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Items: 36

1.

MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.

Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS.

J Med Chem. 2018 Oct 11;61(19):8847-8858. doi: 10.1021/acs.jmedchem.8b01026. Epub 2018 Sep 24.

2.

A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD).

Haymond A, Dowdy T, Johny C, Johnson C, Ball H, Dailey A, Schweibenz B, Villarroel K, Young R, Mantooth CJ, Patel T, Bases J, Dowd CS, Couch RD.

Anal Biochem. 2018 Feb 1;542:63-75. doi: 10.1016/j.ab.2017.11.018. Epub 2017 Nov 24.

3.

Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.

San Jose G, Jackson ER, Haymond A, Johny C, Edwards RL, Wang X, Brothers RC, Edelstein EK, Odom AR, Boshoff HI, Couch RD, Dowd CS.

ACS Infect Dis. 2016 Dec 9;2(12):923-935. Epub 2016 Oct 12.

4.

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Chofor R, Sooriyaarachchi S, Risseeuw MD, Bergfors T, Pouyez J, Johny C, Haymond A, Everaert A, Dowd CS, Maes L, Coenye T, Alex A, Couch RD, Jones TA, Wouters J, Mowbray SL, Van Calenbergh S.

J Med Chem. 2015 Apr 9;58(7):2988-3001. doi: 10.1021/jm5014264. Epub 2015 Mar 31.

PMID:
25781377
5.

Alcohol induced alterations to the human fecal VOC metabolome.

Couch RD, Dailey A, Zaidi F, Navarro K, Forsyth CB, Mutlu E, Engen PA, Keshavarzian A.

PLoS One. 2015 Mar 9;10(3):e0119362. doi: 10.1371/journal.pone.0119362. eCollection 2015.

6.

Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

Haymond A, Johny C, Dowdy T, Schweibenz B, Villarroel K, Young R, Mantooth CJ, Patel T, Bases J, San Jose G, Jackson ER, Dowd CS, Couch RD.

PLoS One. 2014 Aug 29;9(8):e106243. doi: 10.1371/journal.pone.0106243. eCollection 2014.

7.

Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro.

Chofor R, Risseeuw MD, Pouyez J, Johny C, Wouters J, Dowd CS, Couch RD, Van Calenbergh S.

Molecules. 2014 Feb 24;19(2):2571-87. doi: 10.3390/molecules19022571.

8.

The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.

Jackson ER, San Jose G, Brothers RC, Edelstein EK, Sheldon Z, Haymond A, Johny C, Boshoff HI, Couch RD, Dowd CS.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):649-53. doi: 10.1016/j.bmcl.2013.11.067. Epub 2013 Dec 4.

9.

The approach to sample acquisition and its impact on the derived human fecal microbiome and VOC metabolome.

Couch RD, Navarro K, Sikaroodi M, Gillevet P, Forsyth CB, Mutlu E, Engen PA, Keshavarzian A.

PLoS One. 2013 Nov 18;8(11):e81163. doi: 10.1371/journal.pone.0081163. eCollection 2013.

10.

Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.

San Jose G, Jackson ER, Uh E, Johny C, Haymond A, Lundberg L, Pinkham C, Kehn-Hall K, Boshoff HI, Couch RD, Dowd CS.

Medchemcomm. 2013 Jul 1;4(7):1099-1104.

11.

Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy.

McKenney ES, Sargent M, Khan H, Uh E, Jackson ER, San Jose G, Couch RD, Dowd CS, van Hoek ML.

PLoS One. 2012;7(10):e38167. doi: 10.1371/journal.pone.0038167. Epub 2012 Oct 15.

12.

Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis.

Li RW, Wu S, Li W, Navarro K, Couch RD, Hill D, Urban JF Jr.

Infect Immun. 2012 Jun;80(6):2150-7. doi: 10.1128/IAI.00141-12. Epub 2012 Apr 9.

13.

Personalized medicine: changing the paradigm of drug development.

Couch RD, Mott BT.

Methods Mol Biol. 2012;823:367-78. doi: 10.1007/978-1-60327-216-2_24.

PMID:
22081358
14.

Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation.

Tsang A, Seidle H, Jawaid S, Zhou W, Smith C, Couch RD.

PLoS One. 2011;6(6):e20884. doi: 10.1371/journal.pone.0020884. Epub 2011 Jun 9.

15.

Solid-phase microextraction and the human fecal VOC metabolome.

Dixon E, Clubb C, Pittman S, Ammann L, Rasheed Z, Kazmi N, Keshavarzian A, Gillevet P, Rangwala H, Couch RD.

PLoS One. 2011 Apr 8;6(4):e18471. doi: 10.1371/journal.pone.0018471.

16.

Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity.

Jawaid S, Gertz M, Corsino C, Cheung J, Seidle H, Couch RD.

Indian J Biochem Biophys. 2010 Dec;47(6):331-9.

PMID:
21355415
17.

Bacteria-induced static batch fungal fermentation of the diterpenoid cyathin A(3), a small-molecule inducer of nerve growth factor.

Dixon E, Schweibenz T, Hight A, Kang B, Dailey A, Kim S, Chen MY, Kim Y, Neale S, Groth A, Ike T, Khan S, Schweibenz B, Lieu D, Stone D, Orellana T, Couch RD.

J Ind Microbiol Biotechnol. 2011 May;38(5):607-15. doi: 10.1007/s10295-010-0805-7. Epub 2010 Aug 17.

PMID:
20714781
18.

Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

Jawaid S, Seidle H, Zhou W, Abdirahman H, Abadeer M, Hix JH, van Hoek ML, Couch RD.

PLoS One. 2009 Dec 14;4(12):e8288. doi: 10.1371/journal.pone.0008288.

19.

Characterization of a nonspecific phosphopantetheinyl transferase from Pseudomonas syringae pv. syringae FF5.

Seidle HF, Couch RD, Parry RJ.

Arch Biochem Biophys. 2006 Feb 15;446(2):167-74. Epub 2005 Dec 29.

PMID:
16423321
20.

2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis.

Couch RD, Ganem NJ, Zhou M, Popov VM, Honda T, Veenstra TD, Sporn MB, Anderson AC.

Mol Pharmacol. 2006 Apr;69(4):1158-65. Epub 2006 Jan 11.

PMID:
16407469
21.

Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.

Couch RD, Browning RG, Honda T, Gribble GW, Wright DL, Sporn MB, Anderson AC.

Bioorg Med Chem Lett. 2005 May 2;15(9):2215-9.

PMID:
15837296
22.

Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets.

Honda T, Janosik T, Honda Y, Han J, Liby KT, Williams CR, Couch RD, Anderson AC, Sporn MB, Gribble GW.

J Med Chem. 2004 Sep 23;47(20):4923-32.

PMID:
15369396
23.

Rational elimination of Aspergillus terreus sulochrin production.

Couch RD, Gaucher GM.

J Biotechnol. 2004 Mar 4;108(2):171-8.

PMID:
15129726
24.

Mycobacterium chelonei keratopathy with visual rehabilitation by a triple procedure.

Crane TB, Stevens RE, Couch RD, Lee TL, Terui R.

Ophthalmic Surg. 1990 Nov;21(11):802-6.

PMID:
2270167
25.

Travel, time zones, and sudden cardiac death. Emporiatric pathology.

Couch RD.

Am J Forensic Med Pathol. 1990 Jun;11(2):106-11.

PMID:
2343836
26.

Herpes simplex culture in a small laboratory.

Couch RD, Brinkworth S, Elpern DJ.

Hawaii Med J. 1988 Sep;47(9):413-5. No abstract available.

PMID:
2846470
27.

Fatal sardine poisoning. A fatal case of fish poisoning in Hawaii associated with the Marquesan sardine.

Melton RJ, Randall JE, Fusetani N, Weiner RS, Couch RD, Sims JK.

Hawaii Med J. 1984 Apr;43(4):114, 116, 118-20 passim. No abstract available.

PMID:
6724888
28.

Sudden cardiac death following adriamycin therapy.

Couch RD, Loh KK, Sugino J.

Cancer. 1981 Jul 1;48(1):38-9.

PMID:
6940649
29.

Spongy degeneration of the CNS: an instance of the rare juvenile form.

Goodhue WW Jr, Couch RD, Namiki H.

Arch Neurol. 1979 Aug;36(8):481-4.

PMID:
508159
30.

Computer diagnosis--review and comment.

Couch RD.

Pathol Annu. 1976;11:141-59. Review. No abstract available.

PMID:
794802
31.

Curriculum in medical technology--1972. Introduction.

Couch RD.

Tech Bull Regist Med Technol. 1968 Jul;38(7):177. No abstract available.

PMID:
5667703
32.

PATTERNS IN CLINICAL CHEMISTRY. LOW SERUM SODIUM AND CHLORIDE IN HOSPITALIZED PATIENTS.

LINDBERG DA, VANPEENEN HJ, COUCH RD.

Am J Clin Pathol. 1965 Sep;44:315-21. No abstract available.

PMID:
14334733
33.

Mesenteric ischemia without vascular occlusion.

GOODING RA, COUCH RD.

Arch Surg. 1962 Aug;85:186-91. No abstract available.

PMID:
13900285
34.

Granular cell ameloblastic fibroma. Report of 2 cases in adults, with observations of its similarity to congenital epulis.

COUCH RD, MORRIS EE, VELLIOS F.

Am J Clin Pathol. 1962 Apr;37:398-404. No abstract available.

PMID:
13881689
35.

Aminophylline poisoning; report of a case with complete pathologic and toxicologic findings.

COUCH RD, FRANZ M, FORNEY RB.

Am J Clin Pathol. 1958 Nov;30(5):435-8. No abstract available.

PMID:
13594915
36.

Disease of the Antrum of Highmore.

Couch RD.

Am J Dent Sci. 1851 Jul;1(4):497-498. No abstract available.

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