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Items: 1 to 50 of 60

1.

Discovery of GSK3527497: A candidate for the inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).

Brooks CA, Barton LS, Behm DJ, Brnardic E, Costell M, Holt DA, Jolivette LJ, Matthews JM, McAtee JJ, McCleland BW, Patterson JR, Pero JE, Rivero RA, Roethke TJ, Sanchez RM, Shenje R, Terrell LR, Lawhorn BG.

J Med Chem. 2019 Sep 18. doi: 10.1021/acs.jmedchem.9b01247. [Epub ahead of print]

PMID:
31532662
2.

Profilin 1 Negatively Regulates Osteoclast Migration in Postnatal Skeletal Growth, Remodeling, and Homeostasis in Mice.

Shirakawa J, Kajikawa S, Böttcher RT, Costell M, Izu Y, Hayata T, Noda M, Ezura Y.

JBMR Plus. 2019 Jan 17;3(6):e10130. doi: 10.1002/jbm4.10130. eCollection 2019 Jun.

3.

Integrin activation by talin, kindlin and mechanical forces.

Sun Z, Costell M, Fässler R.

Nat Cell Biol. 2019 Jan;21(1):25-31. doi: 10.1038/s41556-018-0234-9. Epub 2019 Jan 2. Review.

PMID:
30602766
4.

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.

Pero JE, Matthews JM, Behm DJ, Brnardic EJ, Brooks C, Budzik BW, Costell MH, Donatelli CA, Eisennagel SH, Erhard K, Fischer MC, Holt DA, Jolivette LJ, Li H, Li P, McAtee JJ, McCleland BW, Pendrak I, Posobiec LM, Rivera KLK, Rivero RA, Roethke TJ, Sender MR, Shu A, Terrell LR, Vaidya K, Xu X, Lawhorn BG.

J Med Chem. 2018 Dec 27;61(24):11209-11220. doi: 10.1021/acs.jmedchem.8b01344. Epub 2018 Dec 12.

PMID:
30500190
5.

Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4).

Brnardic EJ, Ye G, Brooks C, Donatelli C, Barton L, McAtee J, Sanchez RM, Shu A, Erhard K, Terrell L, Graczyk-Millbrandt G, He Y, Costell MH, Behm DJ, Roethke T, Stoy P, Holt DA, Lawhorn BG.

J Med Chem. 2018 Nov 8;61(21):9738-9755. doi: 10.1021/acs.jmedchem.8b01317. Epub 2018 Oct 18.

PMID:
30335378
6.

Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice.

Almonte-Becerril M, Gimeno-LLuch I, Villarroya O, Benito-Jardón M, Kouri JB, Costell M.

PLoS One. 2018 Jun 5;13(6):e0198559. doi: 10.1371/journal.pone.0198559. eCollection 2018.

7.

Corrigendum: Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second.

Strohmeyer N, Bharadwaj M, Costell M, Fässler R, Müller DJ.

Nat Mater. 2017 Dec 19;17(1):103. doi: 10.1038/nmat5054.

PMID:
29255228
8.

Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second.

Strohmeyer N, Bharadwaj M, Costell M, Fässler R, Müller DJ.

Nat Mater. 2017 Dec;16(12):1262-1270. doi: 10.1038/nmat5023. Epub 2017 Nov 6. Erratum in: Nat Mater. 2017 Dec 19;17 (1):103.

PMID:
29115292
9.

Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization.

Moulisová V, Gonzalez-García C, Cantini M, Rodrigo-Navarro A, Weaver J, Costell M, Sabater I Serra R, Dalby MJ, García AJ, Salmerón-Sánchez M.

Biomaterials. 2017 May;126:61-74. doi: 10.1016/j.biomaterials.2017.02.024. Epub 2017 Feb 21.

10.

Profilin1 is expressed in osteocytes and regulates cell shape and migration.

Lin W, Izu Y, Smriti A, Kawasaki M, Pawaputanon C, Böttcher RT, Costell M, Moriyama K, Noda M, Ezura Y.

J Cell Physiol. 2018 Jan;233(1):259-268. doi: 10.1002/jcp.25872. Epub 2017 May 3.

PMID:
28233307
11.

The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes.

Benito-Jardón M, Klapproth S, Gimeno-LLuch I, Petzold T, Bharadwaj M, Müller DJ, Zuchtriegel G, Reichel CA, Costell M.

Elife. 2017 Jan 16;6. pii: e22264. doi: 10.7554/eLife.22264.

12.

Profilin1 activity in cerebellar granule neurons is required for radial migration in vivo.

Kullmann JA, Wickertsheim I, Minnerup L, Costell M, Friauf E, Rust MB.

Cell Adh Migr. 2015;9(3):247-53. doi: 10.4161/19336918.2014.983804. Epub 2014 Dec 12.

13.

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation.

Klingberg F, Chow ML, Koehler A, Boo S, Buscemi L, Quinn TM, Costell M, Alman BA, Genot E, Hinz B.

J Cell Biol. 2014 Oct 27;207(2):283-97. doi: 10.1083/jcb.201402006. Epub 2014 Oct 20.

14.

Changes in the integrins expression are related with the osteoarthritis severity in an experimental animal model in rats.

Almonte-Becerril M, Costell M, Kouri JB.

J Orthop Res. 2014 Sep;32(9):1161-6. doi: 10.1002/jor.22649. Epub 2014 May 17.

15.

Profilin 1 is required for peripheral nervous system myelination.

Montani L, Buerki-Thurnherr T, de Faria JP, Pereira JA, Dias NG, Fernandes R, Gonçalves AF, Braun A, Benninger Y, Böttcher RT, Costell M, Nave KA, Franklin RJ, Meijer D, Suter U, Relvas JB.

Development. 2014 Apr;141(7):1553-61. doi: 10.1242/dev.101840. Epub 2014 Mar 5.

16.

Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow.

Zheng J, Lu Z, Kocabas F, Böttcher RT, Costell M, Kang X, Liu X, Deberardinis RJ, Wang Q, Chen GQ, Sadek H, Zhang CC.

Blood. 2014 Feb 13;123(7):992-1001. doi: 10.1182/blood-2013-04-498469. Epub 2014 Jan 2.

17.

Development of a culture of sustainability in health care organizations.

Ramirez B, West DJ, Costell MM.

J Health Organ Manag. 2013;27(5):665-72.

PMID:
24341182
18.

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.

Thalji RK, McAtee JJ, Belyanskaya S, Brandt M, Brown GD, Costell MH, Ding Y, Dodson JW, Eisennagel SH, Fries RE, Gross JW, Harpel MR, Holt DA, Israel DI, Jolivette LJ, Krosky D, Li H, Lu Q, Mandichak T, Roethke T, Schnackenberg CG, Schwartz B, Shewchuk LM, Xie W, Behm DJ, Douglas SA, Shaw AL, Marino JP Jr.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3584-8. doi: 10.1016/j.bmcl.2013.04.019. Epub 2013 Apr 16.

PMID:
23664879
19.

Chronic inhibition of 11 β -hydroxysteroid dehydrogenase type 1 activity decreases hypertension, insulin resistance, and hypertriglyceridemia in metabolic syndrome.

Schnackenberg CG, Costell MH, Krosky DJ, Cui J, Wu CW, Hong VS, Harpel MR, Willette RN, Yue TL.

Biomed Res Int. 2013;2013:427640. doi: 10.1155/2013/427640. Epub 2013 Mar 18.

20.

Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro.

Gustafsson E, Almonte-Becerril M, Bloch W, Costell M.

PLoS One. 2013;8(1):e53715. doi: 10.1371/journal.pone.0053715. Epub 2013 Jan 8.

21.

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN.

Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.

22.

Purkinje cell loss and motor coordination defects in profilin1 mutant mice.

Kullmann JA, Neumeyer A, Wickertsheim I, Böttcher RT, Costell M, Deitmer JW, Witke W, Friauf E, Rust MB.

Neuroscience. 2012 Oct 25;223:355-64. doi: 10.1016/j.neuroscience.2012.07.055. Epub 2012 Aug 3.

PMID:
22864186
23.

Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.

Costell MH, Ancellin N, Bernard RE, Zhao S, Upson JJ, Morgan LA, Maniscalco K, Olzinski AR, Ballard VL, Herry K, Grondin P, Dodic N, Mirguet O, Bouillot A, Gellibert F, Coatney RW, Lepore JJ, Jucker BM, Jolivette LJ, Willette RN, Schnackenberg CG, Behm DJ.

Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012.

24.

Profilin1 regulates sternum development and endochondral bone formation.

Miyajima D, Hayata T, Suzuki T, Hemmi H, Nakamoto T, Notomi T, Amagasa T, Böttcher RT, Costell M, Fässler R, Ezura Y, Noda M.

J Biol Chem. 2012 Sep 28;287(40):33545-53. Epub 2012 Jul 6.

25.

Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis.

Stenzel D, Lundkvist A, Sauvaget D, Busse M, Graupera M, van der Flier A, Wijelath ES, Murray J, Sobel M, Costell M, Takahashi S, Fässler R, Yamaguchi Y, Gutmann DH, Hynes RO, Gerhardt H.

Development. 2011 Oct;138(20):4451-63. doi: 10.1242/dev.071381. Epub 2011 Aug 31.

26.

α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice.

Girós A, Grgur K, Gossler A, Costell M.

PLoS One. 2011;6(7):e22002. doi: 10.1371/journal.pone.0022002. Epub 2011 Jul 22.

27.

Profilin 1 is required for abscission during late cytokinesis of chondrocytes.

Böttcher RT, Wiesner S, Braun A, Wimmer R, Berna A, Elad N, Medalia O, Pfeifer A, Aszódi A, Costell M, Fässler R.

EMBO J. 2009 Apr 22;28(8):1157-69. doi: 10.1038/emboj.2009.58. Epub 2009 Mar 5.

28.

Perlecan is critical for heart stability.

Sasse P, Malan D, Fleischmann M, Roell W, Gustafsson E, Bostani T, Fan Y, Kolbe T, Breitbach M, Addicks K, Welz A, Brem G, Hescheler J, Aszodi A, Costell M, Bloch W, Fleischmann BK.

Cardiovasc Res. 2008 Dec 1;80(3):435-44. doi: 10.1093/cvr/cvn225. Epub 2008 Aug 10.

PMID:
18694874
29.

The role of integrin binding sites in fibronectin matrix assembly in vivo.

Leiss M, Beckmann K, Girós A, Costell M, Fässler R.

Curr Opin Cell Biol. 2008 Oct;20(5):502-7. doi: 10.1016/j.ceb.2008.06.001. Epub 2008 Jul 21. Review.

PMID:
18586094
30.

PPARdelta activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure.

Jucker BM, Doe CP, Schnackenberg CG, Olzinski AR, Maniscalco K, Williams C, Hu TC, Lenhard SC, Costell M, Bernard R, Sarov-Blat L, Steplewski K, Willette RN.

J Cardiovasc Pharmacol. 2007 Jul;50(1):25-34.

PMID:
17666912
31.

Perlecan controls neurogenesis in the developing telencephalon.

Girós A, Morante J, Gil-Sanz C, Fairén A, Costell M.

BMC Dev Biol. 2007 Apr 5;7:29.

32.

Rosiglitazone protects against ischemia/reperfusion-induced leukocyte adhesion in the zucker diabetic fatty rat.

Johns DG, Ao Z, Eybye M, Olzinski A, Costell M, Gruver S, Smith SA, Douglas SA, Macphee CH.

J Pharmacol Exp Ther. 2005 Dec;315(3):1020-7. Epub 2005 Aug 25.

PMID:
16123307
33.

Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN.

Garl PJ, Wenzlau JM, Walker HA, Whitelock JM, Costell M, Weiser-Evans MC.

Circ Res. 2004 Feb 6;94(2):175-83. Epub 2003 Dec 1.

PMID:
14656929
34.

Development of the coronary arteries in a murine model of transposition of great arteries.

González-Iriarte M, Carmona R, Pérez-Pomares JM, Macías D, Costell M, Muñoz-Chápuli R.

J Mol Cell Cardiol. 2003 Jul;35(7):795-802.

PMID:
12818570
35.

Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease.

Sáez-Valero J, Costell M, Sjögren M, Andreasen N, Blennow K, Luque JM.

J Neurosci Res. 2003 Apr 1;72(1):132-6.

PMID:
12645087
36.
37.

Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice.

Costell M, Carmona R, Gustafsson E, González-Iriarte M, Fässler R, Muñoz-Chápuli R.

Circ Res. 2002 Jul 26;91(2):158-64.

PMID:
12142349
38.

Oral lavage with polyethylene glycol reduces microbial colonization in the gastrointestinal tract of broilers.

Farhat A, Maddox CW, Edwards ME, Costell MH, Hadley JA, Vasilatos-Younken R.

Poult Sci. 2002 Apr;81(4):585-9.

PMID:
11989760
39.

Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.

Henry MD, Satz JS, Brakebusch C, Costell M, Gustafsson E, Fässler R, Campbell KP.

J Cell Sci. 2001 Mar;114(Pt 6):1137-44.

40.

Perlecan maintains the integrity of cartilage and some basement membranes.

Costell M, Gustafsson E, Aszódi A, Mörgelin M, Bloch W, Hunziker E, Addicks K, Timpl R, Fässler R.

J Cell Biol. 1999 Nov 29;147(5):1109-22.

42.

Characterization of recombinant perlecan domain I and its substitution by glycosaminoglycans and oligosaccharides.

Costell M, Mann K, Yamada Y, Timpl R.

Eur J Biochem. 1997 Jan 15;243(1-2):115-21.

43.

Structural characterization of recombinant domain II of the basement membrane proteoglycan perlecan.

Costell M, Sasaki T, Mann K, Yamada Y, Timpl R.

FEBS Lett. 1996 Nov 4;396(2-3):127-31.

44.

Structural and cell-adhesive properties of three recombinant fragments derived from perlecan domain III.

Schulze B, Sasaki T, Costell M, Mann K, Timpl R.

Matrix Biol. 1996 Nov;15(5):349-57.

PMID:
8981331
45.
46.

A smaller initial dose protects mice against several lethal doses of ammonium acetate.

Costell M, O'Connor JE, Grisolía S.

Biochem Biophys Res Commun. 1990 Mar 30;167(3):1263-70.

PMID:
2322271
47.

New roles of carnitine metabolism in ammonia cytotoxicity.

O'Connor JE, Costell M.

Adv Exp Med Biol. 1990;272:183-95. Review.

PMID:
2103686
48.

Age-dependent decrease of carnitine content in muscle of mice and humans.

Costell M, O'Connor JE, Grisolía S.

Biochem Biophys Res Commun. 1989 Jun 30;161(3):1135-43.

PMID:
2742580
49.

Carbamyl glutamate prevents the potentiation of ammonia toxicity by sodium benzoate.

O'Connor JE, Costell M, Grisolía S.

Eur J Pediatr. 1989 Apr;148(6):540-2.

PMID:
2744016
50.

Effect of L-carnitine on ketone bodies, redox state and free amino acids in the liver of hyperammonemic mice.

O'Connor JE, Costell M, Míguez MP, Portolés M, Grisolía S.

Biochem Pharmacol. 1987 Oct 1;36(19):3169-73.

PMID:
3663232

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