Sort by
Items per page

Send to

Choose Destination

Search results

Items: 24


Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.

Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A.

EBioMedicine. 2016 Oct;12:208-218. doi: 10.1016/j.ebiom.2016.09.004. Epub 2016 Sep 9.


Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.

Melillo B, Liang S, Park J, Schön A, Courter JR, LaLonde JM, Wendler DJ, Princiotto AM, Seaman MS, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB 3rd.

ACS Med Chem Lett. 2016 Jan 19;7(3):330-4. doi: 10.1021/acsmedchemlett.5b00471. eCollection 2016 Mar 10.


Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity.

Richard J, Veillette M, Ding S, Zoubchenok D, Alsahafi N, Coutu M, Brassard N, Park J, Courter JR, Melillo B, Smith AB 3rd, Shaw GM, Hahn BH, Sodroski J, Kaufmann DE, Finzi A.

EBioMedicine. 2015 Dec 9;3:122-134. doi: 10.1016/j.ebiom.2015.12.004. eCollection 2016 Jan.


Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells.

Lee WS, Richard J, Lichtfuss M, Smith AB 3rd, Park J, Courter JR, Melillo BN, Sodroski JG, Kaufmann DE, Finzi A, Parsons MS, Kent SJ.

J Virol. 2015 Dec 9;90(4):2021-30. doi: 10.1128/JVI.02717-15. Print 2016 Feb 15.


CD4 mimetics sensitize HIV-1-infected cells to ADCC.

Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB 3rd, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2687-94. doi: 10.1073/pnas.1506755112. Epub 2015 May 4.


Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.

Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB 3rd, Kwong PD, Blanchard SC, Mothes W.

Science. 2014 Nov 7;346(6210):759-63. doi: 10.1126/science.1254426. Epub 2014 Oct 8.


CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies.

Madani N, Princiotto AM, Schön A, LaLonde J, Feng Y, Freire E, Park J, Courter JR, Jones DM, Robinson J, Liao HX, Moody MA, Permar S, Haynes B, Smith AB 3rd, Wyatt R, Sodroski J.

J Virol. 2014 Jun;88(12):6542-55. doi: 10.1128/JVI.00540-14. Epub 2014 Apr 2.


Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.

Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, LaLonde JM, Smith AB 3rd.

Acc Chem Res. 2014 Apr 15;47(4):1228-37. doi: 10.1021/ar4002735. Epub 2014 Feb 6. Review.


Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site.

Kwon YD, LaLonde JM, Yang Y, Elban MA, Sugawara A, Courter JR, Jones DM, Smith AB 3rd, Debnath AK, Kwong PD.

PLoS One. 2014 Jan 28;9(1):e85940. doi: 10.1371/journal.pone.0085940. eCollection 2014.


The design and synthesis of alanine-rich α-helical peptides constrained by an S,S-tetrazine photochemical trigger: a fragment union approach.

Courter JR, Abdo M, Brown SP, Tucker MJ, Hochstrasser RM, Smith AB 3rd.

J Org Chem. 2014 Jan 17;79(2):759-68. doi: 10.1021/jo402680v. Epub 2013 Dec 20.


Nonequilibrium dynamics of helix reorganization observed by transient 2D IR spectroscopy.

Tucker MJ, Abdo M, Courter JR, Chen J, Brown SP, Smith AB 3rd, Hochstrasser RM.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17314-9. doi: 10.1073/pnas.1311876110. Epub 2013 Oct 8.


Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization.

Lalonde JM, Le-Khac M, Jones DM, Courter JR, Park J, Schön A, Princiotto AM, Wu X, Mascola JR, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB 3rd.

ACS Med Chem Lett. 2013 Mar 14;4(3):338-343.


Weekend bias in Citizen Science data reporting: implications for phenology studies.

Courter JR, Johnson RJ, Stuyck CM, Lang BA, Kaiser EW.

Int J Biometeorol. 2013 Sep;57(5):715-20. doi: 10.1007/s00484-012-0598-7. Epub 2012 Oct 28.


Design, synthesis, and photochemical validation of peptide linchpins containing the S,S-tetrazine phototrigger.

Abdo M, Brown SP, Courter JR, Tucker MJ, Hochstrasser RM, Smith AB 3rd.

Org Lett. 2012 Jul 6;14(13):3518-21. doi: 10.1021/ol301490h. Epub 2012 Jun 26.


Di-Cysteine S,S-Tetrazine: A Potential Ultra-fast Photochemical Trigger to Explore the Early Events of Peptide/Protein Folding.

Tucker MJ, Abdo M, Courter JR, Chen J, Smith AB 3rd, Hochstrasser RM.

J Photochem Photobiol A Chem. 2012 Apr 15;234:156-163. Epub 2012 Feb 17.


Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.

LaLonde JM, Kwon YD, Jones DM, Sun AW, Courter JR, Soeta T, Kobayashi T, Princiotto AM, Wu X, Schön A, Freire E, Kwong PD, Mascola JR, Sodroski J, Madani N, Smith AB 3rd.

J Med Chem. 2012 May 10;55(9):4382-96. doi: 10.1021/jm300265j. Epub 2012 Apr 23.


An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.

Herschhorn A, Finzi A, Jones DM, Courter JR, Sugawara A, Smith AB 3rd, Sodroski JG.

PLoS One. 2011;6(11):e26731. doi: 10.1371/journal.pone.0026731. Epub 2011 Nov 1.


Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

Haim H, Strack B, Kassa A, Madani N, Wang L, Courter JR, Princiotto A, McGee K, Pacheco B, Seaman MS, Smith AB 3rd, Sodroski J.

PLoS Pathog. 2011 Jun;7(6):e1002101. doi: 10.1371/journal.ppat.1002101. Epub 2011 Jun 23.


Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.

Gift SK, Zentner IJ, Schön A, McFadden K, Umashankara M, Rajagopal S, Contarino M, Duffy C, Courter JR, Zhang MY, Gershoni JM, Cocklin S, Dimitrov DS, Smith AB 3rd, Freire E, Chaiken IM.

Biochemistry. 2011 Apr 12;50(14):2756-68. doi: 10.1021/bi101160r. Epub 2011 Mar 18.


Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.

Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schön A, Freire E, Sodroski J, Smith AB 3rd.

Bioorg Med Chem. 2011 Jan 1;19(1):91-101. doi: 10.1016/j.bmc.2010.11.049. Epub 2010 Nov 26.


Tetrazine phototriggers: probes for peptide dynamics.

Tucker MJ, Courter JR, Chen J, Atasoylu O, Smith AB 3rd, Hochstrasser RM.

Angew Chem Int Ed Engl. 2010 May 10;49(21):3612-6. doi: 10.1002/anie.201000500. No abstract available.


Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state.

Haim H, Si Z, Madani N, Wang L, Courter JR, Princiotto A, Kassa A, DeGrace M, McGee-Estrada K, Mefford M, Gabuzda D, Smith AB 3rd, Sodroski J.

PLoS Pathog. 2009 Apr;5(4):e1000360. doi: 10.1371/journal.ppat.1000360. Epub 2009 Apr 3.


Identification of a human immunodeficiency virus type 1 envelope glycoprotein variant resistant to cold inactivation.

Kassa A, Finzi A, Pancera M, Courter JR, Smith AB 3rd, Sodroski J.

J Virol. 2009 May;83(9):4476-88. doi: 10.1128/JVI.02110-08. Epub 2009 Feb 11.


Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

Madani N, Schön A, Princiotto AM, Lalonde JM, Courter JR, Soeta T, Ng D, Wang L, Brower ET, Xiang SH, Kwon YD, Huang CC, Wyatt R, Kwong PD, Freire E, Smith AB 3rd, Sodroski J.

Structure. 2008 Nov 12;16(11):1689-701. doi: 10.1016/j.str.2008.09.005.

Supplemental Content

Loading ...
Support Center