Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 128

1.

The effects of UDP-sugars, UDP and Mg2+on uridine diphosphate glucuronosyltransferase activity in human liver microsomes.

Walia G, Smith AD, Riches Z, Collier AC, Coughtrie MWH.

Xenobiotica. 2018 Sep;48(9):882-890. doi: 10.1080/00498254.2017.1376260. Epub 2017 Sep 26.

PMID:
28868965
2.

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)-How Does the Endoplasmic Reticulum Membrane Influence Their Function?

Liu Y, Coughtrie MWH.

Pharmaceutics. 2017 Aug 30;9(3). pii: E32. doi: 10.3390/pharmaceutics9030032. Review.

3.

Function and organization of the human cytosolic sulfotransferase (SULT) family.

Coughtrie MWH.

Chem Biol Interact. 2016 Nov 25;259(Pt A):2-7. doi: 10.1016/j.cbi.2016.05.005. Epub 2016 May 9. Review.

PMID:
27174136
4.

The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer.

Mao X, Gauche C, Coughtrie MW, Bui C, Gulberti S, Merhi-Soussi F, Ramalanjaona N, Bertin-Jung I, Diot A, Dumas D, De Freitas Caires N, Thompson AM, Bourdon JC, Ouzzine M, Fournel-Gigleux S.

Oncogene. 2016 Sep 22;35(38):5043-55. doi: 10.1038/onc.2016.44. Epub 2016 Apr 4.

PMID:
27041583
5.

Ontogeny of Human Conjugating Enzymes.

Coughtrie MW.

Drug Metab Lett. 2015;9(2):99-108. Review.

PMID:
26031463
6.

Characterization of bovine phenol sulfotransferases: evidence of a major role for SULT1B1 in the liver.

Choughule KV, Locuson CW, Coughtrie MW.

Xenobiotica. 2015;45(6):495-502. doi: 10.3109/00498254.2014.997325. Epub 2014 Dec 24.

PMID:
25539458
7.

Luminal accumulation of newly synthesized morphine-3-glucuronide in rat liver microsomal vesicles.

Révész K, Tóth B, Staines AG, Coughtrie MW, Mandl J, Csala M.

Biofactors. 2013 May-Jun;39(3):271-8. doi: 10.1002/biof.1067. Epub 2012 Dec 22.

PMID:
23281118
8.

Neonatal development of hepatic UGT1A9: implications of pediatric pharmacokinetics.

Miyagi SJ, Milne AM, Coughtrie MW, Collier AC.

Drug Metab Dispos. 2012 Jul;40(7):1321-7. doi: 10.1124/dmd.111.043752. Epub 2012 Apr 5.

9.

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.

Gulberti S, Jacquinet JC, Chabel M, Ramalanjaona N, Magdalou J, Netter P, Coughtrie MW, Ouzzine M, Fournel-Gigleux S.

Glycobiology. 2012 Apr;22(4):561-71. doi: 10.1093/glycob/cwr172. Epub 2011 Dec 7.

PMID:
22156920
10.

Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum.

Tucker TG, Milne AM, Fournel-Gigleux S, Fenner KS, Coughtrie MW.

Biochem Pharmacol. 2012 Jan 15;83(2):279-85. doi: 10.1016/j.bcp.2011.10.017. Epub 2011 Oct 31.

PMID:
22062654
11.

A novel method for the immunoquantification of UDP-glucuronosyltransferases in human tissue.

Milne AM, Burchell B, Coughtrie MW.

Drug Metab Dispos. 2011 Dec;39(12):2258-63. doi: 10.1124/dmd.111.041699. Epub 2011 Aug 31.

PMID:
21880828
12.

Antiplatelet drug interactions.

Mackenzie IS, Coughtrie MW, MacDonald TM, Wei L.

J Intern Med. 2010 Dec;268(6):516-29. doi: 10.1111/j.1365-2796.2010.02299.x. Epub 2010 Nov 14. Review.

13.

Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway.

Talhaoui I, Bui C, Oriol R, Mulliert G, Gulberti S, Netter P, Coughtrie MW, Ouzzine M, Fournel-Gigleux S.

J Biol Chem. 2010 Nov 26;285(48):37342-58. doi: 10.1074/jbc.M110.151951. Epub 2010 Sep 14.

14.

Molecular characterization of β1,4-galactosyltransferase 7 genetic mutations linked to the progeroid form of Ehlers-Danlos syndrome (EDS).

Bui C, Talhaoui I, Chabel M, Mulliert G, Coughtrie MW, Ouzzine M, Fournel-Gigleux S.

FEBS Lett. 2010 Sep 24;584(18):3962-8. doi: 10.1016/j.febslet.2010.08.001. Epub 2010 Aug 6.

15.

The use of hepatocytes to investigate UDP-glucuronosyltransferases and sulfotransferases.

Fournel-Gigleux S, Coughtrie MW, Ouzzine M, Magdalou J.

Methods Mol Biol. 2010;640:309-26. doi: 10.1007/978-1-60761-688-7_17.

PMID:
20645060
16.

Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.

Bui C, Ouzzine M, Talhaoui I, Sharp S, Prydz K, Coughtrie MW, Fournel-Gigleux S.

FASEB J. 2010 Feb;24(2):436-50. doi: 10.1096/fj.09-136291. Epub 2009 Oct 7.

PMID:
19812376
17.

Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: the SULT "pie".

Riches Z, Stanley EL, Bloomer JC, Coughtrie MW.

Drug Metab Dispos. 2009 Nov;37(11):2255-61. doi: 10.1124/dmd.109.028399. Epub 2009 Aug 13.

18.

Molecular basis for acceptor substrate specificity of the human beta1,3-glucuronosyltransferases GlcAT-I and GlcAT-P involved in glycosaminoglycan and HNK-1 carbohydrate epitope biosynthesis, respectively.

Fondeur-Gelinotte M, Lattard V, Gulberti S, Oriol R, Mulliert G, Coughtrie MW, Magdalou J, Netter P, Ouzzine M, Fournel-Gigleux S.

Glycobiology. 2007 Aug;17(8):857-67. Epub 2007 Jun 13.

PMID:
17567734
19.

Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation.

Itäaho K, Alakurtti S, Yli-Kauhaluoma J, Taskinen J, Coughtrie MW, Kostiainen R.

Biochem Pharmacol. 2007 Aug 1;74(3):504-10. Epub 2007 May 10.

PMID:
17548063
20.
21.

Protocol for the smoking, nicotine and pregnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy.

Coleman T, Thornton J, Britton J, Lewis S, Watts K, Coughtrie MW, Mannion C, Marlow N, Godfrey C.

BMC Health Serv Res. 2007 Jan 3;7:2.

22.
24.

Substrate specificity of human hepatic udp-glucuronosyltransferases.

Burchell B, Lockley DJ, Staines A, Uesawa Y, Coughtrie MW.

Methods Enzymol. 2005;400:46-57.

PMID:
16399342
25.
26.

Down-regulation of dehydroepiandrosterone sulfotransferase gene in human hepatocellular carcinoma.

Huang LR, Coughtrie MW, Hsu HC.

Mol Cell Endocrinol. 2005 Feb 28;231(1-2):87-94. Epub 2004 Dec 8.

PMID:
15713538
27.

Plasma catecholamines and the counterregulatory responses to hypoglycemia in infants: a critical role for epinephrine and cortisol.

Jackson L, Williams FL, Burchell A, Coughtrie MW, Hume R.

J Clin Endocrinol Metab. 2004 Dec;89(12):6251-6.

PMID:
15579785
28.

Evidence for multiple glucuronide transporters in rat liver microsomes.

Csala M, Staines AG, Bánhegyi G, Mandl J, Coughtrie MW, Burchell B.

Biochem Pharmacol. 2004 Oct 1;68(7):1353-62.

PMID:
15345325
29.

Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1.

Staines AG, Sindelar P, Coughtrie MW, Burchell B.

Biochem J. 2004 Dec 15;384(Pt 3):637-45.

30.

N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7.

Staines AG, Coughtrie MW, Burchell B.

J Pharmacol Exp Ther. 2004 Dec;311(3):1131-7. Epub 2004 Aug 3.

PMID:
15292462
31.

cDNA cloning, functional expression, and characterization of chicken sulfotransferases belonging to the SULT1B and SULT1C families.

Wilson LA, Reyns GE, Darras VM, Coughtrie MW.

Arch Biochem Biophys. 2004 Aug 1;428(1):64-72.

PMID:
15234270
32.

A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily.

Blanchard RL, Freimuth RR, Buck J, Weinshilboum RM, Coughtrie MW.

Pharmacogenetics. 2004 Mar;14(3):199-211. Review.

PMID:
15167709
33.
35.

CoMFA modeling of enzyme kinetics: K(m) values for sulfation of diverse phenolic substrates by human catecholamine sulfotransferase SULT1A3.

Sipilä J, Hood AM, Coughtrie MW, Taskinen J.

J Chem Inf Comput Sci. 2003 Sep-Oct;43(5):1563-9.

PMID:
14502490
36.
37.

Characterization of rat iodothyronine sulfotransferases.

Kester MH, Kaptein E, Roest TJ, van Dijk CH, Tibboel D, Meinl W, Glatt H, Coughtrie MW, Visser TJ.

Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E592-8. Epub 2003 May 28.

38.
39.

Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters.

Kester MH, Bulduk S, van Toor H, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Schuur AG, Brouwer A, Visser TJ.

J Clin Endocrinol Metab. 2002 Mar;87(3):1142-50.

PMID:
11889178
40.

Characterization of iodothyronine sulfatase activities in human and rat liver and placenta.

Kester MH, Kaptein E, Van Dijk CH, Roest TJ, Tibboel D, Coughtrie MW, Visser TJ.

Endocrinology. 2002 Mar;143(3):814-9.

PMID:
11861502
41.

Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.

Ireson CR, Jones DJ, Orr S, Coughtrie MW, Boocock DJ, Williams ML, Farmer PB, Steward WP, Gescher AJ.

Cancer Epidemiol Biomarkers Prev. 2002 Jan;11(1):105-11.

42.
43.

Differential expression of sulfotransferase enzymes involved in thyroid hormone metabolism during human placental development.

Stanley EL, Hume R, Visser TJ, Coughtrie MW.

J Clin Endocrinol Metab. 2001 Dec;86(12):5944-55.

PMID:
11739469
44.

Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer.

Bamber DE, Fryer AA, Strange RC, Elder JB, Deakin M, Rajagopal R, Fawole A, Gilissen RA, Campbell FC, Coughtrie MW.

Pharmacogenetics. 2001 Nov;11(8):679-85.

PMID:
11692076
45.

Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain.

Richard K, Hume R, Kaptein E, Stanley EL, Visser TJ, Coughtrie MW.

J Clin Endocrinol Metab. 2001 Jun;86(6):2734-42.

PMID:
11397879
46.

Thyroid hormone metabolism and the developing human lung.

Hume R, Richard K, Kaptein E, Stanley EL, Visser TJ, Coughtrie MW.

Biol Neonate. 2001 May;80 Suppl 1:18-21. Review.

PMID:
11359040
47.

Influence of culture system and medium enrichment on sulfotransferase and sulfatase expression in male rat hepatocyte cultures.

Slaus K, Coughtrie MW, Sharp S, Vanhaecke T, Vercruysse A, Rogiers V.

Biochem Pharmacol. 2001 May 1;61(9):1107-17.

PMID:
11301044
48.

Interactions between dietary chemicals and human sulfotransferases-molecular mechanisms and clinical significance.

Coughtrie MW, Johnston LE.

Drug Metab Dispos. 2001 Apr;29(4 Pt 2):522-8.

PMID:
11259344
49.

Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs.

Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ.

Endocrinology. 2000 May;141(5):1897-900.

PMID:
10803601
50.

Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa.

Tashiro A, Sasano H, Nishikawa T, Yabuki N, Muramatsu Y, Coughtrie MW, Nagura H, Hongo M.

J Steroid Biochem Mol Biol. 2000 Mar;72(3-4):149-54.

PMID:
10775806

Supplemental Content

Loading ...
Support Center