoria F, Perazzo H.

PLoS One. 2017 Mar 22;12(3):e0174453. doi: 10.1371/journal.pone.0174453. eCollection 2017.


Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola.

Perdigão J, Clemente S, Ramos J, Masakidi P, Machado D, Silva C, Couto I, Viveiros M, Taveira N, Portugal I.

Sci Rep. 2017 Feb 23;7:42814. doi: 10.1038/srep42814.


Therapeutic impact of colon capsule endoscopy with PillCam™ COLON 2 after incomplete standard colonoscopy: a Spanish multicenter study.

Nogales Ó, García-Lledó J, Luján M, Nicolás D, Juanmartiñena JF, González-Suárez B, Sánchez Ceballos F, Couto I, Olmedo J, Garfia C, Carretero C, Fernández Urién I, Rodríguez S, Asteinza M, Olivencia P, Masedo Á, Muñoz-Navas M, Merino B, González Asanza C.

Rev Esp Enferm Dig. 2017 May;109(5):322-327. doi: 10.17235/reed.2017.4369/2016.


In vitro and in silico analysis of the efficiency of tetrahydropyridines as drug efflux inhibitors in Escherichia coli.

Silva L Jr, Carrion LL, von Groll A, Costa SS, Junqueira E, Ramos DF, Cantos J, Seus VR, Couto I, Fernandes LD, Bonacorso HG, Martins MA, Zanatta N, Viveiros M, Machado KS, Almeida da Silva PE.

Int J Antimicrob Agents. 2017 Mar;49(3):308-314. doi: 10.1016/j.ijantimicag.2016.11.024. Epub 2017 Jan 30.


Genetic diversity, transmission dynamics, and drug resistance of Mycobacterium tuberculosis in Luanda, Angola.

Perdigão J, Clemente S, Ramos J, Masakidi P, Machado D, Silva C, Couto I, Viveiros M, Taveira N, Portugal I.

Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S38-S39. doi: 10.1016/j.ijmyco.2016.09.050. Epub 2016 Nov 12.


Feeding preference of Plutella xylostella for leaves treated with plant extracts.

Couto IF, Fuchs ML, Pereira FF, Mauad M, Scalon SP, Dresch DM, Mussury RM.

An Acad Bras Cienc. 2016;88(3 Suppl):1781-1789. doi: 10.1590/0001-3765201620150236. Epub 2016 Oct 24.


An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria.

Costa SS, Lopes E, Azzali E, Machado D, Coelho T, da Silva PE, Viveiros M, Pieroni M, Couto I.

Assay Drug Dev Technol. 2016 Nov;14(9):524-534.


Beyond extensively drug-resistant tuberculosis in Lisbon, Portugal: a case of linezolid resistance acquisition presenting as an iliopsoas abscess.

Perdigão J, Maltez F, Machado D, Silva H, Pereira C, Silva C, Couto I, Viveiros M, Portugal I.

Int J Antimicrob Agents. 2016 Nov;48(5):569-570. doi: 10.1016/j.ijantimicag.2016.07.026. Epub 2016 Sep 29. No abstract available.


Boosting Effect of 2-Phenylquinoline Efflux Inhibitors in Combination with Macrolides against Mycobacterium smegmatis and Mycobacterium avium.

Machado D, Cannalire R, Santos Costa S, Manfroni G, Tabarrini O, Cecchetti V, Couto I, Viveiros M, Sabatini S.

ACS Infect Dis. 2015 Dec 11;1(12):593-603. doi: 10.1021/acsinfecdis.5b00052. Epub 2015 Jul 23.


Prevention and Control of Antimicrobial Resistant Healthcare-Associated Infections: The Microbiology Laboratory Rocks!

Simões AS, Couto I, Toscano C, Gonçalves E, Póvoa P, Viveiros M, Lapão LV.

Front Microbiol. 2016 Jun 7;7:855. doi: 10.3389/fmicb.2016.00855. eCollection 2016. Review.


Plasmid-Borne Antimicrobial Resistance of Staphylococcus aureus Isolated in a Hospital in Lisbon, Portugal.

Costa SS, Palma C, Kadlec K, Fessler AT, Viveiros M, Melo-Cristino J, Schwarz S, Couto I.

Microb Drug Resist. 2016 Dec;22(8):617-626. Epub 2016 Jun 16.


Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.

Machado D, Pires D, Perdigão J, Couto I, Portugal I, Martins M, Amaral L, Anes E, Viveiros M.

PLoS One. 2016 Feb 26;11(2):e0149326. doi: 10.1371/journal.pone.0149326. eCollection 2016.


Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus.

Santos Costa S, Viveiros M, Rosato AE, Melo-Cristino J, Couto I.

BMC Microbiol. 2015 Oct 24;15:232. doi: 10.1186/s12866-015-0572-8.


Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy.

Pieroni M, Machado D, Azzali E, Santos Costa S, Couto I, Costantino G, Viveiros M.

J Med Chem. 2015 Aug 13;58(15):5842-53. doi: 10.1021/acs.jmedchem.5b00428. Epub 2015 Aug 3.


Direct Detection by the Xpert MTB/RIF Assay and Characterization of Multi and Poly Drug-Resistant Tuberculosis in Guinea-Bissau, West Africa.

Rabna P, Ramos J, Ponce G, Sanca L, Mané M, Armada A, Machado D, Vieira F, Gomes VF, Martins E, Colombatti R, Riccardi F, Perdigão J, Sotero J, Portugal I, Couto I, Atouguia J, Rodrigues A, Viveiros M.

PLoS One. 2015 May 27;10(5):e0127536. doi: 10.1371/journal.pone.0127536. eCollection 2015.


Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.

Coelho T, Machado D, Couto I, Maschmann R, Ramos D, von Groll A, Rossetti ML, Silva PA, Viveiros M.

Front Microbiol. 2015 Apr 28;6:330. doi: 10.3389/fmicb.2015.00330. eCollection 2015.


Enhancing activity of antibiotics against Staphylococcus aureus: Zanthoxylum capense constituents and derivatives.

Cabral V, Luo X, Junqueira E, Costa SS, Mulhovo S, Duarte A, Couto I, Viveiros M, Ferreira MJ.

Phytomedicine. 2015 Apr 15;22(4):469-76. doi: 10.1016/j.phymed.2015.02.003. Epub 2015 Mar 5.


Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.

Perdigão J, Silva H, Machado D, Macedo R, Maltez F, Silva C, Jordao L, Couto I, Mallard K, Coll F, Hill-Cawthorne GA, McNerney R, Pain A, Clark TG, Viveiros M, Portugal I.

BMC Genomics. 2014 Nov 18;15:991. doi: 10.1186/1471-2164-15-991.


Nested and multiplex real-time PCR using dual-labeled probes: detecting and discriminating Mycobacterium tuberculosis complex members in cultures and animal tissues.

Costa P, Couto I, Viveiros M, Inácio J.

Methods Mol Biol. 2015;1247:133-43. doi: 10.1007/978-1-4939-2004-4_9.


Rapid identification of veterinary-relevant Mycobacterium tuberculosis complex species using 16S rDNA, IS6110 and Regions of Difference-targeted dual-labelled hydrolysis probes.

Costa P, Amaro A, Ferreira AS, Machado D, Albuquerque T, Couto I, Botelho A, Viveiros M, Inácio J.

J Microbiol Methods. 2014 Dec;107:13-22. doi: 10.1016/j.mimet.2014.08.017. Epub 2014 Sep 2.


Relatedness of Mycobacterium avium subspecies hominissuis clinical isolates of human and porcine origins assessed by MLVA.

Leão C, Canto A, Machado D, Sanches IS, Couto I, Viveiros M, Inácio J, Botelho A.

Vet Microbiol. 2014 Sep 17;173(1-2):92-100. doi: 10.1016/j.vetmic.2014.06.027. Epub 2014 Jul 8.


Membrane transport systems and the biodegradation potential and pathogenicity of genus Rhodococcus.

de Carvalho CC, Costa SS, Fernandes P, Couto I, Viveiros M.

Front Physiol. 2014 Apr 4;5:133. doi: 10.3389/fphys.2014.00133. eCollection 2014. Review.


Assessment of the BD MGIT TBc identification test for the detection of Mycobacterium tuberculosis complex in a network of mycobacteriology laboratories.

Machado D, Ramos J, Couto I, Cadir N, Narciso I, Coelho E, Viegas S, Viveiros M.

Biomed Res Int. 2014;2014:398108. doi: 10.1155/2014/398108. Epub 2014 Jan 23.


Gold nanoprobes for multi loci assessment of multi-drug resistant tuberculosis.

Pedrosa P, Veigas B, Machado D, Couto I, Viveiros M, Baptista PV.

Tuberculosis (Edinb). 2014 May;94(3):332-7. doi: 10.1016/ Epub 2014 Jan 9.


Standing of nucleic acid testing strategies in veterinary diagnosis laboratories to uncover Mycobacterium tuberculosis complex members.

Costa P, Botelho A, Couto I, Viveiros M, Inácio J.

Front Mol Biosci. 2014 Oct 15;1:16. doi: 10.3389/fmolb.2014.00016. eCollection 2014. Review.


Enhanced detection of tuberculous mycobacteria in animal tissues using a semi-nested probe-based real-time PCR.

Costa P, Ferreira AS, Amaro A, Albuquerque T, Botelho A, Couto I, Cunha MV, Viveiros M, Inácio J.

PLoS One. 2013 Nov 21;8(11):e81337. doi: 10.1371/journal.pone.0081337. eCollection 2013.


Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis.

Veigas B, Pedrosa P, Couto I, Viveiros M, Baptista PV.

J Nanobiotechnology. 2013 Nov 25;11:38. doi: 10.1186/1477-3155-11-38.


GidB mutation as a phylogenetic marker for Q1 cluster Mycobacterium tuberculosis isolates and intermediate-level streptomycin resistance determinant in Lisbon, Portugal.

Perdigão J, Macedo R, Machado D, Silva C, Jordão L, Couto I, Viveiros M, Portugal I.

Clin Microbiol Infect. 2014 May;20(5):O278-84. doi: 10.1111/1469-0691.12392. Epub 2013 Nov 4.


Biocide and antimicrobial susceptibility of methicillin-resistant staphylococcal isolates from horses.

Couto N, Belas A, Tilley P, Couto I, Gama LT, Kadlec K, Schwarz S, Pomba C.

Vet Microbiol. 2013 Sep 27;166(1-2):299-303. doi: 10.1016/j.vetmic.2013.05.011. Epub 2013 Jun 10.


Genetic relatedness, antimicrobial and biocide susceptibility comparative analysis of methicillin-resistant and -susceptible Staphylococcus pseudintermedius from Portugal.

Couto N, Belas A, Couto I, Perreten V, Pomba C.

Microb Drug Resist. 2014 Aug;20(4):364-71. doi: 10.1089/mdr.2013.0043. Epub 2013 Jul 2.

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