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Items: 1 to 50 of 223


Sam68 is required for the growth and survival of nonmelanoma skin cancer.

Fu K, Sun X, Xia X, Hobbs RP, Guo Y, Coulombe PA, Wan F.

Cancer Med. 2019 Oct;8(13):6106-6113. doi: 10.1002/cam4.2513. Epub 2019 Aug 22.


Involvement of G-quadruplex regions in mammalian replication origin activity.

Prorok P, Artufel M, Aze A, Coulombe P, Peiffer I, Lacroix L, Guédin A, Mergny JL, Damaschke J, Schepers A, Ballester B, Méchali M.

Nat Commun. 2019 Jul 22;10(1):3274. doi: 10.1038/s41467-019-11104-0.


Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

Zieman AG, Poll BG, Ma J, Coulombe PA.

Hum Mol Genet. 2019 Jul 1;28(13):2255-2270. doi: 10.1093/hmg/ddz050.


The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.

Coulombe P, Nassar J, Peiffer I, Stanojcic S, Sterkers Y, Delamarre A, Bocquet S, Méchali M.

Nat Commun. 2019 Jun 3;10(1):2426. doi: 10.1038/s41467-019-10321-x.


Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.

Coulombe P, Paliouras GN, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, Dauphinee S, Umlandt P, Xiang P, Kyle AH, Minchinton AI, Humphries RK, Hoodless PA, Parker JDK, Wright JL, Karsan A.

Cell Rep. 2019 May 7;27(6):1769-1780.e4. doi: 10.1016/j.celrep.2019.04.039.


Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma: new insights into skin epithelial homeostasis and avenues for treatment.

Zieman AG, Coulombe PA.

Br J Dermatol. 2019 Apr 25. doi: 10.1111/bjd.18033. [Epub ahead of print] Review.


Pain mechanisms in hereditary palmoplantar keratodermas.

Weinberg RL, Coulombe PA, Polydefkis M, Caterina MJ.

Br J Dermatol. 2019 Mar 18. doi: 10.1111/bjd.17880. [Epub ahead of print] Review.


Non-canonical processes that shape the cell migration landscape.

Majumdar R, Steen K, Coulombe PA, Parent CA.

Curr Opin Cell Biol. 2019 Apr;57:123-134. doi: 10.1016/ Epub 2019 Mar 7. Review.


Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.

Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche S.

Mol Cell Biol. 2019 Mar 1;39(6). pii: e00527-18. doi: 10.1128/MCB.00527-18. Print 2019 Mar 15.


Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

Wang F, Chen S, Liu HB, Parent CA, Coulombe PA.

J Cell Biol. 2018 Dec 3;217(12):4314-4330. doi: 10.1083/jcb.201712130. Epub 2018 Nov 2.


Types I and II Keratin Intermediate Filaments.

Jacob JT, Coulombe PA, Kwan R, Omary MB.

Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a018275. doi: 10.1101/cshperspect.a018275. Review.


The keratin 16 null phenotype is modestly impacted by genetic strain background in mice.

Zieman A, Coulombe PA.

Exp Dermatol. 2018 Jun;27(6):672-674. doi: 10.1111/exd.13509. Epub 2018 Apr 19.


Sexual Dimorphism in Response to an NRF2 Inducer in a Model for Pachyonychia Congenita.

Kerns ML, Hakim JMC, Zieman A, Lu RG, Coulombe PA.

J Invest Dermatol. 2018 May;138(5):1094-1100. doi: 10.1016/j.jid.2017.09.054. Epub 2017 Dec 24.


Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite L, Coulombe PA, Schäfer M, Dinkova-Kostova AT, Paus R, Haslam IS.

Bioessays. 2017 Aug;39(8). doi: 10.1002/bies.201700029. Epub 2017 Jul 7. Review.


The Molecular Revolution in Cutaneous Biology: Keratin Genes and their Associated Disease: Diversity, Opportunities, and Challenges.

Coulombe PA.

J Invest Dermatol. 2017 May;137(5):e67-e71. doi: 10.1016/j.jid.2016.04.039. Review.


How nurse gender influences patient priority assignments in US emergency departments.

Vigil JM, Coulombe P, Alcock J, Stith SS, Kruger E, Cichowski S.

Pain. 2017 Mar;158(3):377-382. doi: 10.1097/j.pain.0000000000000725.


Randomized, split-body, single-blinded clinical trial of topical broccoli sprout extract: Assessing the feasibility of its use in keratin-based disorders.

Kerns ML, Guss L, Fahey J, Cohen B, Hakim JM, Sung S, Lu RG, Coulombe PA.

J Am Acad Dermatol. 2017 Mar;76(3):449-453.e1. doi: 10.1016/j.jaad.2016.10.009. Epub 2016 Nov 23.


Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo.

Hobbs RP, Batazzi AS, Han MC, Coulombe PA.

Oncogene. 2016 Oct 27;35(43):5653-5662. doi: 10.1038/onc.2016.102. Epub 2016 Apr 11.


Discovery of keratin function and role in genetic diseases: the year that 1991 was.

Coulombe PA.

Mol Biol Cell. 2016 Sep 15;27(18):2807-10. doi: 10.1091/mbc.E15-09-0625. Review.


Keratins Are Going Nuclear.

Hobbs RP, Jacob JT, Coulombe PA.

Dev Cell. 2016 Aug 8;38(3):227-33. doi: 10.1016/j.devcel.2016.07.022.


Maternal touch and infant affect in the Still Face Paradigm: A cross-cultural examination.

Lowe JR, Coulombe P, Moss NC, Rieger RE, Aragón C, MacLean PC, Caprihan A, Phillips JP, Handal AJ.

Infant Behav Dev. 2016 Aug;44:110-20. doi: 10.1016/j.infbeh.2016.06.009. Epub 2016 Jun 27.


Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes.

Kerns ML, Hakim JM, Lu RG, Guo Y, Berroth A, Kaspar RL, Coulombe PA.

J Clin Invest. 2016 Jun 1;126(6):2356-66. doi: 10.1172/JCI84870. Epub 2016 May 16.


Patient Ethnicity Affects Triage Assessments and Patient Prioritization in U.S. Department of Veterans Affairs Emergency Departments.

Vigil JM, Coulombe P, Alcock J, Kruger E, Stith SS, Strenth C, Parshall M, Cichowski SB.

Medicine (Baltimore). 2016 Apr;95(14):e3191. doi: 10.1097/MD.0000000000003191.


Club Cell-16 and RelB as Novel Determinants of Arterial Stiffness in Exacerbating COPD Patients.

Labonté LE, Bourbeau J, Daskalopoulou SS, Zhang M, Coulombe P, Garland K, Baglole CJ.

PLoS One. 2016 Feb 25;11(2):e0149974. doi: 10.1371/journal.pone.0149974. eCollection 2016.


Proteomic data on the nuclear interactome of human MCM9.

Hutchins JR, Traver S, Coulombe P, Peiffer I, Kitzmann M, Latreille D, Méchali M.

Data Brief. 2015 Dec 11;6:410-5. doi: 10.1016/j.dib.2015.11.055. eCollection 2016 Mar.


Skin Keratins.

Wang F, Zieman A, Coulombe PA.

Methods Enzymol. 2016;568:303-50. doi: 10.1016/bs.mie.2015.09.032. Epub 2015 Nov 19.


The chromatin environment shapes DNA replication origin organization and defines origin classes.

Cayrou C, Ballester B, Peiffer I, Fenouil R, Coulombe P, Andrau JC, van Helden J, Méchali M.

Genome Res. 2015 Dec;25(12):1873-85. doi: 10.1101/gr.192799.115. Epub 2015 Nov 11.


MCM9 Is Required for Mammalian DNA Mismatch Repair.

Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, Méchali M.

Mol Cell. 2015 Sep 3;59(5):831-9. doi: 10.1016/j.molcel.2015.07.010. Epub 2015 Aug 20.


Complementary roles of specific cysteines in keratin 14 toward the assembly, organization, and dynamics of intermediate filaments in skin keratinocytes.

Feng X, Coulombe PA.

J Biol Chem. 2015 Sep 11;290(37):22507-19. doi: 10.1074/jbc.M115.654749. Epub 2015 Jul 27.


Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.

Hobbs RP, DePianto DJ, Jacob JT, Han MC, Chung BM, Batazzi AS, Poll BG, Guo Y, Han J, Ong S, Zheng W, Taube JM, Čiháková D, Wan F, Coulombe PA.

Nat Genet. 2015 Aug;47(8):933-8. doi: 10.1038/ng.3355. Epub 2015 Jul 13.


The Curse of Curves: Sex Differences in the Associations Between Body Shape and Pain Expression.

Vigil JM, Strenth CR, Mueller AA, DiDomenico J, Beltran DG, Coulombe P, Smith JE.

Hum Nat. 2015 Jun;26(2):235-54. doi: 10.1007/s12110-015-9232-9.


Ethnic Disparities in Emergency Severity Index Scores among U.S. Veteran's Affairs Emergency Department Patients.

Vigil JM, Alcock J, Coulombe P, McPherson L, Parshall M, Murata A, Brislen H.

PLoS One. 2015 May 29;10(5):e0126792. doi: 10.1371/journal.pone.0126792. eCollection 2015.


DNA replication origin activation in space and time.

Fragkos M, Ganier O, Coulombe P, Méchali M.

Nat Rev Mol Cell Biol. 2015 Jun;16(6):360-74. doi: 10.1038/nrm4002. Review.


Experimenter Effects on Pain Reporting in Women Vary across the Menstrual Cycle.

Vigil JM, DiDomenico J, Strenth C, Coulombe P, Kruger E, Mueller AA, Guevara Beltran D, Adams I.

Int J Endocrinol. 2015;2015:520719. doi: 10.1155/2015/520719. Epub 2015 Mar 29.


A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes.

Feng X, Coulombe PA.

J Cell Biol. 2015 Apr 13;209(1):59-72. doi: 10.1083/jcb.201408079.


Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.

Chung BM, Arutyunov A, Ilagan E, Yao N, Wills-Karp M, Coulombe PA.

J Cell Biol. 2015 Mar 2;208(5):613-27. doi: 10.1083/jcb.201408026. Epub 2015 Feb 23.


Alterations in the expression of the NF-κB family member RelB as a novel marker of cardiovascular outcomes during acute exacerbations of chronic obstructive pulmonary disease.

Labonté L, Coulombe P, Zago M, Bourbeau J, Baglole CJ.

PLoS One. 2014 Nov 19;9(11):e112965. doi: 10.1371/journal.pone.0112965. eCollection 2014.


Periderm prevents pathological epithelial adhesions during embryogenesis.

Richardson RJ, Hammond NL, Coulombe PA, Saloranta C, Nousiainen HO, Salonen R, Berry A, Hanley N, Headon D, Karikoski R, Dixon MJ.

J Clin Invest. 2014 Sep;124(9):3891-900. doi: 10.1172/JCI71946. Epub 2014 Aug 18.


Pain patients and who they live with: a correlational study of coresidence patterns and pain interference.

Vigil JM, Pendleton P, Coulombe P, Vowles KE, Alcock J, Smith BW.

Pain Res Manag. 2014 Jul-Aug;19(4):e109-14.


Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.

Alvarado DM, Coulombe PA.

J Biol Chem. 2014 Jul 11;289(28):19435-47. doi: 10.1074/jbc.M114.553867. Epub 2014 May 27.


Report of the 10th Annual International Pachyonychia Congenita Consortium Meeting.

van Steensel MAM, Coulombe PA, Kaspar RL, Milstone LM, McLean IWH, Roop DR, Smith FJD, Sprecher E, Schwartz ME.

J Invest Dermatol. 2014 Mar;134(3):588-591. doi: 10.1038/jid.2013.392. No abstract available.


PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage.

Tsanov N, Kermi C, Coulombe P, Van der Laan S, Hodroj D, Maiorano D.

Nucleic Acids Res. 2014 Apr;42(6):3692-706. doi: 10.1093/nar/gkt1400. Epub 2014 Jan 14.


Keratin 16 regulates innate immunity in response to epidermal barrier breach.

Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19537-42. doi: 10.1073/pnas.1309576110. Epub 2013 Nov 11.


Networking galore: intermediate filaments and cell migration.

Chung BM, Rotty JD, Coulombe PA.

Curr Opin Cell Biol. 2013 Oct;25(5):600-12. doi: 10.1016/ Epub 2013 Jul 22. Review.


A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing.

Coulombe P, Grégoire D, Tsanov N, Méchali M.

Nat Commun. 2013;4:2065. doi: 10.1038/ncomms3065.


The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles.

Coulombe PA, Caterina MJ.

Genes Dev. 2013 Jun 15;27(12):1315-7. doi: 10.1101/gad.223172.113.


Genetic and epigenetic determinants of DNA replication origins, position and activation.

Méchali M, Yoshida K, Coulombe P, Pasero P.

Curr Opin Genet Dev. 2013 Apr;23(2):124-31. doi: 10.1016/j.gde.2013.02.010. Epub 2013 Mar 28. Review.


Keratin intermediate filament proteins - novel regulators of inflammation and immunity in skin.

Hobbs RP, Lessard JC, Coulombe PA.

J Cell Sci. 2012 Nov 15;125(Pt 22):5257-8. doi: 10.1242/jcs.122929. No abstract available.


The expanding significance of keratin intermediate filaments in normal and diseased epithelia.

Pan X, Hobbs RP, Coulombe PA.

Curr Opin Cell Biol. 2013 Feb;25(1):47-56. doi: 10.1016/ Epub 2012 Dec 25. Review.


Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading.

Kim JS, Lee CH, Su BY, Coulombe PA.

Biophys J. 2012 Nov 7;103(9):1828-38. doi: 10.1016/j.bpj.2012.09.016.

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