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Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis.

Grieco G, Wang T, Delcorte O, Spourquet C, Janssens V, Strickaert A, Gaide Chevronnay HP, Liao XH, Bilanges B, Refetoff S, Vanhaesebroeck B, Maenhaut C, Courtoy PJ, Pierreux CE.

Thyroid. 2019 Dec 2. doi: 10.1089/thy.2019.0182. [Epub ahead of print]


Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression.

Janssens V, Gaide Chevronnay HP, Marie S, Vincent MF, Van Der Smissen P, Nevo N, Vainio S, Nielsen R, Christensen EI, Jouret F, Antignac C, Pierreux CE, Courtoy PJ.

J Am Soc Nephrol. 2019 Nov;30(11):2177-2190. doi: 10.1681/ASN.2019040371. Epub 2019 Sep 23.


Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.

Grieco G, Janssens V, Gaide Chevronnay HP, N'Kuli F, Van Der Smissen P, Wang T, Shan J, Vainio S, Bilanges B, Jouret F, Vanhaesebroeck B, Pierreux CE, Courtoy PJ.

Sci Rep. 2018 Sep 20;8(1):14133. doi: 10.1038/s41598-018-32389-z.


Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation.

Degosserie J, Heymans C, Spourquet C, Halbout M, D'Auria L, Van Der Smissen P, Vertommen D, Courtoy PJ, Tyteca D, Pierreux CE.

J Extracell Vesicles. 2018 Jun 28;7(1):1487250. doi: 10.1080/20013078.2018.1487250. eCollection 2018.


GATM Mutations Cause a Dominant Fibrillar Conformational Disease in Mitochondria-When Eternity Kills.

Courtoy PJ, Henriet P.

J Am Soc Nephrol. 2018 Jul;29(7):1787-1789. doi: 10.1681/ASN.2018040450. Epub 2018 May 22. No abstract available.


Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.

Johanns M, Lemoine P, Janssens V, Grieco G, Moestrup SK, Nielsen R, Christensen EI, Courtoy PJ, Emonard H, Marbaix E, Henriet P.

Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.


Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21.

Welsby I, Detienne S, N'Kuli F, Thomas S, Wouters S, Bechtold V, De Wit D, Gineste R, Reinheckel T, Elouahabi A, Courtoy PJ, Didierlaurent AM, Goriely S.

Front Immunol. 2017 Jan 5;7:663. doi: 10.3389/fimmu.2016.00663. eCollection 2016.


The renal Fanconi syndrome in cystinosis: pathogenic insights and therapeutic perspectives.

Cherqui S, Courtoy PJ.

Nat Rev Nephrol. 2017 Feb;13(2):115-131. doi: 10.1038/nrneph.2016.182. Epub 2016 Dec 19. Review.


Tubular proteinuria in patients with HNF1α mutations: HNF1α drives endocytosis in the proximal tubule.

Terryn S, Tanaka K, Lengelé JP, Olinger E, Dubois-Laforgue D, Garbay S, Kozyraki R, Van Der Smissen P, Christensen EI, Courtoy PJ, Bellanné-Chantelot C, Timsit J, Pontoglio M, Devuyst O.

Kidney Int. 2016 May;89(5):1075-1089. doi: 10.1016/j.kint.2016.01.027. Epub 2016 Mar 29.


Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.

Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsée J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE.

Development. 2016 Jun 1;143(11):1958-70. doi: 10.1242/dev.134171. Epub 2016 Apr 11.


Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Rocca CJ, Liao XH, Refetoff S, Pierreux CE, Cherqui S, Courtoy PJ.

Endocrinology. 2016 Apr;157(4):1363-71. doi: 10.1210/en.2015-1762. Epub 2016 Jan 26.


Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

Chachoua I, Pecquet C, El-Khoury M, Nivarthi H, Albu RI, Marty C, Gryshkova V, Defour JP, Vertenoeil G, Ngo A, Koay A, Raslova H, Courtoy PJ, Choong ML, Plo I, Vainchenker W, Kralovics R, Constantinescu SN.

Blood. 2016 Mar 10;127(10):1325-35. doi: 10.1182/blood-2015-11-681932. Epub 2015 Dec 14.


Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling.

Andrzejewska Z, Nevo N, Thomas L, Chhuon C, Bailleux A, Chauvet V, Courtoy PJ, Chol M, Guerrera IC, Antignac C.

J Am Soc Nephrol. 2016 Jun;27(6):1678-88. doi: 10.1681/ASN.2014090937. Epub 2015 Oct 8.


ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei.

Brennand A, Rico E, Rigden DJ, Van Der Smissen P, Courtoy PJ, Michels PA.

PLoS One. 2015 Jun 19;10(6):e0130365. doi: 10.1371/journal.pone.0130365. eCollection 2015.


Cholesterol segregates into submicrometric domains at the living erythrocyte membrane: evidence and regulation.

Carquin M, Conrard L, Pollet H, Van Der Smissen P, Cominelli A, Veiga-da-Cunha M, Courtoy PJ, Tyteca D.

Cell Mol Life Sci. 2015 Dec;72(23):4633-51. doi: 10.1007/s00018-015-1951-x. Epub 2015 Jun 16.


A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Liao XH, Abid Y, Nevo N, Antignac C, Refetoff S, Cherqui S, Pierreux CE, Courtoy PJ.

Endocrinology. 2015 Jun;156(6):2349-64. doi: 10.1210/en.2014-1672. Epub 2015 Mar 26.


Induction of post-menstrual regeneration by ovarian steroid withdrawal in the functionalis of xenografted human endometrium.

Coudyzer P, Lemoine P, Po C, Jordan BF, Van Der Smissen P, Courtoy PJ, Henriet P, Marbaix E.

Hum Reprod. 2015 May;30(5):1156-68. doi: 10.1093/humrep/dev043. Epub 2015 Mar 6.


Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch.

Tyteca D, Nishino T, Debaix H, Van Der Smissen P, N'Kuli F, Hoffmann D, Cnops Y, Rabolli V, van Loo G, Beyaert R, Huaux F, Devuyst O, Courtoy PJ.

PLoS One. 2015 Feb 26;10(2):e0117398. doi: 10.1371/journal.pone.0117398. eCollection 2015.


Brief reports: Lysosomal cross-correction by hematopoietic stem cell-derived macrophages via tunneling nanotubes.

Naphade S, Sharma J, Gaide Chevronnay HP, Shook MA, Yeagy BA, Rocca CJ, Ur SN, Lau AJ, Courtoy PJ, Cherqui S.

Stem Cells. 2015 Jan;33(1):301-9. doi: 10.1002/stem.1835.


Validation of housekeeping gene and impact on normalized gene expression in clear cell renal cell carcinoma: critical reassessment of YBX3/ZONAB/CSDA expression.

Dupasquier S, Delmarcelle AS, Marbaix E, Cosyns JP, Courtoy PJ, Pierreux CE.

BMC Mol Biol. 2014 May 16;15:9. doi: 10.1186/1471-2199-15-9.


Endogenous sphingomyelin segregates into submicrometric domains in the living erythrocyte membrane.

Carquin M, Pollet H, Veiga-da-Cunha M, Cominelli A, Van Der Smissen P, N'kuli F, Emonard H, Henriet P, Mizuno H, Courtoy PJ, Tyteca D.

J Lipid Res. 2014 Jul;55(7):1331-42. doi: 10.1194/jlr.M048538. Epub 2014 May 14.


Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions.

Cominelli A, Gaide Chevronnay HP, Lemoine P, Courtoy PJ, Marbaix E, Henriet P.

Mol Hum Reprod. 2014 Aug;20(8):767-75. doi: 10.1093/molehr/gau034. Epub 2014 May 8.


A unique C-terminal domain allows retention of matrix metalloproteinase-27 in the endoplasmic reticulum.

Cominelli A, Halbout M, N'Kuli F, Lemoine P, Courtoy PJ, Marbaix E, Tyteca D, Henriet P.

Traffic. 2014 Apr;15(4):401-17. doi: 10.1111/tra.12149. Epub 2014 Feb 6.


A short treatment with galactomannan GM-CT-01 corrects the functions of freshly isolated human tumor-infiltrating lymphocytes.

Demotte N, Bigirimana R, Wieërs G, Stroobant V, Squifflet JL, Carrasco J, Thielemans K, Baurain JF, Van Der Smissen P, Courtoy PJ, van der Bruggen P.

Clin Cancer Res. 2014 Apr 1;20(7):1823-33. doi: 10.1158/1078-0432.CCR-13-2459. Epub 2014 Feb 13.


Time course of pathogenic and adaptation mechanisms in cystinotic mouse kidneys.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, N'Kuli F, Nevo N, Guiot Y, Levtchenko E, Marbaix E, Pierreux CE, Cherqui S, Antignac C, Courtoy PJ.

J Am Soc Nephrol. 2014 Jun;25(6):1256-69. doi: 10.1681/ASN.2013060598. Epub 2014 Feb 13.


Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features.

Gualdrón-López M, Chevalier N, Van Der Smissen P, Courtoy PJ, Rigden DJ, Michels PAM.

Biochim Biophys Acta. 2013 Dec;1833(12):3076-3092. doi: 10.1016/j.bbamcr.2013.08.008. Epub 2013 Aug 27.


Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.

Liu Y, Lai YC, Hill EV, Tyteca D, Carpentier S, Ingvaldsen A, Vertommen D, Lantier L, Foretz M, Dequiedt F, Courtoy PJ, Erneux C, Viollet B, Shepherd PR, Tavaré JM, Jensen J, Rider MH.

Biochem J. 2013 Oct 15;455(2):195-206. doi: 10.1042/BJ20130644.


Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation.

Coudyzer P, Lemoine P, Jordan BF, Gallez B, Galant C, Nisolle M, Courtoy PJ, Henriet P, Marbaix E.

FASEB J. 2013 Sep;27(9):3711-9. doi: 10.1096/fj.13-232074. Epub 2013 May 31.


Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.

Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE.

Dev Biol. 2013 Sep 1;381(1):227-40. doi: 10.1016/j.ydbio.2013.04.022. Epub 2013 May 21.


Class III phosphoinositide 3-kinase/VPS34 and dynamin are critical for apical endocytic recycling.

Carpentier S, N'Kuli F, Grieco G, Van Der Smissen P, Janssens V, Emonard H, Bilanges B, Vanhaesebroeck B, Gaide Chevronnay HP, Pierreux CE, Tyteca D, Courtoy PJ.

Traffic. 2013 Aug;14(8):933-48. doi: 10.1111/tra.12079. Epub 2013 Jun 3.


Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.

Pierrot N, Tyteca D, D'auria L, Dewachter I, Gailly P, Hendrickx A, Tasiaux B, Haylani LE, Muls N, N'kuli F, Laquerrière A, Demoulin JB, Campion D, Brion JP, Courtoy PJ, Kienlen-Campard P, Octave JN.

EMBO Mol Med. 2013 Apr;5(4):608-25. doi: 10.1002/emmm.201202215.


Androgen deprivation and androgen receptor competition by bicalutamide induce autophagy of hormone-resistant prostate cancer cells and confer resistance to apoptosis.

Boutin B, Tajeddine N, Vandersmissen P, Zanou N, Van Schoor M, Mondin L, Courtoy PJ, Tombal B, Gailly P.

Prostate. 2013 Jul;73(10):1090-102. doi: 10.1002/pros.22658. Epub 2013 Mar 26.


In vitro correction of disorders of lysosomal transport by microvesicles derived from baculovirus-infected Spodoptera cells.

Thoene J, Goss T, Witcher M, Mullet J, N'Kuli F, Van Der Smissen P, Courtoy P, Hahn SH.

Mol Genet Metab. 2013 May;109(1):77-85. doi: 10.1016/j.ymgme.2013.01.014. Epub 2013 Feb 4.


Micrometric segregation of fluorescent membrane lipids: relevance for endogenous lipids and biogenesis in erythrocytes.

D'Auria L, Fenaux M, Aleksandrowicz P, Van Der Smissen P, Chantrain C, Vermylen C, Vikkula M, Courtoy PJ, Tyteca D.

J Lipid Res. 2013 Apr;54(4):1066-76. doi: 10.1194/jlr.M034314. Epub 2013 Jan 14. Erratum in: J Lipid Res. 2013 Jul;54(7):2029.


Studying nonobstructive azoospermia in cystinosis: histologic examination of testes and epididymis and sperm analysis in a Ctns⁻/⁻ mouse model.

Besouw MT, van Pelt AM, Gaide Chevronnay HP, Courtoy PJ, Pastore A, Goossens E, Devuyst O, Antignac C, Levtchenko EN.

Fertil Steril. 2012 Jul;98(1):162-5. doi: 10.1016/j.fertnstert.2012.03.050. Epub 2012 May 10.


Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.

Pecquet C, Diaconu CC, Staerk J, Girardot M, Marty C, Royer Y, Defour JP, Dusa A, Besancenot R, Giraudier S, Villeval JL, Knoops L, Courtoy PJ, Vainchenker W, Constantinescu SN.

Blood. 2012 May 17;119(20):4625-35. doi: 10.1182/blood-2011-08-372524. Epub 2012 Feb 29.


Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization.

Ben Khalifa N, Tyteca D, Courtoy PJ, Renauld JC, Constantinescu SN, Octave JN, Kienlen-Campard P.

Neurodegener Dis. 2012;10(1-4):92-5. doi: 10.1159/000335225. Epub 2012 Feb 10.


Structural features of the KPI domain control APP dimerization, trafficking, and processing.

Ben Khalifa N, Tyteca D, Marinangeli C, Depuydt M, Collet JF, Courtoy PJ, Renauld JC, Constantinescu S, Octave JN, Kienlen-Campard P.

FASEB J. 2012 Feb;26(2):855-67. doi: 10.1096/fj.11-190207. Epub 2011 Nov 15.


Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition.

Elens L, Tyteca D, Panin N, Courtoy P, Lison D, Demoulin JB, Haufroid V.

Pharmacogenet Genomics. 2011 Dec;21(12):884-93. doi: 10.1097/FPC.0b013e32834d672b.


Determinants of the enzymatic activity and the subcellular localization of aspartate N-acetyltransferase.

Tahay G, Wiame E, Tyteca D, Courtoy PJ, Van Schaftingen E.

Biochem J. 2012 Jan 1;441(1):105-12. doi: 10.1042/BJ20111179.


Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic.

Denamur S, Tyteca D, Marchand-Brynaert J, Van Bambeke F, Tulkens PM, Courtoy PJ, Mingeot-Leclercq MP.

Free Radic Biol Med. 2011 Nov 1;51(9):1656-65. doi: 10.1016/j.freeradbiomed.2011.07.015. Epub 2011 Jul 23.


Segmental and subcellular distribution of CFTR in the kidney.

Jouret F, Courtoy PJ, Devuyst O.

Methods Mol Biol. 2011;741:285-99. doi: 10.1007/978-1-61779-117-8_19.


Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.

Selvais C, D'Auria L, Tyteca D, Perrot G, Lemoine P, Troeberg L, Dedieu S, Noël A, Nagase H, Henriet P, Courtoy PJ, Marbaix E, Emonard H.

FASEB J. 2011 Aug;25(8):2770-81. doi: 10.1096/fj.10-169508. Epub 2011 Apr 25.


A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis.

Raynaud P, Tate J, Callens C, Cordi S, Vandersmissen P, Carpentier R, Sempoux C, Devuyst O, Pierreux CE, Courtoy P, Dahan K, Delbecque K, Lepreux S, Pontoglio M, Guay-Woodford LM, Lemaigre FP.

Hepatology. 2011 Jun;53(6):1959-66. doi: 10.1002/hep.24292. Epub 2011 May 2.


Segregation of fluorescent membrane lipids into distinct micrometric domains: evidence for phase compartmentation of natural lipids?

D'auria L, Van der Smissen P, Bruyneel F, Courtoy PJ, Tyteca D.

PLoS One. 2011 Feb 28;6(2):e17021. doi: 10.1371/journal.pone.0017021.


Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes.

Medts T, de Diesbach P, Cominelli A, N'Kuli F, Tyteca D, Courtoy PJ.

Exp Cell Res. 2010 Nov 15;316(19):3239-53. doi: 10.1016/j.yexcr.2010.09.001. Epub 2010 Sep 9. Erratum in: Exp Cell Res. 2011 Jul 15;317(12):1785.


Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.

Pierreux CE, Cordi S, Hick AC, Achouri Y, Ruiz de Almodovar C, Prévot PP, Courtoy PJ, Carmeliet P, Lemaigre FP.

Dev Biol. 2010 Nov 1;347(1):216-27. doi: 10.1016/j.ydbio.2010.08.024. Epub 2010 Aug 31.


A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice.

Demotte N, Wieërs G, Van Der Smissen P, Moser M, Schmidt C, Thielemans K, Squifflet JL, Weynand B, Carrasco J, Lurquin C, Courtoy PJ, van der Bruggen P.

Cancer Res. 2010 Oct 1;70(19):7476-88. doi: 10.1158/0008-5472.CAN-10-0761. Epub 2010 Aug 18.


Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands.

Gaide Chevronnay HP, Lemoine P, Courtoy PJ, Marbaix E, Henriet P.

Endocrinology. 2010 Sep;151(9):4515-26. doi: 10.1210/en.2009-1398. Epub 2010 Jul 21.


Live-cell imaging with water-soluble aminophenoxazinone dyes synthesised through laccase biocatalysis.

Bruyneel F, D'Auria L, Payen O, Courtoy PJ, Marchand-Brynaert J.

Chembiochem. 2010 Jul 5;11(10):1451-7. doi: 10.1002/cbic.201000145.


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