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Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.

Han TK, Proctor WR, Costales CL, Cai H, Everett RS, Thakker DR.

J Pharmacol Exp Ther. 2015 Mar;352(3):519-28. doi: 10.1124/jpet.114.220350. Epub 2015 Jan 6.


Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.

Han TK, Everett RS, Proctor WR, Ng CM, Costales CL, Brouwer KL, Thakker DR.

Mol Pharmacol. 2013 Aug;84(2):182-9. doi: 10.1124/mol.112.084517. Epub 2013 May 16.


Direct activation of human phospholipase C by its well known inhibitor u73122.

Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, Thakker DR.

J Biol Chem. 2011 Apr 8;286(14):12407-16. doi: 10.1074/jbc.M110.191783. Epub 2011 Jan 25.

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