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Items: 14

1.

Transcriptional Reprogramming and Inhibition of Tumor-propagating Stem-like Cells by EC-8042 in ERG-positive Prostate Cancer.

Shinde D, Albino D, Zoma M, Mutti A, Mapelli SN, Civenni G, Kokanovic A, Merulla J, Perez-Escuredo J, Costales P, Morìs F, Catapano CV, Carbone GM.

Eur Urol Oncol. 2019 Jul;2(4):415-424. doi: 10.1016/j.euo.2018.08.024. Epub 2018 Sep 24.

PMID:
31277777
2.

The multikinase inhibitor EC-70124 synergistically increased the antitumor activity of doxorubicin in sarcomas.

Estupiñan O, Santos L, Rodriguez A, Fernandez-Nevado L, Costales P, Perez-Escuredo J, Hermosilla MA, Oro P, Rey V, Tornin J, Allonca E, Fernandez-Garcia MT, Alvarez-Fernandez C, Braña A, Astudillo A, Menendez ST, Moris F, Rodriguez R.

Int J Cancer. 2019 Jul 1;145(1):254-266. doi: 10.1002/ijc.32081. Epub 2019 Jan 14.

PMID:
30575954
3.

IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q- AML.

Lopez-Millan B, Diaz de la Guardia R, Roca-Ho H, Anguita E, Islam ABMMK, Romero-Moya D, Prieto C, Gutierrez-Agüera F, Bejarano-Garcia JA, Perez-Simon JA, Costales P, Rovira M, Marín P, Menendez S, Iglesias M, Fuster JL, Urbano-Ispizua A, Anjos-Afonso F, Bueno C, Menendez P.

Oncoimmunology. 2018 Jul 26;7(9):e1477460. doi: 10.1080/2162402X.2018.1477460. eCollection 2018.

4.

Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia.

Puente-Moncada N, Costales P, Antolín I, Núñez LE, Oro P, Hermosilla MA, Pérez-Escuredo J, Ríos-Lombardía N, Sanchez-Sanchez AM, Luño E, Rodríguez C, Martín V, Morís F.

Mol Cancer Ther. 2018 Mar;17(3):614-624. doi: 10.1158/1535-7163.MCT-17-0530. Epub 2018 Jan 16.

5.

EC-70124, a Novel Glycosylated Indolocarbazole Multikinase Inhibitor, Reverts Tumorigenic and Stem Cell Properties in Prostate Cancer by Inhibiting STAT3 and NF-κB.

Civenni G, Longoni N, Costales P, Dallavalle C, García Inclán C, Albino D, Nuñez LE, Morís F, Carbone GM, Catapano CV.

Mol Cancer Ther. 2016 May;15(5):806-18. doi: 10.1158/1535-7163.MCT-15-0791. Epub 2016 Jan 29.

6.

K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells.

Costales P, Fuentes-Prior P, Castellano J, Revuelta-Lopez E, Corral-Rodríguez MÁ, Nasarre L, Badimon L, Llorente-Cortes V.

J Biol Chem. 2015 Jun 12;290(24):14852-65. doi: 10.1074/jbc.M115.638361. Epub 2015 Apr 27.

7.

Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers.

Mira-Pascual L, Cabrera-Rubio R, Ocon S, Costales P, Parra A, Suarez A, Moris F, Rodrigo L, Mira A, Collado MC.

J Gastroenterol. 2015 Feb;50(2):167-79. doi: 10.1007/s00535-014-0963-x. Epub 2014 May 9.

PMID:
24811328
8.

Molecular and functional characterization of LRP1 promoter polymorphism c.1-25 C>G (rs138854007).

Aledo R, Costales P, Ciudad C, Noé V, Llorente-Cortes V, Badimon L.

Atherosclerosis. 2014 Mar;233(1):178-85. doi: 10.1016/j.atherosclerosis.2013.12.014. Epub 2014 Jan 8.

PMID:
24529141
9.

Lipopolysaccharide downregulates CD91/low-density lipoprotein receptor-related protein 1 expression through SREBP-1 overexpression in human macrophages.

Costales P, Castellano J, Revuelta-López E, Cal R, Aledo R, Llampayas O, Nasarre L, Juarez C, Badimon L, Llorente-Cortés V.

Atherosclerosis. 2013 Mar;227(1):79-88. doi: 10.1016/j.atherosclerosis.2012.12.021. Epub 2012 Dec 31.

PMID:
23312784
10.

Hypoxia stimulates low-density lipoprotein receptor-related protein-1 expression through hypoxia-inducible factor-1α in human vascular smooth muscle cells.

Castellano J, Aledo R, Sendra J, Costales P, Juan-Babot O, Badimon L, Llorente-Cortés V.

Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1411-20. doi: 10.1161/ATVBAHA.111.225490. Epub 2011 Mar 31.

PMID:
21454812
11.

Selective role of sterol regulatory element binding protein isoforms in aggregated LDL-induced vascular low density lipoprotein receptor-related protein-1 expression.

Costales P, Aledo R, Vérnia S, Das A, Shah VH, Casado M, Badimon L, Llorente-Cortés V.

Atherosclerosis. 2010 Dec;213(2):458-68. doi: 10.1016/j.atherosclerosis.2010.09.034. Epub 2010 Oct 8.

PMID:
20980003
12.

Angiotensin II upregulates LDL receptor-related protein (LRP1) expression in the vascular wall: a new pro-atherogenic mechanism of hypertension.

Sendra J, Llorente-Cortés V, Costales P, Huesca-Gómez C, Badimon L.

Cardiovasc Res. 2008 Jun 1;78(3):581-9. doi: 10.1093/cvr/cvn043. Epub 2008 Feb 15.

PMID:
18281370
13.

Sterol regulatory element-binding protein-2 negatively regulates low density lipoprotein receptor-related protein transcription.

Llorente-Cortés V, Costales P, Bernués J, Camino-Lopez S, Badimon L.

J Mol Biol. 2006 Jun 16;359(4):950-60. Epub 2006 Apr 21.

PMID:
16697011
14.

Cholesteryl esters of aggregated LDL are internalized by selective uptake in human vascular smooth muscle cells.

Llorente-Cortés V, Otero-Viñas M, Camino-López S, Costales P, Badimon L.

Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):117-23. Epub 2005 Oct 27.

PMID:
16254205

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