Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 23

1.

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.

Coussens NP, Kales SC, Henderson MJ, Lee OW, Horiuchi KY, Wang Y, Chen Q, Kuznetsova E, Wu J, Chakka S, Cheff DM, Cheng KC, Shinn P, Brimacombe KR, Shen M, Simeonov A, Lal-Nag M, Ma H, Jadhav A, Hall MD.

J Biol Chem. 2018 Aug 31;293(35):13750-13765. doi: 10.1074/jbc.RA118.004274. Epub 2018 Jun 26.

2.

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase.

Martinez NJ, Asawa RR, Cyr MG, Zakharov A, Urban DJ, Roth JS, Wallgren E, Klumpp-Thomas C, Coussens NP, Rai G, Yang SM, Hall MD, Marugan JJ, Simeonov A, Henderson MJ.

Sci Rep. 2018 Jun 21;8(1):9472. doi: 10.1038/s41598-018-27834-y.

3.

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP.

Clin Transl Sci. 2018 Sep;11(5):461-470. doi: 10.1111/cts.12570. Epub 2018 Jul 24.

4.

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444. doi: 10.1126/scitranslmed.aaf7444.

PMID:
29444979
5.

Better living through chemistry: Addressing emerging antibiotic resistance.

Coussens NP, Molinaro AL, Culbertson KJ, Peryea T, Zahoránszky-Köhalmi G, Hall MD, Daines DA.

Exp Biol Med (Maywood). 2018 Mar;243(6):538-553. doi: 10.1177/1535370218755659. Epub 2018 Feb 6.

PMID:
29409348
6.

Inhibition of Protein-Protein Interactions: Cell-Based Assays.

Wade M, Méndez J, Coussens NP, Arkin MR, Glicksman MA.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2017 Nov 20.

7.

Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration-Approved Drugs.

Coussens NP, Braisted JC, Peryea T, Sittampalam GS, Simeonov A, Hall MD.

Pharmacol Rev. 2017 Oct;69(4):479-496. doi: 10.1124/pr.117.013755. Review.

8.

In Search of System-Wide Productivity Gains - The Role of Global Collaborations in Preclinical Translation.

Ussi AE, de Kort M, Coussens NP, Aittokallio T, Hajduch M.

Clin Transl Sci. 2017 Nov;10(6):423-425. doi: 10.1111/cts.12498. Epub 2017 Sep 19. No abstract available.

PMID:
28929592
9.

Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.

Davis MI, Patrick SL, Blanding WM, Dwivedi V, Suryadi J, Golden JE, Coussens NP, Lee OW, Shen M, Boxer MB, Hall MD, Sharlow ER, Drew ME, Morris JC.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6023-33. doi: 10.1128/AAC.00914-16. Print 2016 Oct.

10.

Structure of a heterogeneous, glycosylated, lipid-bound, in vivo-grown protein crystal at atomic resolution from the viviparous cockroach Diploptera punctata.

Banerjee S, Coussens NP, Gallat FX, Sathyanarayanan N, Srikanth J, Yagi KJ, Gray JS, Tobe SS, Stay B, Chavas LM, Ramaswamy S.

IUCrJ. 2016 Jun 27;3(Pt 4):282-93. doi: 10.1107/S2052252516008903. eCollection 2016 Jul 1.

11.

Early Drug Discovery and Development Guidelines: For Academic Researchers, Collaborators, and Start-up Companies.

Strovel J, Sittampalam S, Coussens NP, Hughes M, Inglese J, Kurtz A, Andalibi A, Patton L, Austin C, Baltezor M, Beckloff M, Weingarten M, Weir S.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 1 [updated 2016 Jul 1].

12.

AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions.

Yasgar A, Jadhav A, Simeonov A, Coussens NP.

Methods Mol Biol. 2016;1439:77-98. doi: 10.1007/978-1-4939-3673-1_5.

13.

Wake me when it's over - Bacterial toxin-antitoxin proteins and induced dormancy.

Coussens NP, Daines DA.

Exp Biol Med (Maywood). 2016 Jun;241(12):1332-42. doi: 10.1177/1535370216651938. Epub 2016 May 22. Review.

14.

Fluorescence polarization assays in high-throughput screening and drug discovery: a review.

Hall MD, Yasgar A, Peryea T, Braisted JC, Jadhav A, Simeonov A, Coussens NP.

Methods Appl Fluoresc. 2016 Apr 28;4(2):022001. doi: 10.1088/2050-6120/4/2/022001.

15.

The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.

Balagopalan L, Kortum RL, Coussens NP, Barr VA, Samelson LE.

J Biol Chem. 2015 Oct 30;290(44):26422-9. doi: 10.1074/jbc.R115.665869. Epub 2015 Sep 9. Review.

16.

In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology?

Gallat FX, Matsugaki N, Coussens NP, Yagi KJ, Boudes M, Higashi T, Tsuji D, Tatano Y, Suzuki M, Mizohata E, Tono K, Joti Y, Kameshima T, Park J, Song C, Hatsui T, Yabashi M, Nango E, Itoh K, Coulibaly F, Tobe S, Ramaswamy S, Stay B, Iwata S, Chavas LM.

Philos Trans R Soc Lond B Biol Sci. 2014 Jul 17;369(1647):20130497. doi: 10.1098/rstb.2013.0497.

17.

Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.

Mol Cell Biol. 2013 Nov;33(21):4140-51. doi: 10.1128/MCB.00410-13. Epub 2013 Aug 26.

18.
19.

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3.

Tang LY, Yamashita M, Coussens NP, Tang Y, Wang X, Li C, Deng CX, Cheng SY, Zhang YE.

EMBO J. 2011 Nov 1;30(23):4777-89. doi: 10.1038/emboj.2011.393.

20.

The LAT story: a tale of cooperativity, coordination, and choreography.

Balagopalan L, Coussens NP, Sherman E, Samelson LE, Sommers CL.

Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a005512. doi: 10.1101/cshperspect.a005512. Epub 2010 Jul 7. Review.

21.

Characterization of the N-acetyl-5-neuraminic acid-binding site of the extracytoplasmic solute receptor (SiaP) of nontypeable Haemophilus influenzae strain 2019.

Johnston JW, Coussens NP, Allen S, Houtman JC, Turner KH, Zaleski A, Ramaswamy S, Gibson BW, Apicella MA.

J Biol Chem. 2008 Jan 11;283(2):855-65. Epub 2007 Oct 18.

22.

Crystal structure of the Nod1 caspase activation and recruitment domain.

Coussens NP, Mowers JC, McDonald C, Nuñez G, Ramaswamy S.

Biochem Biophys Res Commun. 2007 Feb 2;353(1):1-5. Epub 2006 Dec 6.

23.

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations.

Gioannini TL, Teghanemt A, Zhang D, Coussens NP, Dockstader W, Ramaswamy S, Weiss JP.

Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4186-91. Epub 2004 Mar 9.

Supplemental Content

Loading ...
Support Center