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Items: 39


Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats.

Boghosian JD, Luethy A, Cotten JF.

J Pharmacol Exp Ther. 2018 Jul;366(1):105-112. doi: 10.1124/jpet.118.248377. Epub 2018 Apr 19.


Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells.

Jounaidi Y, Cotten JF, Miller KW, Forman SA.

Cancer Res. 2017 Nov 1;77(21):5938-5951. doi: 10.1158/0008-5472.CAN-17-1007. Epub 2017 Sep 15.


The effect of atomoxetine, a selective norepinephrine reuptake inhibitor, on respiratory arrest and cardiorespiratory function in the DBA/1 mouse model of SUDEP.

Zhao H, Cotten JF, Long X, Feng HJ.

Epilepsy Res. 2017 Nov;137:139-144. doi: 10.1016/j.eplepsyres.2017.08.005. Epub 2017 Aug 24.


Halogenated Ether, Alcohol, and Alkane Anesthetics Activate TASK-3 Tandem Pore Potassium Channels Likely through a Common Mechanism.

Luethy A, Boghosian JD, Srikantha R, Cotten JF.

Mol Pharmacol. 2017 Jun;91(6):620-629. doi: 10.1124/mol.117.108290. Epub 2017 Mar 21.


Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats.

Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K.

Anesth Analg. 2016 Nov;123(5):1210-1219.


A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2.

Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Moreno Duarte I, Cotten JF, Eikermann-Haerter K, Deng H, Chamberlin NL, Isaacs L, Briken V, Eikermann M.

Anesthesiology. 2016 Aug;125(2):333-45. doi: 10.1097/ALN.0000000000001199.


5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest.

Zhang H, Zhao H, Yang X, Xue Q, Cotten JF, Feng HJ.

Epilepsia. 2016 Aug;57(8):1228-35. doi: 10.1111/epi.13430. Epub 2016 Jun 15.


Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore.

Chokshi RH, Larsen AT, Bhayana B, Cotten JF.

Mol Pharmacol. 2015 Nov;88(5):926-34. doi: 10.1124/mol.115.100107. Epub 2015 Aug 12.


Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice.

Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJ.

Epilepsy Behav. 2015 Apr;45:1-7. doi: 10.1016/j.yebeh.2015.02.013. Epub 2015 Mar 13.


Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats.

Diaz-Gil D, Mueller N, Moreno-Duarte I, Lin H, Ayata C, Cusin C, Cotten JF, Eikermann M.

Pharmaceuticals (Basel). 2014 Dec 29;8(1):21-37. doi: 10.3390/ph8010021.


The latest pharmacologic ventilator.

Cotten JF.

Anesthesiology. 2014 Sep;121(3):442-4. doi: 10.1097/ALN.0000000000000368. No abstract available.


The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol.

Ge R, Pejo E, Gallin H, Jeffrey S, Cotten JF, Raines DE.

Anesth Analg. 2014 Mar;118(3):563-7. doi: 10.1213/ANE.0000000000000069.


Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase.

Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE.

Anesth Analg. 2013 Jun;116(6):1249-56. doi: 10.1213/ANE.0b013e31828b3637. Epub 2013 Mar 14.


TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats.

Cotten JF.

Anesth Analg. 2013 Apr;116(4):810-6. doi: 10.1213/ANE.0b013e318284469d. Epub 2013 Mar 4.


Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling.

Wong KF, Gong JJ, Cotten JF, Solt K, Brown EN.

IEEE Trans Biomed Eng. 2013 Apr;60(4):1118-25. doi: 10.1109/TBME.2012.2225834. Epub 2012 Oct 25.


Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs.

Ge R, Pejo E, Husain SS, Cotten JF, Raines DE.

Anesthesiology. 2012 Nov;117(5):1037-43. doi: 10.1097/ALN.0b013e31826d3de2.


Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats.

Pejo E, Ge R, Banacos N, Cotten JF, Husain SS, Raines DE.

Anesthesiology. 2012 May;116(5):1057-65. doi: 10.1097/ALN.0b013e3182515403.


Correcting for serial dependence in studies of respiratory dynamics.

Gong JJ, Wong KF, Cotten JF, Solt K, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:1721-4. doi: 10.1109/IEMBS.2011.6090493.


Covalent modification of a volatile anesthetic regulatory site activates TASK-3 (KCNK9) tandem-pore potassium channels.

Conway KE, Cotten JF.

Mol Pharmacol. 2012 Mar;81(3):393-400. doi: 10.1124/mol.111.076281. Epub 2011 Dec 6.


In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate.

Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE.

Anesth Analg. 2012 Aug;115(2):297-304. doi: 10.1213/ANE.0b013e3182320559. Epub 2011 Sep 29.


Methylphenidate actively induces emergence from general anesthesia.

Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN.

Anesthesiology. 2011 Oct;115(4):791-803. doi: 10.1097/ALN.0b013e31822e92e5.


Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.

Pejo E, Feng Y, Chao W, Cotten JF, Le Ge R, Raines DE.

Crit Care Med. 2012 Jan;40(1):187-92. doi: 10.1097/CCM.0b013e31822d7924.


Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.

Cotten JF, Le Ge R, Banacos N, Pejo E, Husain SS, Williams JH, Raines DE.

Anesthesiology. 2011 Oct;115(4):764-73. doi: 10.1097/ALN.0b013e31821950de.


p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.

Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW.

J Med Chem. 2010 Sep 9;53(17):6432-44. doi: 10.1021/jm100498u.


Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.

Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE.

Anesthesiology. 2010 Mar;112(3):637-44. doi: 10.1097/ALN.0b013e3181cf40ed.


Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity.

Solt K, Kelly EW, Cotten JF, Raines DE.

Anesth Analg. 2010 Feb 1;110(2):455-60. doi: 10.1213/ANE.0b013e3181c5f689. Epub 2009 Nov 16.


Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.

Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE.

Anesthesiology. 2009 Aug;111(2):240-9. doi: 10.1097/ALN.0b013e3181ae63d1.


Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.

Keshavaprasad B, Liu C, Au JD, Kindler CH, Cotten JF, Yost CS.

Anesth Analg. 2005 Oct;101(4):1042-9, table of contents.


Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress.

Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler PE, Yost CS.

Brain Res. 2005 Jan 21;1031(2):164-73.


Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics.

Liu C, Au JD, Zou HL, Cotten JF, Yost CS.

Anesth Analg. 2004 Dec;99(6):1715-22, table of contents.


Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2).

Cotten JF, Zou HL, Liu C, Au JD, Yost CS.

Brain Res Mol Brain Res. 2004 Sep 28;128(2):112-20.


Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNS.

Callahan R, Labunskiy DA, Logvinova A, Abdallah M, Liu C, Cotten JF, Yost CS.

Biochem Biophys Res Commun. 2004 Jun 25;319(2):525-30.


Cystic fibrosis transmembrane conductance regulator Cl- channels with R domain deletions and translocations show phosphorylation-dependent and -independent activity.

Baldursson O, Ostedgaard LS, Rokhlina T, Cotten JF, Welsh MJ.

J Biol Chem. 2001 Jan 19;276(3):1904-10. Epub 2000 Oct 18.


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