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Items: 27


Growth factor signaling pathways in vascular development and disease.

Grant ZL, Coultas L.

Growth Factors. 2019 Apr;37(1-2):53-67. doi: 10.1080/08977194.2019.1635591. Epub 2019 Jul 8.


Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling.

Williams SP, Odell AF, Karnezis T, Farnsworth RH, Gould CM, Li J, Paquet-Fifield S, Harris NC, Walter A, Gregory JL, Lamont SF, Liu R, Takano EA, Nowell CJ, Bower NI, Resnick D, Smyth GK, Coultas L, Hogan BM, Fox SB, Mueller SN, Simpson KJ, Achen MG, Stacker SA.

Sci Signal. 2017 Oct 3;10(499). pii: eaal2987. doi: 10.1126/scisignal.aal2987.


Endothelial cell apoptosis in angiogenesis and vessel regression.

Watson EC, Grant ZL, Coultas L.

Cell Mol Life Sci. 2017 Dec;74(24):4387-4403. doi: 10.1007/s00018-017-2577-y. Epub 2017 Jun 23. Review.


Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis.

Watson EC, Koenig MN, Grant ZL, Whitehead L, Trounson E, Dewson G, Coultas L.

Development. 2016 Aug 15;143(16):2973-82. doi: 10.1242/dev.137513. Epub 2016 Jul 28.


Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1.

Watson EC, Whitehead L, Adams RH, Dewson G, Coultas L.

Cell Death Differ. 2016 Aug;23(8):1371-9. doi: 10.1038/cdd.2016.20. Epub 2016 Mar 4.


Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3.

Koenig MN, Naik E, Rohrbeck L, Herold MJ, Trounson E, Bouillet P, Thomas T, Voss AK, Strasser A, Coultas L.

Cell Death Differ. 2014 Nov;21(11):1687-95. doi: 10.1038/cdd.2014.90. Epub 2014 Jun 27.


Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas.

Shahrabi-Farahani S, Wang L, Zwaans BM, Santana JM, Shimizu A, Takashima S, Kreuter M, Coultas L, D'Amore PA, Arbeit JM, Akslen LA, Bielenberg DR.

Lab Invest. 2014 Jul;94(7):752-65. doi: 10.1038/labinvest.2014.66. Epub 2014 May 5.


Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

Okamoto T, Coultas L, Metcalf D, van Delft MF, Glaser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Huang DC.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):261-6. doi: 10.1073/pnas.1321259110. Epub 2013 Dec 20.


Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm.

Loebel DA, Studdert JB, Power M, Radziewic T, Jones V, Coultas L, Jackson Y, Rao RS, Steiner K, Fossat N, Robb L, Tam PP.

Development. 2011 Oct;138(20):4511-22. doi: 10.1242/dev.063867. Epub 2011 Sep 8.


Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells.

Naik E, O'Reilly LA, Asselin-Labat ML, Merino D, Lin A, Cook M, Coultas L, Bouillet P, Adams JM, Strasser A.

J Exp Med. 2011 Jul 4;208(7):1351-8. doi: 10.1084/jem.20100951. Epub 2011 Jun 6.


Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms.

Coultas L, Nieuwenhuis E, Anderson GA, Cabezas J, Nagy A, Henkelman RM, Hui CC, Rossant J.

Blood. 2010 Jul 29;116(4):653-60. doi: 10.1182/blood-2009-12-256644. Epub 2010 Mar 25.


Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.

Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE.

Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L45-56. doi: 10.1152/ajplung.90550.2008. Epub 2009 Nov 6.


Three-dimensional analysis of vascular development in the mouse embryo.

Walls JR, Coultas L, Rossant J, Henkelman RM.

PLoS One. 2008 Aug 6;3(8):e2853. doi: 10.1371/journal.pone.0002853.


Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

Coultas L, Terzano S, Thomas T, Voss A, Reid K, Stanley EG, Scott CL, Bouillet P, Bartlett P, Ham J, Adams JM, Strasser A.

J Cell Sci. 2007 Jun 15;120(Pt 12):2044-52. Epub 2007 May 29.


Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.

Hellström M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalén M, Gerhardt H, Betsholtz C.

Nature. 2007 Feb 15;445(7129):776-80. Epub 2007 Jan 28.


Endothelial cells and VEGF in vascular development.

Coultas L, Chawengsaksophak K, Rossant J.

Nature. 2005 Dec 15;438(7070):937-45. Review.


Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis.

Coultas L, Bouillet P, Loveland KL, Meachem S, Perlman H, Adams JM, Strasser A.

EMBO J. 2005 Nov 16;24(22):3963-73. Epub 2005 Nov 3.


BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L, Adams JM, Strasser A, Villunger A.

Blood. 2005 Dec 15;106(13):4131-8. Epub 2005 Aug 23.


The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim.

Nikrad M, Johnson T, Puthalalath H, Coultas L, Adams J, Kraft AS.

Mol Cancer Ther. 2005 Mar;4(3):443-9.


Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.

Coultas L, Bouillet P, Stanley EG, Brodnicki TC, Adams JM, Strasser A.

Mol Cell Biol. 2004 Feb;24(4):1570-81.


p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.

Villunger A, Michalak EM, Coultas L, Müllauer F, Böck G, Ausserlechner MJ, Adams JM, Strasser A.

Science. 2003 Nov 7;302(5647):1036-8. Epub 2003 Sep 18.


Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region.

Coultas L, Pellegrini M, Visvader JE, Lindeman GJ, Chen L, Adams JM, Huang DC, Strasser A.

Cell Death Differ. 2003 Feb;10(2):185-92.


The role of the Bcl-2 protein family in cancer.

Coultas L, Strasser A.

Semin Cancer Biol. 2003 Apr;13(2):115-23. Review.


Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation.

Coultas L, Huang DC, Adams JM, Strasser A.

Cell Death Differ. 2002 Nov;9(11):1163-6. No abstract available.


BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes.

Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, Puthalakath H, Pellegrini M, Cory S, Adams JM, Strasser A.

Nature. 2002 Feb 21;415(6874):922-6. Erratum in: Nature 2002 Jul 4;618(6893):108.


Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.

Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A.

Science. 2001 Sep 7;293(5536):1829-32. Erratum in: Science 2002 Aug 16;297(5584):1122.


The molecular control of DNA damage-induced cell death.

Coultas L, Strasser A.

Apoptosis. 2000 Dec;5(6):491-507. Review.


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