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Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression.

Ryffel B, Huang F, Robinet P, Panek C, Couillin I, Erard F, Piotet J, Le Bert M, Mackowiak C, Torres Arias M, Dimier-Poisson I, Zheng SG.

Front Immunol. 2019 Apr 18;10:702. doi: 10.3389/fimmu.2019.00702. eCollection 2019.


Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization.

Baroja-Mazo A, Compan V, Martín-Sánchez F, Tapia-Abellán A, Couillin I, Pelegrín P.

Sci Rep. 2019 Apr 8;9(1):5788. doi: 10.1038/s41598-019-42298-4.


Inflammation drives nitric oxide synthase 2 expression by γδ T cells and affects the balance between melanoma and vitiligo associated melanoma.

Douguet L, Bod L, Labarthe L, Lengagne R, Kato M, Couillin I, Prévost-Blondel A.

Oncoimmunology. 2018 Jul 30;7(9):e1484979. doi: 10.1080/2162402X.2018.1484979. eCollection 2018.


The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin.

Fanny M, Nascimento M, Baron L, Schricke C, Maillet I, Akbal M, Riteau N, Le Bert M, Quesniaux V, Ryffel B, Gombault A, Même S, Même W, Couillin I.

Front Immunol. 2018 Jun 25;9:1476. doi: 10.3389/fimmu.2018.01476. eCollection 2018.


Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.

Dossi E, Blauwblomme T, Moulard J, Chever O, Vasile F, Guinard E, Le Bert M, Couillin I, Pallud J, Capelle L, Huberfeld G, Rouach N.

Sci Transl Med. 2018 May 30;10(443). pii: eaar3796. doi: 10.1126/scitranslmed.aar3796.


Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis.

Kasabova M, Villeret B, Gombault A, Lecaille F, Reinheckel T, Marchand-Adam S, Couillin I, Lalmanach G.

Respir Res. 2016 Sep 22;17(1):118.


Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension.

Parpaleix A, Amsellem V, Houssaini A, Abid S, Breau M, Marcos E, Sawaki D, Delcroix M, Quarck R, Maillard A, Couillin I, Ryffel B, Adnot S.

Eur Respir J. 2016 Aug;48(2):470-83. doi: 10.1183/13993003.01448-2015. Epub 2016 Jul 13.


Adenosine produced from adenine nucleotides through an interaction between apoptotic cells and engulfing macrophages contributes to the appearance of transglutaminase 2 in dying thymocytes.

Sándor K, Pallai A, Duró E, Legendre P, Couillin I, Sághy T, Szondy Z.

Amino Acids. 2017 Mar;49(3):671-681. doi: 10.1007/s00726-016-2257-5. Epub 2016 May 28.


Assessment of Inflammasome Activation by Cytokine and Danger Signal Detection.

Riteau N, Gombault A, Couillin I.

Methods Mol Biol. 2016;1417:63-74. doi: 10.1007/978-1-4939-3566-6_3.


Inflammasome, IL-1 and inflammation in ozone-induced lung injury.

Michaudel C, Couturier-Maillard A, Chenuet P, Maillet I, Mura C, Couillin I, Gombault A, Quesniaux VF, Huaux F, Ryffel B.

Am J Clin Exp Immunol. 2016 Mar 23;5(1):33-40. eCollection 2016. Review.


IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages.

Gicquel T, Robert S, Loyer P, Victoni T, Bodin A, Ribault C, Gleonnec F, Couillin I, Boichot E, Lagente V.

FASEB J. 2015 Oct;29(10):4162-73. doi: 10.1096/fj.14-267393. Epub 2015 Jun 26.


The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.

Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, Panek C, Le Bert M, Lagente V, Rassendren F, Riteau N, Couillin I.

Cell Death Dis. 2015 Feb 5;6:e1629. doi: 10.1038/cddis.2014.576.


The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles.

Rabolli V, Badissi AA, Devosse R, Uwambayinema F, Yakoub Y, Palmai-Pallag M, Lebrun A, De Gussem V, Couillin I, Ryffel B, Marbaix E, Lison D, Huaux F.

Part Fibre Toxicol. 2014 Dec 13;11:69. doi: 10.1186/s12989-014-0069-x.


Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives.

Roger S, Jelassi B, Couillin I, Pelegrin P, Besson P, Jiang LH.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2584-602. doi: 10.1016/j.bbamem.2014.10.029. Epub 2014 Nov 14. Review.


B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis.

François A, Gombault A, Villeret B, Alsaleh G, Fanny M, Gasse P, Adam SM, Crestani B, Sibilia J, Schneider P, Bahram S, Quesniaux V, Ryffel B, Wachsmann D, Gottenberg JE, Couillin I.

J Autoimmun. 2015 Jan;56:1-11. doi: 10.1016/j.jaut.2014.08.003. Epub 2014 Oct 23.


IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.

Huaux F, Lo Re S, Giordano G, Uwambayinema F, Devosse R, Yakoub Y, Panin N, Palmai-Pallag M, Rabolli V, Delos M, Marbaix E, Dauguet N, Couillin I, Ryffel B, Renauld JC, Lison D.

J Pathol. 2015 Apr;235(5):698-709. doi: 10.1002/path.4487. Epub 2015 Jan 20.


Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice.

Re SL, Giordano G, Yakoub Y, Devosse R, Uwambayinema F, Couillin I, Ryffel B, Marbaix E, Lison D, Huaux F.

PLoS One. 2014 Jul 22;9(7):e99383. doi: 10.1371/journal.pone.0099383. eCollection 2014. Erratum in: PLoS One. 2014;9(12):e116134. Giordano, Giulia [added].


The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.

Baroja-Mazo A, Martín-Sánchez F, Gomez AI, Martínez CM, Amores-Iniesta J, Compan V, Barberà-Cremades M, Yagüe J, Ruiz-Ortiz E, Antón J, Buján S, Couillin I, Brough D, Arostegui JI, Pelegrín P.

Nat Immunol. 2014 Aug;15(8):738-48. doi: 10.1038/ni.2919. Epub 2014 Jun 22.


Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.

Gicquel T, Victoni T, Fautrel A, Robert S, Gleonnec F, Guezingar M, Couillin I, Catros V, Boichot E, Lagente V.

Clin Exp Pharmacol Physiol. 2014 Apr;41(4):279-86. doi: 10.1111/1440-1681.12214.


CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model.

Besnard AG, Struyf S, Guabiraba R, Fauconnier L, Rouxel N, Proost P, Uyttenhove C, Van Snick J, Couillin I, Ryffel B.

J Leukoc Biol. 2013 Dec;94(6):1317-23. doi: 10.1189/jlb.0313140. Epub 2013 Aug 23.


ATP release and purinergic signaling in NLRP3 inflammasome activation.

Gombault A, Baron L, Couillin I.

Front Immunol. 2013 Jan 8;3:414. doi: 10.3389/fimmu.2012.00414. eCollection 2012.


ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation.

Riteau N, Baron L, Villeret B, Guillou N, Savigny F, Ryffel B, Rassendren F, Le Bert M, Gombault A, Couillin I.

Cell Death Dis. 2012 Oct 11;3:e403. doi: 10.1038/cddis.2012.144.


Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion.

Rigato C, Swinnen N, Buckinx R, Couillin I, Mangin JM, Rigo JM, Legendre P, Le Corronc H.

J Neurosci. 2012 Aug 22;32(34):11559-73.


Inflammasome-IL-1-Th17 response in allergic lung inflammation.

Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, Le Bert M, Quesniaux V, Ryffel B.

J Mol Cell Biol. 2012 Feb;4(1):3-10. doi: 10.1093/jmcb/mjr042. Epub 2011 Dec 6. Review.


IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.

Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, Fick L, Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I.

PLoS One. 2011;6(8):e23185. doi: 10.1371/journal.pone.0023185. Epub 2011 Aug 16.


NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant.

Besnard AG, Guillou N, Tschopp J, Erard F, Couillin I, Iwakura Y, Quesniaux V, Ryffel B, Togbe D.

Allergy. 2011 Aug;66(8):1047-57. doi: 10.1111/j.1398-9995.2011.02586.x. Epub 2011 Mar 28.


Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics.

Maillet I, Schnyder-Candrian S, Couillin I, Quesniaux VF, Erard F, Moser R, Fleury S, Kanda A, Dombrowicz D, Szymkowski DE, Ryffel B.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):731-9. doi: 10.1165/rcmb.2010-0512OC. Epub 2011 Feb 4.


Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.

Doisne JM, Soulard V, Bécourt C, Amniai L, Henrot P, Havenar-Daughton C, Blanchet C, Zitvogel L, Ryffel B, Cavaillon JM, Marie JC, Couillin I, Benlagha K.

J Immunol. 2011 Jan 15;186(2):662-6. doi: 10.4049/jimmunol.1002725. Epub 2010 Dec 17.


Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β.

Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19449-54. doi: 10.1073/pnas.1008155107. Epub 2010 Oct 25.


Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis.

Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, Kanellopoulos J, Quesniaux VF, Marchand-Adam S, Crestani B, Ryffel B, Couillin I.

Am J Respir Crit Care Med. 2010 Sep 15;182(6):774-83. doi: 10.1164/rccm.201003-0359OC. Epub 2010 Jun 3.


Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis.

Giordano G, van den Brûle S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, Couillin I, Ryffel B, Michiels T, Renauld JC, Lison D, Huaux F.

Toxicol Sci. 2010 Aug;116(2):682-92. doi: 10.1093/toxsci/kfq158. Epub 2010 May 31.


IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.

Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brûle S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F.

J Immunol. 2010 Jun 1;184(11):6367-77. doi: 10.4049/jimmunol.0900459. Epub 2010 Apr 26.


IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.

Couillin I, Vasseur V, Charron S, Gasse P, Tavernier M, Guillet J, Lagente V, Fick L, Jacobs M, Coelho FR, Moser R, Ryffel B.

J Immunol. 2009 Dec 15;183(12):8195-202. doi: 10.4049/jimmunol.0803154.


Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.

Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, Couillin I.

Am J Respir Crit Care Med. 2009 May 15;179(10):903-13. doi: 10.1164/rccm.200808-1274OC. Epub 2009 Feb 12.


Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent.

Doz E, Noulin N, Boichot E, Guénon I, Fick L, Le Bert M, Lagente V, Ryffel B, Schnyder B, Quesniaux VF, Couillin I.

J Immunol. 2008 Jan 15;180(2):1169-78.


Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury.

Togbe D, Schnyder-Candrian S, Schnyder B, Doz E, Noulin N, Janot L, Secher T, Gasse P, Lima C, Coelho FR, Vasseur V, Erard F, Ryffel B, Couillin I, Moser R.

Int J Exp Pathol. 2007 Dec;88(6):387-91. Review.


IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.

Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I.

J Clin Invest. 2007 Dec;117(12):3786-99.


Control of allergic reactions in mice by an active anti-murine IL-4 immunization.

Le Buanec H, Paturance S, Couillin I, Schnyder-Candrian S, Larcier P, Ryffel B, Bizzini B, Bensussan A, Burny A, Gallo R, Zagury D, Peltre G.

Vaccine. 2007 Oct 10;25(41):7206-16. Epub 2007 Aug 3.


T cell-derived TNF down-regulates acute airway response to endotoxin.

Togbe D, Grivennikov SI, Noulin N, Couillin I, Maillet I, Jacobs M, Maret M, Fick L, Nedospasov SA, Quesniaux VF, Schnyder B, Schnyder-Candrian S.

Eur J Immunol. 2007 Mar;37(3):768-79.


Interleukin-17 is a negative regulator of established allergic asthma.

Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B.

J Exp Med. 2006 Nov 27;203(12):2715-25. Epub 2006 Nov 13.


Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways.

Togbe D, Aurore G, Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Vasseur V, Akira S, Hoebe K, Beutler B, Ryffel B, Couillin I.

Lab Invest. 2006 Nov;86(11):1126-35. Epub 2006 Sep 18.


TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation.

Togbe D, Schnyder-Candrian S, Schnyder B, Couillin I, Maillet I, Bihl F, Malo D, Ryffel B, Quesniaux VF.

J Leukoc Biol. 2006 Sep;80(3):451-7. Epub 2006 Jun 29.


Histamine scavenging attenuates endotoxin-induced acute lung injury.

Ryffel B, Couillin I, Maillet I, Schnyder B, Paesen GC, Nuttall P, Weston-Davies W.

Ann N Y Acad Sci. 2005 Nov;1056:197-205.


Arthropod-derived protein EV131 inhibits histamine action and allergic asthma.

Weston-Davies W, Couillin I, Schnyder S, Schnyder B, Moser R, Lissina O, Paesen GC, Nuttall P, Ryffel B.

Ann N Y Acad Sci. 2005 Nov;1056:189-96.


Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin.

Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Maillet I, Robert T, Vargaftig BB, Ryffel B, Couillin I.

J Immunol. 2005 Nov 15;175(10):6861-9.


Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome.

Schnyder-Candrian S, Quesniaux VF, Di Padova F, Maillet I, Noulin N, Couillin I, Moser R, Erard F, Vargaftig BB, Ryffel B, Schnyder B.

J Immunol. 2005 Jul 1;175(1):262-9.


Arthropod-derived histamine-binding protein prevents murine allergic asthma.

Couillin I, Maillet I, Vargaftig BB, Jacobs M, Paesen GC, Nuttall PA, Lefort J, Moser R, Weston-Davies W, Ryffel B.

J Immunol. 2004 Sep 1;173(5):3281-6.


DNA vaccination of macaques with several different Nef sequences induces multispecific T cell responses.

Couillin I, Letourneur F, Lefèbvre P, Guillet JG, Martinon F.

Virology. 2001 Jan 5;279(1):136-45.


Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens.

Couillin I, Pol S, Mancini M, Driss F, Bréchot C, Tiollais P, Michel ML.

J Infect Dis. 1999 Jul;180(1):15-26. Erratum in: J Infect Dis 1999 Nov;180(5):1756.


Immunotherapy of chronic hepatitis B by anti HBV vaccine.

Pol S, Couillin I, Michel ML, Driss F, Nalpas B, Carnot F, Berthelot P, Bréchot C.

Acta Gastroenterol Belg. 1998 Apr-Jun;61(2):228-33.


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