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Digital Lung Auscultation: Will Early Diagnosis of Fibrotic Interstitial Lung Disease Become a Reality?

Richeldi L, Cottin V, Würtemberger G, Kreuter M, Calvello M, Sgalla G.

Am J Respir Crit Care Med. 2019 May 31. doi: 10.1164/rccm.201902-0306LE. [Epub ahead of print] No abstract available.


Lung Diseases in Inflammatory Myopathies.

Barba T, Mainbourg S, Nasser M, Lega JC, Cottin V.

Semin Respir Crit Care Med. 2019 Apr;40(2):255-270. doi: 10.1055/s-0039-1685187. Epub 2019 May 28.


The Ariane-IPF ERS Clinical Research Collaboration: seeking collaboration through launch of a federation of European registries on idiopathic pulmonary fibrosis.

Cottin V, Annesi-Maesano I, Günther A, Galvin L, Kreuter M, Powell P, Prasse A, Reynolds G, Richeldi L, Spagnolo P, Valenzuela C, Wijsenbeek M, Wuyts WA, Crestani B; Ariane-IPF Clinical Research Collaboration consortium.

Eur Respir J. 2019 May 23;53(5). pii: 1900539. doi: 10.1183/13993003.00539-2019. Print 2019 May. No abstract available.


Non-severe eosinophilic granulomatosis with polyangiitis: long-term outcomes after remission-induction trial.

Puéchal X, Pagnoux C, Baron G, Lifermann F, Geffray L, Quémeneur T, Saraux JL, Wislez M, Cottin V, Ruivard M, Limal N, Aouba A, Bonnotte B, Néel A, Agard C, Cohen P, Terrier B, Le Jeunne C, Mouthon L, Ravaud P, Guillevin L; French Vasculitis Study Group investigators .

Rheumatology (Oxford). 2019 May 5. pii: kez139. doi: 10.1093/rheumatology/kez139. [Epub ahead of print]


Association of Angiotensin Modulators With the Course of Idiopathic Pulmonary Fibrosis.

Kreuter M, Lederer DJ, Molina-Molina M, Noth I, Valenzuela C, Frankenstein L, Weycker D, Atwood M, Kirchgaessler KU, Cottin V.

Chest. 2019 Apr 29. pii: S0012-3692(19)30882-7. doi: 10.1016/j.chest.2019.04.015. [Epub ahead of print]


A step-wise approach for establishing a multidisciplinary team for the management of tuberous sclerosis complex: a Delphi consensus report.

Auvin S, Bissler JJ, Cottin V, Fujimoto A, Hofbauer GFL, Jansen AC, Jóźwiak S, Kerecuk L, Kingswood JC, Moavero R, Torra R, Villanueva V.

Orphanet J Rare Dis. 2019 Apr 30;14(1):91. doi: 10.1186/s13023-019-1072-y.


Exome sequencing and pathogenicity-network analysis of 5 French families implicate mTOR signalling and autophagy in familial sarcoidosis.

Calender A, Lim CX, Weichhart T, Buisson A, Besnard V, Rollat-Farnier PA, Bardel C, Roy P, Cottin V, Devouassoux G, Finat A, Pinson S, Lebecque S, Nunes H, Israel-Biet D, Bentaher A, Valeyre D, Pacheco Y; in the frame of GSF (Group Sarcoidosis France).

Eur Respir J. 2019 Apr 25. pii: 1900430. doi: 10.1183/13993003.00430-2019. [Epub ahead of print] No abstract available.


Identifying chronic thromboembolic pulmonary hypertension through the French national hospital discharge database.

Cottin V, Avot D, Lévy-Bachelot L, Baxter CA, Ramey DR, Catella L, Bénard S, Sitbon O, Teal S.

PLoS One. 2019 Apr 18;14(4):e0214649. doi: 10.1371/journal.pone.0214649. eCollection 2019.


Study protocol: exploring the efficacy of cyclophosphamide added to corticosteroids for treating acute exacerbation of idiopathic pulmonary fibrosis; a randomized double-blind, placebo-controlled, multi-center phase III trial (EXAFIP).

Naccache JM, Montil M, Cadranel J, Cachanado M, Cottin V, Crestani B, Valeyre D, Wallaert B, Simon T, Nunes H.

BMC Pulm Med. 2019 Apr 11;19(1):75. doi: 10.1186/s12890-019-0830-x.


A 2-Year Observational Study in Patients Suffering from Idiopathic Pulmonary Fibrosis and Treated with Pirfenidone: A French Ancillary Study of PASSPORT.

Jouneau S, Gamez AS, Traclet J, Nunes H, Marchand-Adam S, Kessler R, Israël-Biet D, Borie R, Strombom I, Scalori A, Crestani B, Valeyre D, Cottin V.

Respiration. 2019 Apr 9:1-10. doi: 10.1159/000496735. [Epub ahead of print]


Cancer incidence in patients with pre-capillary pulmonary hypertension.

Bravos E, Cottin V, Dauphin C, Bouvaist H, Traclet J, Trésorier R, Margelidon-Cozzolino V, Bezzeghoud S, Ahmad K, Accassat S, De Magalhaes E, Mornex JF, Pison C, Bertoletti L.

J Heart Lung Transplant. 2019 Mar 15. pii: S1053-2498(19)31430-5. doi: 10.1016/j.healun.2019.03.007. [Epub ahead of print] No abstract available.


A Rare Case of an Abdominal Aneurysm in a Patient with Lymphangioleiomyomatosis: A Case Report.

Chérrez-Ojeda I, Espinoza-Plaza J, Cottin V, Chérrez S.

Perm J. 2019;23. pii: 18-170. doi: 10.7812/TPP/18-170.


Orbital mass in ANCA-associated vasculitides: data on clinical, biological, radiological and histological presentation, therapeutic management, and outcome from 59 patients.

Durel CA, Hot A, Trefond L, Aumaitre O, Pugnet G, Samson M, Abad S, Belot A, Blanchard-Delaunay C, Cohen P, Cohen-Aubard F, Cottin V, Crestani B, Moreuil C, Durupt S, Garzaro M, Girszyn N, Godeau B, Hachulla E, Jamilloux Y, Jego P, Killian M, Lazaro E, Le Gallou T, Liozon E, Martin T, Papo T, Perlat A, Pillet P, Guillevin L, Terrier B; French Vasculitis Study Group (FVSG).

Rheumatology (Oxford). 2019 Mar 18. pii: kez071. doi: 10.1093/rheumatology/kez071. [Epub ahead of print]


Molecular endpoints for establishing target engagement by novel idiopathic pulmonary fibrosis therapies.

Wolters PJ, Cottin V.

Eur Respir J. 2019 Mar 18;53(3). pii: 1900283. doi: 10.1183/13993003.00283-2019. Print 2019 Mar. No abstract available.


Pulmonary fibrosis: "idiopathic" is not "cryptogenic".

Cottin V.

Eur Respir J. 2019 Mar 18;53(3). pii: 1802314. doi: 10.1183/13993003.02314-2018. Print 2019 Mar. No abstract available.


Epilepsy in tuberous sclerosis complex: Findings from the TOSCA Study.

Nabbout R, Belousova E, Benedik MP, Carter T, Cottin V, Curatolo P, Dahlin M, D Amato L, d'Augères GB, de Vries PJ, Ferreira JC, Feucht M, Fladrowski C, Hertzberg C, Jozwiak S, Lawson JA, Macaya A, Marques R, O'Callaghan F, Qin J, Sander V, Sauter M, Shah S, Takahashi Y, Touraine R, Youroukos S, Zonnenberg B, Jansen A, Kingswood JC; TOSCA Consortium and TOSCA Investigators.

Epilepsia Open. 2018 Dec 21;4(1):73-84. doi: 10.1002/epi4.12286. eCollection 2019 Mar.


Pulmonary alveolar proteinosis.

Trapnell BC, Nakata K, Bonella F, Campo I, Griese M, Hamilton J, Wang T, Morgan C, Cottin V, McCarthy C.

Nat Rev Dis Primers. 2019 Mar 7;5(1):16. doi: 10.1038/s41572-019-0066-3. Review.


Fibrosing interstitial lung diseases: knowns and unknowns.

Cottin V, Wollin L, Fischer A, Quaresma M, Stowasser S, Harari S.

Eur Respir Rev. 2019 Feb 27;28(151). pii: 180100. doi: 10.1183/16000617.0100-2018. Print 2019 Mar 31. Review.


Lung function outcomes in the INPULSIS® trials of nintedanib in idiopathic pulmonary fibrosis.

Brown KK, Flaherty KR, Cottin V, Raghu G, Inoue Y, Azuma A, Huggins JT, Richeldi L, Stowasser S, Stansen W, Schlenker-Herceg R, Maher TM, Wells AU.

Respir Med. 2019 Jan;146:42-48. doi: 10.1016/j.rmed.2018.11.012. Epub 2018 Nov 19.


Interstitial lung disease associated with systemic sclerosis (SSc-ILD).

Cottin V, Brown KK.

Respir Res. 2019 Jan 18;20(1):13. doi: 10.1186/s12931-019-0980-7. Review.


Therapeutic effects of nintedanib are not influenced by emphysema in the INPULSIS trials.

Cottin V, Azuma A, Raghu G, Stansen W, Stowasser S, Schlenker-Herceg R, Kolb M.

Eur Respir J. 2019 Apr 18;53(4). pii: 1801655. doi: 10.1183/13993003.01655-2018. Print 2019 Apr. No abstract available.


Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland Connective Tissue Disease-Associated Interstitial Lung Disease Summit: A Multidisciplinary Approach to Address Challenges and Opportunities.

Fischer A, Strek ME, Cottin V, Dellaripa PF, Bernstein EJ, Brown KK, Danoff SK, Distler O, Hirani N, Jones KD, Khanna D, Lee JS, Lynch DA, Maher TM, Millar AB, Raghu G, Silver RM, Steen VD, Volkmann ER, Mullan RH, O'Dwyer DN, Donnelly SC.

QJM. 2019 Feb 1;112(2):81-93. doi: 10.1093/qjmed/hcy272. No abstract available.


Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland Connective Tissue Disease-Associated Interstitial Lung Disease Summit: A Multidisciplinary Approach to Address Challenges and Opportunities.

Fischer A, Strek ME, Cottin V, Dellaripa PF, Bernstein EJ, Brown KK, Danoff SK, Distler O, Hirani N, Jones KD, Khanna D, Lee JS, Lynch DA, Maher TM, Millar AB, Raghu G, Silver RM, Steen VD, Volkmann ER, Mullan RH, O'Dwyer DN, Donnelly SC.

Arthritis Rheumatol. 2019 Feb;71(2):182-195. doi: 10.1002/art.40769. Epub 2019 Jan 3. No abstract available.


Widening the landscape of heritable pulmonary hypertension mutations in paediatric and adult cases.

Eyries M, Montani D, Nadaud S, Girerd B, Levy M, Bourdin A, Trésorier R, Chaouat A, Cottin V, Sanfiorenzo C, Prevot G, Reynaud-Gaubert M, Dromer C, Houeijeh A, Nguyen K, Coulet F, Bonnet D, Humbert M, Soubrier F.

Eur Respir J. 2019 Mar 14;53(3). pii: 1801371. doi: 10.1183/13993003.01371-2018. Print 2019 Mar.


Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases.

Cottin V, Hirani NA, Hotchkin DL, Nambiar AM, Ogura T, Otaola M, Skowasch D, Park JS, Poonyagariyagorn HK, Wuyts W, Wells AU.

Eur Respir Rev. 2018 Dec 21;27(150). pii: 180076. doi: 10.1183/16000617.0076-2018. Print 2018 Dec 31. Review.


Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis.

Barba T, Fort R, Cottin V, Provencher S, Durieu I, Jardel S, Hot A, Reynaud Q, Lega JC.

Autoimmun Rev. 2019 Feb;18(2):113-122. doi: 10.1016/j.autrev.2018.07.013. Epub 2018 Dec 17.


Targeting interleukin-13 in idiopathic pulmonary fibrosis: from promising path to dead end.

Wijsenbeek MS, Kool M, Cottin V.

Eur Respir J. 2018 Dec 13;52(6). pii: 1802111. doi: 10.1183/13993003.02111-2018. Print 2018 Dec. No abstract available.


Air travel and incidence of pneumothorax in lymphangioleiomyomatosis.

Gonano C, Pasquier J, Daccord C, Johnson SR, Harari S, Leclerc V, Falconer L, Miano E, Cordier JF, Cottin V, Lazor R.

Orphanet J Rare Dis. 2018 Dec 13;13(1):222. doi: 10.1186/s13023-018-0964-6.


Regulator of telomere length 1 (RTEL1) mutations are associated with heterogeneous pulmonary and extra-pulmonary phenotypes.

Borie R, Bouvry D, Cottin V, Gauvain C, Cazes A, Debray MP, Cadranel J, Dieude P, Degot T, Dominique S, Gamez AS, Jaillet M, Juge PA, Londono-Vallejo A, Mailleux A, Mal H, Boileau C, Menard C, Nunes H, Prevot G, Quetant S, Revy P, Traclet J, Wemeau-Stervinou L, Wislez M, Kannengiesser C, Crestani B.

Eur Respir J. 2019 Feb 7;53(2). pii: 1800508. doi: 10.1183/13993003.00508-2018. Print 2019 Feb.


Impact of comorbidities and delay in diagnosis in elderly patients with pulmonary hypertension.

Ginoux M, Turquier S, Chebib N, Glerant JC, Traclet J, Philit F, Sénéchal A, Mornex JF, Cottin V.

ERJ Open Res. 2018 Nov 28;4(4). pii: 00100-2018. doi: 10.1183/23120541.00100-2018. eCollection 2018 Oct.


[Etiological diagnosis of pulmonary hypertension: A cause of difficult diagnosis].

Rigaud P, Traclet J, Cottin V.

Rev Mal Respir. 2019 Mar;36(3):350-354. doi: 10.1016/j.rmr.2018.11.004. Epub 2018 Nov 22. French.


Combined pulmonary fibrosis and emphysema in systemic sclerosis: A syndrome associated with heavy morbidity and mortality.

Champtiaux N, Cottin V, Chassagnon G, Chaigne B, Valeyre D, Nunes H, Hachulla E, Launay D, Crestani B, Cazalets C, Jego P, Bussone G, Bérezné A, Guillevin L, Revel MP, Cordier JF, Mouthon L; Groupe d'Etudes et de Recherche sur les Maladies « Orphelines » pulmonaires (GERM«O»P).

Semin Arthritis Rheum. 2018 Oct 13. pii: S0049-0172(17)30511-5. doi: 10.1016/j.semarthrit.2018.10.011. [Epub ahead of print]


Alveolar Hemorrhage in Vasculitis (Primary and Secondary).

Nasser M, Cottin V.

Semin Respir Crit Care Med. 2018 Aug;39(4):482-493. doi: 10.1055/s-0038-1668533. Epub 2018 Nov 7. Review.


12q13.12q13.13 microdeletion encompassing ACVRL1 and SCN8A genes: Clinical report of a new contiguous gene syndrome.

Poisson A, Lesca G, Chatron N, Favre E, Cottin V, Gamondes D, Sanlaville D, Edery P, Giraud S, Demily C, Dupuis-Girod S.

Eur J Med Genet. 2018 Oct 30. pii: S1769-7212(18)30557-3. doi: 10.1016/j.ejmg.2018.10.017. [Epub ahead of print]


Long-term safety of pirfenidone: results of the prospective, observational PASSPORT study.

Cottin V, Koschel D, Günther A, Albera C, Azuma A, Sköld CM, Tomassetti S, Hormel P, Stauffer JL, Strombom I, Kirchgaessler KU, Maher TM.

ERJ Open Res. 2018 Oct 19;4(4). pii: 00084-2018. doi: 10.1183/23120541.00084-2018. eCollection 2018 Oct.


MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease.

Juge PA, Lee JS, Ebstein E, Furukawa H, Dobrinskikh E, Gazal S, Kannengiesser C, Ottaviani S, Oka S, Tohma S, Tsuchiya N, Rojas-Serrano J, González-Pérez MI, Mejía M, Buendía-Roldán I, Falfán-Valencia R, Ambrocio-Ortiz E, Manali E, Papiris SA, Karageorgas T, Boumpas D, Antoniou K, van Moorsel CHM, van der Vis J, de Man YA, Grutters JC, Wang Y, Borie R, Wemeau-Stervinou L, Wallaert B, Flipo RM, Nunes H, Valeyre D, Saidenberg-Kermanac'h N, Boissier MC, Marchand-Adam S, Frazier A, Richette P, Allanore Y, Sibilia J, Dromer C, Richez C, Schaeverbeke T, Lioté H, Thabut G, Nathan N, Amselem S, Soubrier M, Cottin V, Clément A, Deane K, Walts AD, Fingerlin T, Fischer A, Ryu JH, Matteson EL, Niewold TB, Assayag D, Gross A, Wolters P, Schwarz MI, Holers M, Solomon JJ, Doyle T, Rosas IO, Blauwendraat C, Nalls MA, Debray MP, Boileau C, Crestani B, Schwartz DA, Dieudé P.

N Engl J Med. 2018 Dec 6;379(23):2209-2219. doi: 10.1056/NEJMoa1801562. Epub 2018 Oct 20.


Lung Biopsy in Interstitial Lung Diseases: There Is More than One Way to Cook an Egg.

Nasser M, Cottin V.

Respiration. 2018;96(5):403-405. doi: 10.1159/000493157. Epub 2018 Oct 9. No abstract available.


Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration.

Chebib N, Archer F, Bobet-Erny A, Leroux C, Cottin V.

Sci Rep. 2018 Oct 2;8(1):14698. doi: 10.1038/s41598-018-32795-3.


Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: design of a double-blind, randomised, placebo-controlled phase II trial.

Maher TM, Corte TJ, Fischer A, Kreuter M, Lederer DJ, Molina-Molina M, Axmann J, Kirchgaessler KU, Cottin V.

BMJ Open Respir Res. 2018 Sep 4;5(1):e000289. doi: 10.1136/bmjresp-2018-000289. eCollection 2018.


Haemodynamics and serial risk assessment in systemic sclerosis associated pulmonary arterial hypertension.

Weatherald J, Boucly A, Launay D, Cottin V, Prévot G, Bourlier D, Dauphin C, Chaouat A, Savale L, Jaïs X, Jevnikar M, Traclet J, De Groote P, Simonneau G, Hachulla E, Mouthon L, Montani D, Humbert M, Sitbon O.

Eur Respir J. 2018 Oct 18;52(4). pii: 1800678. doi: 10.1183/13993003.00678-2018. Print 2018 Oct.


TSC-associated neuropsychiatric disorders (TAND): findings from the TOSCA natural history study.

de Vries PJ, Belousova E, Benedik MP, Carter T, Cottin V, Curatolo P, Dahlin M, D'Amato L, d'Augères GB, Ferreira JC, Feucht M, Fladrowski C, Hertzberg C, Jozwiak S, Kingswood JC, Lawson JA, Macaya A, Marques R, Nabbout R, O'Callaghan F, Qin J, Sander V, Sauter M, Shah S, Takahashi Y, Touraine R, Youroukos S, Zonnenberg B, Jansen AC; TOSCA Consortium and TOSCA Investigators.

Orphanet J Rare Dis. 2018 Sep 10;13(1):157. doi: 10.1186/s13023-018-0901-8.


Should Patients With Interstitial Lung Disease Be Seen by Experts?

Cottin V, Castillo D, Poletti V, Kreuter M, Corte TJ, Spagnolo P.

Chest. 2018 Sep;154(3):713-714. doi: 10.1016/j.chest.2018.05.044. No abstract available.


Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline.

Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, Behr J, Cottin V, Danoff SK, Morell F, Flaherty KR, Wells A, Martinez FJ, Azuma A, Bice TJ, Bouros D, Brown KK, Collard HR, Duggal A, Galvin L, Inoue Y, Jenkins RG, Johkoh T, Kazerooni EA, Kitaichi M, Knight SL, Mansour G, Nicholson AG, Pipavath SNJ, Buendía-Roldán I, Selman M, Travis WD, Walsh S, Wilson KC; American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Society.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):e44-e68. doi: 10.1164/rccm.201807-1255ST.


Investigating the effects of nintedanib on biomarkers of extracellular matrix turnover in patients with IPF: design of the randomised placebo-controlled INMARK®trial.

Maher TM, Stowasser S, Nishioka Y, White ES, Cottin V, Noth I, Selman M, Blahova Z, Wachtlin D, Diefenbach C, Jenkins RG.

BMJ Open Respir Res. 2018 Aug 20;5(1):e000325. doi: 10.1136/bmjresp-2018-000325. eCollection 2018.


Safety of right heart catheterization for pulmonary hypertension in very elderly patients.

Ginoux M, Cottin V, Glérant JC, Traclet J, Philit F, Sénéchal A, Mornex JF, Turquier S.

Pulm Circ. 2018 Oct-Dec;8(4):2045894018799272. doi: 10.1177/2045894018799272. Epub 2018 Aug 20.


Idiopathic pulmonary fibrosis: time for greater expectations?

Wuyts W, Cottin V.

Eur Respir J. 2018 Aug 2;52(2). pii: 1801312. doi: 10.1183/13993003.01312-2018. Print 2018 Aug. No abstract available.


The Respiratory System in Autoimmune Vascular Diseases.

Nasser M, Cottin V.

Respiration. 2018;96(1):12-28. doi: 10.1159/000486899. Epub 2018 Jul 4. Review.


Lung histopathology of non-infectious pulmonary complications after allogeneic haematopoietic stem cell transplantation.

Meignin V, Thivolet-Bejui F, Kambouchner M, Hussenet C, Bondeelle L, Mitchell A, Chagnon K, Begueret H, Segers V, Cottin V, Tazi A, Chevret S, Danel C, Bergeron A.

Histopathology. 2018 Nov;73(5):832-842. doi: 10.1111/his.13697. Epub 2018 Aug 19.


Recent advances in the pathobiology and clinical management of lymphangioleiomyomatosis.

Harari S, Spagnolo P, Cocconcelli E, Luisi F, Cottin V.

Curr Opin Pulm Med. 2018 Sep;24(5):469-476. doi: 10.1097/MCP.0000000000000502. Review.


Pulmonary Arteriovenous Malformation After Metastatic Gestational Trophoblastic Tumor.

Costa C, Massardier J, Gamondes D, Cottin V.

Arch Bronconeumol. 2019 Jan;55(1):57-59. doi: 10.1016/j.arbres.2018.04.013. Epub 2018 Jun 6. English, Spanish. No abstract available.

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