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Plasma Biomarkers and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: New Tools for Better Patient Selection?

Costantini A, Takam Kamga P, Dumenil C, Chinet T, Emile JF, Giroux Leprieur E.

Cancers (Basel). 2019 Aug 29;11(9). pii: E1269. doi: 10.3390/cancers11091269. Review.


Associations between sex, age and spiritual well-being scores on the EORTC QLQ-SWB32 for patients receiving palliative care for cancer: A further analysis of data from an international validation study.

Rohde GE, Young T, Winstanley J, Arraras JI, Black K, Boyle F, Bredart A, Costantini A, Guo J, Irarrazaval ME, Kobayashi K, Kruizinga R, Navarro M, Omidvari S, Serpentini S, Spry N, van Laarhoven H, Yang G, Vivat B.

Eur J Cancer Care (Engl). 2019 Aug 21:e13145. doi: 10.1111/ecc.13145. [Epub ahead of print]


'Metaphyseal dysplasia without hypotrichosis' can present with late-onset extraskeletal manifestations.

Vakkilainen S, Costantini A, Taskinen M, Wartiovaara-Kautto U, Mäkitie O.

J Med Genet. 2019 Aug 14. pii: jmedgenet-2019-106131. doi: 10.1136/jmedgenet-2019-106131. [Epub ahead of print]


Health tourism: an opportunity for sustainable development.

Illario M, De Luca V, Leonardini L, Kucharczyk M, Parent AS, Dantas C, Jegundo AL, van Staalduinen W, Ganzarain J, Comisso L, Bramezza C, Carriazo AM, Maritati A, Tramontano G, Capozzi P, Goossens E, Cotrone C, Costantini A, Ciliberti M, Femiano M, d'Amore A, Forlenza M, Ruggiero R, Bianchi A, Augustin L, Marrazzo V, Dello Ioio T, Capaldo S, Crudeli A, De Cesare G, Cuccaro F, Bracale G, Tramontano D, Postiglione A, Matera C, Coscioni E, Bousquet J.

Transl Med UniSa. 2019 Jan 6;19:109-115. eCollection 2019 Jan-Jun.


Positive plasma cotinine during platinum-based chemotherapy is associated with poor response rate in advanced non-small cell lung cancer patients.

Dacosta-Noble P, Costantini A, Dumenil C, Dumoulin J, Helly de Tauriers P, Giraud V, Labrune S, Emile JF, Alvarez JC, Chinet T, Giroux Leprieur E.

PLoS One. 2019 Jul 1;14(7):e0219080. doi: 10.1371/journal.pone.0219080. eCollection 2019.


Control of Gram-negative multi-drug resistant microorganisms in an Italian ICU: Rapid decline as a result of a multifaceted intervention, including conservative use of antibiotics.

Frattari A, Savini V, Polilli E, Di Marco G, Lucisano G, Corridoni S, Spina T, Costantini A, Nicolucci A, Fazii P, Viale P, Parruti G.

Int J Infect Dis. 2019 Jul;84:153-162. doi: 10.1016/j.ijid.2019.04.002.


A SOA Based Solution for MDRO Surveillance and Improved Antibiotic Prescription in the Abruzzo Region.

Gazzarata R, Monteverde ME, Bonetto M, Savini V, Polilli E, Corridoni S, Costantini A, Santoleri F, Rapacchiale G, Palmieri D, Melena S, Di Girolamo A, Sciacca A, De Benedictis M, D'Alberto H, Galleani G, Giacomini M, Parruti G.

Stud Health Technol Inform. 2019;261:49-54.


The NOTECHS+: A Short Scale Designed for Assessing the Non-technical Skills (and more) in the Aviation and the Emergency Personnel.

Ceschi A, Costantini A, Zagarese V, Avi E, Sartori R.

Front Psychol. 2019 May 7;10:902. doi: 10.3389/fpsyg.2019.00902. eCollection 2019.


Theories for Computing Prosocial Behavior.

Costantini A, Scalco A, Sartori R, Tur EM, Ceschi A.

Nonlinear Dynamics Psychol Life Sci. 2019 Apr;23(2):297-313.


Nivolumab-refractory patients with advanced non-small-cell lung cancer.

Costantini A, Fallet V, Corny J, Friard S, Chouaid C, Duchemann B, Giroux-Leprieur E, Taillade L, Doucet L, Brosseau S, Wislez M, Tredaniel J, Cadranel J.

Lung Cancer. 2019 Apr;130:128-134. doi: 10.1016/j.lungcan.2019.01.015. Epub 2019 Feb 14.


New Insights Into Monogenic Causes of Osteoporosis.

Mäkitie RE, Costantini A, Kämpe A, Alm JJ, Mäkitie O.

Front Endocrinol (Lausanne). 2019 Feb 25;10:70. doi: 10.3389/fendo.2019.00070. eCollection 2019. Review.


Durability of first-line regimens including integrase strand transfer inhibitors (INSTIs): data from a real-life setting.

d'Arminio Monforte A, Cozzi-Lepri A, Di Biagio A, Marchetti G, Lo Caputo S, Rusconi S, Gianotti N, Mazzotta V, Mazzarello G, Costantini A, Castagna A, Antinori A; ICONA Foundation Study Group.

J Antimicrob Chemother. 2019 May 1;74(5):1363-1367. doi: 10.1093/jac/dky566.


Early metabolic response to chemoradiotherapy by interim FDG PET/CT is associated with better overall survival and histological response in esophageal cancers.

Hammoudi N, Hennequin C, Vercellino L, Costantini A, Valverde A, Cattan P, Quéro L.

Dig Liver Dis. 2019 Jun;51(6):887-893. doi: 10.1016/j.dld.2018.12.006. Epub 2018 Dec 23.


Dosage adjustments in pivotal clinical trials with oral targeted therapies in solid tumors conducted in Europe.

Lasala R, Santoleri F, Romagnoli A, Musicco F, Costantini A.

Eur J Clin Pharmacol. 2019 May;75(5):697-706. doi: 10.1007/s00228-018-02621-w. Epub 2019 Jan 8.


Endoscope-Assisted Far Lateral Approach to the Craniovertebral Junction with Neuronavigation: A Cadaver Laboratory Experience.

Signorelli F, Pace M, Stumpo V, Ciappetta P, Costantini A, Olivi A, Visocchi M.

Acta Neurochir Suppl. 2019;125:165-169. doi: 10.1007/978-3-319-62515-7_24.


Transoral Approach to the Craniovertebral Junction: A Neuronavigated Cadaver Study.

Signorelli F, Costantini A, Stumpo V, Conforti G, Olivi A, Visocchi M.

Acta Neurochir Suppl. 2019;125:51-55. doi: 10.1007/978-3-319-62515-7_8.


Novel fibronectin mutations and expansion of the phenotype in spondylometaphyseal dysplasia with "corner fractures".

Costantini A, Valta H, Baratang NV, Yap P, Bertola DR, Yamamoto GL, Kim CA, Chen J, Wierenga KJ, Fanning EA, Escobar L, McWalter K, McLaughlin H, Willaert R, Begtrup A, Alm JJ, Reinhardt DP, Mäkitie O, Campeau PM.

Bone. 2019 Apr;121:163-171. doi: 10.1016/j.bone.2018.12.020. Epub 2018 Dec 30.


General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States.

Nolte S, Liegl G, Petersen MA, Aaronson NK, Costantini A, Fayers PM, Groenvold M, Holzner B, Johnson CD, Kemmler G, Tomaszewski KA, Waldmann A, Young TE, Rose M; EORTC Quality of Life Group.

Eur J Cancer. 2019 Jan;107:153-163. doi: 10.1016/j.ejca.2018.11.024. Epub 2018 Dec 19.


Establishing the European Norm for the health-related quality of life domains of the computer-adaptive test EORTC CAT Core.

Liegl G, Petersen MA, Groenvold M, Aaronson NK, Costantini A, Fayers PM, Holzner B, Johnson CD, Kemmler G, Tomaszewski KA, Waldmann A, Young TE, Rose M, Nolte S; EORTC Quality of Life Group.

Eur J Cancer. 2019 Jan;107:133-141. doi: 10.1016/j.ejca.2018.11.023. Epub 2018 Dec 18.


Accounting for Individual Differences in Decision-Making Competence: Personality and Gender Differences.

Weller J, Ceschi A, Hirsch L, Sartori R, Costantini A.

Front Psychol. 2018 Nov 23;9:2258. doi: 10.3389/fpsyg.2018.02258. eCollection 2018.


Use and costs of originator and biosimilar erythropoiesis-stimulating agents in the treatment of chemotherapy-induced anemia: real-world evidence from an Italian hospital.

Santoleri F, Romagnoli A, Costantini A.

Future Oncol. 2019 Jan;15(1):45-51. doi: 10.2217/fon-2018-0333. Epub 2018 Nov 23.


Comparison of Tonic vs. Burst Spinal Cord Stimulation During Trial Period.

Demartini L, Terranova G, Innamorato MA, Dario A, Sofia M, Angelini C, Duse G, Costantini A, Leoni MLG.

Neuromodulation. 2019 Apr;22(3):327-332. doi: 10.1111/ner.12867. Epub 2018 Oct 17.


Yeast distribution in Grignolino grapes growing in a new vineyard in Piedmont and the technological characterization of indigenous Saccharomyces spp. strains.

Vaudano E, Quinterno G, Costantini A, Pulcini L, Pessione E, Garcia-Moruno E.

Int J Food Microbiol. 2019 Jan 16;289:154-161. doi: 10.1016/j.ijfoodmicro.2018.09.016. Epub 2018 Sep 18.


A Thousand and One Laparoscopic Heller Myotomies for Esophageal Achalasia: a 25-Year Experience at a Single Tertiary Center.

Costantini M, Salvador R, Capovilla G, Vallese L, Costantini A, Nicoletti L, Briscolini D, Valmasoni M, Merigliano S.

J Gastrointest Surg. 2019 Jan;23(1):23-35. doi: 10.1007/s11605-018-3956-x. Epub 2018 Sep 20.


Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance.

Giroux-Leprieur E, Costantini A, Ding VW, He B.

Int J Mol Sci. 2018 Sep 19;19(9). pii: E2835. doi: 10.3390/ijms19092835. Review.


Predictive role of plasmatic biomarkers in advanced non-small cell lung cancer treated by nivolumab.

Costantini A, Julie C, Dumenil C, Hélias-Rodzewicz Z, Tisserand J, Dumoulin J, Giraud V, Labrune S, Chinet T, Emile JF, Giroux Leprieur E.

Oncoimmunology. 2018 Apr 20;7(8):e1452581. doi: 10.1080/2162402X.2018.1452581. eCollection 2018.


A novel MYT1L mutation in a patient with severe early-onset obesity and intellectual disability.

Loid P, Mäkitie R, Costantini A, Viljakainen H, Pekkinen M, Mäkitie O.

Am J Med Genet A. 2018 Sep;176(9):1972-1975. doi: 10.1002/ajmg.a.40370. Epub 2018 Jul 28.


Rare Copy Number Variants in Array-Based Comparative Genomic Hybridization in Early-Onset Skeletal Fragility.

Costantini A, Skarp S, Kämpe A, Mäkitie RE, Pettersson M, Männikkö M, Jiao H, Taylan F, Lindstrand A, Mäkitie O.

Front Endocrinol (Lausanne). 2018 Jul 10;9:380. doi: 10.3389/fendo.2018.00380. eCollection 2018.


The EORTC CAT Core-The computer adaptive version of the EORTC QLQ-C30 questionnaire.

Petersen MA, Aaronson NK, Arraras JI, Chie WC, Conroy T, Costantini A, Dirven L, Fayers P, Gamper EM, Giesinger JM, Habets EJJ, Hammerlid E, Helbostad J, Hjermstad MJ, Holzner B, Johnson C, Kemmler G, King MT, Kaasa S, Loge JH, Reijneveld JC, Singer S, Taphoorn MJB, Thamsborg LH, Tomaszewski KA, Velikova G, Verdonck-de Leeuw IM, Young T, Groenvold M; European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group.

Eur J Cancer. 2018 Sep;100:8-16. doi: 10.1016/j.ejca.2018.04.016. Epub 2018 Jun 21.


Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals.

Costantini A, Viola N, Berretta A, Galeazzi R, Matacchione G, Sabbatinelli J, Storci G, De Matteis S, Butini L, Rippo MR, Procopio AD, Caraceni D, Antonicelli R, Olivieri F, Bonafè M.

Aging (Albany NY). 2018 Jun 8;10(6):1268-1280. doi: 10.18632/aging.101465.


A novel frameshift deletion in PLS3 causing severe primary osteoporosis.

Costantini A, Krallis PΝ, Kämpe A, Karavitakis EM, Taylan F, Mäkitie O, Doulgeraki A.

J Hum Genet. 2018 Aug;63(8):923-926. doi: 10.1038/s10038-018-0472-5. Epub 2018 Jun 8.


Understanding the quality of life (QOL) issues in survivors of cancer: towards the development of an EORTC QOL cancer survivorship questionnaire.

van Leeuwen M, Husson O, Alberti P, Arraras JI, Chinot OL, Costantini A, Darlington AS, Dirven L, Eichler M, Hammerlid EB, Holzner B, Johnson CD, Kontogianni M, Kjær TK, Morag O, Nolte S, Nordin A, Pace A, Pinto M, Polz K, Ramage J, Reijneveld JC, Serpentini S, Tomaszewski KA, Vassiliou V, Verdonck-de Leeuw IM, Vistad I, Young TE, Aaronson NK, van de Poll-Franse LV; EORTC QLG.

Health Qual Life Outcomes. 2018 Jun 4;16(1):114. doi: 10.1186/s12955-018-0920-0.


First-line antiretroviral therapy with efavirenz plus tenofovir disiproxil fumarate/emtricitabine or rilpivirine plus tenofovir disiproxil fumarate/emtricitabine: a durability comparison.

Taramasso L, Di Biagio A, Maggiolo F, Tavelli A, Lo Caputo S, Bonora S, Zaccarelli M, Caramello P, Costantini A, Viscoli C, d'Arminio Monforte A, Cozzi-Lepri A; Italian Cohort Naive Antiretrovirals (ICONA) Foundation Study Group.

HIV Med. 2018 May 30. doi: 10.1111/hiv.12628. [Epub ahead of print]


Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study.

Stagnaro E, Parodi S, Costantini AS, Crosignani P, Miligi L, Nanni O, Piro S, Ramazzotti V, Rodella S, Tumino R, Vindigni C, Vineis P.

Epidemiol Infect. 2018 Sep;146(12):1572-1574. doi: 10.1017/S0950268818001413. Epub 2018 May 30.


Efficacy of next treatment received after nivolumab progression in patients with advanced nonsmall cell lung cancer.

Costantini A, Corny J, Fallet V, Renet S, Friard S, Chouaid C, Duchemann B, Giroux-Leprieur E, Taillade L, Doucet L, Nguenang M, Jouveshomme S, Wislez M, Tredaniel J, Cadranel J.

ERJ Open Res. 2018 Apr 20;4(2). pii: 00120-2017. doi: 10.1183/23120541.00120-2017. eCollection 2018 Apr.


Benefits in pain perception, ability function and health-related quality of life in patients with failed back surgery syndrome undergoing spinal cord stimulation in a clinical practice setting.

Scalone L, Zucco F, Lavano A, Costantini A, De Rose M, Poli P, Fortini G, Demartini L, De Simone E, Menardo V, Meglio M, Cozzolino P, Cortesi PA, Mantovani LG.

Health Qual Life Outcomes. 2018 Apr 19;16(1):68. doi: 10.1186/s12955-018-0887-x.


How Do You Manage Change in Organizations? Training, Development, Innovation, and Their Relationships.

Sartori R, Costantini A, Ceschi A, Tommasi F.

Front Psychol. 2018 Mar 15;9:313. doi: 10.3389/fpsyg.2018.00313. eCollection 2018.


Expansion of the clinical spectrum of frontometaphyseal dysplasia 2 caused by the recurrent mutation p.Pro485Leu in MAP3K7.

Costantini A, Wallgren-Pettersson C, Mäkitie O.

Eur J Med Genet. 2018 Oct;61(10):612-615. doi: 10.1016/j.ejmg.2018.04.004. Epub 2018 Apr 14.


High-dose thiamine and essential tremor.

Costantini A.

BMJ Case Rep. 2018 Mar 30;2018. pii: bcr-2017-223945. doi: 10.1136/bcr-2017-223945.


Increased Response Rates to Salvage Chemotherapy Administered after PD-1/PD-L1 Inhibitors in Patients with Non-Small Cell Lung Cancer.

Costantini A, Cadranel J.

J Thorac Oncol. 2018 Apr;13(4):e55-e56. doi: 10.1016/j.jtho.2017.11.113. No abstract available.


Autosomal Recessive Osteogenesis Imperfecta Caused by a Novel Homozygous COL1A2 Mutation.

Costantini A, Tournis S, Kämpe A, Ul Ain N, Taylan F, Doulgeraki A, Mäkitie O.

Calcif Tissue Int. 2018 Sep;103(3):353-358. doi: 10.1007/s00223-018-0414-4. Epub 2018 Mar 23.


Mild Cognitive Impairment in Parkinson's Disease-What Is It?

Weil RS, Costantini AA, Schrag AE.

Curr Neurol Neurosci Rep. 2018 Mar 10;18(4):17. doi: 10.1007/s11910-018-0823-9. Review.


Using a treatment diary to improve the medication adherence in patients with chronic myeloid leukaemia.

Santoleri F, Lasala R, Logreco A, Ranucci E, Costantini A.

J Oncol Pharm Pract. 2019 Jul;25(5):1035-1041. doi: 10.1177/1078155218759184. Epub 2018 Feb 20.


Immunotherapy: a new standard of care in thoracic malignancies? A summary of the European Respiratory Society research seminar of the Thoracic Oncology Assembly.

Costantini A, Grynovska M, Lucibello F, Moisés J, Pagès F, Tsao MS, Shepherd FA, Bouchaab H, Garassino M, Aerts JGJV, Mazières J, Mondini M, Berghmans T, Meert AP, Cadranel J.

Eur Respir J. 2018 Feb 14;51(2). pii: 1702072. doi: 10.1183/13993003.02072-2017. Print 2018 Feb.


Phase 1-3 of the cross-cultural development of an EORTC questionnaire for the assessment of sexual health in cancer patients: the EORTC SHQ-22.

Oberguggenberger AS, Nagele E, Inwald EC, Tomaszewski K, Lanceley A, Nordin A, Creutzberg CL, Kuljanic K, Kardamakis D, Schmalz C, Arraras J, Costantini A, Almont T, Wei-Chu C, Dehandschutter S, Winters Z, Greimel E; EORTC Quality of Life Group.

Cancer Med. 2018 Mar;7(3):635-645. doi: 10.1002/cam4.1338. Epub 2018 Feb 13.


Incidence and predictors of single drug discontinuation according to the presence of HCV coinfection in HIV patients from the ICONA Foundation Cohort Study.

Leone S, Shanyinde M, Cozzi Lepri A, Lampe FC, Caramello P, Costantini A, Giacometti A, De Luca A, Cingolani A, Ceccherini Silberstein F, Puoti M, Gori A, d'Arminio Monforte A; ICONA Foundation Cohort Study.

Eur J Clin Microbiol Infect Dis. 2018 May;37(5):871-881. doi: 10.1007/s10096-017-3180-8. Epub 2018 Jan 9.


The natural history of achalasia: Evidence of a continuum-"The evolutive pattern theory".

Salvador R, Voltarel G, Savarino E, Capovilla G, Pesenti E, Perazzolo A, Nicoletti L, Costantini A, Merigliano S, Costantini M.

Dig Liver Dis. 2018 Apr;50(4):342-347. doi: 10.1016/j.dld.2017.11.012. Epub 2017 Nov 26.


Frozen Microemulsions for MAPLE Immobilization of Lipase.

Califano V, Bloisi F, Perretta G, Aronne A, Ausanio G, Costantini A, Vicari L.

Molecules. 2017 Dec 5;22(12). pii: E2153. doi: 10.3390/molecules22122153.


Malnutrition upon Hospital Admission in Geriatric Patients: Why Assess It?

Orlandoni P, Venturini C, Jukic Peladic N, Costantini A, Di Rosa M, Cola C, Giorgini N, Basile R, Fagnani D, Sparvoli D, David S.

Front Nutr. 2017 Oct 30;4:50. doi: 10.3389/fnut.2017.00050. eCollection 2017.

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