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Early HCV viral kinetics under DAAs may optimize duration of therapy in patients with compensated cirrhosis.

Gambato M, Canini L, Lens S, Graw F, Perpiñan E, Londoño MC, Uprichard SL, Mariño Z, Reverter E, Bartres C, González P, Pla A, Costa J, Burra P, Cotler SJ, Forns X, Dahari H.

Liver Int. 2018 Nov 30. doi: 10.1111/liv.14014. [Epub ahead of print]


Modeling of patient virus titers suggests that availability of a vaccine could reduce hepatitis C virus transmission among injecting drug users.

Major M, Gutfraind A, Shekhtman L, Cui Q, Kachko A, Cotler SJ, Hajarizadeh B, Sacks-Davis R, Page K, Boodram B, Dahari H.

Sci Transl Med. 2018 Jul 11;10(449). pii: eaao4496. doi: 10.1126/scitranslmed.aao4496.


Inhibition of insulin-like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival.

Wang F, Bank T, Malnassy G, Arteaga M, Shang N, Dalheim A, Ding X, Cotler SJ, Denning MF, Nishimura MI, Breslin P, Qiu W.

Hepatol Commun. 2018 Apr 17;2(6):732-746. doi: 10.1002/hep4.1181. eCollection 2018 Jun.


Gender disparities in liver transplant candidates with nonalcoholic steatohepatitis.

Loy VM, Joyce C, Bello S, VonRoenn N, Cotler SJ.

Clin Transplant. 2018 Aug;32(8):e13297. doi: 10.1111/ctr.13297. Epub 2018 Jul 19.


Pharmacokinetics and pharmacodynamics modeling of lonafarnib in patients with chronic hepatitis delta virus infection.

Canini L, Koh C, Cotler SJ, Uprichard SL, Winters MA, Han MAT, Kleiner DE, Idilman R, Yurdaydin C, Glenn JS, Heller T, Dahari H.

Hepatol Commun. 2017 May 19;1(4):288-292. doi: 10.1002/hep4.1043. eCollection 2017 Jun.


Studies on the Tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans.

Khan MW, Ding X, Cotler SJ, Clarke M, Layden BT.

J Histochem Cytochem. 2018 May;66(5):385-392. doi: 10.1369/0022155418756849. Epub 2018 Feb 5.


HCV kinetic and modeling analyses project shorter durations to cure under combined therapy with daclatasvir and asunaprevir in chronic HCV-infected patients.

Canini L, Imamura M, Kawakami Y, Uprichard SL, Cotler SJ, Dahari H, Chayama K.

PLoS One. 2017 Dec 7;12(12):e0187409. doi: 10.1371/journal.pone.0187409. eCollection 2017.


Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth).

Parrinello CM, Rudolph BJ, Lazo M, Gallo LC, Thyagarajan B, Cotler SJ, Qi Q, Seeherunvong T, Vidot DC, Strickler HD, Kaplan RC, Isasi CR.

J Clin Gastroenterol. 2017 Nov 3. doi: 10.1097/MCG.0000000000000946. [Epub ahead of print]


Case Series of 10 Patients with Cirrhosis Undergoing Emergent Repair of Ruptured Umbilical Hernias: Natural History and Predictors of Outcomes.

Malespin M, Moore CM, Fialho A, de Melo SW Jr, Benyashvili T, Kothari AN, di Sabato D, Kallwitz ER, Cotler SJ, Lu AD.

Exp Clin Transplant. 2017 Jul 11. doi: 10.6002/ect.2017.0086. [Epub ahead of print]


Modeling HCV cure after an ultra-short duration of therapy with direct acting agents.

Goyal A, Lurie Y, Meissner EG, Major M, Sansone N, Uprichard SL, Cotler SJ, Dahari H.

Antiviral Res. 2017 Aug;144:281-285. doi: 10.1016/j.antiviral.2017.06.019. Epub 2017 Jun 30.


End of treatment RNA-positive/sustained viral response in an individual with acute hepatitis C virus infection treated with direct-acting antivirals.

Shteyer E, Dahari H, Gafanovich I, Dery I, Wolf D, Cotler SJ, Lurie Y.

Therap Adv Gastroenterol. 2017 May;10(5):429-430. doi: 10.1177/1756283X17694808. Epub 2017 Feb 1. No abstract available.


Adverse Effect of Post-Discharge Care Fragmentation on Outcomes after Readmissions after Liver Transplantation.

Kothari AN, Loy VM, Brownlee SA, Ezure Y, Schaidle-Blackburn C, Cotler SJ, di Sabato D, Kuo PC, Lu AD.

J Am Coll Surg. 2017 Jul;225(1):62-67. doi: 10.1016/j.jamcollsurg.2017.03.017. Epub 2017 Apr 9.


Early Hospital Readmissions and Mortality in Patients With Decompensated Cirrhosis Enrolled in a Large National Health Insurance Administrative Database.

Scaglione SJ, Metcalfe L, Kliethermes S, Vasilyev I, Tsang R, Caines A, Mumtaz S, Goyal V, Khalid A, Shoham D, Markossian T, Luke A, Underwood H, Cotler SJ.

J Clin Gastroenterol. 2017 Oct;51(9):839-844. doi: 10.1097/MCG.0000000000000826.


Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites.

Venepalli NK, Modayil MV, Berg SA, Nair TD, Parepally M, Rajaram P, Gaba RC, Bui JT, Huang Y, Cotler SJ.

World J Hepatol. 2017 Mar 8;9(7):391-400. doi: 10.4254/wjh.v9.i7.391.


Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies.

Malespin M, Benyashvili T, Uprichard SL, Perelson AS, Dahari H, Cotler SJ.

Therap Adv Gastroenterol. 2017 Jan;10(1):68-73. doi: 10.1177/1756283X16672392. Epub 2016 Oct 17.


Hepatitis B Stigma and Knowledge among Vietnamese in Ho Chi Minh City and Chicago.

Dam L, Cheng A, Tran P, Wong SS, Hershow R, Cotler S, Cotler SJ.

Can J Gastroenterol Hepatol. 2016;2016:1910292. doi: 10.1155/2016/1910292. Epub 2016 Dec 22.


The time and cost investment required to obtain and initiate direct-acting antiviral therapy.

Loy V, Benyashvili T, Adams W, Pavkov D, O'Mahoney M, Cotler SJ.

Antivir Ther. 2016;21(8):731-733. doi: 10.3851/IMP3068. Epub 2016 Jul 14.


Hepatitis C virus cures after direct acting antiviral-related drug-induced liver injury: Case report.

Hasin Y, Shteingart S, Dahari H, Gafanovich I, Floru S, Braun M, Shlomai A, Verstandig A, Dery I, Uprichard SL, Cotler SJ, Lurie Y.

World J Hepatol. 2016 Jul 18;8(20):858-62. doi: 10.4254/wjh.v8.i20.858.


Resurrection of response-guided therapy for sofosbuvir combination therapies.

Dahari H, Halfon P, Cotler SJ.

J Hepatol. 2016 Sep;65(3):462-4. doi: 10.1016/j.jhep.2016.05.028. Epub 2016 May 27. No abstract available.


An assessment of racial differences in the upper limits of normal ALT levels in children and the effect of obesity on elevated values.

Kliethermes S, Ma M, Purtell C, Balasubramanian N, Gonzalez B, Layden TJ, Cotler SJ.

Pediatr Obes. 2017 Oct;12(5):363-372. doi: 10.1111/ijpo.12152. Epub 2016 May 30.


FAK Kinase Activity Is Required for the Progression of c-MET/β-Catenin-Driven Hepataocellular Carcinoma.

Shang N, Arteaga M, Zaidi A, Cotler SJ, Breslin P, Ding X, Kuo P, Nishimura M, Zhang J, Qiu W.

Gene Expr. 2016;17(1):79-88. doi: 10.3727/105221616X691604. Epub 2016 May 2.


Inhibition of SIRT2 suppresses hepatic fibrosis.

Arteaga M, Shang N, Ding X, Yong S, Cotler SJ, Denning MF, Shimamura T, Breslin P, Lüscher B, Qiu W.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1155-68. doi: 10.1152/ajpgi.00271.2015. Epub 2016 Apr 28.


Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer.

Kataria Y, Deaton RJ, Enk E, Jin M, Petrauskaite M, Dong L, Goldenberg JR, Cotler SJ, Jensen DM, van Breemen RB, Gann PH.

BMC Gastroenterol. 2016 Feb 29;16:30. doi: 10.1186/s12876-016-0432-5.


HCV kinetic and modeling analyses indicate similar time to cure among sofosbuvir combination regimens with daclatasvir, simeprevir or ledipasvir.

Dahari H, Canini L, Graw F, Uprichard SL, Araújo ES, Penaranda G, Coquet E, Chiche L, Riso A, Renou C, Bourliere M, Cotler SJ, Halfon P.

J Hepatol. 2016 Jun;64(6):1232-9. doi: 10.1016/j.jhep.2016.02.022. Epub 2016 Feb 22.


Cure prevents more than transmission of hepatitis C virus.

Dahari H, Cotler SJ, Feld JJ.

Hepatology. 2016 Sep;64(3):1003-4. doi: 10.1002/hep.28449. Epub 2016 Mar 7. No abstract available.


Protease inhibitors partially overcome the interferon nonresponse phenotype in patients with chronic hepatitis C.

Duarte-Rojo A, Fischer SE, Adeyi O, Zita D, Deneke MG, Selzner N, Chen L, Malespin M, Cotler SJ, McGilvray ID, Feld JJ.

J Viral Hepat. 2016 May;23(5):340-7. doi: 10.1111/jvh.12494. Epub 2015 Dec 29.


Mathematical Modeling of Hepatitis C Prevalence Reduction with Antiviral Treatment Scale-Up in Persons Who Inject Drugs in Metropolitan Chicago.

Echevarria D, Gutfraind A, Boodram B, Major M, Del Valle S, Cotler SJ, Dahari H.

PLoS One. 2015 Aug 21;10(8):e0135901. doi: 10.1371/journal.pone.0135901. eCollection 2015.


Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial.

Koh C, Canini L, Dahari H, Zhao X, Uprichard SL, Haynes-Williams V, Winters MA, Subramanya G, Cooper SL, Pinto P, Wolff EF, Bishop R, Ai Thanda Han M, Cotler SJ, Kleiner DE, Keskin O, Idilman R, Yurdaydin C, Glenn JS, Heller T.

Lancet Infect Dis. 2015 Oct;15(10):1167-1174. doi: 10.1016/S1473-3099(15)00074-2. Epub 2015 Jul 16.


Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics.

Dahari H, Shteingart S, Gafanovich I, Cotler SJ, D'Amato M, Pohl RT, Weiss G, Ashkenazi YJ, Tichler T, Goldin E, Lurie Y.

Liver Int. 2015 Feb;35(2):289-94. doi: 10.1111/liv.12692. Epub 2014 Oct 10.


Prevalence of suspected nonalcoholic fatty liver disease in Hispanic/Latino individuals differs by heritage.

Kallwitz ER, Daviglus ML, Allison MA, Emory KT, Zhao L, Kuniholm MH, Chen J, Gouskova N, Pirzada A, Talavera GA, Youngblood ME, Cotler SJ.

Clin Gastroenterol Hepatol. 2015 Mar;13(3):569-76. doi: 10.1016/j.cgh.2014.08.037. Epub 2014 Sep 15.


FAK is required for c-Met/β-catenin-driven hepatocarcinogenesis.

Shang N, Arteaga M, Zaidi A, Stauffer J, Cotler SJ, Zeleznik-Le NJ, Zhang J, Qiu W.

Hepatology. 2015 Jan;61(1):214-26. doi: 10.1002/hep.27402. Epub 2014 Nov 25.


Understanding early serum hepatitis D virus and hepatitis B surface antigen kinetics during pegylated interferon-alpha therapy via mathematical modeling.

Guedj J, Rotman Y, Cotler SJ, Koh C, Schmid P, Albrecht J, Haynes-Williams V, Liang TJ, Hoofnagle JH, Heller T, Dahari H.

Hepatology. 2014 Dec;60(6):1902-10. doi: 10.1002/hep.27357. Epub 2014 Oct 27.


Presurgical transarterial chemoembolization does not increase biliary stricture incidence in orthotopic liver transplant patients.

Casadaban L, Malespin M, Cheung A, McGuffey RA, Boulay BR, Halline AG, Brown RD, Cotler SJ, Jeon H, Bui JT, Gaba RC.

Transplant Proc. 2014 Jun;46(5):1413-9. doi: 10.1016/j.transproceed.2014.03.012.


Severity of liver disease affects HCV kinetics in patients treated with intravenous silibinin monotherapy.

Canini L, DebRoy S, Mariño Z, Conway JM, Crespo G, Navasa M, D'Amato M, Ferenci P, Cotler SJ, Forns X, Perelson AS, Dahari H.

Antivir Ther. 2015;20(2):149-55. doi: 10.3851/IMP2806. Epub 2014 Jun 10.


Association of genetic variants with rapid fibrosis: progression after liver transplantation for hepatitis C.

Layden JE, Tayo BO, Cotler SJ, Clark NM, Baraoidan K, Friedman SL, Cooper RS.

Transplantation. 2014 May 27;97(10):1072-8. doi: 10.1097/01.TP.0000440953.06886.a3.


Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children.

Malespin M, Sleesman B, Lau A, Wong SS, Cotler SJ.

J Clin Gastroenterol. 2015 Apr;49(4):345-9. doi: 10.1097/MCG.0000000000000121.


Individualized treatment for patients with low HCV load (genotype 1): a viral kinetic approach.

Dahari H, Cotler SJ.

Hepatology. 2014 Jun;59(6):2422-3. doi: 10.1002/hep.26772. Epub 2014 Apr 14. No abstract available.


Biomechanics and functionality of hepatocytes in liver cirrhosis.

Sun S, Song Z, Cotler SJ, Cho M.

J Biomech. 2014 Jun 27;47(9):2205-10. doi: 10.1016/j.jbiomech.2013.10.050. Epub 2013 Nov 8.


Imaging surveillance and multidisciplinary review improves curative therapy access and survival in HCC patients.

Gaba RC, Kallwitz ER, Parvinian A, Bui JT, Von Roenn NM, Berkes JL, Cotler SJ.

Ann Hepatol. 2013 Sep-Oct;12(5):766-73.


Physical activity and metabolic syndrome in liver transplant recipients.

Kallwitz ER, Loy V, Mettu P, Von Roenn N, Berkes J, Cotler SJ.

Liver Transpl. 2013 Oct;19(10):1125-31. doi: 10.1002/lt.23710. Epub 2013 Aug 15.


Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life.

Guedj J, Dahari H, Rong L, Sansone ND, Nettles RE, Cotler SJ, Layden TJ, Uprichard SL, Perelson AS.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3991-6. doi: 10.1073/pnas.1203110110. Epub 2013 Feb 19.


Prognostic capability of different liver disease scoring systems for prediction of early mortality after transjugular intrahepatic portosystemic shunt creation.

Gaba RC, Couture PM, Bui JT, Knuttinen MG, Walzer NM, Kallwitz ER, Berkes JL, Cotler SJ.

J Vasc Interv Radiol. 2013 Mar;24(3):411-20, 420.e1-4; quiz 421. doi: 10.1016/j.jvir.2012.10.026. Epub 2013 Jan 9.


Understanding triphasic HCV decline during treatment in the era of IL28B polymorphisms and direct acting antiviral agents via mathematical modeling.

Dahari H, Cotler SJ, Layden TJ, Perelson AS.

J Hepatol. 2013 Apr;58(4):840-2. doi: 10.1016/j.jhep.2012.08.029. Epub 2012 Dec 13. No abstract available.


Quantitative morphometric analysis of hepatocellular carcinoma: development of a programmed algorithm and preliminary application.

Yap FY, Bui JT, Knuttinen MG, Walzer NM, Cotler SJ, Owens CA, Berkes JL, Gaba RC.

Diagn Interv Radiol. 2013 Mar-Apr;19(2):97-105. doi: 10.4261/1305-3825.DIR.5973-12.1.


Barriers to treatment of hepatitis B in an urban Chinatown community.

Malespin M, Wong S, Siqueira F, Luc B, Ravaee B, Vainder C, Cotler SJ.

J Clin Gastroenterol. 2012 Sep;46(8):e66-70. doi: 10.1097/MCG.0b013e31824e159c.


Impact of donor and recipient race on survival after hepatitis C-related liver transplantation.

Layden JE, Cotler SJ, Grim SA, Fischer MJ, Lucey MR, Clark NM.

Transplantation. 2012 Feb 27;93(4):444-9. doi: 10.1097/TP.0b013e3182406a94.


Characterizing hepatitis B stigma in Chinese immigrants.

Cotler SJ, Cotler S, Xie H, Luc BJ, Layden TJ, Wong SS.

J Viral Hepat. 2012 Feb;19(2):147-52. doi: 10.1111/j.1365-2893.2011.01462.x. Epub 2011 May 4.


TIPS for treatment of variceal hemorrhage: clinical outcomes in 128 patients at a single institution over a 12-year period.

Gaba RC, Omene BO, Podczerwinski ES, Knuttinen MG, Cotler SJ, Kallwitz ER, Berkes JL, Walzer NM, Bui JT, Owens CA.

J Vasc Interv Radiol. 2012 Feb;23(2):227-35. doi: 10.1016/j.jvir.2011.10.015. Epub 2011 Dec 16.


Characterization of antigenic variants of hepatitis C virus in immune evasion.

Wang JH, Pianko MJ, Ke X, Herskovic A, Hershow R, Cotler SJ, Chen W, Chen ZW, Rong L.

Virol J. 2011 Jul 29;8:377. doi: 10.1186/1743-422X-8-377.


Chronic hepatitis C virus infection and increases in viral load in a prospective cohort of young, HIV-uninfected injection drug users.

Boodram B, Hershow RC, Cotler SJ, Ouellet LJ.

Drug Alcohol Depend. 2011 Dec 15;119(3):166-71. doi: 10.1016/j.drugalcdep.2011.06.005. Epub 2011 Jul 2.

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