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Items: 1 to 50 of 142

1.

Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

Wang F, Chen S, Liu HB, Parent CA, Coulombe PA.

J Cell Biol. 2018 Nov 2. pii: jcb.201712130. doi: 10.1083/jcb.201712130. [Epub ahead of print]

PMID:
30389720
2.

Types I and II Keratin Intermediate Filaments.

Jacob JT, Coulombe PA, Kwan R, Omary MB.

Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a018275. doi: 10.1101/cshperspect.a018275. Review.

3.

The keratin 16 null phenotype is modestly impacted by genetic strain background in mice.

Zieman A, Coulombe PA.

Exp Dermatol. 2018 Jun;27(6):672-674. doi: 10.1111/exd.13509. Epub 2018 Apr 19.

4.

Sexual Dimorphism in Response to an NRF2 Inducer in a Model for Pachyonychia Congenita.

Kerns ML, Hakim JMC, Zieman A, Lu RG, Coulombe PA.

J Invest Dermatol. 2018 May;138(5):1094-1100. doi: 10.1016/j.jid.2017.09.054. Epub 2017 Dec 24.

5.

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite L, Coulombe PA, Schäfer M, Dinkova-Kostova AT, Paus R, Haslam IS.

Bioessays. 2017 Aug;39(8). doi: 10.1002/bies.201700029. Epub 2017 Jul 7. Review.

PMID:
28685843
6.

The Molecular Revolution in Cutaneous Biology: Keratin Genes and their Associated Disease: Diversity, Opportunities, and Challenges.

Coulombe PA.

J Invest Dermatol. 2017 May;137(5):e67-e71. doi: 10.1016/j.jid.2016.04.039. Review.

7.

Randomized, split-body, single-blinded clinical trial of topical broccoli sprout extract: Assessing the feasibility of its use in keratin-based disorders.

Kerns ML, Guss L, Fahey J, Cohen B, Hakim JM, Sung S, Lu RG, Coulombe PA.

J Am Acad Dermatol. 2017 Mar;76(3):449-453.e1. doi: 10.1016/j.jaad.2016.10.009. Epub 2016 Nov 23.

8.

Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo.

Hobbs RP, Batazzi AS, Han MC, Coulombe PA.

Oncogene. 2016 Oct 27;35(43):5653-5662. doi: 10.1038/onc.2016.102. Epub 2016 Apr 11.

9.

Discovery of keratin function and role in genetic diseases: the year that 1991 was.

Coulombe PA.

Mol Biol Cell. 2016 Sep 15;27(18):2807-10. doi: 10.1091/mbc.E15-09-0625. Review.

10.

Keratins Are Going Nuclear.

Hobbs RP, Jacob JT, Coulombe PA.

Dev Cell. 2016 Aug 8;38(3):227-33. doi: 10.1016/j.devcel.2016.07.022.

11.

Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes.

Kerns ML, Hakim JM, Lu RG, Guo Y, Berroth A, Kaspar RL, Coulombe PA.

J Clin Invest. 2016 Jun 1;126(6):2356-66. doi: 10.1172/JCI84870. Epub 2016 May 16.

12.

Skin Keratins.

Wang F, Zieman A, Coulombe PA.

Methods Enzymol. 2016;568:303-50. doi: 10.1016/bs.mie.2015.09.032. Epub 2015 Nov 19.

13.

Complementary roles of specific cysteines in keratin 14 toward the assembly, organization, and dynamics of intermediate filaments in skin keratinocytes.

Feng X, Coulombe PA.

J Biol Chem. 2015 Sep 11;290(37):22507-19. doi: 10.1074/jbc.M115.654749. Epub 2015 Jul 27.

14.

Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.

Hobbs RP, DePianto DJ, Jacob JT, Han MC, Chung BM, Batazzi AS, Poll BG, Guo Y, Han J, Ong S, Zheng W, Taube JM, Čiháková D, Wan F, Coulombe PA.

Nat Genet. 2015 Aug;47(8):933-8. doi: 10.1038/ng.3355. Epub 2015 Jul 13.

15.

A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes.

Feng X, Coulombe PA.

J Cell Biol. 2015 Apr 13;209(1):59-72. doi: 10.1083/jcb.201408079.

16.

Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.

Chung BM, Arutyunov A, Ilagan E, Yao N, Wills-Karp M, Coulombe PA.

J Cell Biol. 2015 Mar 2;208(5):613-27. doi: 10.1083/jcb.201408026. Epub 2015 Feb 23.

17.

Periderm prevents pathological epithelial adhesions during embryogenesis.

Richardson RJ, Hammond NL, Coulombe PA, Saloranta C, Nousiainen HO, Salonen R, Berry A, Hanley N, Headon D, Karikoski R, Dixon MJ.

J Clin Invest. 2014 Sep;124(9):3891-900. doi: 10.1172/JCI71946. Epub 2014 Aug 18.

18.

Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.

Alvarado DM, Coulombe PA.

J Biol Chem. 2014 Jul 11;289(28):19435-47. doi: 10.1074/jbc.M114.553867. Epub 2014 May 27.

19.

Report of the 10th Annual International Pachyonychia Congenita Consortium Meeting.

van Steensel MAM, Coulombe PA, Kaspar RL, Milstone LM, McLean IWH, Roop DR, Smith FJD, Sprecher E, Schwartz ME.

J Invest Dermatol. 2014 Mar;134(3):588-591. doi: 10.1038/jid.2013.392. No abstract available.

20.

Keratin 16 regulates innate immunity in response to epidermal barrier breach.

Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19537-42. doi: 10.1073/pnas.1309576110. Epub 2013 Nov 11.

21.

Networking galore: intermediate filaments and cell migration.

Chung BM, Rotty JD, Coulombe PA.

Curr Opin Cell Biol. 2013 Oct;25(5):600-12. doi: 10.1016/j.ceb.2013.06.008. Epub 2013 Jul 22. Review.

22.

The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles.

Coulombe PA, Caterina MJ.

Genes Dev. 2013 Jun 15;27(12):1315-7. doi: 10.1101/gad.223172.113.

23.

Keratin intermediate filament proteins - novel regulators of inflammation and immunity in skin.

Hobbs RP, Lessard JC, Coulombe PA.

J Cell Sci. 2012 Nov 15;125(Pt 22):5257-8. doi: 10.1242/jcs.122929. No abstract available.

24.

The expanding significance of keratin intermediate filaments in normal and diseased epithelia.

Pan X, Hobbs RP, Coulombe PA.

Curr Opin Cell Biol. 2013 Feb;25(1):47-56. doi: 10.1016/j.ceb.2012.10.018. Epub 2012 Dec 25. Review.

25.

Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading.

Kim JS, Lee CH, Su BY, Coulombe PA.

Biophys J. 2012 Nov 7;103(9):1828-38. doi: 10.1016/j.bpj.2012.09.016.

26.

Keratin intracellular concentration revisited: implications for keratin function in surface epithelia.

Feng X, Zhang H, Margolick JB, Coulombe PA.

J Invest Dermatol. 2013 Mar;133(3):850-853. doi: 10.1038/jid.2012.397. Epub 2012 Nov 29. No abstract available.

27.

An MBoC favorite: identification of novel principles of keratin filament turnover in living cells.

Coulombe PA.

Mol Biol Cell. 2012 Oct;23(20):3926. doi: 10.1091/mbc.E12-02-0160. No abstract available.

28.

Structural basis for heteromeric assembly and perinuclear organization of keratin filaments.

Lee CH, Kim MS, Chung BM, Leahy DJ, Coulombe PA.

Nat Struct Mol Biol. 2012 Jun 17;19(7):707-15. doi: 10.1038/nsmb.2330.

29.

A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair.

Rotty JD, Coulombe PA.

J Cell Biol. 2012 Apr 30;197(3):381-9. doi: 10.1083/jcb.201107078. Epub 2012 Apr 23.

30.

Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.

Lessard JC, Coulombe PA.

J Invest Dermatol. 2012 May;132(5):1384-91. doi: 10.1038/jid.2012.6. Epub 2012 Feb 16.

31.

Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath.

Coulombe PA, Lee CH.

J Invest Dermatol. 2012 Mar;132(3 Pt 2):763-75. doi: 10.1038/jid.2011.450. Epub 2012 Jan 26. Review.

32.

Identification of novel interaction between annexin A2 and keratin 17: evidence for reciprocal regulation.

Chung BM, Murray CI, Van Eyk JE, Coulombe PA.

J Biol Chem. 2012 Mar 2;287(10):7573-81. doi: 10.1074/jbc.M111.301549. Epub 2012 Jan 10.

33.

Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion.

Pan X, Kane LA, Van Eyk JE, Coulombe PA.

J Biol Chem. 2011 Dec 9;286(49):42403-13. doi: 10.1074/jbc.M111.302042. Epub 2011 Oct 17.

34.

Modeling the self-organization property of keratin intermediate filaments.

Kim JS, Lee CH, Coulombe PA.

Biophys J. 2010 Nov 3;99(9):2748-56. doi: 10.1016/j.bpj.2010.09.023.

35.

Differential modulation of keratin expression by sulforaphane occurs via Nrf2-dependent and -independent pathways in skin epithelia.

Kerns M, DePianto D, Yamamoto M, Coulombe PA.

Mol Biol Cell. 2010 Dec;21(23):4068-75. doi: 10.1091/mbc.E10-02-0153. Epub 2010 Oct 6.

36.

Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin.

Depianto D, Kerns ML, Dlugosz AA, Coulombe PA.

Nat Genet. 2010 Oct;42(10):910-4. doi: 10.1038/ng.665. Epub 2010 Sep 26.

37.

Stressing the role of O-GlcNAc: linking cell survival to keratin modification.

Rotty JD, Hart GW, Coulombe PA.

Nat Cell Biol. 2010 Sep;12(9):847-9. doi: 10.1038/ncb0910-847.

PMID:
20811358
38.

Emerging role for the cytoskeleton as an organizer and regulator of translation.

Kim S, Coulombe PA.

Nat Rev Mol Cell Biol. 2010 Jan;11(1):75-81. doi: 10.1038/nrm2818. Review.

PMID:
20027187
39.

Preview. SKPing a hurdle: Sox2 and adult dermal stem cells.

Kellner JC, Coulombe PA.

Cell Stem Cell. 2009 Dec 4;5(6):569-70. doi: 10.1016/j.stem.2009.11.010.

40.

Keratins and protein synthesis: the plot thickens.

Kellner JC, Coulombe PA.

J Cell Biol. 2009 Oct 19;187(2):157-9. doi: 10.1083/jcb.200909134.

41.

Self-organization of keratin intermediate filaments into cross-linked networks.

Lee CH, Coulombe PA.

J Cell Biol. 2009 Aug 10;186(3):409-21. doi: 10.1083/jcb.200810196. Epub 2009 Aug 3.

42.

Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility.

Coulombe PA, Kerns ML, Fuchs E.

J Clin Invest. 2009 Jul;119(7):1784-93. doi: 10.1172/JCI38177. Epub 2009 Jul 1. Review.

43.

Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2.

Huang SM, Lee H, Chung MK, Park U, Yu YY, Bradshaw HB, Coulombe PA, Walker JM, Caterina MJ.

J Neurosci. 2008 Dec 17;28(51):13727-37. doi: 10.1523/JNEUROSCI.5741-07.2008. Erratum in: J Neurosci. 2009 Jan 21;29(3):29.

44.

Hedgehog signaling, keratin 6 induction, and sebaceous gland morphogenesis: implications for pachyonychia congenita and related conditions.

Gu LH, Coulombe PA.

Am J Pathol. 2008 Sep;173(3):752-61. doi: 10.2353/ajpath.2008.071089. Epub 2008 Aug 7.

45.

Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile.

Larouche D, Tong X, Fradette J, Coulombe PA, Germain L.

FASEB J. 2008 May;22(5):1404-15. Epub 2007 Dec 27.

PMID:
18162489
46.

Interaction between the keratin cytoskeleton and eEF1Bgamma affects protein synthesis in epithelial cells.

Kim S, Kellner J, Lee CH, Coulombe PA.

Nat Struct Mol Biol. 2007 Oct;14(10):982-3. Epub 2007 Sep 30.

PMID:
17906640
47.

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex.

Kerns ML, DePianto D, Dinkova-Kostova AT, Talalay P, Coulombe PA.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14460-5. Epub 2007 Aug 27.

48.
49.

Contribution of olfactory neural stem cells to tissue maintenance and regeneration.

Leung CT, Coulombe PA, Reed RR.

Nat Neurosci. 2007 Jun;10(6):720-6. Epub 2007 Apr 29.

PMID:
17468753
50.

Keratin function in skin epithelia: a broadening palette with surprising shades.

Gu LH, Coulombe PA.

Curr Opin Cell Biol. 2007 Feb;19(1):13-23. Epub 2006 Dec 18. Review.

PMID:
17178453

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