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Artificial Intelligence Algorithms and Natural Language Processing for the Recognition of Syncope Patients on Emergency Department Medical Records.

Dipaola F, Gatti M, Pacetti V, Bottaccioli AG, Shiffer D, Minonzio M, Menè R, Giaj Levra A, Solbiati M, Costantino G, Anastasio M, Sini E, Barbic F, Brunetta E, Furlan R.

J Clin Med. 2019 Oct 14;8(10). pii: E1677. doi: 10.3390/jcm8101677.


Genetic, morphological and chemical investigations reveal the genetic origin of Pompia (C. medica tuberosa Risso & Poiteau) - An old endemic Sardinian citrus fruit.

Luro F, Viglietti G, Marchi E, Costantino G, Scarpa GM, Tomi F, Paoli M, Curk F, Ollitrault P.

Phytochemistry. 2019 Sep 11:112083. doi: 10.1016/j.phytochem.2019.112083. [Epub ahead of print]


The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions.

Biagioli M, Carino A, Fiorucci C, Annunziato G, Marchianò S, Bordoni M, Roselli R, Giorgio CD, Castiglione F, Ricci P, Bruno A, Faccini A, Distrutti E, Baldoni M, Costantino G, Fiorucci S.

Nutrients. 2019 Aug 7;11(8). pii: E1820. doi: 10.3390/nu11081820.


Cardiac Autonomic Derangement is Associated with Worse Neurological Outcome in the Very Early Phases of Ischemic Stroke.

Tobaldini E, Sacco RM, Serafino S, Tassi M, Gallone G, Solbiati M, Costantino G, Montano N, Torgano G.

J Clin Med. 2019 Jun 14;8(6). pii: E852. doi: 10.3390/jcm8060852.


Reconstruction of vertebral body in thoracolumbar AO type A post-traumatic fractures by balloon kyphoplasty. A series of 85 patients with a long follow-up and review of literature.

Francaviglia N, Villa A, Maiello M, Costantino G, Alessandrello RF, Meli F, Odierna Contino A, Lipani R, Fiorenza V, Lo Duca B, Ascanio F, Iacopino DG, Maugeri R.

J Neurosurg Sci. 2019 Apr 23. doi: 10.23736/S0390-5616.19.04628-9. [Epub ahead of print]


Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.

Vincetti P, Kaptein SJF, Costantino G, Neyts J, Radi M.

ACS Med Chem Lett. 2019 Jan 23;10(4):558-563. doi: 10.1021/acsmedchemlett.8b00583. eCollection 2019 Apr 11.


Genotyping by sequencing can reveal the complex mosaic genomes in gene pools resulting from reticulate evolution: a case study in diploid and polyploid citrus.

Ahmed D, Comte A, Curk F, Costantino G, Luro F, Dereeper A, Mournet P, Froelicher Y, Ollitrault P.

Ann Bot. 2019 Jul 8;123(7):1231-1251. doi: 10.1093/aob/mcz029.


Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors.

Eren G, Bruno A, Guntekin-Ergun S, Cetin-Atalay R, Ozgencil F, Ozkan Y, Gozelle M, Kaya SG, Costantino G.

J Mol Graph Model. 2019 Jun;89:60-73. doi: 10.1016/j.jmgm.2019.02.014. Epub 2019 Mar 5.


Syncope in a Working-Age Population: Recurrence Risk and Related Risk Factors.

Barbic F, Dipaola F, Casazza G, Borella M, Minonzio M, Solbiati M, Raj SR, Sheldon R, Quinn J, Costantino G, Furlan R.

J Clin Med. 2019 Jan 29;8(2). pii: E150. doi: 10.3390/jcm8020150.


Outcome in ulcerative colitis after switch from adalimumab/golimumab to infliximab: A multicenter retrospective study.

Viola A, Pugliese D, Renna S, Furfaro F, Caprioli F, D'Incà R, Bossa F, Mazza S, Costantino G, Fantini MC, Fiorino G, Alibrandi A, Orlando A, Armuzzi A, Fries W.

Dig Liver Dis. 2019 Apr;51(4):510-515. doi: 10.1016/j.dld.2018.10.013. Epub 2018 Oct 28.


New Hope in Brain Glioma Surgery: The Role of Intraoperative Ultrasound. A Review.

Pino MA, Imperato A, Musca I, Maugeri R, Giammalva GR, Costantino G, Graziano F, Meli F, Francaviglia N, Iacopino DG, Villa A.

Brain Sci. 2018 Nov 19;8(11). pii: E202. doi: 10.3390/brainsci8110202. Review.


Preferential Homologous Chromosome Pairing in a Tetraploid Intergeneric Somatic Hybrid (Citrus reticulata + Poncirus trifoliata) Revealed by Molecular Marker Inheritance.

Kamiri M, Stift M, Costantino G, Dambier D, Kabbage T, Ollitrault P, Froelicher Y.

Front Plant Sci. 2018 Nov 2;9:1557. doi: 10.3389/fpls.2018.01557. eCollection 2018.


Short sleep duration and cardiometabolic risk: from pathophysiology to clinical evidence.

Tobaldini E, Fiorelli EM, Solbiati M, Costantino G, Nobili L, Montano N.

Nat Rev Cardiol. 2019 Apr;16(4):213-224. doi: 10.1038/s41569-018-0109-6. Review.


Refining the structure-activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms.

Magalhães J, Franko N, Annunziato G, Pieroni M, Benoni R, Nikitjuka A, Mozzarelli A, Bettati S, Karawajczyk A, Jirgensons A, Campanini B, Costantino G.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):31-43. doi: 10.1080/14756366.2018.1518959.


Emerging therapeutic strategies for minimal change disease and focal and segmental glomerulosclerosis.

Siligato R, Cernaro V, Nardi C, De Gregorio F, Gembillo G, Costantino G, Conti G, Buemi M, Santoro D.

Expert Opin Investig Drugs. 2018 Nov;27(11):839-879. doi: 10.1080/13543784.2018.1540587. Epub 2018 Oct 30. Review.


Artificial neural networks and risk stratification in emergency departments.

Falavigna G, Costantino G, Furlan R, Quinn JV, Ungar A, Ippoliti R.

Intern Emerg Med. 2019 Mar;14(2):291-299. doi: 10.1007/s11739-018-1971-2. Epub 2018 Oct 23.


Short- vs long-course antibiotic therapy for pneumonia: a comparison of systematic reviews and guidelines for the SIMI Choosing Wisely Campaign.

Furlan L, Erba L, Trombetta L, Sacco R, Colombo G, Casazza G, Solbiati M, Montano N, Marta C, Sbrojavacca R, Perticone F, Corazza GR, Costantino G.

Intern Emerg Med. 2019 Apr;14(3):377-394. doi: 10.1007/s11739-018-1955-2. Epub 2018 Oct 8.


Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases.

Annunziato G, Giovati L, Angeli A, Pavone M, Del Prete S, Pieroni M, Capasso C, Bruno A, Conti S, Magliani W, Supuran CT, Costantino G.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1537-1544. doi: 10.1080/14756366.2018.1516652.


Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics.

Machado D, Azzali E, Couto I, Costantino G, Pieroni M, Viveiros M.

Future Microbiol. 2018 Sep;13:1383-1402. doi: 10.2217/fmb-2018-0110. Epub 2018 Sep 27.


Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives.

Franko N, Grammatoglou K, Campanini B, Costantino G, Jirgensons A, Mozzarelli A.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1343-1351. doi: 10.1080/14756366.2018.1504040.


Effects of Clockwise and Counterclockwise Job Shift Work Rotation on Sleep and Work-Life Balance on Hospital Nurses.

Shiffer D, Minonzio M, Dipaola F, Bertola M, Zamuner AR, Dalla Vecchia LA, Solbiati M, Costantino G, Furlan R, Barbic F.

Int J Environ Res Public Health. 2018 Sep 18;15(9). pii: E2038. doi: 10.3390/ijerph15092038.


Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design.

Magalhães J, Franko N, Annunziato G, Welch M, Dolan SK, Bruno A, Mozzarelli A, Armao S, Jirgensons A, Pieroni M, Costantino G, Campanini B.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1444-1452. doi: 10.1080/14756366.2018.1512596.


Convective Dialysis Reduces Mortality Risk: Results From a Large Observational, Population-Based Analysis.

Cernaro V, Tripepi G, Visconti L, Lacquaniti A, Montalto G, Romeo A, Cimadoro D, Costantino G, Torre F, Santoro D, Buemi M; Workgroup of the Sicilian Registry of Nephrology, Dialysis and Transplantation.

Ther Apher Dial. 2018 Oct;22(5):457-468. doi: 10.1111/1744-9987.12684. Epub 2018 Jul 10.


A woman with abdominal pain, jaundice and elevated CA 19.9.

Fusco A, Baorda F, Porta L, Lemos AA, Caccamo L, Tobaldini E, Costantino G.

Intern Emerg Med. 2019 Jun;14(4):557-560. doi: 10.1007/s11739-018-1879-x. Epub 2018 May 18. No abstract available.


Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation.

Schmaler M, Colone A, Spagnuolo J, Zimmermann M, Lepore M, Kalinichenko A, Bhatia S, Cottier F, Rutishauser T, Pavelka N, Egli A, Azzali E, Pieroni M, Costantino G, Hruz P, Sauer U, Mori L, De Libero G.

Mucosal Immunol. 2018 Jul;11(4):1060-1070. doi: 10.1038/s41385-018-0020-9. Epub 2018 May 9.


Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds.

Kaptein SJF, Vincetti P, Crespan E, Rivera JIA, Costantino G, Maga G, Neyts J, Radi M.

ChemMedChem. 2018 Jul 18;13(14):1371-1376. doi: 10.1002/cmdc.201800178. Epub 2018 Jun 1.


Superior Mesenteric Artery Syndrome in Patients with Crohn's Disease: A Description of 2 Cases Studied with a Novel Magnetic Resonance Enterography (MRE) Procedure.

Cicero G, D'Angelo T, Bottari A, Costantino G, Visalli C, Racchiusa S, Marino MA, Cavallaro M, Frosina L, Blandino A, Mazziotti S.

Am J Case Rep. 2018 Apr 12;19:431-437.


Fever, edema, and shortness of breath: the Scrhödinger's cat paradox displayed on pericardium.

Gesu E, Gelpi G, Piconi S, Righi I, Andrisani MC, Garanzini E, Vespro V, Costantino G.

Intern Emerg Med. 2019 Jan;14(1):103-108. doi: 10.1007/s11739-018-1850-x. Epub 2018 Apr 7. No abstract available.


Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets.

Magalhães J, Annunziato G, Franko N, Pieroni M, Campanini B, Bruno A, Costantino G.

J Chem Inf Model. 2018 Mar 26;58(3):710-723. doi: 10.1021/acs.jcim.7b00733. Epub 2018 Mar 6.


Diagnostic accuracy of ICD-9 code 780.2 for the identification of patients with syncope in the emergency department.

Furlan L, Solbiati M, Pacetti V, Dipaola F, Meda M, Bonzi M, Fiorelli E, Cernuschi G, Alberio D, Casazza G, Montano N, Furlan R, Costantino G.

Clin Auton Res. 2018 Dec;28(6):577-582. doi: 10.1007/s10286-018-0509-z. Epub 2018 Feb 12.


With a Little Help from My Friends: The Role of Intraoperative Fluorescent Dyes in the Surgical Management of High-Grade Gliomas.

Maugeri R, Villa A, Pino M, Imperato A, Giammalva GR, Costantino G, Graziano F, Gulì C, Meli F, Francaviglia N, Iacopino DG.

Brain Sci. 2018 Feb 7;8(2). pii: E31. doi: 10.3390/brainsci8020031. Review.


Prevalence of Pulmonary Embolism in Patients With Syncope.

Costantino G, Ruwald MH, Quinn J, Camargo CA Jr, Dalgaard F, Gislason G, Goto T, Hasegawa K, Kaul P, Montano N, Numé AK, Russo A, Sheldon R, Solbiati M, Sun B, Casazza G.

JAMA Intern Med. 2018 Mar 1;178(3):356-362. doi: 10.1001/jamainternmed.2017.8175.


Long-term follow-up of pediatric MS patients starting treatment with injectable first-line agents: A multicentre, Italian, retrospective, observational study.

Baroncini D, Zaffaroni M, Moiola L, Lorefice L, Fenu G, Iaffaldano P, Simone M, Fanelli F, Patti F, D'Amico E, Capobianco M, Bertolotto A, Gallo P, Margoni M, Miante S, Milani N, Amato MP, Righini I, Bellantonio P, Scandellari C, Costantino G, Scarpini E, Bergamaschi R, Mallucci G, Comi G, Ghezzi A.

Mult Scler. 2019 Mar;25(3):399-407. doi: 10.1177/1352458518754364. Epub 2018 Jan 24. Erratum in: Mult Scler. 2019 Oct;25(11):NP33.


Outcomes in syncope research: a systematic review and critical appraisal.

Solbiati M, Bozzano V, Barbic F, Casazza G, Dipaola F, Quinn JV, Reed MJ, Sheldon RS, Shen WK, Sun BC, Thiruganasambandamoorthy V, Furlan R, Costantino G.

Intern Emerg Med. 2018 Jun;13(4):593-601. doi: 10.1007/s11739-018-1788-z. Epub 2018 Jan 18. Review.


Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.

Biagioli M, Mencarelli A, Carino A, Cipriani S, Marchianò S, Fiorucci C, Donini A, Graziosi L, Baldelli F, Distrutti E, Costantino G, Fiorucci S.

Inflamm Bowel Dis. 2017 Dec 19;24(1):123-135. doi: 10.1093/ibd/izx031.


The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization.

Bruno A, Costantino G, Sartori L, Radi M.

Curr Med Chem. 2019;26(21):3838-3873. doi: 10.2174/0929867324666171107101035.


Serology of Viral Infections and Tuberculosis Screening in an IBD Population Referred to a Tertiary Centre of Southern Italy.

Ardesia M, Costantino G, Mondello P, Alibrandi A, Fries W.

Gastroenterol Res Pract. 2017;2017:4139656. doi: 10.1155/2017/4139656. Epub 2017 Sep 17.


Preliminary Experience with a Novel System of Facet Fixation to Treat Patients with Lumbar Degenerative Disease. A New Perspective in Minimally Invasive Spine Surgery?

Francaviglia N, Costantino G, Villa A, Iacopino DG, Pappalardo MP, Barone F, Gallo C, Contino AO, Meli F, Maugeri R.

J Neurol Surg A Cent Eur Neurosurg. 2018 Jul;79(4):296-301. doi: 10.1055/s-0037-1607196. Epub 2017 Oct 17.


Restoration of normal sympathetic neural function in heart failure following baroreflex activation therapy: final 43-month study report.

Dell'Oro R, Gronda E, Seravalle G, Costantino G, Alberti L, Baronio B, Staine T, Vanoli E, Mancia G, Grassi G.

J Hypertens. 2017 Dec;35(12):2532-2536. doi: 10.1097/HJH.0000000000001498.


Fluorescein for resection of high-grade gliomas: A safety study control in a single center and review of the literature.

Francaviglia N, Iacopino DG, Costantino G, Villa A, Impallaria P, Meli F, Maugeri R.

Surg Neurol Int. 2017 Jul 11;8:145. doi: 10.4103/sni.sni_89_17. eCollection 2017.


Sativex in resistant multiple sclerosis spasticity: Discontinuation study in a large population of Italian patients (SA.FE. study).

Messina S, Solaro C, Righini I, Bergamaschi R, Bonavita S, Bossio RB, Brescia Morra V, Costantino G, Cavalla P, Centonze D, Comi G, Cottone S, Danni MC, Francia A, Gajofatto A, Gasperini C, Zaffaroni M, Petrucci L, Signoriello E, Maniscalco GT, Spinicci G, Matta M, Mirabella M, Pedà G, Castelli L, Rovaris M, Sessa E, Spitaleri D, Paolicelli D, Granata A, Zappia M, Patti F; SA.FE. study group.

PLoS One. 2017 Aug 1;12(8):e0180651. doi: 10.1371/journal.pone.0180651. eCollection 2017.


Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery.

Azzali E, Machado D, Kaushik A, Vacondio F, Flisi S, Cabassi CS, Lamichhane G, Viveiros M, Costantino G, Pieroni M.

J Med Chem. 2017 Aug 24;60(16):7108-7122. doi: 10.1021/acs.jmedchem.7b00793. Epub 2017 Aug 10.


Clinical and economic impact of infliximab one-hour infusion protocol in patients with inflammatory bowel diseases: A multicenter study.

Viola A, Costantino G, Privitera AC, Bossa F, Lauria A, Grossi L, Principi MB, Della Valle N, Cappello M.

World J Gastrointest Pharmacol Ther. 2017 May 6;8(2):131-136. doi: 10.4292/wjgpt.v8.i2.131.


Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells.

Aiello F, Carullo G, Giordano F, Spina E, Nigro A, Garofalo A, Tassini S, Costantino G, Vincetti P, Bruno A, Radi M.

ChemMedChem. 2017 Aug 22;12(16):1279-1285. doi: 10.1002/cmdc.201700145. Epub 2017 Jun 20.


Prognostic indicators in pediatric clinically isolated syndrome.

Iaffaldano P, Simone M, Lucisano G, Ghezzi A, Coniglio G, Brescia Morra V, Salemi G, Patti F, Lugaresi A, Izquierdo G, Bergamaschi R, Cabrera-Gomez JA, Pozzilli C, Millefiorini E, Alroughani R, Boz C, Pucci E, Zimatore GB, Sola P, Lus G, Maimone D, Avolio C, Cocco E, Sajedi SA, Costantino G, Duquette P, Shaygannejad V, Petersen T, Fernández Bolaños R, Paolicelli D, Tortorella C, Spelman T, Margari L, Amato MP, Comi G, Butzkueven H, Trojano M; Italian iMedWeb Registry and the MSBase Registry.

Ann Neurol. 2017 May;81(5):729-739. doi: 10.1002/ana.24938.


Acetate-free biofiltration to remove fibroblast growth factor 23 in hemodialysis patients: a pilot study.

Cernaro V, Lucisano S, Canale V, Bruzzese A, Caccamo D, Costantino G, Buemi M, Santoro D.

J Nephrol. 2018 Jun;31(3):429-433. doi: 10.1007/s40620-017-0393-y. Epub 2017 Apr 11.


Sudarshan Kriya Yoga improves cardiac autonomic control in patients with anxiety-depression disorders.

Toschi-Dias E, Tobaldini E, Solbiati M, Costantino G, Sanlorenzo R, Doria S, Irtelli F, Mencacci C, Montano N.

J Affect Disord. 2017 May;214:74-80. doi: 10.1016/j.jad.2017.03.017. Epub 2017 Mar 7.


Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents.

Pieroni M, Azzali E, Basilico N, Parapini S, Zolkiewski M, Beato C, Annunziato G, Bruno A, Vacondio F, Costantino G.

J Med Chem. 2017 Mar 9;60(5):1959-1970. doi: 10.1021/acs.jmedchem.6b01685. Epub 2017 Feb 14.


Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.

Tassini S, Sun L, Lanko K, Crespan E, Langron E, Falchi F, Kissova M, Armijos-Rivera JI, Delang L, Mirabelli C, Neyts J, Pieroni M, Cavalli A, Costantino G, Maga G, Vergani P, Leyssen P, Radi M.

J Med Chem. 2017 Feb 23;60(4):1400-1416. doi: 10.1021/acs.jmedchem.6b01521. Epub 2017 Feb 10.


Skull Bone Defects Reconstruction with Custom-Made Titanium Graft shaped with Electron Beam Melting Technology: Preliminary Experience in a Series of Ten Patients.

Francaviglia N, Maugeri R, Odierna Contino A, Meli F, Fiorenza V, Costantino G, Giammalva RG, Iacopino DG.

Acta Neurochir Suppl. 2017;124:137-141. doi: 10.1007/978-3-319-39546-3_21.


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