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Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival.

Gast CE, Silk AD, Zarour L, Riegler L, Burkhart JG, Gustafson KT, Parappilly MS, Roh-Johnson M, Goodman JR, Olson B, Schmidt M, Swain JR, Davies PS, Shasthri V, Iizuka S, Flynn P, Watson S, Korkola J, Courtneidge SA, Fischer JM, Jaboin J, Billingsley KG, Lopez CD, Burchard J, Gray J, Coussens LM, Sheppard BC, Wong MH.

Sci Adv. 2018 Sep 12;4(9):eaat7828. doi: 10.1126/sciadv.aat7828. eCollection 2018 Sep.


Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models.

Ouyang X, Barling A, Lesch A, Tyner JW, Choonoo G, Zheng C, Jeng S, West TM, Clayburgh D, Courtneidge SA, McWeeney SK, Kulesz-Martin M.

Cancer Biol Ther. 2018;19(10):921-933. doi: 10.1080/15384047.2018.1451285. Epub 2018 Aug 17.


Tks adaptor proteins at a glance.

Saini P, Courtneidge SA.

J Cell Sci. 2018 Jan 8;131(1). pii: jcs203661. doi: 10.1242/jcs.203661. Review.


SRC Increases MYC mRNA Expression in Estrogen Receptor-Positive Breast Cancer via mRNA Stabilization and Inhibition of p53 Function.

Abdullah C, Korkaya H, Iizuka S, Courtneidge SA.

Mol Cell Biol. 2018 Feb 27;38(6). pii: e00463-17. doi: 10.1128/MCB.00463-17. Print 2018 Mar 15.


Invadosomes are coming: new insights into function and disease relevance.

Paterson EK, Courtneidge SA.

FEBS J. 2018 Jan;285(1):8-27. doi: 10.1111/febs.14123. Epub 2017 Jun 22. Review.


ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.

Eckert MA, Santiago-Medina M, Lwin TM, Kim J, Courtneidge SA, Yang J.

J Cell Sci. 2017 Jun 15;130(12):2036-2048. doi: 10.1242/jcs.198200. Epub 2017 May 3.


The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.

Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA.

Oncotarget. 2016 Nov 29;7(48):78473-78486. doi: 10.18632/oncotarget.12954.


The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo.

Blouw B, Patel M, Iizuka S, Abdullah C, You WK, Huang X, Li JL, Diaz B, Stallcup WB, Courtneidge SA.

PLoS One. 2015 Mar 31;10(3):e0121003. doi: 10.1371/journal.pone.0121003. eCollection 2015.


Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.

Cejudo-Martin P, Yuen A, Vlahovich N, Lock P, Courtneidge SA, Díaz B.

PLoS One. 2014 Sep 26;9(9):e107674. doi: 10.1371/journal.pone.0107674. eCollection 2014.


Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis.

Leong HS, Robertson AE, Stoletov K, Leith SJ, Chin CA, Chien AE, Hague MN, Ablack A, Carmine-Simmen K, McPherson VA, Postenka CO, Turley EA, Courtneidge SA, Chambers AF, Lewis JD.

Cell Rep. 2014 Sep 11;8(5):1558-70. doi: 10.1016/j.celrep.2014.07.050. Epub 2014 Aug 28.


Regulation of invadopodia by the tumor microenvironment.

Gould CM, Courtneidge SA.

Cell Adh Migr. 2014;8(3):226-35. Review.


Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells.

Burger KL, Learman BS, Boucherle AK, Sirintrapun SJ, Isom S, Díaz B, Courtneidge SA, Seals DF.

Prostate. 2014 Feb;74(2):134-48. doi: 10.1002/pros.22735. Epub 2013 Oct 30.


Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.

Díaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge SA.

J Cell Biol. 2013 Apr 15;201(2):279-92. doi: 10.1083/jcb.201209151.


Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma.

Munson JM, Fried L, Rowson SA, Bonner MY, Karumbaiah L, Diaz B, Courtneidge SA, Knaus UG, Brat DJ, Arbiser JL, Bellamkonda RV.

Sci Transl Med. 2012 Mar 28;4(127):127ra36. doi: 10.1126/scitranslmed.3003016.


Cell migration and invasion in human disease: the Tks adaptor proteins.

Courtneidge SA.

Biochem Soc Trans. 2012 Feb;40(1):129-32. doi: 10.1042/BST20110685. Review.


Redox signaling at invasive microdomains in cancer cells.

Díaz B, Courtneidge SA.

Free Radic Biol Med. 2012 Jan 15;52(2):247-56. doi: 10.1016/j.freeradbiomed.2011.09.016. Epub 2011 Sep 29. Review.


A Src-Tks5 pathway is required for neural crest cell migration during embryonic development.

Murphy DA, Diaz B, Bromann PA, Tsai JH, Kawakami Y, Maurer J, Stewart RA, Izpisúa-Belmonte JC, Courtneidge SA.

PLoS One. 2011;6(7):e22499. doi: 10.1371/journal.pone.0022499. Epub 2011 Jul 25. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/d66234d8-b722-4b6d-ab8a-73b5f396c37e.


A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion.

Quintavalle M, Elia L, Price JH, Heynen-Genel S, Courtneidge SA.

Sci Signal. 2011 Jul 26;4(183):ra49. doi: 10.1126/scisignal.2002032.


The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function.

Murphy DA, Courtneidge SA.

Nat Rev Mol Cell Biol. 2011 Jun 23;12(7):413-26. doi: 10.1038/nrm3141. Review.


Podosomal proteins as causes of human syndromes: a role in craniofacial development?

Cejudo-Martin P, Courtneidge SA.

Genesis. 2011 Apr;49(4):209-21. doi: 10.1002/dvg.20732. Epub 2011 Apr 1. Review.


MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro.

Quintavalle M, Elia L, Condorelli G, Courtneidge SA.

J Cell Biol. 2010 Apr 5;189(1):13-22. doi: 10.1083/jcb.200912096. Epub 2010 Mar 29.


Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome.

Iqbal Z, Cejudo-Martin P, de Brouwer A, van der Zwaag B, Ruiz-Lozano P, Scimia MC, Lindsey JD, Weinreb R, Albrecht B, Megarbane A, Alanay Y, Ben-Neriah Z, Amenduni M, Artuso R, Veltman JA, van Beusekom E, Oudakker A, Millán JL, Hennekam R, Hamel B, Courtneidge SA, van Bokhoven H.

Am J Hum Genet. 2010 Feb 12;86(2):254-61. doi: 10.1016/j.ajhg.2010.01.009. Epub 2010 Feb 4.


The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease.

Elia L, Quintavalle M, Zhang J, Contu R, Cossu L, Latronico MV, Peterson KL, Indolfi C, Catalucci D, Chen J, Courtneidge SA, Condorelli G.

Cell Death Differ. 2009 Dec;16(12):1590-8. doi: 10.1038/cdd.2009.153. Epub 2009 Oct 9.


Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.

Gianni D, Diaz B, Taulet N, Fowler B, Courtneidge SA, Bokoch GM.

Sci Signal. 2009 Sep 15;2(88):ra54. doi: 10.1126/scisignal.2000370.


Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation.

Diaz B, Shani G, Pass I, Anderson D, Quintavalle M, Courtneidge SA.

Sci Signal. 2009 Sep 15;2(88):ra53. doi: 10.1126/scisignal.2000368.


Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.

Stylli SS, Stacey TT, Verhagen AM, Xu SS, Pass I, Courtneidge SA, Lock P.

J Cell Sci. 2009 Aug 1;122(Pt 15):2727-40. doi: 10.1242/jcs.046680. Epub 2009 Jul 13.


Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation.

Crimaldi L, Courtneidge SA, Gimona M.

Exp Cell Res. 2009 Sep 10;315(15):2581-92. doi: 10.1016/j.yexcr.2009.06.012. Epub 2009 Jun 18.


The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation.

Buschman MD, Bromann PA, Cejudo-Martin P, Wen F, Pass I, Courtneidge SA.

Mol Biol Cell. 2009 Mar;20(5):1302-11. doi: 10.1091/mbc.E08-09-0949. Epub 2009 Jan 14.


The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics).

Schilsky RL, Gordon G, Gilmer TM, Courtneidge SA, Matrisian LM, Grad O, Nelson WG; Translational Research Working Group.

Clin Cancer Res. 2008 Sep 15;14(18):5685-91. doi: 10.1158/1078-0432.CCR-08-1265.


The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.

Gianni D, Bohl B, Courtneidge SA, Bokoch GM.

Mol Biol Cell. 2008 Jul;19(7):2984-94. doi: 10.1091/mbc.E08-02-0138. Epub 2008 May 7.


A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo.

Blouw B, Seals DF, Pass I, Diaz B, Courtneidge SA.

Eur J Cell Biol. 2008 Sep;87(8-9):555-67. doi: 10.1016/j.ejcb.2008.02.008. Epub 2008 Apr 15.


Assembly and biological role of podosomes and invadopodia.

Gimona M, Buccione R, Courtneidge SA, Linder S.

Curr Opin Cell Biol. 2008 Apr;20(2):235-41. doi: 10.1016/ Epub 2008 Mar 11. Review.


The SRC substrate Tks5, podosomes (invadopodia), and cancer cell invasion.

Courtneidge SA, Azucena EF, Pass I, Seals DF, Tesfay L.

Cold Spring Harb Symp Quant Biol. 2005;70:167-71.


The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells.

Seals DF, Azucena EF Jr, Pass I, Tesfay L, Gordon R, Woodrow M, Resau JH, Courtneidge SA.

Cancer Cell. 2005 Feb;7(2):155-65.


Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts.

Bromann PA, Korkaya H, Webb CP, Miller J, Calvin TL, Courtneidge SA.

J Biol Chem. 2005 Mar 18;280(11):10253-63. Epub 2005 Jan 5.


The interplay between Src family kinases and receptor tyrosine kinases.

Bromann PA, Korkaya H, Courtneidge SA.

Oncogene. 2004 Oct 18;23(48):7957-68. Review.


Cancer: Escape from inhibition.

Courtneidge SA.

Nature. 2003 Apr 24;422(6934):827-8. No abstract available.


The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells.

Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM, Courtneidge SA.

J Biol Chem. 2003 May 9;278(19):16844-51. Epub 2003 Mar 3.


Isolation of novel Src substrates.

Courtneidge SA.

Biochem Soc Trans. 2003 Feb;31(Pt 1):25-8. Review.


The ADAMs family of metalloproteases: multidomain proteins with multiple functions.

Seals DF, Courtneidge SA.

Genes Dev. 2003 Jan 1;17(1):7-30. Review. No abstract available.


The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly.

Scaife RM, Courtneidge SA, Langdon WY.

J Cell Sci. 2003 Feb 1;116(Pt 3):463-73.


Role of Src in signal transduction pathways. The Jubilee Lecture.

Courtneidge SA.

Biochem Soc Trans. 2002 Apr;30(2):11-7.


Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.

Bowman T, Broome MA, Sinibaldi D, Wharton W, Pledger WJ, Sedivy JM, Irby R, Yeatman T, Courtneidge SA, Jove R.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7319-24. Epub 2001 Jun 12.


SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling.

Blake RA, Broome MA, Liu X, Wu J, Gishizky M, Sun L, Courtneidge SA.

Mol Cell Biol. 2000 Dec;20(23):9018-27.


Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.

Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS.

Mol Cell. 2000 Jan;5(1):13-25.


Src family tyrosine kinases and growth factor signaling.

Abram CL, Courtneidge SA.

Exp Cell Res. 2000 Jan 10;254(1):1-13. Review. No abstract available.


The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases.

Broome MA, Galisteo ML, Schlessinger J, Courtneidge SA.

Oncogene. 1999 May 6;18(18):2908-12.


Src promotes PKCdelta degradation.

Blake RA, Garcia-Paramio P, Parker PJ, Courtneidge SA.

Cell Growth Differ. 1999 Apr;10(4):231-41.


The discovery and validation of new drug targets in cancer.

Courtneidge SA, Plowman GD.

Curr Opin Biotechnol. 1998 Dec;9(6):632-6. Review.


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