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Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity.

Butler CW, Keiser AA, Kwapis JL, Berchtold NC, Wall VL, Wood MA, Cotman CW.

Learn Mem. 2019 Nov 15;26(12):485-492. doi: 10.1101/lm.050278.119. Print 2019 Dec.


Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus.

Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM.

Sci Rep. 2019 Nov 4;9(1):15936. doi: 10.1038/s41598-019-52324-0.


Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders.

Ayer AH, Wojta K, Ramos EM, Dokuru D, Chen JA, Karydas AM, Papatriantafyllou JD, Agiomyrgiannakis D, Kamtsadeli V, Tsinia N, Sali D, Gylys KH, Agosta F, Filippi M, Small GW, Bennett DA, Gearing M, Juncos JL, Kramer J, Lee SE, Yokoyama JS, Mendez MF, Chui H, Zarow C, Ringman JM, Kilic U, Babacan-Yildiz G, Levey A, DeCarli CS, Cotman CW, Boxer AL, Miller BL, Coppola G.

Alzheimer Dis Assoc Disord. 2019 Oct-Dec;33(4):327-330. doi: 10.1097/WAD.0000000000000339.


What are the earlier life contributions to reserve and resilience?

Walhovd KB, Howell GR, Ritchie SJ, Staff RT, Cotman CW.

Neurobiol Aging. 2019 Nov;83:135-139. doi: 10.1016/j.neurobiolaging.2019.04.014. Epub 2019 Apr 30.


Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline.

Berchtold NC, Prieto GA, Phelan M, Gillen DL, Baldi P, Bennett DA, Buchman AS, Cotman CW.

Neurobiol Aging. 2019 Jun;78:142-154. doi: 10.1016/j.neurobiolaging.2019.02.012. Epub 2019 Feb 20.


Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM.

Aging Cell. 2019 Jun;18(3):e12919. doi: 10.1111/acel.12919. Epub 2019 Feb 27.


Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites.

Prieto GA, Smith ED, Tong L, Nguyen M, Cotman CW.

ACS Chem Neurosci. 2019 Mar 20;10(3):1197-1203. doi: 10.1021/acschemneuro.8b00511. Epub 2019 Feb 4.


Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.

Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM.

Aging Cell. 2018 Aug;17(4):e12791. doi: 10.1111/acel.12791. Epub 2018 Jun 6.


Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines.

Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J.

Brain Pathol. 2018 May;28(3):427-430. doi: 10.1111/bpa.12573. No abstract available.


IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.

Tong L, Prieto GA, Cotman CW.

J Neuroinflammation. 2018 Apr 30;15(1):127. doi: 10.1186/s12974-018-1158-9.


TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse.

Prieto GA, Tong L, Smith ED, Cotman CW.

Neurochem Res. 2019 Jan;44(1):49-60. doi: 10.1007/s11064-018-2517-8. Epub 2018 Apr 4.


On the road towards the global analysis of human synapses.

Prieto GA, Cotman CW.

Neural Regen Res. 2017 Oct;12(10):1586-1589. doi: 10.4103/1673-5374.217321. Review.


Cytokines and cytokine networks target neurons to modulate long-term potentiation.

Prieto GA, Cotman CW.

Cytokine Growth Factor Rev. 2017 Apr;34:27-33. doi: 10.1016/j.cytogfr.2017.03.005. Epub 2017 Mar 29.


Pattern separation and goal-directed behavior in the aged canine.

Snigdha S, Yassa MA, deRivera C, Milgram NW, Cotman CW.

Learn Mem. 2017 Feb 15;24(3):123-131. doi: 10.1101/lm.043422.116. Print 2017 Mar.


IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking.

Carlos AJ, Tong L, Prieto GA, Cotman CW.

J Neuroinflammation. 2017 Feb 2;14(1):29. doi: 10.1186/s12974-017-0803-z.


Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses.

Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, Lynch G, Cotman CW.

J Neurosci. 2017 Feb 1;37(5):1197-1212. doi: 10.1523/JNEUROSCI.2774-16.2016. Epub 2016 Dec 16.


Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise.

Abbasi A, de Paula Vieira R, Bischof F, Walter M, Movassaghi M, Berchtold NC, Niess AM, Cotman CW, Northoff H.

J Neuroinflammation. 2016 Nov 10;13(1):289.


H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus.

Snigdha S, Prieto GA, Petrosyan A, Loertscher BM, Dieskau AP, Overman LE, Cotman CW.

J Neurosci. 2016 Mar 23;36(12):3611-22. doi: 10.1523/JNEUROSCI.2693-15.2016.


Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial.

Hoffmann K, Sobol NA, Frederiksen KS, Beyer N, Vogel A, Vestergaard K, Brændgaard H, Gottrup H, Lolk A, Wermuth L, Jacobsen S, Laugesen LP, Gergelyffy RG, Høgh P, Bjerregaard E, Andersen BB, Siersma V, Johannsen P, Cotman CW, Waldemar G, Hasselbalch SG.

J Alzheimers Dis. 2016;50(2):443-53. doi: 10.3233/JAD-150817.


Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.

Snigdha S, de Rivera C, Milgram NW, Cotman CW.

Neurobiol Aging. 2016 Jan;37:171-178. doi: 10.1016/j.neurobiolaging.2015.09.015. Epub 2015 Sep 30.


Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.

Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J Jr, Cotman CW.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5078-87. doi: 10.1073/pnas.1514486112. Epub 2015 Aug 24.


Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.

Smith ED, Prieto GA, Tong L, Sears-Kraxberger I, Rice JD, Steward O, Cotman CW.

J Biol Chem. 2014 Jul 25;289(30):20615-29.


Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease.

Berchtold NC, Sabbagh MN, Beach TG, Kim RC, Cribbs DH, Cotman CW.

Neurobiol Aging. 2014 Sep;35(9):1961-72. doi: 10.1016/j.neurobiolaging.2014.03.031. Epub 2014 Apr 2.


Exercise enhances memory consolidation in the aging brain.

Snigdha S, de Rivera C, Milgram NW, Cotman CW.

Front Aging Neurosci. 2014 Feb 3;6:3. doi: 10.3389/fnagi.2014.00003. eCollection 2014.


Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.

Rice RA, Berchtold NC, Cotman CW, Green KN.

Neurobiol Aging. 2014 May;35(5):1002-11. doi: 10.1016/j.neurobiolaging.2013.10.090. Epub 2013 Oct 30.


Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design.

Hoffmann K, Frederiksen KS, Sobol NA, Beyer N, Vogel A, Simonsen AH, Johannsen P, Lolk A, Terkelsen O, Cotman CW, Hasselbalch SG, Waldemar G.

Neuroepidemiology. 2013;41(3-4):198-207. doi: 10.1159/000354632. Epub 2013 Oct 15.


Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.

Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA.

Am J Pathol. 2013 Aug;183(2):369-81. doi: 10.1016/j.ajpath.2013.05.005. Epub 2013 Jun 7.


Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism.

Intlekofer KA, Berchtold NC, Malvaez M, Carlos AJ, McQuown SC, Cunningham MJ, Wood MA, Cotman CW.

Neuropsychopharmacology. 2013 Sep;38(10):2027-34. doi: 10.1038/npp.2013.104. Epub 2013 Apr 24.


β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.

Poon WW, Carlos AJ, Aguilar BL, Berchtold NC, Kawano CK, Zograbyan V, Yaopruke T, Shelanski M, Cotman CW.

J Biol Chem. 2013 Jun 7;288(23):16937-48. doi: 10.1074/jbc.M113.463711. Epub 2013 Apr 18.


A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap.

Snigdha S, Milgram NW, Willis SL, Albert M, Weintraub S, Fortin NJ, Cotman CW.

Neurobiol Aging. 2013 Jul;34(7):1891-901. doi: 10.1016/j.neurobiolaging.2013.01.018. Epub 2013 Feb 20. Review.


Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease.

Berchtold NC, Coleman PD, Cribbs DH, Rogers J, Gillen DL, Cotman CW.

Neurobiol Aging. 2013 Jun;34(6):1653-61. doi: 10.1016/j.neurobiolaging.2012.11.024. Epub 2012 Dec 27.


Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase.

Tong L, Prieto GA, Kramár EA, Smith ED, Cribbs DH, Lynch G, Cotman CW.

J Neurosci. 2012 Dec 5;32(49):17714-24. doi: 10.1523/JNEUROSCI.1253-12.2012.


Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year.

Winchester J, Dick MB, Gillen D, Reed B, Miller B, Tinklenberg J, Mungas D, Chui H, Galasko D, Hewett L, Cotman CW.

Arch Gerontol Geriatr. 2013 Jan-Feb;56(1):96-103. doi: 10.1016/j.archger.2012.06.016. Epub 2012 Sep 5.


Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study.

Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW.

J Neuroinflammation. 2012 Jul 23;9:179. doi: 10.1186/1742-2094-9-179.


Exercise counteracts declining hippocampal function in aging and Alzheimer's disease.

Intlekofer KA, Cotman CW.

Neurobiol Dis. 2013 Sep;57:47-55. doi: 10.1016/j.nbd.2012.06.011. Epub 2012 Jun 30. Review.


Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N; Alzheimer's Disease Genetics Consortium (ADGC), Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL.

Neurology. 2012 Jul 17;79(3):221-8. doi: 10.1212/WNL.0b013e3182605801. Epub 2012 Jun 20.


Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons.

Kim HJ, Park JW, Byun JH, Poon WW, Cotman CW, Fowlkes CC, Jeon NL.

ACS Chem Neurosci. 2012 Jun 20;3(6):433-8.


Clinical trials: new opportunities.

Chapman SB, Cotman CW, Fillit HM, Gallagher M, van Dyck CH.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):773-80. doi: 10.1093/gerona/gls126. Epub 2012 May 8. Review.


Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA; Alzheimer's Disease Genetics Consortium, Ross OA, Rademakers R, Schellenberg GD, Miller BL, Mandelkow E, Geschwind DH.

Hum Mol Genet. 2012 Aug 1;21(15):3500-12. doi: 10.1093/hmg/dds161. Epub 2012 May 3.


Caspase-3 activation as a bifurcation point between plasticity and cell death.

Snigdha S, Smith ED, Prieto GA, Cotman CW.

Neurosci Bull. 2012 Feb;28(1):14-24. doi: 10.1007/s12264-012-1057-5. Review.


Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers.

Deeny SP, Winchester J, Nichol K, Roth SM, Wu JC, Dick M, Cotman CW.

Alzheimers Dement. 2012 Jul;8(4):352-6. doi: 10.1016/j.jalz.2011.04.010. Epub 2012 Jan 9.


Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain.

Snigdha S, Astarita G, Piomelli D, Cotman CW.

Neuroscience. 2012 Jan 27;202:326-33. doi: 10.1016/j.neuroscience.2011.12.002. Epub 2011 Dec 13.


Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.

Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D.

PLoS One. 2011;6(10):e24777. doi: 10.1371/journal.pone.0024777. Epub 2011 Oct 26.


Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain.

Snigdha S, Berchtold N, Astarita G, Saing T, Piomelli D, Cotman CW.

PLoS One. 2011;6(9):e24652. doi: 10.1371/journal.pone.0024652. Epub 2011 Sep 13.


An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease.

Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D.

Neurobiol Aging. 2012 Aug;33(8):1522-32. doi: 10.1016/j.neurobiolaging.2011.03.012. Epub 2011 May 4.


Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD.

Nat Genet. 2011 May;43(5):436-41. doi: 10.1038/ng.801. Epub 2011 Apr 3.


Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs.

Snigdha S, Christie LA, De Rivera C, Araujo JA, Milgram NW, Cotman CW.

Age (Dordr). 2012 Feb;34(1):67-73. doi: 10.1007/s11357-011-9219-3. Epub 2011 Feb 19.


Mild stress facilitates learning and exercise improves retention in aged mice.

Adlard PA, Engesser-Cesar C, Cotman CW.

Exp Gerontol. 2011 Jan;46(1):53-9. doi: 10.1016/j.exger.2010.10.001. Epub 2010 Oct 15. Erratum in: Exp Gerontol. 2011 Oct;46(10):841.


Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease.

Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D.

PLoS One. 2010 Sep 8;5(9):e12538. doi: 10.1371/journal.pone.0012538.

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