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Items: 1 to 50 of 120

1.

Gain-of-function mutations of the V2 vasopressin receptor in nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a cell-based assay to assess constitutive water reabsorption.

Ranieri M, Tamma G, Pellegrino T, Vezzi V, Ambrosio C, Grò C, Di Mise A, Costa T, Valenti G, Cotecchia S.

Pflugers Arch. 2019 Oct;471(10):1291-1304. doi: 10.1007/s00424-019-02307-x. Epub 2019 Sep 5.

PMID:
31486901
2.

AKAP-Lbc mediates protection against doxorubicin-induced cardiomyocyte toxicity.

Caso S, Maric D, Arambasic M, Cotecchia S, Diviani D.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2336-2346. doi: 10.1016/j.bbamcr.2017.09.007. Epub 2017 Sep 18.

3.

Ezrin directly interacts with AQP2 and promotes its endocytosis.

Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Paunescu TG, Brown D, Lu HAJ.

J Cell Sci. 2017 Sep 1;130(17):2914-2925. doi: 10.1242/jcs.204842. Epub 2017 Jul 28.

4.

The alpha1-adrenergic receptors in cardiac hypertrophy: signaling mechanisms and functional implications.

Cotecchia S, Del Vescovo CD, Colella M, Caso S, Diviani D.

Cell Signal. 2015 Oct;27(10):1984-93. doi: 10.1016/j.cellsig.2015.06.009. Epub 2015 Jul 10. Review.

PMID:
26169957
5.

A-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophy.

del Vescovo CD, Cotecchia S, Diviani D.

Mol Cell Biol. 2013 Jan;33(1):14-27. doi: 10.1128/MCB.00887-12. Epub 2012 Oct 22.

6.

Protein-protein interactions at the adrenergic receptors.

Cotecchia S, Stanasila L, Diviani D.

Curr Drug Targets. 2012 Jan;13(1):15-27. Review.

7.

Constitutive activity and inverse agonism at the α(₁a) and α(₁b) adrenergic receptor subtypes.

Cotecchia S.

Methods Enzymol. 2010;485:123-38. doi: 10.1016/B978-0-12-381296-4.00007-5.

PMID:
21050914
8.

The α1-adrenergic receptors: diversity of signaling networks and regulation.

Cotecchia S.

J Recept Signal Transduct Res. 2010 Dec;30(6):410-9. doi: 10.3109/10799893.2010.518152. Epub 2010 Oct 18. Review. Erratum in: J Recept Signal Transduct Res. 2011 Aug;31(4):314.

9.

Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice.

Sanbe A, Tanaka Y, Fujiwara Y, Miyauchi N, Mizutani R, Yamauchi J, Cotecchia S, Koike K, Tsujimoto G, Tanoue A.

Life Sci. 2009 May 22;84(21-22):713-8. doi: 10.1016/j.lfs.2009.02.020. Epub 2009 Feb 26.

PMID:
19249315
10.

Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome.

Garruti G, Cotecchia S, Giampetruzzi F, Giorgino F, Giorgino R.

J Gastrointestin Liver Dis. 2008 Jun;17(2):193-8. Review. Erratum in: J Gastrointestin Liver Dis. 2008 Sep;17(3):368.

11.

Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.

Stanasila L, Abuin L, Dey J, Cotecchia S.

Mol Pharmacol. 2008 Sep;74(3):562-73. doi: 10.1124/mol.107.043422. Epub 2008 Jun 3.

PMID:
18523139
12.

Expression and secretion of the atrial natriuretic peptide in human adipose tissue and preadipocytes.

Garruti G, Giusti V, Nussberger J, Darimont C, Verdumo C, Amstutz C, Puglisi F, Giorgino F, Giorgino R, Cotecchia S.

Obesity (Silver Spring). 2007 Sep;15(9):2181-9.

13.

Alpha1-adrenoceptors are required for normal male sexual function.

Sanbe A, Tanaka Y, Fujiwara Y, Tsumura H, Yamauchi J, Cotecchia S, Koike K, Tsujimoto G, Tanoue A.

Br J Pharmacol. 2007 Oct;152(3):332-40. Epub 2007 Jul 2.

14.

The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy.

Appert-Collin A, Cotecchia S, Nenniger-Tosato M, Pedrazzini T, Diviani D.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10140-5. Epub 2007 May 30.

15.

Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.

Hosoda C, Hiroyama M, Sanbe A, Birumachi J, Kitamura T, Cotecchia S, Simpson PC, Tsujimoto G, Tanoue A.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H514-9. Epub 2007 Mar 23.

16.

Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension.

Faber JE, Szymeczek CL, Cotecchia S, Thomas SA, Tanoue A, Tsujimoto G, Zhang H.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2316-23. Epub 2007 Jan 12.

17.

Constitutive activity and inverse agonism at the alpha1adrenoceptors.

Cotecchia S.

Biochem Pharmacol. 2007 Apr 15;73(8):1076-83. Epub 2006 Nov 27. Review.

PMID:
17125741
18.

Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling.

Stanasila L, Abuin L, Diviani D, Cotecchia S.

J Biol Chem. 2006 Feb 17;281(7):4354-63. Epub 2005 Dec 13.

19.

Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.

Costa T, Cotecchia S.

Trends Pharmacol Sci. 2005 Dec;26(12):618-24. Epub 2005 Nov 2. Review.

PMID:
16260046
20.

Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice.

Hosoda C, Tanoue A, Shibano M, Tanaka Y, Hiroyama M, Koshimizu TA, Cotecchia S, Kitamura T, Tsujimoto G, Koike K.

Br J Pharmacol. 2005 Oct;146(3):456-66.

21.

Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in mice.

Sarang Z, Molnár P, Németh T, Gomba S, Kardon T, Melino G, Cotecchia S, Fésüs L, Szondy Z.

Hepatology. 2005 Sep;42(3):578-87.

PMID:
16108039
22.

Paired activation of two components within muscarinic M3 receptor dimers is required for recruitment of beta-arrestin-1 to the plasma membrane.

Novi F, Stanasila L, Giorgi F, Corsini GU, Cotecchia S, Maggio R.

J Biol Chem. 2005 May 20;280(20):19768-76. Epub 2005 Mar 15.

23.

Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.

Hosoda C, Koshimizu TA, Tanoue A, Nasa Y, Oikawa R, Tomabechi T, Fukuda S, Shinoura H, Oshikawa S, Takeo S, Kitamura T, Cotecchia S, Tsujimoto G.

Mol Pharmacol. 2005 Mar;67(3):912-22. Epub 2004 Dec 14.

PMID:
15598970
24.
25.

Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction.

Townsend SA, Jung AS, Hoe YS, Lefkowitz RY, Khan SA, Lemmon CA, Harrison RW, Lee K, Barouch LA, Cotecchia S, Shoukas AA, Nyhan D, Hare JM, Berkowitz DE.

Hypertension. 2004 Nov;44(5):776-82. Epub 2004 Oct 4.

PMID:
15466664
26.

Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling.

Zhang H, Cotecchia S, Thomas SA, Tanoue A, Tsujimoto G, Faber JE.

Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2106-14. Epub 2004 Jul 1.

27.

Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex.

Diviani D, Abuin L, Cotecchia S, Pansier L.

EMBO J. 2004 Jul 21;23(14):2811-20. Epub 2004 Jul 1.

28.

Structural determinants involved in the activation and regulation of G protein-coupled receptors: lessons from the alpha1-adrenegic receptor subtypes.

Cotecchia S, Stanasila L, Diviani D, Björklöf K, Rossier O, Fanelli F.

Biol Cell. 2004 Jun;96(5):327-33. Review.

PMID:
15207900
29.

Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.

Cotecchia S, Fanelli F, Costa T.

Assay Drug Dev Technol. 2003 Apr;1(2):311-6.

PMID:
15090196
30.

Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype.

Burcelin R, Uldry M, Foretz M, Perrin C, Dacosta A, Nenniger-Tosato M, Seydoux J, Cotecchia S, Thorens B.

J Biol Chem. 2004 Jan 9;279(2):1108-15. Epub 2003 Oct 27.

31.

Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization.

Stanasila L, Perez JB, Vogel H, Cotecchia S.

J Biol Chem. 2003 Oct 10;278(41):40239-51. Epub 2003 Jul 29.

32.

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.

O'Connell TD, Ishizaka S, Nakamura A, Swigart PM, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E, Simpson PC.

J Clin Invest. 2003 Jun;111(11):1783-91.

33.

The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis.

Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S.

J Biol Chem. 2003 May 23;278(21):19331-40. Epub 2003 Mar 18.

34.

The alpha1b-adrenergic receptor subtype: molecular properties and physiological implications.

Cotecchia S, Björklöf K, Rossier O, Stanasila L, Greasley P, Fanelli F.

J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):1-16. Review.

PMID:
12503605
36.

Role of brain alpha 1B-adrenoceptors in modafinil-induced behavioral activity.

Stone EA, Cotecchia S, Lin Y, Quartermain D.

Synapse. 2002 Dec 15;46(4):269-70.

PMID:
12373742
37.

Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

Greasley PJ, Fanelli F, Rossier O, Abuin L, Cotecchia S.

Mol Pharmacol. 2002 May;61(5):1025-32.

PMID:
11961120
38.

Cardiovascular influences of alpha1b-adrenergic receptor defect in mice.

Vecchione C, Fratta L, Rizzoni D, Notte A, Poulet R, Porteri E, Frati G, Guelfi D, Trimarco V, Mulvany MJ, Agabiti-Rosei E, Trimarco B, Cotecchia S, Lembo G.

Circulation. 2002 Apr 9;105(14):1700-7.

PMID:
11940550
39.

Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor.

Del Carmine R, Ambrosio C, Sbraccia M, Cotecchia S, Ijzerman AP, Costa T.

Br J Pharmacol. 2002 Apr;135(7):1715-22.

40.

Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates.

Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP.

J Neurosci. 2002 Apr 1;22(7):2873-84.

41.

Co- and posttranslational modification of the alpha(1B)-adrenergic receptor: effects on receptor expression and function.

Björklöf K, Lundström K, Abuin L, Greasley PJ, Cotecchia S.

Biochemistry. 2002 Apr 2;41(13):4281-91.

PMID:
11914074
42.
43.

Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling.

Greasley PJ, Fanelli F, Scheer A, Abuin L, Nenniger-Tosato M, DeBenedetti PG, Cotecchia S.

J Biol Chem. 2001 Dec 7;276(49):46485-94. Epub 2001 Oct 3.

44.
45.

A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors.

Hein P, Goepel M, Cotecchia S, Michel MC.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Jan;363(1):34-9.

PMID:
11191834
46.

Comparison of [3H]tamsulosin and [3H]prazosin binding to wild-type and constitutively active alpha1B-adrenoceptors.

Hein P, Goepel M, Cotecchia S, Michel MC.

Life Sci. 2000 Jun 23;67(5):503-8.

PMID:
10993115
47.

The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.

Cotecchia S, Rossier O, Fanelli F, Leonardi A, De Benedetti PG.

Pharm Acta Helv. 2000 Mar;74(2-3):173-9. Review.

PMID:
10812955
48.

The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor.

Alewijnse AE, Timmerman H, Jacobs EH, Smit MJ, Roovers E, Cotecchia S, Leurs R.

Mol Pharmacol. 2000 May;57(5):890-8.

PMID:
10779371
49.

Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.

Scheer A, Costa T, Fanelli F, De Benedetti PG, Mhaouty-Kodja S, Abuin L, Nenniger-Tosato M, Cotecchia S.

Mol Pharmacol. 2000 Feb;57(2):219-31.

PMID:
10648631
50.

Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states.

Ambrosio C, Molinari P, Cotecchia S, Costa T.

Mol Pharmacol. 2000 Jan;57(1):198-210.

PMID:
10617695

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