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Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis.

Hendrickx G, Borra VM, Steenackers E, Yorgan TA, Hermans C, Boudin E, Waterval JJ, Jansen IDC, Aydemir TB, Kamerling N, Behets GJ, Plumeyer C, D'Haese PC, Busse B, Everts V, Lammens M, Mortier G, Cousins RJ, Schinke T, Stokroos RJ, Manni JJ, Van Hul W.

PLoS Genet. 2018 Apr 5;14(4):e1007321. doi: 10.1371/journal.pgen.1007321. eCollection 2018 Apr.


The Multiple Faces of the Metal Transporter ZIP14 (SLC39A14).

Aydemir TB, Cousins RJ.

J Nutr. 2018 Feb 1;148(2):174-184. doi: 10.1093/jn/nxx041. Review.


Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress.

Kim MH, Aydemir TB, Kim J, Cousins RJ.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5805-E5814. doi: 10.1073/pnas.1704012114. Epub 2017 Jul 3.


Metal Transporter Zip14 (Slc39a14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity.

Aydemir TB, Kim MH, Kim J, Colon-Perez LM, Banan G, Mareci TH, Febo M, Cousins RJ.

J Neurosci. 2017 Jun 21;37(25):5996-6006. doi: 10.1523/JNEUROSCI.0285-17.2017. Epub 2017 May 23.


Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion.

Aydemir TB, Troche C, Kim J, Kim MH, Teran OY, Leeuwenburgh C, Cousins RJ.

Exp Gerontol. 2016 Dec 1;85:88-94. doi: 10.1016/j.exger.2016.09.013. Epub 2016 Sep 16.


Hepatic ZIP14-mediated Zinc Transport Contributes to Endosomal Insulin Receptor Trafficking and Glucose Metabolism.

Aydemir TB, Troche C, Kim MH, Cousins RJ.

J Biol Chem. 2016 Nov 11;291(46):23939-23951. Epub 2016 Oct 4.


Driving Along the Zinc Road.

Cousins RJ.

Annu Rev Nutr. 2016 Jul 17;36:1-15. doi: 10.1146/annurev-nutr-071715-050854. Epub 2016 Apr 18.


Effect of A One-Week Balanced Diet on Expression of Genes Related to Zinc Metabolism and Inflammation in Type 2 Diabetic Patients.

Lais LL, de Lima Vale SH, Xavier CA, de Araujo Silva A, Aydemir TB, Cousins RJ.

Clin Nutr Res. 2016 Jan;5(1):26-32. doi: 10.7762/cnr.2016.5.1.26. Epub 2016 Jan 29.


Zinc transporter Slc39a14 regulates inflammatory signaling associated with hypertrophic adiposity.

Troche C, Aydemir TB, Cousins RJ.

Am J Physiol Endocrinol Metab. 2016 Feb 15;310(4):E258-68. doi: 10.1152/ajpendo.00421.2015. Epub 2015 Dec 8.


Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation.

Wessels I, Cousins RJ.

Am J Physiol Gastrointest Liver Physiol. 2015 Nov 1;309(9):G768-78. doi: 10.1152/ajpgi.00179.2015. Epub 2015 Aug 13.


Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function.

Guthrie GJ, Aydemir TB, Troche C, Martin AB, Chang SM, Cousins RJ.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G171-8. doi: 10.1152/ajpgi.00021.2014. Epub 2014 Nov 26. Review.


Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization.

Martin AB, Aydemir TB, Guthrie GJ, Samuelson DA, Chang SM, Cousins RJ.

J Nutr. 2013 Dec;143(12):1882-8. doi: 10.3945/jn.113.184457. Epub 2013 Oct 2.


Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia).

Aydemir TB, Chang SM, Guthrie GJ, Maki AB, Ryu MS, Karabiyik A, Cousins RJ.

PLoS One. 2012;7(10):e48679. doi: 10.1371/journal.pone.0048679. Epub 2012 Oct 24.


Proteomic analysis shows the upregulation of erythrocyte dematin in zinc-restricted human subjects.

Ryu MS, Guthrie GJ, Maki AB, Aydemir TB, Cousins RJ.

Am J Clin Nutr. 2012 May;95(5):1096-102. doi: 10.3945/ajcn.111.032862. Epub 2012 Mar 28.


The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice.

Aydemir TB, Sitren HS, Cousins RJ.

Gastroenterology. 2012 Jun;142(7):1536-46.e5. doi: 10.1053/j.gastro.2012.02.046. Epub 2012 Feb 25.


Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis.

Ryu MS, Langkamp-Henken B, Chang SM, Shankar MN, Cousins RJ.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20970-5. doi: 10.1073/pnas.1117207108. Epub 2011 Dec 14.


MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction.

Lichten LA, Ryu MS, Guo L, Embury J, Cousins RJ.

PLoS One. 2011;6(6):e21526. doi: 10.1371/journal.pone.0021526. Epub 2011 Jun 27.


Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron.

Pinilla-Tenas JJ, Sparkman BK, Shawki A, Illing AC, Mitchell CJ, Zhao N, Liuzzi JP, Cousins RJ, Knutson MD, Mackenzie B.

Am J Physiol Cell Physiol. 2011 Oct;301(4):C862-71. doi: 10.1152/ajpcell.00479.2010. Epub 2011 Jun 8.


Gastrointestinal factors influencing zinc absorption and homeostasis.

Cousins RJ.

Int J Vitam Nutr Res. 2010 Oct;80(4-5):243-8. doi: 10.1024/0300-9831/a000030. Review.


STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells.

Guo L, Lichten LA, Ryu MS, Liuzzi JP, Wang F, Cousins RJ.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2818-23. doi: 10.1073/pnas.0914941107. Epub 2010 Jan 27.


Plenary Lecture 2: Transcription factors, regulatory elements and nutrient-gene communication.

Cousins RJ, Aydemir TB, Lichten LA.

Proc Nutr Soc. 2010 Feb;69(1):91-4. doi: 10.1017/S0029665109991790. Epub 2009 Dec 8. Review.


Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells.

Aydemir TB, Liuzzi JP, McClellan S, Cousins RJ.

J Leukoc Biol. 2009 Aug;86(2):337-48. doi: 10.1189/jlb.1208759. Epub 2009 Apr 28.


Mammalian zinc transporters: nutritional and physiologic regulation.

Lichten LA, Cousins RJ.

Annu Rev Nutr. 2009;29:153-76. doi: 10.1146/annurev-nutr-033009-083312. Review.


Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes.

Lichten LA, Liuzzi JP, Cousins RJ.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G860-7. doi: 10.1152/ajpgi.90676.2008. Epub 2009 Jan 29.


Krüppel-like factor 4 regulates adaptive expression of the zinc transporter Zip4 in mouse small intestine.

Liuzzi JP, Guo L, Chang SM, Cousins RJ.

Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G517-23. doi: 10.1152/ajpgi.90568.2008. Epub 2009 Jan 15. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1391.


Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.

Li M, Zhang Y, Liu Z, Bharadwaj U, Wang H, Wang X, Zhang S, Liuzzi JP, Chang SM, Cousins RJ, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18636-41. Epub 2007 Nov 14.


Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.

Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJ.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13612-7. Epub 2006 Sep 1.


Mammalian zinc transport, trafficking, and signals.

Cousins RJ, Liuzzi JP, Lichten LA.

J Biol Chem. 2006 Aug 25;281(34):24085-9. Epub 2006 Jun 22. Review. No abstract available.


Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations.

Aydemir TB, Blanchard RK, Cousins RJ.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1699-704. Epub 2006 Jan 24.


Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response.

Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6843-8. Epub 2005 Apr 29.


Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis.

Liuzzi JP, Bobo JA, Lichten LA, Samuelson DA, Cousins RJ.

Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14355-60. Epub 2004 Sep 20.


Mammalian zinc transporters.

Liuzzi JP, Cousins RJ.

Annu Rev Nutr. 2004;24:151-72. Review.


A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells.

Cousins RJ, Blanchard RK, Popp MP, Liu L, Cao J, Moore JB, Green CL.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6952-7. Epub 2003 May 19.


Regulation of zinc metabolism and genomic outcomes.

Cousins RJ, Blanchard RK, Moore JB, Cui L, Green CL, Liuzzi JP, Cao J, Bobo JA.

J Nutr. 2003 May;133(5 Suppl 1):1521S-6S. doi: 10.1093/jn/133.5.1521S. Review.


Dietary zinc modulates gene expression in murine thymus: results from a comprehensive differential display screening.

Moore JB, Blanchard RK, Cousins RJ.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3883-8. Epub 2003 Mar 19.


Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation.

Liuzzi JP, Bobo JA, Cui L, McMahon RJ, Cousins RJ.

J Nutr. 2003 Feb;133(2):342-51.


Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response.

Lanningham-Foster L, Green CL, Langkamp-Henken B, Davis BA, Nguyen KT, Bender BS, Cousins RJ.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1197-203.


cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes.

Moore JB, Blanchard RK, McCormack WT, Cousins RJ.

J Nutr. 2001 Dec;131(12):3189-96.


Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis.

Cao J, Bobo JA, Liuzzi JP, Cousins RJ.

J Leukoc Biol. 2001 Oct;70(4):559-66.


Dietary zinc deficiency increases uroguanylin accumulation in rat kidney.

Cui L, Blanchard RK, Cousins RJ.

Kidney Int. 2001 Apr;59(4):1424-31.


Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats.

Liuzzi JP, Blanchard RK, Cousins RJ.

J Nutr. 2001 Jan;131(1):46-52.


L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells.

Kim AH, Sheline CT, Tian M, Higashi T, McMahon RJ, Cousins RJ, Choi DW.

Brain Res. 2000 Dec 15;886(1-2):99-107.


Prouroguanylin overproduction and localization in the intestine of zinc-deficient rats.

Cui L, Blanchard RK, Coy LM, Cousins RJ.

J Nutr. 2000 Nov;130(11):2726-32.


Regulation of cysteine-rich intestinal protein, a zinc finger protein, by mediators of the immune response.

Cousins RJ, Lanningham-Foster L.

J Infect Dis. 2000 Sep;182 Suppl 1:S81-4. Review.


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