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Items: 23


Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer.

Schiffmann LM, Fritsch M, Gebauer F, Günther SD, Stair NR, Seeger JM, Thangarajah F, Dieplinger G, Bludau M, Alakus H, Göbel H, Quaas A, Zander T, Hilberg F, Bruns CJ, Kashkar H, Coutelle O.

Br J Cancer. 2019 Jan;120(1):69-78. doi: 10.1038/s41416-018-0198-3. Epub 2018 Oct 31.


A combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition.

Schiffmann LM, Brunold M, Liwschitz M, Goede V, Loges S, Wroblewski M, Quaas A, Alakus H, Stippel D, Bruns CJ, Hallek M, Kashkar H, Hacker UT, Coutelle O.

Br J Cancer. 2017 Feb 28;116(5):600-608. doi: 10.1038/bjc.2017.13. Epub 2017 Jan 31.


Evaluation of Angiopoietin-2 as a biomarker in gastric cancer: results from the randomised phase III AVAGAST trial.

Hacker UT, Escalona-Espinosa L, Consalvo N, Goede V, Schiffmann L, Scherer SJ, Hedge P, Van Cutsem E, Coutelle O, Büning H.

Br J Cancer. 2016 Apr 12;114(8):855-62. doi: 10.1038/bjc.2016.30. Epub 2016 Mar 31.


IAP antagonization promotes inflammatory destruction of vascular endothelium.

Witt A, Seeger JM, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jüngst C, Schauss AC, Schüll S, Wohlleber D, Knolle PA, Krönke M, Mauch C, Kashkar H.

EMBO Rep. 2015 Jun;16(6):719-27. doi: 10.15252/embr.201439616. Epub 2015 Mar 30.


Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours.

Coutelle O, Schiffmann LM, Liwschitz M, Brunold M, Goede V, Hallek M, Kashkar H, Hacker UT.

Br J Cancer. 2015 Feb 3;112(3):495-503. doi: 10.1038/bjc.2014.629. Epub 2015 Jan 6.


Prognostic serum cytokines in classical Hodgkin lymphoma--letter.

Coutelle O, Büning H, Plütschow A, Fuchs M, Escalona-Espinosa L, Engert A, Hacker U.

Clin Cancer Res. 2014 Dec 15;20(24):6633. doi: 10.1158/1078-0432.CCR-14-1735. No abstract available.


BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H.

EMBO J. 2014 Oct 1;33(19):2171-87. doi: 10.15252/embj.201387244. Epub 2014 Jul 23.


Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.

Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H.

EMBO Mol Med. 2014 May;6(5):624-39. doi: 10.1002/emmm.201303016.


Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.

Brinkmann K, Zigrino P, Witt A, Schell M, Ackermann L, Broxtermann P, Schüll S, Andree M, Coutelle O, Yazdanpanah B, Seeger JM, Klubertz D, Drebber U, Hacker UT, Krönke M, Mauch C, Hoppe T, Kashkar H.

Cell Rep. 2013 Mar 28;3(3):881-91. doi: 10.1016/j.celrep.2013.02.014. Epub 2013 Mar 14.


Analysis of Tie2-expressing monocytes (TEM) in patients with colorectal cancer.

Goede V, Coutelle O, Shimabukuro-Vornhagen A, Holtick U, Neuneier J, Koslowsky TC, Weihrauch MR, von Bergwelt-Baildon M, Hacker UT.

Cancer Invest. 2012 Mar;30(3):225-30. doi: 10.3109/07357907.2011.636114. Epub 2011 Dec 15.


Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction.

Kwiecinski M, Noetel A, Elfimova N, Trebicka J, Schievenbusch S, Strack I, Molnar L, von Brandenstein M, Töx U, Nischt R, Coutelle O, Dienes HP, Odenthal M.

PLoS One. 2011;6(9):e24568. doi: 10.1371/journal.pone.0024568. Epub 2011 Sep 9.


Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis.

Uhrig S, Coutelle O, Wiehe T, Perabo L, Hallek M, Büning H.

Gene Ther. 2012 Feb;19(2):210-8. doi: 10.1038/gt.2011.78. Epub 2011 Jun 9.


Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles.

Stahnke S, Lux K, Uhrig S, Kreppel F, Hösel M, Coutelle O, Ogris M, Hallek M, Büning H.

Virology. 2011 Jan 5;409(1):77-83. doi: 10.1016/j.virol.2010.09.025. Epub 2010 Oct 25.


Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy.

Goede V, Coutelle O, Neuneier J, Reinacher-Schick A, Schnell R, Koslowsky TC, Weihrauch MR, Cremer B, Kashkar H, Odenthal M, Augustin HG, Schmiegel W, Hallek M, Hacker UT.

Br J Cancer. 2010 Oct 26;103(9):1407-14. doi: 10.1038/sj.bjc.6605925. Epub 2010 Oct 5.


Elevated XIAP expression alone does not confer chemoresistance.

Seeger JM, Brinkmann K, Yazdanpanah B, Haubert D, Pongratz C, Coutelle O, Krönke M, Kashkar H.

Br J Cancer. 2010 Jun 8;102(12):1717-23. doi: 10.1038/sj.bjc.6605704. Epub 2010 May 18.


Combined paracrine and endocrine AAV9 mediated expression of hepatocyte growth factor for the treatment of renal fibrosis.

Schievenbusch S, Strack I, Scheffler M, Nischt R, Coutelle O, Hösel M, Hallek M, Fries JW, Dienes HP, Odenthal M, Büning H.

Mol Ther. 2010 Jul;18(7):1302-9. doi: 10.1038/mt.2010.71. Epub 2010 Apr 27.


The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack.

Seeger JM, Schmidt P, Brinkmann K, Hombach AA, Coutelle O, Zigrino P, Wagner-Stippich D, Mauch C, Abken H, Krönke M, Kashkar H.

Cancer Res. 2010 Mar 1;70(5):1825-34. doi: 10.1158/0008-5472.CAN-09-3175. Epub 2010 Feb 23.


Complete remission in a colon cancer patient with a large, irresectable liver metastasis after XELOX/cetuximab/bevacizumab treatment.

Weihrauch MR, Stippel D, Fries JW, Arnold D, Bovenschulte H, Coutelle O, Hacker U.

Onkologie. 2008 Sep;31(8-9):464-7. doi: 10.1159/000142388. Epub 2008 Aug 12.


Recent developments in adeno-associated virus vector technology.

Büning H, Perabo L, Coutelle O, Quadt-Humme S, Hallek M.

J Gene Med. 2008 Jul;10(7):717-33. doi: 10.1002/jgm.1205. Review.


Hedgehog signalling is required for maintenance of myf5 and myoD expression and timely terminal differentiation in zebrafish adaxial myogenesis.

Coutelle O, Blagden CS, Hampson R, Halai C, Rigby PW, Hughes SM.

Dev Biol. 2001 Aug 1;236(1):136-50.


The neural cell adhesion molecule L1: genomic organisation and differential splicing is conserved between man and the pufferfish Fugu.

Coutelle O, Nyakatura G, Taudien S, Elgar G, Brenner S, Platzer M, Drescher B, Jouet M, Kenwrick S, Rosenthal A.

Gene. 1998 Feb 16;208(1):7-15.


Large-scale production of DNA sequencing templates by microtitre format PCR.

Rosenthal A, Coutelle O, Craxton M.

Nucleic Acids Res. 1993 Jan 11;21(1):173-4. No abstract available.

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