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Items: 1 to 50 of 239

1.

Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia.

Al-Allaf FA, Abduljaleel Z, Athar M, Taher MM, Khan W, Mehmet H, Colakogullari M, Apostolidou S, Bigger B, Waddington S, Coutelle C, Themis M, Al-Ahdal MN, Al-Mohanna FA, Al-Hassnan ZN, Bouazzaoui A.

Noncoding RNA Res. 2018 Nov 22;4(1):1-14. doi: 10.1016/j.ncrna.2018.11.005. eCollection 2019 Mar.

2.

An important step on the long path to clinical application of in utero gene therapy.

Coutelle C.

Gene Ther. 2018 Oct;25(7):451-453. doi: 10.1038/s41434-018-0046-3. Epub 2018 Oct 5. No abstract available.

PMID:
30291314
3.

Transduction of fetal mice with a feline lentiviral vector induces liver tumors which exhibit an E2F activation signature.

Condiotti R, Goldenberg D, Giladi H, Schnitzer-Perlman T, Waddington SN, Buckley SM, Heim D, Cheung W, Themis M, Coutelle C, Simerzin A, Osejindu E, Wege H, Themis M, Galun E.

Mol Ther. 2014 Jan;22(1):59-68. doi: 10.1038/mt.2013.193. Epub 2013 Aug 28.

4.

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.

Nowrouzi A, Cheung WT, Li T, Zhang X, Arens A, Paruzynski A, Waddington SN, Osejindu E, Reja S, von Kalle C, Wang Y, Al-Allaf F, Gregory L, Themis M, Holder M, Dighe N, Ruthe A, Buckley SM, Bigger B, Montini E, Thrasher AJ, Andrews R, Roberts TP, Newbold RF, Coutelle C, Schmidt M, Themis M.

Mol Ther. 2013 Feb;21(2):324-37. doi: 10.1038/mt.2012.224. Epub 2012 Nov 13.

5.

Risks, benefits and ethical, legal, and societal considerations for translation of prenatal gene therapy to human application.

Coutelle C, Ashcroft R.

Methods Mol Biol. 2012;891:371-87. doi: 10.1007/978-1-61779-873-3_17. Review.

PMID:
22648781
6.

Monitoring for potential adverse effects of prenatal gene therapy: mouse models for developmental aberrations and inadvertent germ line transmission.

Coutelle C, Waddington SN, Themis M.

Methods Mol Biol. 2012;891:329-40. doi: 10.1007/978-1-61779-873-3_15.

PMID:
22648779
7.

Monitoring for potential adverse effects of prenatal gene therapy: use of large animal models with relevance to human application.

Mehta V, Abi-Nader KN, Carr D, Wallace J, Coutelle C, Waddington SN, Peebles D, David AL.

Methods Mol Biol. 2012;891:291-328. doi: 10.1007/978-1-61779-873-3_14.

PMID:
22648778
8.

Vector systems for prenatal gene therapy: choosing vectors for different applications.

Coutelle C, Waddington SN.

Methods Mol Biol. 2012;891:41-53. doi: 10.1007/978-1-61779-873-3_3. Review.

PMID:
22648767
9.

The concept of prenatal gene therapy.

Coutelle C, Waddington SN.

Methods Mol Biol. 2012;891:1-7. doi: 10.1007/978-1-61779-873-3_1.

PMID:
22648765
10.

Trial and error: how the unclonable human mitochondrial genome was cloned in yeast.

Bigger BW, Liao AY, Sergijenko A, Coutelle C.

Pharm Res. 2011 Nov;28(11):2863-70. doi: 10.1007/s11095-011-0527-1. Epub 2011 Jul 9.

PMID:
21739320
11.

Gene and cell therapy for cystic fibrosis: from bench to bedside.

Conese M, Ascenzioni F, Boyd AC, Coutelle C, De Fino I, De Smedt S, Rejman J, Rosenecker J, Schindelhauer D, Scholte BJ.

J Cyst Fibros. 2011 Jun;10 Suppl 2:S114-28. doi: 10.1016/S1569-1993(11)60017-9. Review.

12.

Recent advances in fetal gene therapy.

Buckley SM, Rahim AA, Chan JK, David AL, Peebles DM, Coutelle C, Waddingtont SN.

Ther Deliv. 2011 Apr;2(4):461-9.

PMID:
22826854
13.

Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver.

Argyros O, Wong SP, Fedonidis C, Tolmachov O, Waddington SN, Howe SJ, Niceta M, Coutelle C, Harbottle RP.

J Mol Med (Berl). 2011 May;89(5):515-29. doi: 10.1007/s00109-010-0713-3. Epub 2011 Feb 8.

PMID:
21301798
14.

LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectives.

Al-Allaf FA, Coutelle C, Waddington SN, David AL, Harbottle R, Themis M.

Int Arch Med. 2010 Dec 13;3:36. doi: 10.1186/1755-7682-3-36.

15.

In utero gene transfer to the mouse nervous system.

Rahim AA, Wong AM, Buckley SM, Chan JK, David AL, Cooper JD, Coutelle C, Peebles DM, Waddington SN.

Biochem Soc Trans. 2010 Dec;38(6):1489-93. doi: 10.1042/BST0381489. Review.

PMID:
21118113
16.

Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage.

Wong SP, Argyros O, Coutelle C, Harbottle RP.

Gene Ther. 2011 Jan;18(1):82-7. doi: 10.1038/gt.2010.116. Epub 2010 Aug 26.

PMID:
20739959
17.

Ultrasonographic development of the fetal sheep stomach and evaluation of early gestation ultrasound-guided in utero intragastric injection.

David AL, Abi-Nader KN, Weisz B, Shaw SW, Themis M, Cook T, Coutelle C, Rodeck CH, Peebles DM.

Taiwan J Obstet Gynecol. 2010 Mar;49(1):23-9. doi: 10.1016/S1028-4559(10)60004-6.

18.

Strategies for the episomal modification of cells.

Wong SP, Argyros O, Coutelle C, Harbottle RP.

Curr Opin Mol Ther. 2009 Aug;11(4):433-41. Review.

PMID:
19649988
19.

Luciferin detection after intranasal vector delivery is improved by intranasal rather than intraperitoneal luciferin administration.

Buckley SM, Howe SJ, Rahim AA, Buning H, McIntosh J, Wong SP, Baker AH, Nathwani A, Thrasher AJ, Coutelle C, McKay TR, Waddington SN.

Hum Gene Ther. 2008 Oct;19(10):1050-6. doi: 10.1089/hum.2008.023.

PMID:
18847316
20.

Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector.

Argyros O, Wong SP, Niceta M, Waddington SN, Howe SJ, Coutelle C, Miller AD, Harbottle RP.

Gene Ther. 2008 Dec;15(24):1593-605. doi: 10.1038/gt.2008.113. Epub 2008 Jul 17.

PMID:
18633447
21.

Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression.

Buckley SM, Howe SJ, Sheard V, Ward NJ, Coutelle C, Thrasher AJ, Waddington SN, McKay TR.

Gene Ther. 2008 Aug;15(16):1167-75. doi: 10.1038/gt.2008.74. Epub 2008 Apr 24.

PMID:
18432275
22.

Intra-amniotic delivery of CFTR-expressing adenovirus does not reverse cystic fibrosis phenotype in inbred CFTR-knockout mice.

Buckley SM, Waddington SN, Jezzard S, Bergau A, Themis M, MacVinish LJ, Cuthbert AW, Colledge WH, Coutelle C.

Mol Ther. 2008 May;16(5):819-24. doi: 10.1038/mt.2008.26. Epub 2008 Mar 25.

23.

Why Bother?: Is In Utero Gene Therapy Worth the Effort?

Coutelle C.

Mol Ther. 2008 Feb;16(2):219-220. doi: 10.1038/sj.mt.6300401. Epub 2016 Dec 7. No abstract available.

PMID:
28178537
24.

Why bother? Is in utero gene therapy worth the effort?

Coutelle C.

Mol Ther. 2008 Feb;16(2):219-20. doi: 10.1038/sj.mt.6300401. No abstract available.

25.

Fetal gene transfer.

Waddington SN, Buckley SM, David AL, Peebles DM, Rodeck CH, Coutelle C.

Curr Opin Mol Ther. 2007 Oct;9(5):432-8. Review.

PMID:
17932807
26.

Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection.

Hibbitt OC, Harbottle RP, Waddington SN, Bursill CA, Coutelle C, Channon KM, Wade-Martins R.

J Gene Med. 2007 Jun;9(6):488-97.

PMID:
17471590
28.

Clinically applicable procedure for gene delivery to fetal gut by ultrasound-guided gastric injection: toward prenatal prevention of early-onset intestinal diseases.

David AL, Peebles DM, Gregory L, Waddington SN, Themis M, Weisz B, Ruthe A, Lawrence L, Cook T, Rodeck CH, Coutelle C.

Hum Gene Ther. 2006 Jul;17(7):767-79.

PMID:
16839275
29.

Ultrasound-guided injection and occlusion of the trachea in fetal sheep.

David AL, Weisz B, Gregory L, Themis M, Cook T, Roubliova X, Deprest J, Coutelle C, Rodeck CH, Peebles DM.

Ultrasound Obstet Gynecol. 2006 Jul;28(1):82-8.

30.

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro.

Tolmachov O, Ma YL, Themis M, Patel P, Spohr H, Macleod KT, Ullrich ND, Kienast Y, Coutelle C, Peters NS.

BMC Cardiovasc Disord. 2006 Jun 6;6:25.

31.

Corrigendum to "Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice".

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Themis M, Holder MV, Buckley SM, Dighe N, Ruthe AT, Mistry A, Bigger B, Rahim A, Nguyen TH, Trono D, Thrasher AJ, Coutelle C.

Mol Ther. 2006 Apr;13(4):830. doi: 10.1016/j.ymthe.2005.10.003. Epub 2005 Nov 3. No abstract available.

32.

Nuclear-targeted minicircle to enhance gene transfer with non-viral vectors in vitro and in vivo.

Vaysse L, Gregory LG, Harbottle RP, Perouzel E, Tolmachov O, Coutelle C.

J Gene Med. 2006 Jun;8(6):754-63.

PMID:
16532508
33.
34.

Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX.

Bigger BW, Siapati EK, Mistry A, Waddington SN, Nivsarkar MS, Jacobs L, Perrett R, Holder MV, Ridler C, Kemball-Cook G, Ali RR, Forbes SJ, Coutelle C, Wright N, Alison M, Thrasher AJ, Bonnet D, Themis M.

Gene Ther. 2006 Jan;13(2):117-26.

PMID:
16163377
35.

Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy.

Weisz B, David AL, Gregory LG, Perocheau D, Ruthe A, Waddington SN, Themis M, Cook T, Coutelle C, Rodeck CH, Peebles DM.

Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):1105-9.

PMID:
16157120
36.

Gene therapy progress and prospects: fetal gene therapy--first proofs of concept--some adverse effects.

Coutelle C, Themis M, Waddington SN, Buckley SM, Gregory LG, Nivsarkar MS, David AL, Peebles D, Weisz B, Rodeck C.

Gene Ther. 2005 Nov;12(22):1601-7. Review.

PMID:
16136161
37.

Factors influencing adenovirus-mediated airway transduction in fetal mice.

Buckley SM, Waddington SN, Jezzard S, Lawrence L, Schneider H, Holder MV, Themis M, Coutelle C.

Mol Ther. 2005 Sep;12(3):484-92.

38.

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Themis M, Holder MV, Buckley SM, Dighe N, Ruthe AT, Mistry A, Bigger B, Rahim A, Nguyen TH, Trono D, Thrasher AJ, Coutelle C.

Mol Ther. 2005 Oct;12(4):763-71. Erratum in: Mol Ther. 2006 Apr;13(4):830.

39.

Coupled analysis of bacterial transformants and ligation mixture by duplex PCR enables detection of fatal instability of a nascent recombinant plasmid.

Al-Allaf FA, Tolmachov O, Themis M, Coutelle C.

J Biochem Biophys Methods. 2005 Aug 31;64(2):142-6.

PMID:
16054701
40.

Synthesis and application of integrin targeting lipopeptides in targeted gene delivery.

Waterhouse JE, Harbottle RP, Keller M, Kostarelos K, Coutelle C, Jorgensen MR, Miller AD.

Chembiochem. 2005 Jul;6(7):1212-23.

PMID:
15937988
41.

In utero gene therapy: current challenges and perspectives.

Waddington SN, Kramer MG, Hernandez-Alcoceba R, Buckley SM, Themis M, Coutelle C, Prieto J.

Mol Ther. 2005 May;11(5):661-76. Review.

42.

Accurate size gauging of ExoIII/S1-generated deletions by PCR analysis of ligation mixtures.

Al-Allaf F, Tolmachov O, Themis M, Coutelle C.

Anal Biochem. 2005 Apr 15;339(2):348-50. No abstract available.

PMID:
15797577
43.

Complement inhibition rescued mice allowing observation of transgene expression following intraportal delivery of baculovirus in mice.

Hoare J, Waddington S, Thomas HC, Coutelle C, McGarvey MJ.

J Gene Med. 2005 Mar;7(3):325-33.

PMID:
15521052
44.

Fetal and neonatal gene therapy: benefits and pitfalls.

Waddington SN, Kennea NL, Buckley SM, Gregory LG, Themis M, Coutelle C.

Gene Ther. 2004 Oct;11 Suppl 1:S92-7. Review.

PMID:
15454963
45.

Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogens.

Coutelle C, Höhn B, Benesova M, Oneta CM, Quattrochi P, Roth HJ, Schmidt-Gayk H, Schneeweiss A, Bastert G, Seitz HK.

Int J Oncol. 2004 Oct;25(4):1127-32.

PMID:
15375565
46.

Association of metabolic gene polymorphisms with alcohol consumption in controls.

Raimondi S, Benhamou S, Coutelle C, Garte S, Hayes R, Kiemeney L, Lazarus P, Marchand LL, Morita S, Povey A, Romkes M, Zijno A, Taioli E.

Biomarkers. 2004 Mar-Apr;9(2):180-9.

PMID:
15370874
47.

Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.

Waddington SN, Nivsarkar MS, Mistry AR, Buckley SM, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder MV, Brittan M, Georgiadis A, Al-Allaf F, Bigger BW, Gregory LG, Cook HT, Ali RR, Thrasher A, Tuddenham EG, Themis M, Coutelle C.

Blood. 2004 Nov 1;104(9):2714-21. Epub 2004 Jul 1. Erratum in: Blood. 2006 Mar 1;107(5):1750.

PMID:
15231566
48.

Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy.

Gregory LG, Waddington SN, Holder MV, Mitrophanous KA, Buckley SM, Mosley KL, Bigger BW, Ellard FM, Walmsley LE, Lawrence L, Al-Allaf F, Kingsman S, Coutelle C, Themis M.

Gene Ther. 2004 Jul;11(14):1117-25.

PMID:
15141156
49.

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls.

Smits KM, Benhamou S, Garte S, Weijenberg MP, Alamanos Y, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Boffetta P, Bouchardy C, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Coutelle C, Daly AK, Muzi G, Dolzan V, Duzhak TG, Farker K, Golka K, Haugen A, Hein DW, Hildesheim A, Hirvonen A, Hsieh LL, Ingelman-Sundberg M, Kalina I, Kang D, Katoh T, Kihara M, Ono-Kihara M, Kim H, Kiyohara C, Kremers P, Lazarus P, Le Marchand L, Lechner MC, London S, Manni JJ, Maugard CM, Morgan GJ, Morita S, Nazar-Stewart V, Kristensen VN, Oda Y, Parl FF, Peters WH, Rannug A, Rebbeck T, Pinto LF, Risch A, Romkes M, Salagovic J, Schoket B, Seidegard J, Shields PG, Sim E, Sinnett D, Strange RC, Stucker I, Sugimura H, To-Figueras J, Vineis P, Yu MC, Zheng W, Pedotti P, Taioli E.

Int J Cancer. 2004 Jun 10;110(2):266-70.

50.

Reduced toxicity of F-deficient Sendai virus vector in the mouse fetus.

Waddington SN, Buckley SM, Bernloehr C, Bossow S, Ungerechts G, Cook T, Gregory L, Rahim A, Themis M, Neubert WJ, Coutelle C, Lauer UM, Bitzer M.

Gene Ther. 2004 Apr;11(7):599-608.

PMID:
14724676

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