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Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding.

Costa AP, Court MH, Burke NS, Zhu Z, Mealey KL, Villarino NF.

Drug Metab Dispos. 2019 Oct;47(10):1024-1031. doi: 10.1124/dmd.119.087304. Epub 2019 Sep 3.


Absolute quantitation of drug metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals inter-breed variability.

Martinez SE, Shi J, Zhu HJ, Perez Jimenez TE, Zhu Z, Court MH.

Drug Metab Dispos. 2019 Aug 19. pii: dmd.119.088070. doi: 10.1124/dmd.119.088070. [Epub ahead of print]


Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.

Enimil A, Antwi S, Yang H, Dompreh A, Alghamdi WA, Gillani FS, Orstin A, Bosomtwe D, Opoku T, Norman J, Wiesner L, Langaee T, Peloquin CA, Court MH, Greenblatt DJ, Kwara A.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00839-19. doi: 10.1128/AAC.00839-19. Print 2019 Oct.


Personalized medicine: going to the dogs?

Mealey KL, Martinez SE, Villarino NF, Court MH.

Hum Genet. 2019 May;138(5):467-481. doi: 10.1007/s00439-019-02020-w. Epub 2019 Apr 28. Review.


Genomes of Three Closely Related Caribbean Amazons Provide Insight for Species History and Conservation.

Kolchanova S, Kliver S, Komissarov A, Dobrinin P, Tamazian G, Grigorev K, Wolfsberger WW, Majeske AJ, Velez-Valentin J, Valentin de la Rosa R, Paul-Murphy JR, Guzman DS, Court MH, Rodriguez-Flores JL, Martínez-Cruzado JC, Oleksyk TK.

Genes (Basel). 2019 Jan 16;10(1). pii: E54. doi: 10.3390/genes10010054.


Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study.

Malkawi M, Woolcock AD, Lee PM, Court MH, Moore GE, Hogan DF.

J Feline Med Surg. 2019 Oct;21(10):951-958. doi: 10.1177/1098612X18810887. Epub 2018 Nov 14.


Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old.

Kwara A, Yang H, Antwi S, Enimil A, Gillani FS, Dompreh A, Ortsin A, Opoku T, Bosomtwe D, Sarfo A, Wiesner L, Norman J, Alghamdi WA, Langaee T, Peloquin CA, Court MH, Greenblatt DJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01657-18. doi: 10.1128/AAC.01657-18. Print 2019 Jan.


Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs.

Perez Jimenez TE, Kukanich B, Joo H, Mealey KL, Grubb TL, Greene SA, Court MH.

Drug Metab Dispos. 2019 Jan;47(1):15-25. doi: 10.1124/dmd.118.083444. Epub 2018 Oct 26.


Investigation into the causes of aspirin resistance in healthy dogs.

Haines JM, Lee PM, Hegedus RM, Hwang JK, Court MH.

J Vet Pharmacol Ther. 2019 Mar;42(2):160-170. doi: 10.1111/jvp.12725. Epub 2018 Oct 9.


High interindividual variability in plasma clopidogrel active metabolite concentrations in healthy cats is associated with sex and cytochrome P450 2C genetic polymorphism.

Lee PM, Faus MCL, Court MH.

J Vet Pharmacol Ther. 2019 Jan;42(1):16-25. doi: 10.1111/jvp.12717. Epub 2018 Sep 24.


Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.

Perez Jimenez TE, Mealey KL, Schnider D, Grubb TL, Greene SA, Court MH.

J Vet Pharmacol Ther. 2018 Dec;41(6):815-824. doi: 10.1111/jvp.12706. Epub 2018 Aug 16.


Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.

Martinez MN, Court MH, Fink-Gremmels J, Mealey KL.

J Vet Pharmacol Ther. 2018 Aug;41(4):E57-E67. doi: 10.1111/jvp.12670. Epub 2018 Jun 19. Review.


Ex vivo binding of the immunosuppressant mycophenolic acid to dog and cat plasma proteins and the effect of co-incubated dexamethasone and prednisolone.

Morassi A, Rivera-Vélez SM, Slovak JE, Court MH, Villarino NF.

J Vet Pharmacol Ther. 2018 Aug;41(4):513-521. doi: 10.1111/jvp.12507. Epub 2018 Apr 23.


Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.

Dompreh A, Tang X, Zhou J, Yang H, Topletz A, Adu Ahwireng E, Antwi S, Enimil A, Langaee T, Peloquin CA, Court MH, Kwara A.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02099-17. doi: 10.1128/AAC.02099-17. Print 2018 Mar.


Pharmacokinetics of Mycophenolic Acid after Intravenous Administration of Mycophenolate Mofetil to Healthy Cats.

Slovak JE, Rivera SM, Hwang JK, Court MH, Villarino NF.

J Vet Intern Med. 2017 Nov;31(6):1827-1832. doi: 10.1111/jvim.14827. Epub 2017 Sep 11.


Pharmacokinetics of a Sustained-release Formulation of Meloxicam After Subcutaneous Administration to Hispaniolan Amazon Parrots (Amazona ventralis).

Guzman DS, Court MH, Zhu Z, Summa N, Paul-Murphy JR.

J Avian Med Surg. 2017 Sep;31(3):219-224. doi: 10.1647/2016-202.


Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers.

Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ.

J Pharmacol Exp Ther. 2017 Sep;362(3):431-440. doi: 10.1124/jpet.117.242107. Epub 2017 Jun 29.


Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma.

Lyngby JG, Court MH, Lee PM.

J Vet Cardiol. 2017 Aug;19(4):384-395. doi: 10.1016/j.jvc.2017.03.004. Epub 2017 Jun 9.


Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach.

Papageorgiou I, Court MH.

Biochem Pharmacol. 2017 Aug 1;137:93-106. doi: 10.1016/j.bcp.2017.04.017. Epub 2017 Apr 19.


Establishment of reference ranges and evaluation of in vitro concentration-dependent platelet inhibition by acetylsalicylic acid for multiple electrode impedance aggregometry in healthy dogs.

Haines JM, Lee PM, Hegedus RM, Hwang JK, Court MH.

J Vet Pharmacol Ther. 2017 Dec;40(6):618-628. doi: 10.1111/jvp.12405. Epub 2017 Apr 6.


Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.

Perez TE, Mealey KL, Burke NS, Grubb TL, Court MH, Greene SA.

Vet Anaesth Analg. 2017 Mar;44(2):370-374. doi: 10.1016/j.vaa.2016.05.003. Epub 2017 Jan 11.


Simultaneous determination of mycophenolic acid and its glucuronide and glycoside derivatives in canine and feline plasma by UHPLC-UV.

Rivera SM, Hwang JK, Slovak JE, Court MH, Villarino NF.

Biomed Chromatogr. 2017 Aug;31(8). doi: 10.1002/bmc.3942. Epub 2017 Feb 27.


Pharmacokinetics of terbinafine in little brown myotis (Myotis lucifugus) infected with Pseudogymnoascus destructans.

Court MH, Robbins AH, Whitford AM, Beck EV, Tseng FS, Reeder DM.

Am J Vet Res. 2017 Jan;78(1):90-99. doi: 10.2460/ajvr.78.1.90.


Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs).

Perez Jimenez TE, Mealey KL, Grubb TL, Greene SA, Court MH.

Drug Metab Dispos. 2016 Dec;44(12):1963-1972. doi: 10.1124/dmd.116.071902. Epub 2016 Oct 6. Erratum in: Drug Metab Dispos. 2017 Jul;45(7):706.


Development and validation of an ultrafast chromatographic method for quantification of the immunosuppressant mycophenolic acid in canine, feline and human plasma.

Rivera Vélez SM, Morassi A, Court MH, Slovak JE, Villarino NF.

J Pharm Biomed Anal. 2016 Nov 30;131:94-102. doi: 10.1016/j.jpba.2016.08.012. Epub 2016 Aug 12.


Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver.

Papageorgiou I, Freytsis M, Court MH.

Biochem Pharmacol. 2016 Oct 1;117:78-87. doi: 10.1016/j.bcp.2016.08.014. Epub 2016 Aug 13.


Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes.

Slovak JE, Mealey K, Court MH.

J Vet Pharmacol Ther. 2017 Apr;40(2):123-129. doi: 10.1111/jvp.12338. Epub 2016 Jun 15.


Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms.

Street CM, Zhu Z, Finel M, Court MH.

Xenobiotica. 2017 Jan;47(1):1-10. doi: 10.3109/00498254.2016.1156784. Epub 2016 Mar 21.


The pharmacokinetics of intravenous fenoldopam in healthy, awake cats.

O'Neill KE, Labato MA, Court MH.

J Vet Pharmacol Ther. 2016 Apr;39(2):202-4. doi: 10.1111/jvp.12274. Epub 2016 Jan 14.


Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2.

Lewis RS, Fidel J, Dassanayake S, Court MH, Burke NS, Mealey KL.

Vet Comp Oncol. 2017 Jun;15(2):411-420. doi: 10.1111/vco.12177. Epub 2015 Oct 14.


Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing.

Gammal RS, Court MH, Haidar CE, Iwuchukwu OF, Gaur AH, Alvarellos M, Guillemette C, Lennox JL, Whirl-Carrillo M, Brummel SS, Ratain MJ, Klein TE, Schackman BR, Caudle KE, Haas DW; Clinical Pharmacogenetics Implementation Consortium.

Clin Pharmacol Ther. 2016 Apr;99(4):363-9. doi: 10.1002/cpt.269. Epub 2015 Nov 9. Review.


Soy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomes.

Redmon JM, Shrestha B, Cerundolo R, Court MH.

Xenobiotica. 2016;46(5):406-15. doi: 10.3109/00498254.2015.1086038. Epub 2015 Sep 14.


Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen.

Zhao Y, Harmatz JS, Epstein CR, Nakagawa Y, Kurosaki C, Nakamura T, Kadota T, Giesing D, Court MH, Greenblatt DJ.

Br J Clin Pharmacol. 2015 Nov;80(5):1076-85. doi: 10.1111/bcp.12644. Epub 2015 Jun 8.


A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients.

Chen S, Laverdiere I, Tourancheau A, Jonker D, Couture F, Cecchin E, Villeneuve L, Harvey M, Court MH, Innocenti F, Toffoli G, Lévesque E, Guillemette C.

Pharmacogenomics J. 2015 Dec;15(6):513-20. doi: 10.1038/tpj.2015.12. Epub 2015 Mar 17.


Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.

Court MH, Almutairi FE, Greenblatt DJ, Hazarika S, Sheng H, Klein K, Zanger UM, Bourgea J, Patten CJ, Kwara A.

Antimicrob Agents Chemother. 2014 Jul;58(7):4145-52. doi: 10.1128/AAC.02532-14. Epub 2014 May 12.


Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes.

Haas DW, Kwara A, Richardson DM, Baker P, Papageorgiou I, Acosta EP, Morse GD, Court MH.

J Antimicrob Chemother. 2014 Aug;69(8):2175-82. doi: 10.1093/jac/dku110. Epub 2014 Apr 11.


Factors associated with variability in rifampin plasma pharmacokinetics and the relationship between rifampin concentrations and induction of efavirenz clearance.

Kwara A, Cao L, Yang H, Poethke P, Kurpewski J, Tashima KT, Mahjoub BD, Court MH, Peloquin CA.

Pharmacotherapy. 2014 Mar;34(3):265-71. doi: 10.1002/phar.1388. Epub 2014 Jan 13.


Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.

Court MH, Peter I, Hazarika S, Vasiadi M, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group.

Drug Metab Dispos. 2014 Jan;42(1):28-32. doi: 10.1124/dmd.113.053546. Epub 2013 Oct 8.


Feline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms.

Court MH.

Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1039-54. doi: 10.1016/j.cvsm.2013.05.002. Review.


Canine cytochrome P-450 pharmacogenetics.

Court MH.

Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1027-38. doi: 10.1016/j.cvsm.2013.05.001. Epub 2013 Jun 13.


Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.

Yasar U, Greenblatt DJ, Guillemette C, Court MH.

J Pharm Pharmacol. 2013 Jun;65(6):874-83. doi: 10.1111/jphp.12053. Epub 2013 Mar 21.


Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan Amazon parrots (Amazona ventralis).

Molter CM, Court MH, Cole GA, Gagnon DJ, Hazarika S, Paul-Murphy JR.

Am J Vet Res. 2013 Mar;74(3):375-80. doi: 10.2460/ajvr.74.3.375.


The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure.

Court MH, Freytsis M, Wang X, Peter I, Guillemette C, Hazarika S, Duan SX, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group.

J Pharmacol Exp Ther. 2013 May;345(2):297-307. doi: 10.1124/jpet.112.202010. Epub 2013 Feb 13.


Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results.

Hanley MJ, Masse G, Harmatz JS, Court MH, Greenblatt DJ.

Clin Pharmacol Ther. 2012 Nov;92(5):651-7. doi: 10.1038/clpt.2012.170. Epub 2012 Oct 10.


Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers.

Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ.

Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. doi: 10.1111/j.1365-2125.2012.04450.x.


Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers.

Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ, Court MH.

Br J Clin Pharmacol. 2013 Feb;75(2):450-62. doi: 10.1111/j.1365-2125.2012.04364.x.


Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues.

Court MH, Zhang X, Ding X, Yee KK, Hesse LM, Finel M.

Xenobiotica. 2012 Mar;42(3):266-77. doi: 10.3109/00498254.2011.618954. Epub 2011 Oct 13.


Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases.

Bratton SM, Mosher CM, Khallouki F, Finel M, Court MH, Moran JH, Radominska-Pandya A.

J Pharmacol Exp Ther. 2012 Jan;340(1):46-55. doi: 10.1124/jpet.111.184721. Epub 2011 Oct 4.


Preliminary pharmacokinetics and cardiovascular effects of fenoldopam continuous rate infusion in six healthy dogs.

Bloom CA, Labato MA, Hazarika S, Court MH.

J Vet Pharmacol Ther. 2012 Jun;35(3):224-30. doi: 10.1111/j.1365-2885.2011.01319.x. Epub 2011 Jul 6.

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