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Items: 22

1.

Three Faces of Mercaptopurine Cytotoxicity in vitro: Methylation, Nucleotide Homeostasis and Deoxythioguanosine in DNA.

Coulthard SA, McGarrity S, Sahota K, Berry P, Redfern CPF.

Drug Metab Dispos. 2018 Jun 8. pii: dmd.118.081844. doi: 10.1124/dmd.118.081844. [Epub ahead of print]

PMID:
29884651
2.

Metabolites of endophytic fungi from Australian native plants as potential anticancer agents.

Zaferanloo B, Pepper SA, Coulthard SA, Redfern CPF, Palombo EA.

FEMS Microbiol Lett. 2018 May 1;365(9). doi: 10.1093/femsle/fny078.

PMID:
29590360
3.

Azathioprine with Allopurinol: Lower Deoxythioguanosine in DNA and Transcriptome Changes Indicate Mechanistic Differences to Azathioprine Alone.

Coulthard SA, Berry P, McGarrity S, McLaughlin S, Ansari A, Redfern CPF.

Inflamm Bowel Dis. 2017 Jun;23(6):946-955. doi: 10.1097/MIB.0000000000001131.

4.

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

Nicoletti P, Aithal GP, Bjornsson ES, Andrade RJ, Sawle A, Arrese M, Barnhart HX, Bondon-Guitton E, Hayashi PH, Bessone F, Carvajal A, Cascorbi I, Cirulli ET, Chalasani N, Conforti A, Coulthard SA, Daly MJ, Day CP, Dillon JF, Fontana RJ, Grove JI, Hallberg P, Hernández N, Ibáñez L, Kullak-Ublick GA, Laitinen T, Larrey D, Lucena MI, Maitland-van der Zee AH, Martin JH, Molokhia M, Pirmohamed M, Powell EE, Qin S, Serrano J, Stephens C, Stolz A, Wadelius M, Watkins PB, Floratos A, Shen Y, Nelson MR, Urban TJ, Daly AK; International Drug-Induced Liver Injury Consortium, Drug-Induced Liver Injury Network Investigators, and International Serious Adverse Events Consortium.

Gastroenterology. 2017 Apr;152(5):1078-1089. doi: 10.1053/j.gastro.2016.12.016. Epub 2016 Dec 30.

5.

Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients.

Coulthard SA, Berry P, McGarrity S, Ansari A, Redfern CPF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 15;1028:175-180. doi: 10.1016/j.jchromb.2016.06.017. Epub 2016 Jun 15.

6.

HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.

Nicoletti P, Werk AN, Sawle A, Shen Y, Urban TJ, Coulthard SA, Bjornsson ES, Cascorbi I, Floratos A, Stammschulte T, Gundert-Remy U, Nelson MR, Aithal GP, Daly AK; International Drug-induced Liver Injury Consortium.

Pharmacogenet Genomics. 2016 May;26(5):218-24. doi: 10.1097/FPC.0000000000000209.

PMID:
26959717
7.

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.

Kalman LV, Agúndez J, Appell ML, Black JL, Bell GC, Boukouvala S, Bruckner C, Bruford E, Caudle K, Coulthard SA, Daly AK, Del Tredici A, den Dunnen JT, Drozda K, Everts RE, Flockhart D, Freimuth RR, Gaedigk A, Hachad H, Hartshorne T, Ingelman-Sundberg M, Klein TE, Lauschke VM, Maglott DR, McLeod HL, McMillin GA, Meyer UA, Müller DJ, Nickerson DA, Oetting WS, Pacanowski M, Pratt VM, Relling MV, Roberts A, Rubinstein WS, Sangkuhl K, Schwab M, Scott SA, Sim SC, Thirumaran RK, Toji LH, Tyndale RF, van Schaik R, Whirl-Carrillo M, Yeo K, Zanger UM.

Clin Pharmacol Ther. 2016 Feb;99(2):172-85. doi: 10.1002/cpt.280. Epub 2015 Nov 20. Review.

8.

Nomenclature for alleles of the thiopurine methyltransferase gene.

Appell ML, Berg J, Duley J, Evans WE, Kennedy MA, Lennard L, Marinaki T, McLeod HL, Relling MV, Schaeffeler E, Schwab M, Weinshilboum R, Yeoh AE, McDonagh EM, Hebert JM, Klein TE, Coulthard SA.

Pharmacogenet Genomics. 2013 Apr;23(4):242-8. doi: 10.1097/FPC.0b013e32835f1cc0.

9.

Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers.

Zaremba T, Thomas HD, Cole M, Coulthard SA, Plummer ER, Curtin NJ.

Biochem J. 2011 Jun 15;436(3):671-9. doi: 10.1042/BJ20101723.

PMID:
21434873
10.

Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers.

Coulthard SA, Redfern CP, Vikingsson S, Lindqvist-Appell M, Skoglund K, Jakobsen-Falk I, Hall AG, Taylor GA, Hogarth LA.

Mol Cancer Ther. 2011 Mar;10(3):495-504. doi: 10.1158/1535-7163.MCT-10-0798. Epub 2011 Jan 31.

11.

Thiopurines: factors influencing toxicity and response.

Fotoohi AK, Coulthard SA, Albertioni F.

Biochem Pharmacol. 2010 May 1;79(9):1211-20. doi: 10.1016/j.bcp.2010.01.006. Epub 2010 Jan 21.

PMID:
20096268
12.

Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.

Stanulla M, Schaeffeler E, Möricke A, Coulthard SA, Cario G, Schrauder A, Kaatsch P, Dördelmann M, Welte K, Zimmermann M, Reiter A, Eichelbaum M, Riehm H, Schrappe M, Schwab M.

Blood. 2009 Aug 13;114(7):1314-8. doi: 10.1182/blood-2008-12-193250. Epub 2009 Jun 17.

13.

The effect of thiopurine drugs on DNA methylation in relation to TPMT expression.

Hogarth LA, Redfern CP, Teodoridis JM, Hall AG, Anderson H, Case MC, Coulthard SA.

Biochem Pharmacol. 2008 Oct 15;76(8):1024-35. doi: 10.1016/j.bcp.2008.07.026. Epub 2008 Jul 30.

PMID:
18708030
14.

Expression levels of asparagine synthetase in blasts from children and adults with acute lymphoblastic leukaemia.

Leslie M, Case MC, Hall AG, Coulthard SA.

Br J Haematol. 2006 Mar;132(6):740-2.

PMID:
16487174
15.

The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment.

Coulthard SA, Matheson EC, Hall AG, Hogarth LA.

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1385-91. Review.

PMID:
15571264
16.

Chemotherapy individualization.

Veal GJ, Coulthard SA, Boddy AV.

Invest New Drugs. 2003 May;21(2):149-56. Review.

PMID:
12889736
17.

Molecular diagnostics: a healthcare perspective.

Hall AG, Coulthard SA, Irving JA.

Expert Rev Mol Diagn. 2003 Jan;3(1):13-6. Review.

PMID:
12528360
18.

The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.

Coulthard SA, Hogarth LA, Little M, Matheson EC, Redfern CP, Minto L, Hall AG.

Mol Pharmacol. 2002 Jul;62(1):102-9.

19.

Recent advances in the pharmacogenomics of thiopurine methyltransferase.

Coulthard SA, Hall AG.

Pharmacogenomics J. 2001;1(4):254-61. Review.

PMID:
11908768
20.

The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase.

Hall AG, Hamilton P, Minto L, Coulthard SA.

J Biochem Biophys Methods. 2001 Jan 30;47(1-2):65-71.

PMID:
11179762
21.

A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations.

Coulthard SA, Rabello C, Robson J, Howell C, Minto L, Middleton PG, Gandhi MK, Jackson G, McLelland J, O'Brien H, Smith S, Reid MM, Pearson AD, Hall AG.

Br J Haematol. 2000 Sep;110(3):599-604.

PMID:
10997970
22.

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