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Items: 1 to 50 of 88

1.

High specificity and sensitivity of Zika EDIII-based ELISA diagnosis highlighted by a large human reference panel.

Denis J, Attoumani S, Gravier P, Tenebray B, Garnier A, Briolant S, de Laval F, Chastres V, Grard G, Leparc-Goffart I, Coutard B, Badaut C.

PLoS Negl Trop Dis. 2019 Sep 20;13(9):e0007747. doi: 10.1371/journal.pntd.0007747. eCollection 2019 Sep.

2.

Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner.

Bauer L, Manganaro R, Zonsics B, Strating JRPM, El Kazzi P, Lorenzo Lopez M, Ulferts R, van Hoey C, Maté MJ, Langer T, Coutard B, Brancale A, van Kuppeveld FJM.

ACS Infect Dis. 2019 Sep 13;5(9):1609-1623. doi: 10.1021/acsinfecdis.9b00179. Epub 2019 Jul 31.

3.

Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain.

Tsika AC, Melekis E, Tsatsouli SA, Papageorgiou N, Maté MJ, Canard B, Coutard B, Bentrop D, Spyroulias GA.

J Mol Biol. 2019 May 31;431(12):2283-2297. doi: 10.1016/j.jmb.2019.04.013. Epub 2019 Apr 16.

PMID:
30998933
4.

Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose.

Makrynitsa GI, Ntonti D, Marousis KD, Birkou M, Matsoukas MT, Asami S, Bentrop D, Papageorgiou N, Canard B, Coutard B, Spyroulias GA.

J Struct Biol. 2019 Apr 1;206(1):119-127. doi: 10.1016/j.jsb.2019.02.008. Epub 2019 Feb 27.

PMID:
30825649
5.

Comparative study of chikungunya Virus-Like Particles and Pseudotyped-Particles used for serological detection of specific immunoglobulin M.

Theillet G, Martinez J, Steinbrugger C, Lavillette D, Coutard B, Papageorgiou N, Dalbon P, Leparc-Goffart I, Bedin F.

Virology. 2019 Mar;529:195-204. doi: 10.1016/j.virol.2019.01.027. Epub 2019 Jan 30.

PMID:
30721816
6.

Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein.

Nguyen THV, Lichière J, Canard B, Papageorgiou N, Attoumani S, Ferron F, Coutard B.

Acta Crystallogr D Struct Biol. 2019 Jan 1;75(Pt 1):8-15. doi: 10.1107/S2059798318014948. Epub 2019 Jan 4.

PMID:
30644840
7.

Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay.

Ferreira-Ramos AS, Li C, Eydoux C, Contreras JM, Morice C, Quérat G, Gigante A, Pérez Pérez MJ, Jung ML, Canard B, Guillemot JC, Decroly E, Coutard B.

Antiviral Res. 2019 Mar;163:59-69. doi: 10.1016/j.antiviral.2019.01.003. Epub 2019 Jan 11.

PMID:
30639438
8.

[Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs].

Martin B, Valle C, Coutard B, Canard B, Debart F, Decroly É.

Med Sci (Paris). 2018 Nov;34(11):919-921. doi: 10.1051/medsci/2018230. Epub 2018 Dec 10. French. No abstract available.

PMID:
30526829
9.

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors.

Hernandez J, Hoffer L, Coutard B, Querat G, Roche P, Morelli X, Decroly E, Barral K.

Eur J Med Chem. 2019 Jan 1;161:323-333. doi: 10.1016/j.ejmech.2018.09.056. Epub 2018 Oct 23.

PMID:
30368131
10.

The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure.

Martin B, Coutard B, Guez T, Paesen GC, Canard B, Debart F, Vasseur JJ, Grimes JM, Decroly E.

Nucleic Acids Res. 2018 Sep 6;46(15):7902-7912. doi: 10.1093/nar/gky637.

11.

The European Virus Archive goes global: A growing resource for research.

Romette JL, Prat CM, Gould EA, de Lamballerie X, Charrel R, Coutard B, Fooks AR, Bardsley M, Carroll M, Drosten C, Drexler JF, Günther S, Klempa B, Pinschewer D, Klimkait T, Avsic-Zupanc T, Capobianchi MR, Dicaro A, Ippolito G, Nitsche A, Koopmans M, Reusken C, Gorbalenya A, Raoul H, Bourhy H, Mettenleiter T, Reiche S, Batten C, Sabeta C, Paweska JT, Eropkin M, Zverev V, Hu Z, Mac Cullough S, Mirazimi A, Pradel F, Lieutaud P.

Antiviral Res. 2018 Oct;158:127-134. doi: 10.1016/j.antiviral.2018.07.017. Epub 2018 Jul 29. Review.

12.

NMR study of non-structural proteins-part III: 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Chikungunya virus (CHIKV).

Lykouras MV, Tsika AC, Lichière J, Papageorgiou N, Coutard B, Bentrop D, Spyroulias GA.

Biomol NMR Assign. 2018 Apr;12(1):31-35. doi: 10.1007/s12104-017-9775-2. Epub 2017 Sep 5.

PMID:
28875416
13.

Toscana virus nucleoprotein oligomer organization observed in solution.

Baklouti A, Goulet A, Lichière J, Canard B, Charrel RN, Ferron F, Coutard B, Papageorgiou N.

Acta Crystallogr D Struct Biol. 2017 Aug 1;73(Pt 8):650-659. doi: 10.1107/S2059798317008774. Epub 2017 Jul 28.

PMID:
28777080
14.

Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay.

Aouadi W, Eydoux C, Coutard B, Martin B, Debart F, Vasseur JJ, Contreras JM, Morice C, Quérat G, Jung ML, Canard B, Guillemot JC, Decroly E.

Antiviral Res. 2017 Aug;144:330-339. doi: 10.1016/j.antiviral.2017.06.021. Epub 2017 Jul 1.

PMID:
28676301
15.

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

Gigante A, Gómez-SanJuan A, Delang L, Li C, Bueno O, Gamo AM, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Decroly E, Coutard B, Querat G, Neyts J, Pérez-Pérez MJ.

Antiviral Res. 2017 Aug;144:216-222. doi: 10.1016/j.antiviral.2017.06.003. Epub 2017 Jun 12.

16.

Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.

Coutard B, Barral K, Lichière J, Selisko B, Martin B, Aouadi W, Lombardia MO, Debart F, Vasseur JJ, Guillemot JC, Canard B, Decroly E.

J Virol. 2017 Feb 14;91(5). pii: e02202-16. doi: 10.1128/JVI.02202-16. Print 2017 Mar 1.

17.

Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights.

Fili S, Valmas A, Christopoulou M, Spiliopoulou M, Nikolopoulos N, Lichière J, Logotheti S, Karavassili F, Rosmaraki E, Fitch A, Wright J, Beckers D, Degen T, Nénert G, Hilgenfeld R, Papageorgiou N, Canard B, Coutard B, Margiolaki I.

Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):877-884. Epub 2016 Nov 25.

18.

Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.

Benmansour F, Trist I, Coutard B, Decroly E, Querat G, Brancale A, Barral K.

Eur J Med Chem. 2017 Jan 5;125:865-880. doi: 10.1016/j.ejmech.2016.10.007. Epub 2016 Oct 5.

PMID:
27750202
19.

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.

Delang L, Li C, Tas A, Quérat G, Albulescu IC, De Burghgraeve T, Guerrero NA, Gigante A, Piorkowski G, Decroly E, Jochmans D, Canard B, Snijder EJ, Pérez-Pérez MJ, van Hemert MJ, Coutard B, Leyssen P, Neyts J.

Sci Rep. 2016 Aug 22;6:31819. doi: 10.1038/srep31819.

20.

Viral Macro Domains Reverse Protein ADP-Ribosylation.

Li C, Debing Y, Jankevicius G, Neyts J, Ahel I, Coutard B, Canard B.

J Virol. 2016 Sep 12;90(19):8478-86. doi: 10.1128/JVI.00705-16. Print 2016 Oct 1.

21.

Complete Coding Sequences of Six Toscana Virus Strains Isolated from Human Patients in France.

Baklouti A, Leparc-Goffart I, Piorkowski G, Coutard B, Papageorgiou N, De Lamballerie X, Charrel RN.

Genome Announc. 2016 May 26;4(3). pii: e00454-16. doi: 10.1128/genomeA.00454-16.

22.

Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering.

Papageorgiou N, Lichière J, Baklouti A, Ferron F, Sévajol M, Canard B, Coutard B.

Acta Crystallogr D Struct Biol. 2016 Feb;72(Pt 2):192-202. doi: 10.1107/S2059798315024328. Epub 2016 Jan 22.

PMID:
26894667
23.

Complete Coding Sequences of Three Toscana Virus Strains Isolated from Sandflies in France.

Baklouti A, Leparc Goffard I, Piorkowski G, Coutard B, Papageorgiou N, De Lamballerie X, Charrel RN.

Genome Announc. 2016 Feb 11;4(1). pii: e01676-15. doi: 10.1128/genomeA.01676-15.

24.

Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C.

Ulferts R, de Boer SM, van der Linden L, Bauer L, Lyoo HR, Maté MJ, Lichière J, Canard B, Lelieveld D, Omta W, Egan D, Coutard B, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2627-38. doi: 10.1128/AAC.02182-15. Print 2016 May.

25.

Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection.

Sommerstein R, Flatz L, Remy MM, Malinge P, Magistrelli G, Fischer N, Sahin M, Bergthaler A, Igonet S, Ter Meulen J, Rigo D, Meda P, Rabah N, Coutard B, Bowden TA, Lambert PH, Siegrist CA, Pinschewer DD.

PLoS Pathog. 2015 Nov 20;11(11):e1005276. doi: 10.1371/journal.ppat.1005276. eCollection 2015 Nov.

26.

Characterisation of Structural Proteins from Chronic Bee Paralysis Virus (CBPV) Using Mass Spectrometry.

Chevin A, Coutard B, Blanchard P, Dabert-Gay AS, Ribière-Chabert M, Thiéry R.

Viruses. 2015 Jun 23;7(6):3329-44. doi: 10.3390/v7062774.

27.

mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research.

Li C, Guillén J, Rabah N, Blanjoie A, Debart F, Vasseur JJ, Canard B, Decroly E, Coutard B.

J Virol. 2015 Aug;89(16):8292-303. doi: 10.1128/JVI.00599-15. Epub 2015 Jun 3.

28.

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ.

PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar.

29.

Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain.

Guillén J, Lichière J, Rabah N, Beitzel BF, Canard B, Coutard B.

Virus Res. 2015 Apr 2;201:94-100. doi: 10.1016/j.virusres.2015.02.018. Epub 2015 Feb 25.

PMID:
25725151
30.

The megavirus chilensis Cu,Zn-superoxide dismutase: the first viral structure of a typical cellular copper chaperone-independent hyperstable dimeric enzyme.

Lartigue A, Burlat B, Coutard B, Chaspoul F, Claverie JM, Abergel C.

J Virol. 2015 Jan;89(1):824-32. doi: 10.1128/JVI.02588-14. Epub 2014 Oct 29.

31.

NMR study of non-structural proteins--part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV).

Makrynitsa GI, Ntonti D, Marousis KD, Tsika AC, Lichière J, Papageorgiou N, Coutard B, Bentrop D, Spyroulias GA.

Biomol NMR Assign. 2015 Oct;9(2):247-51. doi: 10.1007/s12104-014-9584-9. Epub 2014 Oct 8.

PMID:
25291978
32.

NMR study of non-structural proteins--part I: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV).

Melekis E, Tsika AC, Lichière J, Chasapis CT, Margiolaki I, Papageorgiou N, Coutard B, Bentrop D, Spyroulias GA.

Biomol NMR Assign. 2015 Apr;9(1):191-5. doi: 10.1007/s12104-014-9572-0. Epub 2014 Sep 13.

PMID:
25217003
33.

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery.

Coutard B, Decroly E, Li C, Sharff A, Lescar J, Bricogne G, Barral K.

Antiviral Res. 2014 Jun;106:61-70. doi: 10.1016/j.antiviral.2014.03.013. Epub 2014 Apr 1.

PMID:
24704437
34.

The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site.

Vives-Adrian L, Lujan C, Oliva B, van der Linden L, Selisko B, Coutard B, Canard B, van Kuppeveld FJ, Ferrer-Orta C, Verdaguer N.

J Virol. 2014 May;88(10):5595-607. doi: 10.1128/JVI.03502-13. Epub 2014 Mar 5.

35.

Improving the soluble expression of recombinant proteins by randomly shuffling 5' and 3' coding-sequence ends.

Bignon C, Li C, Lichière J, Canard B, Coutard B.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2580-2. doi: 10.1107/S0907444913018751. Epub 2013 Nov 19.

PMID:
24311598
36.

SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets.

Subissi L, Imbert I, Ferron F, Collet A, Coutard B, Decroly E, Canard B.

Antiviral Res. 2014 Jan;101:122-30. doi: 10.1016/j.antiviral.2013.11.006. Epub 2013 Nov 20. Review.

PMID:
24269475
37.

Evidence for novel hepaciviruses in rodents.

Drexler JF, Corman VM, Müller MA, Lukashev AN, Gmyl A, Coutard B, Adam A, Ritz D, Leijten LM, van Riel D, Kallies R, Klose SM, Gloza-Rausch F, Binger T, Annan A, Adu-Sarkodie Y, Oppong S, Bourgarel M, Rupp D, Hoffmann B, Schlegel M, Kümmerer BM, Krüger DH, Schmidt-Chanasit J, Setién AA, Cottontail VM, Hemachudha T, Wacharapluesadee S, Osterrieder K, Bartenschlager R, Matthee S, Beer M, Kuiken T, Reusken C, Leroy EM, Ulrich RG, Drosten C.

PLoS Pathog. 2013;9(6):e1003438. doi: 10.1371/journal.ppat.1003438. Epub 2013 Jun 20.

38.

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Barral K, Sallamand C, Petzold C, Coutard B, Collet A, Thillier Y, Zimmermann J, Vasseur JJ, Canard B, Rohayem J, Debart F, Decroly E.

Antiviral Res. 2013 Sep;99(3):292-300. doi: 10.1016/j.antiviral.2013.06.001. Epub 2013 Jun 12.

PMID:
23769894
39.

3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses.

Tan J, George S, Kusov Y, Perbandt M, Anemüller S, Mesters JR, Norder H, Coutard B, Lacroix C, Leyssen P, Neyts J, Hilgenfeld R.

J Virol. 2013 Apr;87(8):4339-51. doi: 10.1128/JVI.01123-12. Epub 2013 Feb 6.

40.

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

Ulferts R, van der Linden L, Thibaut HJ, Lanke KH, Leyssen P, Coutard B, De Palma AM, Canard B, Neyts J, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2013 Apr;57(4):1952-6. doi: 10.1128/AAC.02084-12. Epub 2013 Jan 18.

41.

The European Virus Archive: a new resource for virology research.

Gould EA, de Lamballerie X, Coutard B, Fooks AR, Outlaw M, Drosten C, Guenther S, Klempa B, Pinschewer D, Avsic-Zupanc T, Sabeta C, Lukashev A, Eropkin M, Koslov A, Zverev V, Lvov D, Zhebrun A, Shipulin G, Niedrig M, Gao Fu G, Dong Liang G, Ippolito G, Koray E, Romette JL.

Antiviral Res. 2012 Aug;95(2):167-71. doi: 10.1016/j.antiviral.2012.05.005. Epub 2012 May 22. Review.

PMID:
22626637
42.

[Capping strategies in RNA viruses].

Bouvet M, Ferron F, Imbert I, Gluais L, Selisko B, Coutard B, Canard B, Decroly E.

Med Sci (Paris). 2012 Apr;28(4):423-9. doi: 10.1051/medsci/2012284021. Epub 2012 Apr 25. Review. French.

43.

Single pH buffer refolding screen for protein from inclusion bodies.

Coutard B, Danchin EG, Oubelaid R, Canard B, Bignon C.

Protein Expr Purif. 2012 Apr;82(2):352-9. doi: 10.1016/j.pep.2012.01.014. Epub 2012 Feb 4.

PMID:
22343064
44.

Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen.

Le Breton M, Meyniel-Schicklin L, Deloire A, Coutard B, Canard B, de Lamballerie X, Andre P, Rabourdin-Combe C, Lotteau V, Davoust N.

BMC Microbiol. 2011 Oct 20;11:234. doi: 10.1186/1471-2180-11-234.

45.

Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93.

Costenaro L, Kaczmarska Z, Arnan C, Janowski R, Coutard B, Solà M, Gorbalenya AE, Norder H, Canard B, Coll M.

J Virol. 2011 Oct;85(20):10764-73. doi: 10.1128/JVI.05062-11. Epub 2011 Aug 10.

46.

Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.

Decroly E, Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B.

PLoS Pathog. 2011 May;7(5):e1002059. doi: 10.1371/journal.ppat.1002059. Epub 2011 May 26.

47.

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes.

Ferron F, Li Z, Danek EI, Luo D, Wong Y, Coutard B, Lantez V, Charrel R, Canard B, Walz T, Lescar J.

PLoS Pathog. 2011 May;7(5):e1002030. doi: 10.1371/journal.ppat.1002030. Epub 2011 May 12.

48.

Arenaviruses and hantaviruses: from epidemiology and genomics to antivirals.

Charrel RN, Coutard B, Baronti C, Canard B, Nougairede A, Frangeul A, Morin B, Jamal S, Schmidt CL, Hilgenfeld R, Klempa B, de Lamballerie X.

Antiviral Res. 2011 May;90(2):102-14. doi: 10.1016/j.antiviral.2011.02.009. Epub 2011 Feb 26. Review.

PMID:
21356244
49.

Comparative production analysis of three phlebovirus nucleoproteins under denaturing or non-denaturing conditions for crystallographic studies.

Lantez V, Dalle K, Charrel R, Baronti C, Canard B, Coutard B.

PLoS Negl Trop Dis. 2011 Jan 4;5(1):e936. doi: 10.1371/journal.pntd.0000936.

50.

Picornavirus non-structural proteins as targets for new anti-virals with broad activity.

Norder H, De Palma AM, Selisko B, Costenaro L, Papageorgiou N, Arnan C, Coutard B, Lantez V, De Lamballerie X, Baronti C, Solà M, Tan J, Neyts J, Canard B, Coll M, Gorbalenya AE, Hilgenfeld R.

Antiviral Res. 2011 Mar;89(3):204-18. doi: 10.1016/j.antiviral.2010.12.007. Epub 2011 Jan 12. Review.

PMID:
21236302

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