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Items: 39

1.

Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates.

Yadav DB, Maloney JA, Wildsmith KR, Fuji RN, Meilandt WJ, Solanoy H, Lu Y, Peng K, Wilson B, Chan P, Gadkar K, Kosky A, Goo M, Daugherty A, Couch JA, Keene T, Hayes K, Nikolas LJ, Lane D, Switzer R, Adams E, Watts RJ, Scearce-Levie K, Prabhu S, Shafer L, Thakker DR, Hildebrand K, Atwal JK.

Br J Pharmacol. 2017 Nov;174(22):4173-4185. doi: 10.1111/bph.14021. Epub 2017 Oct 6.

PMID:
28859225
2.

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.

Lo M, Kim HS, Tong RK, Bainbridge TW, Vernes JM, Zhang Y, Lin YL, Chung S, Dennis MS, Zuchero YJ, Watts RJ, Couch JA, Meng YG, Atwal JK, Brezski RJ, Spiess C, Ernst JA.

J Biol Chem. 2017 Mar 3;292(9):3900-3908. doi: 10.1074/jbc.M116.767749. Epub 2017 Jan 11.

3.

Preexisting Antibodies to an F(ab')2 Antibody Therapeutic and Novel Method for Immunogenicity Assessment.

Ruppel J, Brady A, Elliott R, Leddy C, Palencia M, Coleman D, Couch JA, Wakshull E.

J Immunol Res. 2016;2016:2921758. doi: 10.1155/2016/2921758. Epub 2016 Jun 16.

4.

Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain.

Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, Ramanujan S, Joseph S.

CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):283-91. doi: 10.1002/psp4.12081. Epub 2016 May 17.

5.

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.

Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S.

Eur J Pharm Biopharm. 2016 Apr;101:53-61. doi: 10.1016/j.ejpb.2016.01.009. Epub 2016 Jan 25.

PMID:
26820920
6.

Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation.

Couch JA, Zhang G, Beyer JC, de Zafra CL, Gupta P, Kamath AV, Lewin-Koh N, Tarrant J, Allamneni KP, Cain G, Yee S, Ross S, Cook R, Tsai SP, Ruppel J, Ridgway JB, Paluch M, Hass PE, Franklin J, Yan M.

Clin Cancer Res. 2016 Mar 15;22(6):1469-79. doi: 10.1158/1078-0432.CCR-15-1380. Epub 2015 Nov 20.

7.

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.

Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, Ernst JA, Scearce-Levie K, Couch JA, Dennis MS, Watts RJ.

Sci Transl Med. 2014 Nov 5;6(261):261ra154. doi: 10.1126/scitranslmed.3009835.

8.

Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, Solanoy H, Tong RK, Hoyte K, Luk W, Lu Y, Gadkar K, Prabhu S, Ordonia BA, Nguyen Q, Lin Y, Lin Z, Balazs M, Scearce-Levie K, Ernst JA, Dennis MS, Watts RJ.

Sci Transl Med. 2013 May 1;5(183):183ra57, 1-12. doi: 10.1126/scitranslmed.3005338.

9.

Sylvian fissure morphology in Prader-Willi syndrome and early-onset morbid obesity.

Miller JL, Couch JA, Leonard CM, Schwenk K, Towler SD, Shuster J, Goldstone AP, He G, Driscoll DJ, Liu Y.

Genet Med. 2007 Aug;9(8):536-43.

PMID:
17700392
10.

Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity.

Miller JL, Goldstone AP, Couch JA, Shuster J, He G, Driscoll DJ, Liu Y, Schmalfuss IM.

Am J Med Genet A. 2008 Mar 1;146A(5):570-7.

PMID:
17431897
11.

Enhanced activation of reward mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome.

Miller JL, James GA, Goldstone AP, Couch JA, He G, Driscoll DJ, Liu Y.

J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):615-9. Epub 2006 Dec 8. Erratum in: J Neurol Neurosurg Psychiatry. 2007 Aug;78(8):912.

12.

Intracranial abnormalities detected by three-dimensional magnetic resonance imaging in Prader-Willi syndrome.

Miller JL, Couch JA, Schmalfuss I, He G, Liu Y, Driscoll DJ.

Am J Med Genet A. 2007 Mar 1;143A(5):476-83.

PMID:
17103438
13.

robo2 and robo3 interact with eagle to regulate serotonergic neuron differentiation.

Couch JA, Chen J, Rieff HI, Uri EM, Condron BG.

Development. 2004 Mar;131(5):997-1006.

15.

Toxicity and Pathogenicity Testing of the Insect Pest Control Fungus Metarhizium anisopliae

Genthner FJ, Chancy CA, Couch JA, Foss SS, Middaugh DP, George SE, Warren MA, Bantle JA.

Arch Environ Contam Toxicol. 1998 Aug;35(2):317-24.

PMID:
9680524
16.

Continuing development of fish species as additional experimental models in cancer research.

Couch JA.

Toxicol Pathol. 1996 Sep-Oct;24(5):602. No abstract available.

PMID:
8923682
18.

The genome of the tropical tree Theobroma cacao L.

Couch JA, Zintel HA, Fritz PJ.

Mol Gen Genet. 1993 Feb;237(1-2):123-8.

PMID:
8455550
22.

Debate: mouse versus minnow: the future of fish in carcinogenicity testing.

Dawe CJ, Couch JA.

Natl Cancer Inst Monogr. 1984 May;65:223-35. No abstract available.

PMID:
6749256
23.
24.

Should sperm donors be screened for sexually transmitted diseases?

Mascola L, Colwell BY, Couch JA.

N Engl J Med. 1983 Oct 27;309(17):1058. No abstract available.

PMID:
6688655
25.

The effect of thiopentone and fazadinium on intraocular pressure.

Couch JA, Eltringham RJ, Magauran DM.

Anaesthesia. 1979 Jun;34(6):586-90.

26.
27.

Interaction of chemical pollutants and virus in a crustacean: a novel bioassay system.

Couch JA, Courtney L.

Ann N Y Acad Sci. 1978 Sep 29;298:497-504. Review.

PMID:
101112
28.

Kepone-induced scoliosis and its histological consequences in fish.

Couch JA, Winstead JT, Goodman LR.

Science. 1977 Aug 5;197(4303):585-7.

PMID:
69318
29.

Ultrastructural study of lesions in gills of a marine shrimp exposed to cadmium.

Couch JA.

J Invertebr Pathol. 1977 May;29(3):267-88. No abstract available.

PMID:
858942
30.

Attempts to increase Baculovirus prevalence in shrimp by chemical exposure.

Couch JA.

Prog Exp Tumor Res. 1976;20:304-14. No abstract available.

PMID:
790466
31.

Toxicity of Aroclor-R 1254 and its physiological activity in several estuarine organisms.

Nimmo DR, Hansen DJ, Couch JA, Cooley NR, Parrish PR, Lowe JI.

Arch Environ Contam Toxicol. 1975;3(1):22-39.

PMID:
805570
32.

An enzootic nuclear polyhedrosis virus of pink shrimp: ultrastructure, prevalence, and enhancement.

Couch JA.

J Invertebr Pathol. 1974 Nov;24(3):311-31. No abstract available.

PMID:
4613755
33.

Pathological effects of Urosporidium (Haplosporida) infection in microphallid metacercariae.

Couch JA.

J Invertebr Pathol. 1974 May;23(3):389-96. No abstract available.

PMID:
4208304
34.

Sarcoma-like disease in a single specimen of the American oyster.

Couch JA.

Bibl Haematol. 1970;(36):647. No abstract available.

PMID:
4950975
35.

An unusual lesion in the mantle of the american oyster, Crassostrea virginica.

Couch JA.

Natl Cancer Inst Monogr. 1969 Jul;31:557-62. No abstract available.

PMID:
5374695
36.

Concurrent haplosporidian infections of the oyster, Crassostrea virginica (Gmelin).

Couch JA.

J Parasitol. 1967 Apr;53(2):248-53. No abstract available.

PMID:
4960572
37.

Sporulation of Minchinia nelsoni (Haplosporida, Haplosporidiidae) in Crassostrea virginica (Gmelin).

Couch JA, Farley CA, Rosenfield A.

Science. 1966 Sep 23;153(3743):1529-31.

PMID:
4958377
38.

Brachycoelium ambystomae sp. n. (Trematoda: brachycoelidae) from Ambystoma opacum.

Couch JA.

J Parasitol. 1966 Feb;52(1):46-9. No abstract available.

PMID:
5910457
39.

DICYEMA BILOBUM SP.N. (MESOZOA:DICYEMIDAE) FROM THE NORTHERN GULF OF MEXICO.

COUCH JA, SHORT RB.

J Parasitol. 1964 Oct;50:641-5. No abstract available.

PMID:
14215482

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