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Items: 32


Comparison of CD8+ T Cell Accumulation in the Brain During Human and Murine Cerebral Malaria.

Barrera V, Haley MJ, Strangward P, Attree E, Kamiza S, Seydel KB, Taylor TE, Milner DA Jr, Craig AG, Couper KN.

Front Immunol. 2019 Jul 24;10:1747. doi: 10.3389/fimmu.2019.01747. eCollection 2019.


Infection-Induced Resistance to Experimental Cerebral Malaria Is Dependent Upon Secreted Antibody-Mediated Inhibition of Pathogenic CD8+ T Cell Responses.

Shaw TN, Inkson CA, Villegas-Mendez A, Pattinson DJ, Strangward P, Else KJ, Draper SJ, Zeef LAH, Couper KN.

Front Immunol. 2019 Feb 19;10:248. doi: 10.3389/fimmu.2019.00248. eCollection 2019.


Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.

Strangward P, Haley MJ, Albornoz MG, Barrington J, Shaw T, Dookie R, Zeef L, Baker SM, Winter E, Tzeng TC, Golenbock DT, Cruickshank SM, Allan SM, Craig A, Liew FY, Brough D, Couper KN.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7404-7409. doi: 10.1073/pnas.1801737115. Epub 2018 Jun 28.


Gamma Interferon Mediates Experimental Cerebral Malaria by Signaling within Both the Hematopoietic and Nonhematopoietic Compartments.

Villegas-Mendez A, Strangward P, Shaw TN, Rajkovic I, Tosevski V, Forman R, Muller W, Couper KN.

Infect Immun. 2017 Oct 18;85(11). pii: e01035-16. doi: 10.1128/IAI.01035-16. Print 2017 Nov.


A quantitative brain map of experimental cerebral malaria pathology.

Strangward P, Haley MJ, Shaw TN, Schwartz JM, Greig R, Mironov A, de Souza JB, Cruickshank SM, Craig AG, Milner DA Jr, Allan SM, Couper KN.

PLoS Pathog. 2017 Mar 8;13(3):e1006267. doi: 10.1371/journal.ppat.1006267. eCollection 2017 Mar.


Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria.

Shaw TN, Stewart-Hutchinson PJ, Strangward P, Dandamudi DB, Coles JA, Villegas-Mendez A, Gallego-Delgado J, van Rooijen N, Zindy E, Rodriguez A, Brewer JM, Couper KN, Dustin ML.

PLoS Pathog. 2015 Nov 12;11(11):e1005210. doi: 10.1371/journal.ppat.1005210. eCollection 2015.


Parasite-Specific CD4+ IFN-γ+ IL-10+ T Cells Distribute within Both Lymphoid and Nonlymphoid Compartments and Are Controlled Systemically by Interleukin-27 and ICOS during Blood-Stage Malaria Infection.

Villegas-Mendez A, Shaw TN, Inkson CA, Strangward P, de Souza JB, Couper KN.

Infect Immun. 2015 Oct 12;84(1):34-46. doi: 10.1128/IAI.01100-15. Print 2016 Jan.


IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.

Besnard AG, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw TN, Couper KN, Ryffel B, Liew FY.

PLoS Pathog. 2015 Feb 6;11(2):e1004607. doi: 10.1371/journal.ppat.1004607. eCollection 2015 Feb.


The subcellular location of ovalbumin in Plasmodium berghei blood stages influences the magnitude of T-cell responses.

Lin JW, Shaw TN, Annoura T, Fougère A, Bouchier P, Chevalley-Maurel S, Kroeze H, Franke-Fayard B, Janse CJ, Couper KN, Khan SM.

Infect Immun. 2014 Nov;82(11):4654-65. doi: 10.1128/IAI.01940-14. Epub 2014 Aug 25.


WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways.

Villegas-Mendez A, Gwyer Findlay E, de Souza JB, Grady LM, Saris CJ, Lane TE, Riley EM, Couper KN.

PLoS One. 2013 Nov 7;8(11):e78486. doi: 10.1371/journal.pone.0078486. eCollection 2013.


IL-27 receptor signaling regulates memory CD4+ T cell populations and suppresses rapid inflammatory responses during secondary malaria infection.

Gwyer Findlay E, Villegas-Mendez A, O'Regan N, de Souza JB, Grady LM, Saris CJ, Riley EM, Couper KN.

Infect Immun. 2014 Jan;82(1):10-20. doi: 10.1128/IAI.01091-13. Epub 2013 Oct 7.


IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.

Villegas-Mendez A, de Souza JB, Lavelle SW, Gwyer Findlay E, Shaw TN, van Rooijen N, Saris CJ, Hunter CA, Riley EM, Couper KN.

PLoS Pathog. 2013;9(4):e1003293. doi: 10.1371/journal.ppat.1003293. Epub 2013 Apr 11.


IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection.

Gwyer Findlay E, Villegas-Mendez A, de Souza JB, Inkson CA, Shaw TN, Saris CJ, Hunter CA, Riley EM, Couper KN.

J Immunol. 2013 May 1;190(9):4553-61. doi: 10.4049/jimmunol.1202916. Epub 2013 Mar 27.


IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

Villegas-Mendez A, Greig R, Shaw TN, de Souza JB, Gwyer Findlay E, Stumhofer JS, Hafalla JC, Blount DG, Hunter CA, Riley EM, Couper KN.

J Immunol. 2012 Jul 15;189(2):968-79. doi: 10.4049/jimmunol.1200688. Epub 2012 Jun 20.


The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.

Hafalla JC, Claser C, Couper KN, Grau GE, Renia L, de Souza JB, Riley EM.

PLoS Pathog. 2012 Feb;8(2):e1002504. doi: 10.1371/journal.ppat.1002504. Epub 2012 Feb 2.


Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.

Villegas-Mendez A, de Souza JB, Murungi L, Hafalla JC, Shaw TN, Greig R, Riley EM, Couper KN.

J Immunol. 2011 Sep 15;187(6):2885-97. doi: 10.4049/jimmunol.1100241. Epub 2011 Aug 31.


Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.

Findlay EG, Greig R, Stumhofer JS, Hafalla JC, de Souza JB, Saris CJ, Hunter CA, Riley EM, Couper KN.

J Immunol. 2010 Aug 15;185(4):2482-92. doi: 10.4049/jimmunol.0904019. Epub 2010 Jul 14.


Neutralization of malaria glycosylphosphatidylinositol in vitro by serum IgG from malaria-exposed individuals.

de Souza JB, Runglall M, Corran PH, Okell LC, Kumar S, Gowda DC, Couper KN, Riley EM.

Infect Immun. 2010 Sep;78(9):3920-9. doi: 10.1128/IAI.00359-10. Epub 2010 Jun 21.


Neuropathogenesis of human and murine malaria.

Riley EM, Couper KN, Helmby H, Hafalla JC, de Souza JB, Langhorne J, Jarra WB, Zavala F.

Trends Parasitol. 2010 Jun;26(6):277-8. doi: 10.1016/ Epub 2010 Mar 24. No abstract available.


Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation.

Couper KN, Barnes T, Hafalla JC, Combes V, Ryffel B, Secher T, Grau GE, Riley EM, de Souza JB.

PLoS Pathog. 2010 Jan 29;6(1):e1000744. doi: 10.1371/journal.ppat.1000744.


Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease.

de Souza JB, Hafalla JC, Riley EM, Couper KN.

Parasitology. 2010 Apr;137(5):755-72. doi: 10.1017/S0031182009991715. Epub 2009 Dec 23. Review.


Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection.

Couper KN, Lanthier PA, Perona-Wright G, Kummer LW, Chen W, Smiley ST, Mohrs M, Johnson LL.

J Immunol. 2009 Apr 1;182(7):3985-94. doi: 10.4049/jimmunol.0803053.


IL-10: the master regulator of immunity to infection.

Couper KN, Blount DG, Riley EM.

J Immunol. 2008 May 1;180(9):5771-7. Review.


IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.

Couper KN, Blount DG, Wilson MS, Hafalla JC, Belkaid Y, Kamanaka M, Flavell RA, de Souza JB, Riley EM.

PLoS Pathog. 2008 Feb 29;4(2):e1000004. doi: 10.1371/journal.ppat.1000004.


Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia.

Couper KN, Blount DG, Hafalla JC, van Rooijen N, de Souza JB, Riley EM.

Infect Immun. 2007 Dec;75(12):5806-18. Epub 2007 Oct 8.


Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice.

Couper KN, Blount DG, de Souza JB, Suffia I, Belkaid Y, Riley EM.

J Immunol. 2007 Apr 1;178(7):4136-46.


Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion.

Couper KN, Roberts CW, Brombacher F, Alexander J, Johnson LL.

Infect Immun. 2005 Dec;73(12):8060-8.


Exacerbated susceptibility to infection-stimulated immunopathology in CD1d-deficient mice.

Smiley ST, Lanthier PA, Couper KN, Szaba FM, Boyson JE, Chen W, Johnson LL.

J Immunol. 2005 Jun 15;174(12):7904-11.


ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology.

Couper KN, Chen W, Houston KM, Harnett W, Johnson LL.

Parasite Immunol. 2005 Apr;27(4):147-50.


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