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Should efavirenz be used in children and, if so, how?

Cotton MF, Laughton B, Rabie H.

Lancet HIV. 2019 Feb 12. pii: S2352-3018(18)30337-0. doi: 10.1016/S2352-3018(18)30337-0. [Epub ahead of print] No abstract available.


Operating Room Attire.

Cotton M.

J Am Coll Surg. 2019 Feb;228(2):209-210. doi: 10.1016/j.jamcollsurg.2018.11.001. No abstract available.


A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation.

Violari A, Cotton MF, Kuhn L, Schramm DB, Paximadis M, Loubser S, Shalekoff S, Da Costa Dias B, Otwombe K, Liberty A, McIntyre J, Babiker A, Gibb D, Tiemessen CT.

Nat Commun. 2019 Jan 24;10(1):412. doi: 10.1038/s41467-019-08311-0.


HIV exposed uninfected infants: surviving and thriving or overlooked by success?

Slogrove AL, Powis KM, Cotton MF.

Clin Infect Dis. 2018 Dec 11. doi: 10.1093/cid/ciy1056. [Epub ahead of print] No abstract available.


Lopinavir-ritonavir super-boosting in young HIV-infected children on rifampicin-based tuberculosis therapy compared with lopinavir-ritonavir without rifampicin: a pharmacokinetic modelling and clinical study.

Rabie H, Denti P, Lee J, Masango M, Coovadia A, Pillay S, Liberty A, Simon F, McIlleron H, Cotton MF, Lallemant M.

Lancet HIV. 2018 Dec 6. pii: S2352-3018(18)30293-5. doi: 10.1016/S2352-3018(18)30293-5. [Epub ahead of print]


Conversation on the Ebola outbreak in Sierra Leone with Sinead Walsh and Oliver Johnson.

Cotton M.

Trop Doct. 2018 Oct;48(4):259-260. doi: 10.1177/0049475518807006. No abstract available.


Measles immunity at 4.5 years of age following vaccination at 9 and 15-18 months of age among HIV-infected, HIV-exposed-uninfected and HIV-unexposed children.

Mutsaerts EAML, Nunes MC, van Rijswijk MN, Klipstein-Grobusch K, Otwombe K, Cotton MF, Violari A, Madhi SA.

Clin Infect Dis. 2018 Nov 12. doi: 10.1093/cid/ciy964. [Epub ahead of print]


Effect of HIV exposure and timing of antiretroviral therapy initiation on immune memory responses to diphtheria, tetanus, whole cell pertussis and hepatitis B vaccines.

Simani OE, Izu A, Nunes MC, Violari A, Cotton MF, Van Niekerk N, Adrian PV, Madhi SA.

Expert Rev Vaccines. 2018 Nov 10:1-10. doi: 10.1080/14760584.2019.1547195. [Epub ahead of print]


Vancomycin-resistant Enterococcus faecium Empyema in an Asplenic Patient.

Cotton MJ, Packer CD.

Cureus. 2018 Aug 29;10(8):e3227. doi: 10.7759/cureus.3227.


Considerations in evaluating infectious morbidity and mortality in HIV-exposed uninfected infants.

Slogrove AL, Powis KM, Bettinger JA, Cotton MF.

AIDS. 2018 Nov 28;32(18):2855-2856. doi: 10.1097/QAD.0000000000002049. No abstract available.


'Of Mice and Dementia': A filmed conversation on the use of animals in dementia research.

Tamagnini F, Cotton M, Goodall O, Harrison G, Jeynes C, Palombo F, Tomkow J, Tomkow T, Wedgwood K, Welsman J.

Dementia (London). 2018 Nov;17(8):1055-1063. doi: 10.1177/1471301218789560.


Diagnostic accuracy of the Molteno Adapted Scale for developmental delay in South African toddlers.

Honeth I, Laughton B, Springer PE, Cotton MF, Pretorius C.

Paediatr Int Child Health. 2018 Oct 17:1-7. doi: 10.1080/20469047.2018.1528754. [Epub ahead of print]


Strong sex bias in elite control of paediatric HIV infection.

Vieira VA, Zuidewind P, Muenchhoff M, Roider J, Millar J, Clapson M, Van Zyl A, Shingadia D, Adland E, Athavale R, Grayson N, Ansari MA, Brander C, Guash CF, Naver L, Puthanakit T, Songtaweesin WN, Ananworanich J, Peluso D, Thomé B, Pinto J, Jooste P, Tudor-Williams G, Cotton MF, Goulder P.

AIDS. 2019 Jan 27;33(1):67-75. doi: 10.1097/QAD.0000000000002043.


Naive B Cell Output in HIV-Infected and HIV-Uninfected Children.

Payne H, Chain G, Adams S, Hunter P, Luckhurst N, Gilmour K, Lewis J, Babiker A, Cotton M, Violari A, Gibb D, Callard R, Klein N.

AIDS Res Hum Retroviruses. 2019 Jan;35(1):33-39. doi: 10.1089/AID.2018.0170. Epub 2018 Dec 26.


Prevalence of risk factors for chronic kidney disease in South African youth with perinatally acquired HIV.

Frigati L, Mahtab S, Nourse P, Ray P, Perrazzo S, Machemedze T, Agyei NA, Cotton M, Myer L, Zar H.

Pediatr Nephrol. 2019 Feb;34(2):313-318. doi: 10.1007/s00467-018-4080-6. Epub 2018 Sep 15.


Insulin Resistance in South African Youth Living with Perinatally Acquired HIV Receiving Antiretroviral Therapy.

Frigati LJ, Jao J, Mahtab S, Asafu Agyei NA, Cotton MF, Myer L, Zar HJ.

AIDS Res Hum Retroviruses. 2019 Jan;35(1):56-62. doi: 10.1089/AID.2018.0092. Epub 2018 Sep 25.


Output from the CIHR Canadian HIV Trials Network international postdoctoral fellowship for capacity building in HIV clinical trials.

Mbuagbaw L, Slogrove AL, Sas J, Lengwe Kunda J, Morfaw F, Mukonzo JK, Cao W, Ngomba-Kadima G, Zunza M, Ongolo-Zogo P, Nana PN, Cockcroft A, Andersson N, Sewankambo N, Cotton MF, Li T, Young T, Singer J, Routy JP, Ross CJ, Thin K, Thabane L, Anis AH.

HIV AIDS (Auckl). 2018 Aug 16;10:151-155. doi: 10.2147/HIV.S150107. eCollection 2018.


Can We Improve Stavudine's Safety Profile in Children? Pharmacokinetics of Intracellular Stavudine Triphosphate with Reduced Dosing.

Innes S, van der Laan L, Anderson PL, Cotton M, Denti P.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e00761-18. doi: 10.1128/AAC.00761-18. Print 2018 Nov.


A treatment-support intervention evaluated in South African paediatric populations with HIV infection or tuberculous meningitis.

van Elsland SL, Peters RPH, Kok MO, van Toorn R, Springer P, Cotton MF, Grobbelaar CJ, Aarnoutse R, van Furth AM.

Trop Med Int Health. 2018 Oct;23(10):1129-1140. doi: 10.1111/tmi.13134. Epub 2018 Sep 3.


What Should we do When HIV-Positive Children Fail First-Line Combination Antiretroviral Therapy? A Comparison of 4 ART Management Strategies.

Patten G, Schomaker M, Davies MA, Rabie H, van Zyl G, Technau K, Eley B, Boulle A, Van Dyke RB, Patel K, Sipambo N, Wood R, Tanser F, Giddy J, Cotton M, Nuttall J, Essack G, Karalius B, Seage G lll, Sawry S, Egger M, Fairlie L; for IeDEA Southern Africa.

Pediatr Infect Dis J. 2018 Jul 31. doi: 10.1097/INF.0000000000002156. [Epub ahead of print]


Paediatric ART Adherence in South Africa: A Comprehensive Analysis.

van Elsland SL, Peters RPH, Grobbelaar N, Ketelo P, Kok MO, Cotton MF, van Furth AM.

AIDS Behav. 2019 Feb;23(2):475-488. doi: 10.1007/s10461-018-2235-x.


Rampant infection & multi-resistance.

Cotton M.

Trop Doct. 2018 Jul;48(3):177-178. doi: 10.1177/0049475518782587. No abstract available.


Early Breastfeeding Cessation Among HIV-Infected and HIV-Uninfected Women in Western Cape Province, South Africa.

Zunza M, Esser M, Slogrove A, Bettinger JA, Machekano R, Cotton MF; Mother-Infant Health Study (MIHS) Project Steering Committee.

AIDS Behav. 2018 Jul;22(Suppl 1):114-120. doi: 10.1007/s10461-018-2208-0.


Loss of intraoperative neurological monitoring signals during flexed prone positioning on a hinged open frame during surgery for kyphoscoliosis correction: case report.

Graham RB, Cotton M, Koht A, Koski TR.

J Neurosurg Spine. 2018 Sep;29(3):339-343. doi: 10.3171/2018.1.SPINE17811. Epub 2018 Jun 22.


Perinatal HIV Infection or Exposure Is Associated With Low N-Acetylaspartate and Glutamate in Basal Ganglia at Age 9 but Not 7 Years.

Robertson FC, Holmes MJ, Cotton MF, Dobbels E, Little F, Laughton B, van der Kouwe AJW, Meintjes EM.

Front Hum Neurosci. 2018 May 7;12:145. doi: 10.3389/fnhum.2018.00145. eCollection 2018.


Five year neurodevelopment outcomes of perinatally HIV-infected children on early limited or deferred continuous antiretroviral therapy.

Laughton B, Cornell M, Kidd M, Springer PE, Dobbels EFM, Rensburg AJV, Otwombe K, Babiker A, Gibb DM, Violari A, Kruger M, Cotton MF.

J Int AIDS Soc. 2018 May;21(5):e25106. doi: 10.1002/jia2.25106.


Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial.

Chabala C, Turkova A, Thomason MJ, Wobudeya E, Hissar S, Mave V, van der Zalm M, Palmer M, Kapasa M, Bhavani PK, Balaji S, Raichur PA, Demers AM, Hoddinott G, Owen-Powell E, Kinikar A, Musoke P, Mulenga V, Aarnoutse R, McIlleron H, Hesseling A, Crook AM, Cotton M, Gibb DM; SHINE trial team.

Trials. 2018 Apr 19;19(1):237. doi: 10.1186/s13063-018-2608-5.


Lipoatrophy/lipohypertrophy outcomes after antiretroviral therapy switch in children in the UK/Ireland.

Innes S, Harvey J, Collins IJ, Cotton MF, Judd A.

PLoS One. 2018 Apr 4;13(4):e0194132. doi: 10.1371/journal.pone.0194132. eCollection 2018.


High Incidence of Tuberculosis Infection in HIV-exposed Children Exiting an Isoniazid Preventive Therapy Trial.

Cranmer LM, Draper HR, Mandalakas AM, Kim S, McSherry G, Krezinski E, Coetzee J, Mitchell C, Nachman S, van der Linde M, Cotton MF, Hesseling AC; IMPAACT P1041 Team.

Pediatr Infect Dis J. 2018 Oct;37(10):e254-e256. doi: 10.1097/INF.0000000000001946.


Favourable outcome in a child with symptomatic diagnosis of Glutaric aciduria type 1 despite vertical HIV infection and minor head trauma.

Thomas A, Dobbels EFM, Springer PE, Ackermann C, Cotton MF, Laughton B.

Metab Brain Dis. 2018 Apr;33(2):537-544. doi: 10.1007/s11011-018-0196-4. Epub 2018 Feb 9.


Functional Connectivity Alterations between Networks and Associations with Infant Immune Health within Networks in HIV Infected Children on Early Treatment: A Study at 7 Years.

Toich JTF, Taylor PA, Holmes MJ, Gohel S, Cotton MF, Dobbels E, Laughton B, Little F, van der Kouwe AJW, Biswal B, Meintjes EM.

Front Hum Neurosci. 2018 Jan 11;11:635. doi: 10.3389/fnhum.2017.00635. eCollection 2017.


Factors influencing access of pregnant women and their infants to their local healthcare system: a prospective, multi-centre, observational study.

Madhi SA, Rivera LM, Sáez-Llorens X, Menéndez C, Carrim-Ganey N, Cotton MF, Katzman D, Luttig MM, Candelario R, Baker S, Roychoudhury M.

BMC Pregnancy Childbirth. 2018 Jan 15;18(1):29. doi: 10.1186/s12884-017-1655-3.


Rapid decline of HIV-1 DNA and RNA in infants starting very early antiretroviral therapy may pose a diagnostic challenge.

Veldsman KA, Maritz J, Isaacs S, Katusiime MG, Janse van Rensburg A, Laughton B, Mellors JW, Cotton MF, van Zyl GU.

AIDS. 2018 Mar 13;32(5):629-634. doi: 10.1097/QAD.0000000000001739.


Altered brain morphometry in 7-year old HIV-infected children on early ART.

Nwosu EC, Robertson FC, Holmes MJ, Cotton MF, Dobbels E, Little F, Laughton B, van der Kouwe A, Meintjes EM.

Metab Brain Dis. 2018 Apr;33(2):523-535. doi: 10.1007/s11011-017-0162-6. Epub 2017 Dec 5.


Safety and Efficacy of Atazanavir Powder and Ritonavir in HIV-1-Infected Infants and Children From 3 Months to <11 Years of Age: The PRINCE-2 Study.

Cotton MF, Liberty A, Torres-Escobar I, Gonzalez-Tome MI, Lissens J, Zaru L, Klauck I, Cambilargiu D, Pikora C, Correll TA.

Pediatr Infect Dis J. 2018 Jun;37(6):e149-e156. doi: 10.1097/INF.0000000000001856.


Update on trends in childhood tuberculosis.

Fry S, Barnabas S, Cotton MF.

Curr Opin Pediatr. 2018 Feb;30(1):152-160. doi: 10.1097/MOP.0000000000000581. Review.


Larger Subcortical Gray Matter Structures and Smaller Corpora Callosa at Age 5 Years in HIV Infected Children on Early ART.

Randall SR, Warton CMR, Holmes MJ, Cotton MF, Laughton B, van der Kouwe AJW, Meintjes EM.

Front Neuroanat. 2017 Nov 2;11:95. doi: 10.3389/fnana.2017.00095. eCollection 2017.


Use of Multiplex Quantitative PCR To Evaluate the Impact of Pneumococcal Conjugate Vaccine on Nasopharyngeal Pneumococcal Colonization in African Children.

Olwagen CP, Adrian PV, Nunes MC, Groome MJ, Cotton MF, Violari A, Madhi SA.

mSphere. 2017 Nov 8;2(6). pii: e00404-17. doi: 10.1128/mSphere.00404-17. eCollection 2017 Nov-Dec.


Neuropsychological performance in African children with HIV enrolled in a multisite antiretroviral clinical trial.

Boivin MJ, Barlow-Mosha L, Chernoff MC, Laughton B, Zimmer B, Joyce C, Bwakura-Dangarembizi M, Ratswana M, Abrahams N, Fairlie L, Gous H, Kamthunzi P, McCarthy K, Familiar-Lopez I, Jean-Phillippe P, Coetzee J, Violari A, Cotton MC, Palumbo PE; IMPAACT P1104s Study Team.

AIDS. 2018 Jan 14;32(2):189-204. doi: 10.1097/QAD.0000000000001683.


White Matter Abnormalities in Children with HIV Infection and Exposure.

Jankiewicz M, Holmes MJ, Taylor PA, Cotton MF, Laughton B, van der Kouwe AJW, Meintjes EM.

Front Neuroanat. 2017 Sep 29;11:88. doi: 10.3389/fnana.2017.00088. eCollection 2017.


Thymic Output and CD4 T-Cell Reconstitution in HIV-Infected Children on Early and Interrupted Antiretroviral Treatment: Evidence from the Children with HIV Early Antiretroviral Therapy Trial.

Lewis J, Payne H, Walker AS, Otwombe K, Gibb DM, Babiker AG, Panchia R, Cotton MF, Violari A, Klein N, Callard RE.

Front Immunol. 2017 Sep 20;8:1162. doi: 10.3389/fimmu.2017.01162. eCollection 2017.


The Recombinant Bacille Calmette-Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing.

Nieuwenhuizen NE, Kulkarni PS, Shaligram U, Cotton MF, Rentsch CA, Eisele B, Grode L, Kaufmann SHE.

Front Immunol. 2017 Sep 19;8:1147. doi: 10.3389/fimmu.2017.01147. eCollection 2017. Review.


Trauma care in the districts.

Cotton M.

Trop Doct. 2017 Oct;47(4):285. doi: 10.1177/0049475517732434. No abstract available.


Interpretation of indeterminate HIV-1 PCR results are influenced by changing vertical transmission prevention regimens.

Maritz J, Maharaj JN, Cotton MF, Preiser W.

J Clin Virol. 2017 Oct;95:86-89. doi: 10.1016/j.jcv.2017.08.013.


No evidence of HIV replication in children on antiretroviral therapy.

Van Zyl GU, Katusiime MG, Wiegand A, McManus WR, Bale MJ, Halvas EK, Luke B, Boltz VF, Spindler J, Laughton B, Engelbrecht S, Coffin JM, Cotton MF, Shao W, Mellors JW, Kearney MF.

J Clin Invest. 2017 Oct 2;127(10):3827-3834. doi: 10.1172/JCI94582. Epub 2017 Sep 11.


Isoniazid for preventing tuberculosis in HIV-infected children.

Zunza M, Gray DM, Young T, Cotton M, Zar HJ.

Cochrane Database Syst Rev. 2017 Aug 29;8:CD006418. doi: 10.1002/14651858.CD006418.pub3. Review.


A27 Using whole genome sequence data and minority variant profiles to elucidate transmission patterns during RSV household outbreaks.

Githinji G, Agoti C, Munywoki P, Bett A, Kellam P, Cotton M, Nokes DJ.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.026. doi: 10.1093/ve/vew036.026. eCollection 2017 Mar. No abstract available.


A26 Transmission patterns and evolution of RSV in a community outbreak identified by genomic analysis.

Agoti CN, Munywoki PK, Phan MVT, Otieno JR, Kamau E, Bett A, Kombe I, Githinji G, Medley GF, Cane PA, Kellam P, Cotton M, Nokes DJ.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.025. doi: 10.1093/ve/vew036.025. eCollection 2017 Mar. No abstract available.


[Cutaneous surgery myths and traditions in the Emergency Department].

Henry B, Cotton M, Della Santa V.

Rev Med Suisse. 2017 Aug 9;13(570):1381-1384. French.


Conservative treatment versus surgery for uncomplicated appendicitis in children: a systematic review and meta-analysis.

Kessler U, Mosbahi S, Walker B, Hau EM, Cotton M, Peiry B, Berger S, Egger B.

Arch Dis Child. 2017 Dec;102(12):1118-1124. doi: 10.1136/archdischild-2017-313127. Epub 2017 Aug 17. Review.


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