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Items: 1 to 50 of 117

1.

Digital Technologies and Adherence in Respiratory Diseases: The Road Ahead.

Blakey JD, Bender BG, Dima AL, Weinman J, Safioti G, Costello RW.

Eur Respir J. 2018 Nov 8. pii: 1801147. doi: 10.1183/13993003.01147-2018. [Epub ahead of print] Review.

PMID:
30409819
2.

Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Non-Adherence in Severe Asthma.

Heaney LG, Busby J, Bradding P, Chaudhuri R, Mansur AH, Niven R, Pavord ID, Lindsay JT, Costello RW; Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

Am J Respir Crit Care Med. 2018 Oct 19. doi: 10.1164/rccm.201806-1182OC. [Epub ahead of print]

PMID:
30339770
3.

The future of accreditation of continuing medical education (CME)-continuing professional development (CPD) in Europe: harmonisation through dialogue and consensus.

de Andrade F, Griebenow R, Costello RW, Guenova M, Schaefer R, Chalmers JD, Tichelli A, Raguz D, Stein J.

J Eur CME. 2018 Sep 3;7(1):1506202. doi: 10.1080/21614083.2018.1506202. eCollection 2018.

4.

Eosinophils increase airway sensory nerve density in mice and in human asthma.

Drake MG, Scott GD, Blum ED, Lebold KM, Nie Z, Lee JJ, Fryer AD, Costello RW, Jacoby DB.

Sci Transl Med. 2018 Sep 5;10(457). pii: eaar8477. doi: 10.1126/scitranslmed.aar8477.

PMID:
30185653
5.

Personalising adherence-enhancing interventions using a smart inhaler in patients with COPD: an exploratory cost-effectiveness analysis.

van Boven JFM, Cushen B, Sulaiman I, Greene G, MacHale E, Mokoka MC, Doyle F, Reilly RB, Bennett K, Costello RW.

NPJ Prim Care Respir Med. 2018 Jun 27;28(1):24. doi: 10.1038/s41533-018-0092-8.

6.

A novel statistical method for assessing effective adherence to medication and calculating optimal drug dosages.

Greene G, Costello RW, Cushen B, Sulaiman I, Mac Hale E, Conroy RM, Doyle F.

PLoS One. 2018 Apr 20;13(4):e0195663. doi: 10.1371/journal.pone.0195663. eCollection 2018.

7.

Position paper on current aspects of sponsoring in accredited CME.

Stolz D, Griebenow R, Tichelli A, Ullmann AJ, Costello RW, Michalis L, Guenova M, Sutter S, De Andrade F, Schaefer R.

J Eur CME. 2017 Apr 28;6(1):1312062. doi: 10.1080/21614083.2017.1312062. eCollection 2017.

8.

Evaluation of criteria for clinical control in a prospective, international, multicenter study of patients with COPD.

Miravitlles M, Sliwinski P, Rhee CK, Costello RW, Carter V, Tan J, Lapperre TS, Alcazar B, Gouder C, Esquinas C, García-Rivero JL, Kemppinen A, Tee A, Roman-Rodríguez M, Soler-Cataluña JJ, Price DB.

Respir Med. 2018 Mar;136:8-14. doi: 10.1016/j.rmed.2018.01.019. Epub 2018 Jan 31.

PMID:
29501251
9.

Objective Assessment of Patient Inhaler User Technique Using an Audio-Based Classification Approach.

Taylor TE, Zigel Y, Egan C, Hughes F, Costello RW, Reilly RB.

Sci Rep. 2018 Feb 1;8(1):2164. doi: 10.1038/s41598-018-20523-w.

10.

The Clinical Impact of Different Adherence Behaviors in Patients with Severe Chronic Obstructive Pulmonary Disease.

Cushen B, Sulaiman I, Greene G, MacHale E, Mokoka M, Reilly RB, Bennett K, Doyle F, van Boven JFM, Costello RW.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1630-1633. doi: 10.1164/rccm.201712-2469LE. No abstract available.

PMID:
29351380
11.

Estimation of inhalation flow profile using audio-based methods to assess inhaler medication adherence.

Taylor TE, Lacalle Muls H, Costello RW, Reilly RB.

PLoS One. 2018 Jan 18;13(1):e0191330. doi: 10.1371/journal.pone.0191330. eCollection 2018.

12.

A randomised clinical trial of feedback on inhaler adherence and technique in patients with severe uncontrolled asthma.

Sulaiman I, Greene G, MacHale E, Seheult J, Mokoka M, D'Arcy S, Taylor T, Murphy DM, Hunt E, Lane SJ, Diette GB, FitzGerald JM, Boland F, Sartini Bhreathnach A, Cushen B, Reilly RB, Doyle F, Costello RW.

Eur Respir J. 2018 Jan 4;51(1). pii: 1701126. doi: 10.1183/13993003.01126-2017. Print 2018 Jan.

PMID:
29301919
13.

Reduction in exhaled nitric oxide tracks improved patient inhaler compliance in difficult asthma-a case study.

Hunt E, Flynn D, MacHale E, Costello RW, Murphy DM.

J Asthma. 2017 Dec 26:1-3. doi: 10.1080/02770903.2017.1414237. [Epub ahead of print]

PMID:
29278953
14.

Hospital Resource Utilisation by Patients with Community-Acquired Pneumonia.

McCarthy H, O'Donnell S, Costello RW, Humphreys H.

Ir Med J. 2017 Aug 12;110(7):613.

PMID:
29168995
15.

Advances in Audio-Based Systems to Monitor Patient Adherence and Inhaler Drug Delivery.

Taylor TE, Zigel Y, De Looze C, Sulaiman I, Costello RW, Reilly RB.

Chest. 2018 Mar;153(3):710-722. doi: 10.1016/j.chest.2017.08.1162. Epub 2017 Sep 5. Review.

PMID:
28887061
16.

Physical activity patterns and clusters in 1001 patients with COPD.

Mesquita R, Spina G, Pitta F, Donaire-Gonzalez D, Deering BM, Patel MS, Mitchell KE, Alison J, van Gestel AJ, Zogg S, Gagnon P, Abascal-Bolado B, Vagaggini B, Garcia-Aymerich J, Jenkins SC, Romme EA, Kon SS, Albert PS, Waschki B, Shrikrishna D, Singh SJ, Hopkinson NS, Miedinger D, Benzo RP, Maltais F, Paggiaro P, McKeough ZJ, Polkey MI, Hill K, Man WD, Clarenbach CF, Hernandes NA, Savi D, Wootton S, Furlanetto KC, Cindy Ng LW, Vaes AW, Jenkins C, Eastwood PR, Jarreta D, Kirsten A, Brooks D, Hillman DR, Sant'Anna T, Meijer K, Dürr S, Rutten EP, Kohler M, Probst VS, Tal-Singer R, Gil EG, den Brinker AC, Leuppi JD, Calverley PM, Smeenk FW, Costello RW, Gramm M, Goldstein R, Groenen MT, Magnussen H, Wouters EF, ZuWallack RL, Amft O, Watz H, Spruit MA.

Chron Respir Dis. 2017 Aug;14(3):256-269. doi: 10.1177/1479972316687207. Epub 2017 Feb 24.

17.

Effective deployment of technology-supported management of chronic respiratory conditions: a call for stakeholder engagement.

Costello RW, Dima AL, Ryan D, McIvor RA, Boycott K, Chisholm A, Price D, Blakey JD.

Pragmat Obs Res. 2017 Jul 5;8:119-128. doi: 10.2147/POR.S132316. eCollection 2017.

18.

Colonisation of Irish patients with chronic obstructive pulmonary disease by Streptococcus pneumoniae and analysis of the pneumococcal vaccine coverage: a non-interventional, observational, prospective cohort study.

McCarthy H, Jackson M, Corcoran M, McElligott M, MacHale E, Sulaiman I, Cushen B, Costello RW, Humpreys H.

BMJ Open. 2017 Jul 9;7(7):e013944. doi: 10.1136/bmjopen-2016-013944.

19.

In patients with severe uncontrolled asthma, does knowledge of adherence and inhaler technique using electronic monitoring improve clinical decision making? A protocol for a randomised controlled trial.

Mokoka MC, Lombard L, MacHale EM, Walsh J, Cushen B, Sulaiman I, Carthy DM, Boland F, Doyle F, Hunt E, Murphy DM, Faul J, Butler M, Hetherington K, Mark FitzGerald J, Boven JFV, Heaney LG, Reilly RB, Costello RW.

BMJ Open. 2017 Jun 15;7(6):e015367. doi: 10.1136/bmjopen-2016-015367.

20.

The impact of change of renal replacement therapy modality on sleep quality in patients with end-stage renal disease: a systematic review and meta-analysis.

Kennedy C, Ryan SA, Kane T, Costello RW, Conlon PJ.

J Nephrol. 2018 Feb;31(1):61-70. doi: 10.1007/s40620-017-0409-7. Epub 2017 Jun 1. Review.

PMID:
28573387
21.

Targeting patients with asthma for omalizumab therapy: choosing the right patient to get the best value for money.

Al Said A, Cushen B, Costello RW.

Ther Adv Chronic Dis. 2017 Feb;8(2-3):31-45. doi: 10.1177/2040622317690494. Epub 2017 Feb 1. Review.

22.

The Impact of Common Inhaler Errors on Drug Delivery: Investigating Critical Errors with a Dry Powder Inhaler.

Sulaiman I, Seheult J, Sadasivuni N, MacHale E, Killane I, Giannoutsos S, Cushen B, Mokoka MC, Bhreathnach AS, Boland F, Reilly RB, Costello RW.

J Aerosol Med Pulm Drug Deliv. 2017 Aug;30(4):247-255. doi: 10.1089/jamp.2016.1334. Epub 2017 Mar 9.

PMID:
28277810
23.

The INCATM (Inhaler Compliance AssessmentTM): A comparison with established measures of adherence.

Moran C, Doyle F, Sulaiman I, Bennett K, Greene G, Molloy GJ, Reilly RB, Costello RW, Mellon L.

Psychol Health. 2017 Oct;32(10):1266-1287. doi: 10.1080/08870446.2017.1290243. Epub 2017 Feb 28.

PMID:
28276739
24.

Changes in inhaler inhalation acoustic features during induced bronchoconstriction: a pilot study.

McCartan TA, Taylor TE, Sulaiman I, Costello RW, Reilly RB.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:3749-3752. doi: 10.1109/EMBC.2016.7591543.

PMID:
28269105
25.

Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity.

Spina G, Spruit MA, Alison J, Benzo RP, Calverley PMA, Clarenbach CF, Costello RW, Donaire-Gonzalez D, Dürr S, Garcia-Aymerich J, van Gestel AJR, Gramm M, Hernandes NA, Hill K, Hopkinson NS, Jarreta D, Kohler M, Kirsten AM, Leuppi JD, Magnussen H, Maltais F, Man WD, McKeough ZJ, Mesquita R, Miedinger D, Pitta F, Singh SJ, Smeenk FWJM, Tal-Singer R, Vagaggini B, Waschki B, Watz H, Wouters EFM, Zogg S, den Brinker AC.

Thorax. 2017 Aug;72(8):694-701. doi: 10.1136/thoraxjnl-2016-208900. Epub 2017 Jan 12.

26.

The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes.

Bosnic-Anticevich S, Chrystyn H, Costello RW, Dolovich MB, Fletcher MJ, Lavorini F, Rodríguez-Roisin R, Ryan D, Wan Yau Ming S, Price DB.

Int J Chron Obstruct Pulmon Dis. 2016 Dec 21;12:59-71. doi: 10.2147/COPD.S117196. eCollection 2017.

27.

A pilot study to monitor changes in spirometry and lung volume, following an exacerbation of Chronic Obstructive Pulmonary Disease (COPD), as part of a supported discharge program.

Cushen B, McCormack N, Hennigan K, Sulaiman I, Costello RW, Deering B.

Respir Med. 2016 Oct;119:55-62. doi: 10.1016/j.rmed.2016.08.019. Epub 2016 Aug 24.

28.

Irregular and Ineffective: A Quantitative Observational Study of the Time and Technique of Inhaler Use.

Sulaiman I, Seheult J, MacHale E, D'Arcy S, Boland F, McCrory K, Casey J, Bury G, Al-Alawi M, O'Dwyer S, Ryder SA, Reilly RB, Costello RW.

J Allergy Clin Immunol Pract. 2016 Sep-Oct;4(5):900-909.e2. doi: 10.1016/j.jaip.2016.07.009.

PMID:
27587321
29.

The Seven Stages of Man: The Role of Developmental Stage on Medication Adherence in Respiratory Diseases.

Costello RW, Foster JM, Grigg J, Eakin MN, Canonica W, Yunus F, Ryan D; Respiratory Effectiveness Group.

J Allergy Clin Immunol Pract. 2016 Sep-Oct;4(5):813-20. doi: 10.1016/j.jaip.2016.04.002. Review.

30.

Qualitative investigation into a wearable system for chronic obstructive pulmonary disease: the stakeholders' perspective.

Kayyali R, Savickas V, Spruit MA, Kaimakamis E, Siva R, Costello RW, Chang J, Pierscionek B, Davies N, Vaes AW, Paradiso R, Philip N, Perantoni E, D'Arcy S, Raptopoulos A, Nabhani-Gebara S.

BMJ Open. 2016 Aug 31;6(8):e011657. doi: 10.1136/bmjopen-2016-011657.

31.

Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.

Hennigan K, Conroy PJ, Walsh MT, Amin M, O'Kennedy R, Ramasamy P, Gleich GJ, Siddiqui Z, Glynn S, McCabe O, Mooney C, Harvey BJ, Costello RW, McBryan J.

Clin Immunol. 2016 Oct;171:1-11. doi: 10.1016/j.clim.2016.08.009. Epub 2016 Aug 9.

32.

A Method to Calculate Adherence to Inhaled Therapy that Reflects the Changes in Clinical Features of Asthma.

Sulaiman I, Seheult J, MacHale E, Boland F, O'Dwyer SM, Rapcan V, D'Arcy S, Cushen B, Mokoka M, Killane I, Ryder SA, Reilly RB, Costello RW.

Ann Am Thorac Soc. 2016 Nov;13(11):1894-1903.

PMID:
27467125
33.

Objective Assessment of Adherence to Inhalers by Patients with Chronic Obstructive Pulmonary Disease.

Sulaiman I, Cushen B, Greene G, Seheult J, Seow D, Rawat F, MacHale E, Mokoka M, Moran CN, Sartini Bhreathnach A, MacHale P, Tappuni S, Deering B, Jackson M, McCarthy H, Mellon L, Doyle F, Boland F, Reilly RB, Costello RW.

Am J Respir Crit Care Med. 2017 May 15;195(10):1333-1343. doi: 10.1164/rccm.201604-0733OC. Erratum in: Am J Respir Crit Care Med. 2017 May 15;195(10 ):1407.

PMID:
27409253
34.

Predicting asthma exacerbations employing remotely monitored adherence.

Killane I, Sulaiman I, MacHale E, Breathnach A, Taylor TE, Holmes MS, Reilly RB, Costello RW.

Healthc Technol Lett. 2016 Mar 23;3(1):51-5. doi: 10.1049/htl.2015.0058. eCollection 2016 Mar.

35.

The effect of providing feedback on inhaler technique and adherence from an electronic audio recording device, INCA®, in a community pharmacy setting: study protocol for a randomised controlled trial.

O'Dwyer SM, MacHale E, Sulaiman I, Holmes M, Hughes C, D'Arcy S, Rapcan V, Taylor T, Boland F, Bosnic-Anticevich S, Reilly RB, Ryder SA, Costello RW.

Trials. 2016 May 4;17(1):226. doi: 10.1186/s13063-016-1362-9.

36.

A risk stratification tool for exacerbations of COPD: time to switch to DECAF.

Costello RW, Cushen B.

Thorax. 2016 Jun;71(6):489-90. doi: 10.1136/thoraxjnl-2015-208053. Epub 2016 Feb 16. No abstract available.

PMID:
26883673
37.

Monitoring Inhaler Inhalations Using an Acoustic Sensor Proximal to Inhaler Devices.

Taylor TE, Holmes MS, Sulaiman I, Costello RW, Reilly RB.

J Aerosol Med Pulm Drug Deliv. 2016 Oct;29(5):439-446. Epub 2016 Feb 9.

PMID:
26859629
38.

Influences of gender and anthropometric features on inspiratory inhaler acoustics and peak inspiratory flow rate.

Taylor TE, Holmes MS, Sulaiman I, Costello RW, Reilly RB.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:2227-30. doi: 10.1109/EMBC.2015.7318834.

PMID:
26736734
39.

A protocol for a randomised clinical trial of the effect of providing feedback on inhaler technique and adherence from an electronic device in patients with poorly controlled severe asthma.

Sulaiman I, Mac Hale E, Holmes M, Hughes C, D'Arcy S, Taylor T, Rapcan V, Doyle F, Breathnach A, Seheult J, Murphy D, Hunt E, Lane SJ, Sahadevan A, Crispino G, Diette G, Killane I, Reilly RB, Costello RW.

BMJ Open. 2016 Jan 4;6(1):e009350. doi: 10.1136/bmjopen-2015-009350.

40.

SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins.

Lynn TM, Molloy EL, Masterson JC, Glynn SF, Costello RW, Avdalovic MV, Schelegle ES, Miller LA, Hyde DM, O'Dea S.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):562-73. doi: 10.1165/rcmb.2015-0210OC.

41.

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R, Arron JR, Choy DF, Cowan D, Mansur A, Menzies-Gow A, Adcock I, Chung KF, Corrigan C, Coyle P, Harrison T, Johnston S, Howarth P, Lordan J, Sabroe I, Bigler J, Smith D, Catley M, May R, Pierre L, Stevenson C, Crater G, Keane F, Costello RW, Hudson V, Supple D, Hardman T.

Thorax. 2016 Feb;71(2):187-9. doi: 10.1136/thoraxjnl-2015-207326. Epub 2015 Jul 23. Review.

42.

Identifying Physical Activity Profiles in COPD Patients Using Topic Models.

Spina G, Casale P, Albert PS, Alison J, Garcia-Aymerich J, Costello RW, Hernandes NA, van Gestel AJ, Leuppi JD, Mesquita R, Singh SJ, Smeenk FW, Tal-Singer R, Wouters EF, Spruit MA, den Brinker AC.

IEEE J Biomed Health Inform. 2015 Sep;19(5):1567-76. doi: 10.1109/JBHI.2015.2432033. Epub 2015 May 12.

PMID:
25974957
43.

An acoustic method to automatically detect pressurized metered dose inhaler actuations.

Taylor TE, Holmes MS, Sulaiman I, D'Arcy S, Costello RW, Reilly RB.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:4611-4. doi: 10.1109/EMBC.2014.6944651.

PMID:
25571019
44.

A nurse-led intervention study: Promoting compliance with Diskus Inhaler use in asthma patients.

Mac Hale E, Costello RW, Cowman S.

Nurs Open. 2014 Nov 28;1(1):42-52. eCollection 2014 Dec.

45.

An Acoustic-Based Method to Detect and Quantify the Effect of Exhalation into a Dry Powder Inhaler.

Holmes MS, Seheult JN, O'Connell P, D'Arcy S, Ehrhardt C, Healy AM, Costello RW, Reilly RB.

J Aerosol Med Pulm Drug Deliv. 2015 Aug;28(4):247-53. doi: 10.1089/jamp.2014.1169. Epub 2014 Nov 13.

PMID:
25393346
46.

Investigating the relationship between peak inspiratory flow rate and volume of inhalation from a Diskus™ Inhaler and baseline spirometric parameters: a cross-sectional study.

Seheult JN, Costello S, Tee KC, Bholah T, Al Bannai H, Sulaiman I, Costello RW.

Springerplus. 2014 Sep 2;3:496. doi: 10.1186/2193-1801-3-496. eCollection 2014.

47.

Physiological levels of lipoxin A4 inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium.

Al-Alawi M, Buchanan P, Verriere V, Higgins G, McCabe O, Costello RW, McNally P, Urbach V, Harvey BJ.

Physiol Rep. 2014 Aug 7;2(8). pii: e12093. doi: 10.14814/phy2.12093. Print 2014 Aug 1.

48.

Eosinophil peroxidase induces expression of cholinergic genes via cell surface neural interactions.

Akasheh N, Walsh MT, Costello RW.

Mol Immunol. 2014 Nov;62(1):37-45. doi: 10.1016/j.molimm.2014.05.014. Epub 2014 Jun 14.

PMID:
24937179
49.

A method to assess adherence in inhaler use through analysis of acoustic recordings of inhaler events.

D'Arcy S, MacHale E, Seheult J, Holmes MS, Hughes C, Sulaiman I, Hyland D, O'Reilly C, Glynn S, Al-Zaabi T, McCourt J, Taylor T, Keane F, Killane I, Reilly RB, Costello RW.

PLoS One. 2014 Jun 6;9(6):e98701. doi: 10.1371/journal.pone.0098701. eCollection 2014.

50.

The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus™ dry powder inhaler.

Seheult JN, O'Connell P, Tee KC, Bholah T, Al Bannai H, Sulaiman I, MacHale E, D'Arcy S, Holmes MS, Bergin D, Reeves E, Reilly RB, Crispino-O'Connell G, Ehrhardt C, Healy AM, Costello RW.

Pharm Res. 2014 Oct;31(10):2735-47. doi: 10.1007/s11095-014-1371-x. Epub 2014 May 28.

PMID:
24867420

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