Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 56


CACHD1: A new activity-modifying protein for voltage-gated calcium channels.

Stephens GJ, Cottrell GS.

Channels (Austin). 2019 Dec;13(1):120-123. doi: 10.1080/19336950.2019.1600968. No abstract available.


Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system: more than just receptor cooperation?

Widera D, Martínez Aguilar R, Cottrell GS.

Neural Regen Res. 2019 Jul;14(7):1196-1201. doi: 10.4103/1673-5374.251290.


CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity.

Cottrell GS, Soubrane CH, Hounshell JA, Lin H, Owenson V, Rigby M, Cox PJ, Barker BS, Ottolini M, Ince S, Bauer CC, Perez-Reyes E, Patel MK, Stevens EB, Stephens GJ.

J Neurosci. 2018 Oct 24;38(43):9186-9201. doi: 10.1523/JNEUROSCI.3572-15.2018. Epub 2018 Sep 4.


CGRP Receptor Signalling Pathways.

Cottrell GS.

Handb Exp Pharmacol. 2018 Aug 28. doi: 10.1007/164_2018_130. [Epub ahead of print]


Proton Transport Chains in Glucose Metabolism: Mind the Proton.

Roosterman D, Meyerhof W, Cottrell GS.

Front Neurosci. 2018 Jun 15;12:404. doi: 10.3389/fnins.2018.00404. eCollection 2018. Review.


Characterisation of the vasodilation effects of DHA and EPA, n-3 PUFAs (fish oils), in rat aorta and mesenteric resistance arteries.

Limbu R, Cottrell GS, McNeish AJ.

PLoS One. 2018 Feb 2;13(2):e0192484. doi: 10.1371/journal.pone.0192484. eCollection 2018.


Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization.

Krüger CL, Zeuner MT, Cottrell GS, Widera D, Heilemann M.

Sci Signal. 2017 Oct 31;10(503). pii: eaan1308. doi: 10.1126/scisignal.aan1308.


The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor.

Roux BT, Bauer CC, McNeish AJ, Ward SG, Cottrell GS.

Sci Rep. 2017 Sep 28;7(1):12389. doi: 10.1038/s41598-017-12585-z.


Development and Characterisation of a Novel NF-κB Reporter Cell Line for Investigation of Neuroinflammation.

Zeuner MT, Vallance T, Vaiyapuri S, Cottrell GS, Widera D.

Mediators Inflamm. 2017;2017:6209865. doi: 10.1155/2017/6209865. Epub 2017 Jul 16.


Biased signalling is an essential feature of TLR4 in glioma cells.

Zeuner MT, Krüger CL, Volk K, Bieback K, Cottrell GS, Heilemann M, Widera D.

Biochim Biophys Acta. 2016 Dec;1863(12):3084-3095. doi: 10.1016/j.bbamcr.2016.09.016. Epub 2016 Sep 23.


Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.

Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW.

Br J Pharmacol. 2014 Aug;171(16):3814-26. doi: 10.1111/bph.12738.


G protein-coupled receptors: what a difference a 'partner' makes.

Roux BT, Cottrell GS.

Int J Mol Sci. 2014 Jan 16;15(1):1112-42. doi: 10.3390/ijms15011112. Review.


The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU.

J Biol Chem. 2013 Aug 9;288(32):22942-60. doi: 10.1074/jbc.M113.455774. Epub 2013 Jul 1.


The TGR5 receptor mediates bile acid-induced itch and analgesia.

Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU.

J Clin Invest. 2013 Apr;123(4):1513-30. doi: 10.1172/JCI64551. Epub 2013 Mar 25.


Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (K(Ca)2.3) in cerebral arteries.

McNeish AJ, Jimenez-Altayo F, Cottrell GS, Garland CJ.

PLoS One. 2012;7(10):e46735. doi: 10.1371/journal.pone.0046735. Epub 2012 Oct 8.


Roles of proteolysis in regulation of GPCR function.

Cottrell GS.

Br J Pharmacol. 2013 Feb;168(3):576-90. doi: 10.1111/j.1476-5381.2012.02234.x. Review.


Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries.

McNeish AJ, Roux BT, Aylett SB, Van Den Brink AM, Cottrell GS.

Br J Pharmacol. 2012 Dec;167(8):1679-90. doi: 10.1111/j.1476-5381.2012.02129.x.


Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.

Cottrell GS, Alemi F, Kirkland JG, Grady EF, Corvera CU, Bhargava A.

Peptides. 2012 Jun;35(2):202-11. doi: 10.1016/j.peptides.2012.03.020. Epub 2012 Mar 30.


Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones.

Pelayo JC, Poole DP, Steinhoff M, Cottrell GS, Bunnett NW.

J Physiol. 2011 Nov 1;589(Pt 21):5213-30. doi: 10.1113/jphysiol.2011.214452. Epub 2011 Aug 30.


Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor.

Murphy JE, Roosterman D, Cottrell GS, Padilla BE, Feld M, Brand E, Cedron WJ, Bunnett NW, Steinhoff M.

Am J Physiol Cell Physiol. 2011 Oct;301(4):C780-91. doi: 10.1152/ajpcell.00096.2011. Epub 2011 Jul 27.


Trafficking and signaling of G protein-coupled receptors in the nervous system: implications for disease and therapy.

Bunnett NW, Cottrell GS.

CNS Neurol Disord Drug Targets. 2010 Nov;9(5):539-56. Review.


Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction.

Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW.

Anesthesiology. 2010 Jun;112(6):1452-63. doi: 10.1097/ALN.0b013e3181d94e00.


Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.

Poole DP, Godfrey C, Cattaruzza F, Cottrell GS, Kirkland JG, Pelayo JC, Bunnett NW, Corvera CU.

Neurogastroenterol Motil. 2010 Jul;22(7):814-25, e227-8. doi: 10.1111/j.1365-2982.2010.01487.x. Epub 2010 Mar 12.


Endosomes: a legitimate platform for the signaling train.

Murphy JE, Padilla BE, Hasdemir B, Cottrell GS, Bunnett NW.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17615-22. doi: 10.1073/pnas.0906541106. Epub 2009 Oct 12. Review.


Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.

Hasdemir B, Murphy JE, Cottrell GS, Bunnett NW.

J Biol Chem. 2009 Oct 9;284(41):28453-66. doi: 10.1074/jbc.M109.025692. Epub 2009 Aug 14.


Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.

Amadesi S, Grant AD, Cottrell GS, Vaksman N, Poole DP, Rozengurt E, Bunnett NW.

J Comp Neurol. 2009 Sep 10;516(2):141-56. doi: 10.1002/cne.22104.


Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.

Cottrell GS, Padilla BE, Amadesi S, Poole DP, Murphy JE, Hardt M, Roosterman D, Steinhoff M, Bunnett NW.

J Biol Chem. 2009 Aug 14;284(33):22411-25. doi: 10.1074/jbc.M109.026674. Epub 2009 Jun 16.


Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation.

Cattaruzza F, Cottrell GS, Vaksman N, Bunnett NW.

Br J Pharmacol. 2009 Mar;156(5):730-9. doi: 10.1111/j.1476-5381.2008.00039.x. Epub 2009 Feb 6.


Endothelin-converting enzyme-1 degrades internalized somatostatin-14.

Roosterman D, Kempkes C, Cottrell GS, Padilla BE, Bunnett NW, Turck CW, Steinhoff M.

Endocrinology. 2008 May;149(5):2200-7. doi: 10.1210/en.2007-1628. Epub 2008 Feb 14.


Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins.

Padilla BE, Cottrell GS, Roosterman D, Pikios S, Muller L, Steinhoff M, Bunnett NW.

J Cell Biol. 2007 Dec 3;179(5):981-97. Epub 2007 Nov 26.


4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.

Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24. Epub 2007 Aug 7.


Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury.

Gazzieri D, Trevisani M, Springer J, Harrison S, Cottrell GS, Andre E, Nicoletti P, Massi D, Zecchi S, Nosi D, Santucci M, Gerard NP, Lucattelli M, Lungarella G, Fischer A, Grady EF, Bunnett NW, Geppetti P.

Free Radic Biol Med. 2007 Aug 15;43(4):581-9. Epub 2007 May 18. Erratum in: Free Radic Biol Med. 2007 Dec 15;43(12):1670.


Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.

Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW.

J Biol Chem. 2007 Sep 7;282(36):26089-100. Epub 2007 Jul 10.


Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling.

Roosterman D, Cottrell GS, Padilla BE, Muller L, Eckman CB, Bunnett NW, Steinhoff M.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11838-43. Epub 2007 Jun 25.


Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.

Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF.

Gastroenterology. 2007 Jun;132(7):2422-37. Epub 2007 Apr 13.


Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder.

Kirkland JG, Cottrell GS, Bunnett NW, Corvera CU.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G335-46. Epub 2007 Apr 12.


Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1.

Cottrell GS, Padilla B, Pikios S, Roosterman D, Steinhoff M, Grady EF, Bunnett NW.

J Biol Chem. 2007 Apr 20;282(16):12260-71. Epub 2007 Feb 19.


Agonist-induced endocytosis of rat somatostatin receptor 1.

Roosterman D, Kreuzer OJ, Brune N, Cottrell GS, Bunnett NW, Meyerhof W, Steinhoff M.

Endocrinology. 2007 Mar;148(3):1050-8. Epub 2006 Dec 14.


Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.

Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW.

J Physiol. 2007 Feb 1;578(Pt 3):715-33. Epub 2006 Nov 23.


Proteinase-activated receptors, targets for kallikrein signaling.

Oikonomopoulou K, Hansen KK, Saifeddine M, Tea I, Blaber M, Blaber SI, Scarisbrick I, Andrade-Gordon P, Cottrell GS, Bunnett NW, Diamandis EP, Hollenberg MD.

J Biol Chem. 2006 Oct 27;281(43):32095-112. Epub 2006 Aug 2.


Ubiquitin-dependent down-regulation of the neurokinin-1 receptor.

Cottrell GS, Padilla B, Pikios S, Roosterman D, Steinhoff M, Gehringer D, Grady EF, Bunnett NW.

J Biol Chem. 2006 Sep 22;281(38):27773-83. Epub 2006 Jul 17.


Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.

Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW.

J Physiol. 2006 Sep 1;575(Pt 2):555-71. Epub 2006 Jun 22.


Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat.

Cottrell GS, Roosterman D, Marvizon JC, Song B, Wick E, Pikios S, Wong H, Berthelier C, Tang Y, Sternini C, Bunnett NW, Grady EF.

J Comp Neurol. 2005 Sep 26;490(3):239-55.


Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.

Jacob C, Yang PC, Darmoul D, Amadesi S, Saito T, Cottrell GS, Coelho AM, Singh P, Grady EF, Perdue M, Bunnett NW.

J Biol Chem. 2005 Sep 9;280(36):31936-48. Epub 2005 Jul 18.


c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2.

Jacob C, Cottrell GS, Gehringer D, Schmidlin F, Grady EF, Bunnett NW.

J Biol Chem. 2005 Apr 22;280(16):16076-87. Epub 2005 Feb 11.


Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells.

Dulon S, Leduc D, Cottrell GS, D'Alayer J, Hansen KK, Bunnett NW, Hollenberg MD, Pidard D, Chignard M.

Am J Respir Cell Mol Biol. 2005 May;32(5):411-9. Epub 2005 Feb 10.


Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW.

J Neurosci. 2004 May 5;24(18):4300-12.


Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases.

Roosterman D, Cottrell GS, Schmidlin F, Steinhoff M, Bunnett NW.

J Biol Chem. 2004 Jul 16;279(29):30670-9. Epub 2004 May 5.


Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.

Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM, Corinaldesi R.

Gastroenterology. 2004 Mar;126(3):693-702.


Supplemental Content

Loading ...
Support Center