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Items: 25


CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.

Raspé E, Coulonval K, Pita JM, Paternot S, Rothé F, Twyffels L, Brohée S, Craciun L, Larsimont D, Kruys V, Sandras F, Salmon I, Van Laere S, Piccart M, Ignatiadis M, Sotiriou C, Roger PP.

EMBO Mol Med. 2017 Aug;9(8):1052-1066. doi: 10.15252/emmm.201607084.


JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21.

Colleoni B, Paternot S, Pita JM, Bisteau X, Coulonval K, Davis RJ, Raspé E, Roger PP.

Oncogene. 2017 Jul 27;36(30):4349-4361. doi: 10.1038/onc.2017.7. Epub 2017 Apr 3.


Inhibitory effects of 2-iodohexadecanal on FRTL-5 thyroid cells proliferation.

Thomasz L, Coulonval K, Salvarredi L, Oglio R, Fusco A, Rossich L, Pisarev MA, Roger PP, Juvenal GJ.

Mol Cell Endocrinol. 2015 Mar 15;404:123-31. doi: 10.1016/j.mce.2015.01.038. Epub 2015 Feb 2.


Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model.

Lodewick J, Sampaio C, Boxus M, Rinaldi AS, Coulonval K, Willems L, Roger PP, Bex F.

Retrovirology. 2013 Jul 23;10:75. doi: 10.1186/1742-4690-10-75.


CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP.

PLoS Genet. 2013 May;9(5):e1003546. doi: 10.1371/journal.pgen.1003546. Epub 2013 May 30.


Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation.

Coulonval K, Kooken H, Roger PP.

Mol Biol Cell. 2011 Nov;22(21):3971-85. doi: 10.1091/mbc.E11-02-0136. Epub 2011 Sep 7.


cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

Blancquaert S, Wang L, Paternot S, Coulonval K, Dumont JE, Harris TE, Roger PP.

Mol Endocrinol. 2010 Jul;24(7):1453-68. doi: 10.1210/me.2010-0087. Epub 2010 May 19.


Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase.

Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K, Roger PP.

Cell Cycle. 2010 Feb 15;9(4):689-99. Epub 2010 Feb 12. Review.


Signal transduction in the human thyrocyte and its perversion in thyroid tumors.

Roger PP, van Staveren WC, Coulonval K, Dumont JE, Maenhaut C.

Mol Cell Endocrinol. 2010 May 28;321(1):3-19. doi: 10.1016/j.mce.2009.11.015. Epub 2009 Dec 3. Review.


Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.

Rocha AS, Paternot S, Coulonval K, Dumont JE, Soares P, Roger PP.

Mol Biol Cell. 2008 Nov;19(11):4814-25. doi: 10.1091/mbc.E08-06-0617. Epub 2008 Sep 17.


Regulation of CDK4.

Bockstaele L, Coulonval K, Kooken H, Paternot S, Roger PP.

Cell Div. 2006 Nov 8;1:25.


Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".

Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K.

Mol Cell Biol. 2006 Jul;26(13):5070-85.


Distinct specificities of pRb phosphorylation by CDK4 activated by cyclin D1 or cyclin D3: differential involvement in the distinct mitogenic modes of thyroid epithelial cells.

Paternot S, Arsenijevic T, Coulonval K, Bockstaele L, Dumont JE, Roger PP.

Cell Cycle. 2006 Jan;5(1):61-70. Epub 2006 Jan 18.


Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis.

Coulonval K, Bockstaele L, Paternot S, Roger PP.

J Biol Chem. 2003 Dec 26;278(52):52052-60. Epub 2003 Oct 9.


Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.

Paternot S, Coulonval K, Dumont JE, Roger PP.

J Biol Chem. 2003 Jul 18;278(29):26533-40. Epub 2003 Apr 30.


The role of cyclic AMP and its effect on protein kinase A in the mitogenic action of thyrotropin on the thyroid cell.

Dremier S, Coulonval K, Perpete S, Vandeput F, Fortemaison N, Van Keymeulen A, Deleu S, Ledent C, Clément S, Schurmans S, Dumont JE, Lamy F, Roger PP, Maenhaut C.

Ann N Y Acad Sci. 2002 Jun;968:106-21. Review.


IGF-1 or insulin, and the TSH cyclic AMP cascade separately control dog and human thyroid cell growth and DNA synthesis, and complement each other in inducing mitogenesis.

Deleu S, Pirson I, Coulonval K, Drouin A, Taton M, Clermont F, Roger PP, Nakamura T, Dumont JE, Maenhaut C.

Mol Cell Endocrinol. 1999 Mar 25;149(1-2):41-51.


The cAMP in thyroid: from the TSH receptor to mitogenesis and tumorigenesis.

Uyttersprot N, Allgeier A, Baptist M, Christophe D, Coppee F, Coulonval K, Deleu S, Depoortere F, Dremier S, Lamy F, Ledent C, Maenhaut C, Miot F, Panneels V, Parma J, Parmentier M, Pirson I, Pohl V, Roger P, Savonet V, Taton M, Tonacchera M, van Sande J, Wilkin F, Vassart G, et al.

Adv Second Messenger Phosphoprotein Res. 1997;31:125-40. Review. No abstract available.


c-Myc expression is controlled by the mitogenic cAMP-cascade in thyrocytes.

Pirson I, Coulonval K, Lamy F, Dumont JE.

J Cell Physiol. 1996 Jul;168(1):59-70.


Mitogenic, dedifferentiating, and scattering effects of hepatocyte growth factor on dog thyroid cells.

Dremier S, Taton M, Coulonval K, Nakamura T, Matsumoto K, Dumont JE.

Endocrinology. 1994 Jul;135(1):135-40.


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