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Items: 15


Computational design of three-dimensional RNA structure and function.

Yesselman JD, Eiler D, Carlson ED, Gotrik MR, d'Aquino AE, Ooms AN, Kladwang W, Carlson PD, Shi X, Costantino DA, Herschlag D, Lucks JB, Jewett MC, Kieft JS, Das R.

Nat Nanotechnol. 2019 Sep;14(9):866-873. doi: 10.1038/s41565-019-0517-8. Epub 2019 Aug 19.


Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels.

Hartwick EW, Costantino DA, MacFadden A, Nix JC, Tian S, Das R, Kieft JS.

Nat Commun. 2018 Nov 29;9(1):5074. doi: 10.1038/s41467-018-07542-x.


A folded viral noncoding RNA blocks host cell exoribonucleases through a conformationally dynamic RNA structure.

Steckelberg AL, Akiyama BM, Costantino DA, Sit TL, Nix JC, Kieft JS.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6404-6409. doi: 10.1073/pnas.1802429115. Epub 2018 Jun 4.


Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.

Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS.

Science. 2016 Dec 2;354(6316):1148-1152. Epub 2016 Nov 10.


Initiation of translation in bacteria by a structured eukaryotic IRES RNA.

Colussi TM, Costantino DA, Zhu J, Donohue JP, Korostelev AA, Jaafar ZA, Plank TD, Noller HF, Kieft JS.

Nature. 2015 Mar 5;519(7541):110-3. doi: 10.1038/nature14219. Epub 2015 Feb 4.


The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA.

Colussi TM, Costantino DA, Hammond JA, Ruehle GM, Nix JC, Kieft JS.

Nature. 2014 Jul 17;511(7509):366-9. doi: 10.1038/nature13378. Epub 2014 Jun 8.


The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production.

Chapman EG, Costantino DA, Rabe JL, Moon SL, Wilusz J, Nix JC, Kieft JS.

Science. 2014 Apr 18;344(6181):307-10. doi: 10.1126/science.1250897.


Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome.

Zhu J, Korostelev A, Costantino DA, Donohue JP, Noller HF, Kieft JS.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1839-44. doi: 10.1073/pnas.1018582108. Epub 2011 Jan 18.


Identification and characterization of anion binding sites in RNA.

Kieft JS, Chase E, Costantino DA, Golden BL.

RNA. 2010 Jun;16(6):1118-23. doi: 10.1261/rna.2072710. Epub 2010 Apr 21.


tRNA-mRNA mimicry drives translation initiation from a viral IRES.

Costantino DA, Pfingsten JS, Rambo RP, Kieft JS.

Nat Struct Mol Biol. 2008 Jan;15(1):57-64. Epub 2007 Dec 23.


Individualized implant-based reconstruction of Poland syndrome breast and soft tissue deformities.

Borschel GH, Costantino DA, Cederna PS.

Ann Plast Surg. 2007 Nov;59(5):507-14.


Structural methods for studying IRES function.

Kieft JS, Costantino DA, Filbin ME, Hammond J, Pfingsten JS.

Methods Enzymol. 2007;430:333-71.


Conservation and diversity among the three-dimensional folds of the Dicistroviridae intergenic region IRESes.

Pfingsten JS, Costantino DA, Kieft JS.

J Mol Biol. 2007 Jul 27;370(5):856-69. Epub 2007 May 8.


Structural basis for ribosome recruitment and manipulation by a viral IRES RNA.

Pfingsten JS, Costantino DA, Kieft JS.

Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23.

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