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Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.

Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SA.

Sci Signal. 2018 Dec 4;11(559). pii: eaat1631. doi: 10.1126/scisignal.aat1631.


The binding of captopril to angiotensin I-converting enzyme triggers activation of signaling pathways.

Reis RI, Nogueira MD, Campanha-Rodrigues AL, Pereira LM, Andrade MCC, Parreiras-E-Silva LT, Costa-Neto CM, Mortara RA, Casarini DE.

Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C367-C379. doi: 10.1152/ajpcell.00012.2016. Epub 2018 Jun 6.


Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential.

Corrêa MF, Barbosa ÁJR, Teixeira LB, Duarte DA, Simões SC, Parreiras-E-Silva LT, Balbino AM, Landgraf RG, Bouvier M, Costa-Neto CM, Fernandes JPS.

Front Pharmacol. 2017 Nov 14;8:825. doi: 10.3389/fphar.2017.00825. eCollection 2017.


Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy.

Teixeira LB, Parreiras-E-Silva LT, Bruder-Nascimento T, Duarte DA, Simões SC, Costa RM, Rodríguez DY, Ferreira PAB, Silva CAA, Abrao EP, Oliveira EB, Bouvier M, Tostes RC, Costa-Neto CM.

Sci Rep. 2017 Sep 19;7(1):11903. doi: 10.1038/s41598-017-12074-3.


Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats.

Parreiras-E-Silva LT, Vargas-Pinilla P, Duarte DA, Longo D, Espinoza Pardo GV, Dulor Finkler A, Paixão-Côrtes VR, Paré P, Rovaris DL, Oliveira EB, Caceres RA, Gonçalves GL, Bouvier M, Salzano FM, Lucion AB, Costa-Neto CM, Bortolini MC.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9044-9049. doi: 10.1073/pnas.1711687114. Epub 2017 Aug 7.


Chronic treatment with fluoxetine modulates vascular adrenergic responses by inhibition of pre- and post-synaptic mechanisms.

Pereira CA, Rodrigues FL, Ruginsk SG, Zanotto CZ, Rodrigues JA, Duarte DA, Costa-Neto CM, Resstel LB, Carneiro FS, Tostes RC.

Eur J Pharmacol. 2017 Apr 5;800:70-80. doi: 10.1016/j.ejphar.2017.02.029. Epub 2017 Feb 17.


A Pluridimensional View of Biased Agonism.

Costa-Neto CM, Parreiras-E-Silva LT, Bouvier M.

Mol Pharmacol. 2016 Nov;90(5):587-595. Epub 2016 Sep 16. Review.


Host kinin B1 receptor plays a protective role against melanoma progression.

Maria AG, Dillenburg-Pilla P, Reis RI, Floriano EM, Tefé-Silva C, Ramos SG, Pesquero JB, Nahmias C, Costa-Neto CM.

Sci Rep. 2016 Feb 22;6:22078. doi: 10.1038/srep22078.


Highlight: Kinin 2015 at São Paulo, Brazil.

Buck HS, Calixto JB, Pesquero JB, Campos MM, Viel TA, Costa-Neto CM.

Biol Chem. 2016 Apr;397(4):281-2. doi: 10.1515/hsz-2016-0115. No abstract available.


Recent updates on GPCR biased agonism.

Pupo AS, Duarte DA, Lima V, Teixeira LB, Parreiras-E-Silva LT, Costa-Neto CM.

Pharmacol Res. 2016 Oct;112:49-57. doi: 10.1016/j.phrs.2016.01.031. Epub 2016 Feb 2. Review.


A Novel Vasoactive Proline-Rich Oligopeptide from the Skin Secretion of the Frog Brachycephalus ephippium.

Arcanjo DD, Vasconcelos AG, Comerma-Steffensen SG, Jesus JR, Silva LP, Pires Júnior OR, Costa-Neto CM, Oliveira EB, Migliolo L, Franco OL, Restini CB, Paulo M, Bendhack LM, Bemquerer MP, Oliveira AP, Simonsen U, Leite JR.

PLoS One. 2015 Dec 14;10(12):e0145071. doi: 10.1371/journal.pone.0145071. eCollection 2015.


Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists.

Santos GA, Duarte DA, Parreiras-E-Silva LT, Teixeira FR, Silva-Rocha R, Oliveira EB, Bouvier M, Costa-Neto CM.

Front Pharmacol. 2015 Jul 1;6:131. doi: 10.3389/fphar.2015.00131. eCollection 2015.


Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins.

Costa-Neto CM, Duarte DA, Lima V, Maria AG, Prando EC, Rodríguez DY, Santos GA, Souza PP, Parreiras-E-Silva LT.

Clin Sci (Lond). 2014 Jun;126(11):753-74. doi: 10.1042/CS20130414. Review.


The kinin B1 receptor regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control.

Parreiras-E-Silva LT, Reis RI, Santos GA, Pires-Oliveira M, Pesquero JB, Gomes MD, Godinho RO, Costa-Neto CM.

Clin Sci (Lond). 2014 Aug;127(3):185-94. doi: 10.1042/CS20130358.


Receptor MAS protects mice against hypothermia and mortality induced by endotoxemia.

Souza LL, Duchene J, Todiras M, Azevedo LC, Costa-Neto CM, Alenina N, Santos RA, Bader M.

Shock. 2014 Apr;41(4):331-6. doi: 10.1097/SHK.0000000000000115.


Angiotensin II-independent angiotensin-(1-7) formation in rat hippocampus: involvement of thimet oligopeptidase.

Pereira MG, Souza LL, Becari C, Duarte DA, Camacho FR, Oliveira JA, Gomes MD, Oliveira EB, Salgado MC, Garcia-Cairasco N, Costa-Neto CM.

Hypertension. 2013 Nov;62(5):879-85. doi: 10.1161/HYPERTENSIONAHA.113.01613. Epub 2013 Sep 16.


Activation of the kinin B1 receptor attenuates melanoma tumor growth and metastasis.

Dillenburg-Pilla P, Maria AG, Reis RI, Floriano EM, Pereira CD, De Lucca FL, Ramos SG, Pesquero JB, Jasiulionis MG, Costa-Neto CM.

PLoS One. 2013 May 17;8(5):e64453. doi: 10.1371/journal.pone.0064453. Print 2013.


Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: effect of catalase overexpression.

Barbosa MR, Sampaio IH, Teodoro BG, Sousa TA, Zoppi CC, Queiroz AL, Passos MA, Alberici LC, Teixeira FR, Manfiolli AO, Batista TM, Cappelli AP, Reis RI, Frasson D, Kettelhut IC, Parreiras-e-Silva LT, Costa-Neto CM, Carneiro EM, Curi R, Silveira LR.

Biochim Biophys Acta. 2013 Oct;1832(10):1591-604. doi: 10.1016/j.bbadis.2013.04.029. Epub 2013 May 2.


Shear stress-induced Ang II AT1 receptor activation: G-protein dependent and independent mechanisms.

Barauna VG, Magalhaes FC, Campos LC, Reis RI, Kunapuli SP, Costa-Neto CM, Miyakawa AA, Krieger JE.

Biochem Biophys Res Commun. 2013 May 10;434(3):647-52. doi: 10.1016/j.bbrc.2013.04.005. Epub 2013 Apr 11.


Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway.

Axelband F, Dias J, Miranda F, Ferrão FM, Reis RI, Costa-Neto CM, Lara LS, Vieyra A.

Regul Pept. 2012 Aug 20;177(1-3):27-34. doi: 10.1016/j.regpep.2012.04.004. Epub 2012 May 3.


Angiotensin II facilitates breast cancer cell migration and metastasis.

Rodrigues-Ferreira S, Abdelkarim M, Dillenburg-Pilla P, Luissint AC, di-Tommaso A, Deshayes F, Pontes CL, Molina A, Cagnard N, Letourneur F, Morel M, Reis RI, Casarini DE, Terris B, Couraud PO, Costa-Neto CM, Di Benedetto M, Nahmias C.

PLoS One. 2012;7(4):e35667. doi: 10.1371/journal.pone.0035667. Epub 2012 Apr 20.


Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling.

Martins-Oliveira A, Castro MM, Oliveira DM, Rizzi E, Ceron CS, Guimaraes D, Reis RI, Costa-Neto CM, Casarini DE, Ribeiro AA, Gerlach RF, Tanus-Santos JE.

Int J Cardiol. 2013 Aug 20;167(4):1199-205. doi: 10.1016/j.ijcard.2012.03.137. Epub 2012 Apr 6.


Exposure of luminal membranes of LLC-PK1 cells to ANG II induces dimerization of AT1/AT2 receptors to activate SERCA and to promote Ca2+ mobilization.

Ferrão FM, Lara LS, Axelband F, Dias J, Carmona AK, Reis RI, Costa-Neto CM, Vieyra A, Lowe J.

Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F875-83. doi: 10.1152/ajprenal.00381.2011. Epub 2012 Jan 4.


A Novel Cellular Model to Study Angiotensin II AT2 Receptor Function in Breast Cancer Cells.

Rodrigues-Ferreira S, Morel M, Reis RI, Cormier F, Baud V, Costa-Neto CM, Nahmias C.

Int J Pept. 2012;2012:745027. doi: 10.1155/2012/745027. Epub 2011 Dec 6.


Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides.

Pereira HJ, Souza LL, Costa-Neto CM, Salgado MC, Oliveira EB.

Peptides. 2012 Jan;33(1):67-76. doi: 10.1016/j.peptides.2011.12.001. Epub 2011 Dec 9.


Biological and conformational evaluation of angiotensin II lactam bridge containing analogues.

Oliveira VX Jr, Fázio MA, Silva AF, Campana PT, Pesquero JB, Santos EL, Costa-Neto CM, Miranda A.

Regul Pept. 2011 Dec 10;172(1-3):1-7. doi: 10.1016/j.regpep.2011.05.015. Epub 2011 Jul 23.


6-Mercaptopurine complexes with silver and gold ions: anti-tuberculosis and anti-cancer activities.

Cuin A, Massabni AC, Pereira GA, Leite CQ, Pavan FR, Sesti-Costa R, Heinrich TA, Costa-Neto CM.

Biomed Pharmacother. 2011 Aug;65(5):334-8. doi: 10.1016/j.biopha.2011.04.012. Epub 2011 Jun 12.


Angiotensin-(1-7) decreases LPS-induced inflammatory response in macrophages.

Souza LL, Costa-Neto CM.

J Cell Physiol. 2012 May;227(5):2117-22. doi: 10.1002/jcp.22940.


A new nitrosyl ruthenium complex: synthesis, chemical characterization, in vitro and in vivo antitumor activities and probable mechanism of action.

Heinrich TA, Von Poelhsitz G, Reis RI, Castellano EE, Neves A, Lanznaster M, Machado SP, Batista AA, Costa-Neto CM.

Eur J Med Chem. 2011 Sep;46(9):3616-22. doi: 10.1016/j.ejmech.2011.04.064. Epub 2011 May 19.


Angiotensin II binding to angiotensin I-converting enzyme triggers calcium signaling.

Guimarães PB, Alvarenga ÉC, Siqueira PD, Paredes-Gamero EJ, Sabatini RA, Morais RL, Reis RI, Santos EL, Teixeira LG, Casarini DE, Martin RP, Shimuta SI, Carmona AK, Nakaie CR, Jasiulionis MG, Ferreira AT, Pesquero JL, Oliveira SM, Bader M, Costa-Neto CM, Pesquero JB.

Hypertension. 2011 May;57(5):965-72. doi: 10.1161/HYPERTENSIONAHA.110.167171. Epub 2011 Mar 21.


Effect of the duration of daily aerobic physical training on cardiac autonomic adaptations.

Sant'Ana JE, Pereira MG, Dias da Silva VJ, Dambrós C, Costa-Neto CM, Souza HC.

Auton Neurosci. 2011 Jan 20;159(1-2):32-7. doi: 10.1016/j.autneu.2010.07.006. Epub 2010 Aug 13.


Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy.

Pereira MG, Becari C, Oliveira JA, Salgado MC, Garcia-Cairasco N, Costa-Neto CM.

Clin Sci (Lond). 2010 Aug 17;119(11):477-82. doi: 10.1042/CS20100053.


Stimulation of IL-6 cytokines in fibroblasts by toll-like receptors 2.

Souza PP, Palmqvist P, Lundgren I, Lie A, Costa-Neto CM, Lundberg P, Lerner UH.

J Dent Res. 2010 Aug;89(8):802-7. doi: 10.1177/0022034510366898. Epub 2010 May 26.


Evidences of a role for eukaryotic translation initiation factor 5A (eIF5A) in mouse embryogenesis and cell differentiation.

Parreiras-e-Silva LT, Luchessi AD, Reis RI, Oliver C, Jamur MC, Ramos RG, Oliveira EB, Curi R, Costa-Neto CM.

J Cell Physiol. 2010 Nov;225(2):500-5. doi: 10.1002/jcp.22229.


Pt(II) and Ag(I) complexes with acesulfame: crystal structure and a study of their antitumoral, antimicrobial and antiviral activities.

Cavicchioli M, Massabni AC, Heinrich TA, Costa-Neto CM, Abrão EP, Fonseca BA, Castellano EE, Corbi PP, Lustri WR, Leite CQ.

J Inorg Biochem. 2010 May;104(5):533-40. doi: 10.1016/j.jinorgbio.2010.01.004. Epub 2010 Jan 18.


In vivo electrochemical characterization and inflammatory response of multiwalled carbon nanotube-based electrodes in rat hippocampus.

Minnikanti S, Pereira MG, Jaraiedi S, Jackson K, Costa-Neto CM, Li Q, Peixoto N.

J Neural Eng. 2010 Feb;7(1):16002. doi: 10.1088/1741-2560/7/1/016002. Epub 2010 Jan 6.


Identification of a bioactive compound isolated from Brazilian propolis type 6.

Castro ML, do Nascimento AM, Ikegaki M, Costa-Neto CM, Alencar SM, Rosalen PL.

Bioorg Med Chem. 2009 Jul 15;17(14):5332-5. doi: 10.1016/j.bmc.2009.04.066. Epub 2009 May 3.


Increased expression of GluR2-flip in the hippocampus of the Wistar audiogenic rat strain after acute and kindled seizures.

Gitaí DL, Martinelli HN, Valente V, Pereira MG, Oliveira JA, Elias CF, Bittencourt JC, Leite JP, Costa-Neto CM, Garcia-Cairasco N, Paçó-Larson ML.

Hippocampus. 2010 Jan;20(1):125-33. doi: 10.1002/hipo.20590.


Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation.

Luchessi AD, Cambiaghi TD, Hirabara SM, Lambertucci RH, Silveira LR, Baptista IL, Moriscot AS, Costa-Neto CM, Curi R.

J Cell Physiol. 2009 Mar;218(3):480-9. doi: 10.1002/jcp.21619.


Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging.

Luchessi AD, Cambiaghi TD, Alves AS, Parreiras-E-Silva LT, Britto LR, Costa-Neto CM, Curi R.

Brain Res. 2008 Sep 4;1228:6-13. doi: 10.1016/j.brainres.2008.06.057. Epub 2008 Jun 24.


Lithium thiazolidine-4-carboxylate: synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells.

Corbi PP, Andrade FC, Massabni AC, Heinrich TA, Souza PP, Costa-Neto CM.

Spectrochim Acta A Mol Biomol Spectrosc. 2008 Dec 1;71(3):929-31. doi: 10.1016/j.saa.2008.02.013. Epub 2008 Feb 13.


Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins.

Santos EL, de Picoli Souza K, Cibrián-Uhalte E, Oliveira SM, Bader M, Costa-Neto CM, Oliveira L, Pesquero JB.

Int Immunopharmacol. 2008 Feb;8(2):282-8. doi: 10.1016/j.intimp.2007.09.007. Epub 2007 Oct 4.


Effect of angiotensin converting enzyme inhibitor enalapril on body weight and composition in young rats.

Santos EL, de Picoli Souza K, Guimarães PB, Reis FC, Silva SM, Costa-Neto CM, Luz J, Pesquero JB.

Int Immunopharmacol. 2008 Feb;8(2):247-53. doi: 10.1016/j.intimp.2007.07.021. Epub 2007 Aug 14.


Modulation of B1 and B2 kinin receptors expression levels in the hippocampus of rats after audiogenic kindling and with limbic recruitment, a model of temporal lobe epilepsy.

Pereira MG, Gitaí DL, Paçó-Larson ML, Pesquero JB, Garcia-Cairasco N, Costa-Neto CM.

Int Immunopharmacol. 2008 Feb;8(2):200-5. doi: 10.1016/j.intimp.2007.07.028. Epub 2007 Aug 20.


Participation of kallikrein-kinin system in different pathologies.

Costa-Neto CM, Dillenburg-Pilla P, Heinrich TA, Parreiras-e-Silva LT, Pereira MG, Reis RI, Souza PP.

Int Immunopharmacol. 2008 Feb;8(2):135-42. doi: 10.1016/j.intimp.2007.08.003. Epub 2007 Aug 17. Review.


Carboxypeptidase B and other kininases of the rat coronary and mesenteric arterial bed perfusates.

Oliveira EB, Souza LL, Sivieri DO Jr, Bispo-da-Silva LB, Pereira HJ, Costa-Neto CM, Sousa MV, Salgado MC.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3550-7. Epub 2007 Sep 28.


The N-terminal region of eukaryotic translation initiation factor 5A signals to nuclear localization of the protein.

Parreiras-E-Silva LT, Gomes MD, Oliveira EB, Costa-Neto CM.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):393-8. Epub 2007 Aug 13.


Chemical composition and biological activity of a new type of Brazilian propolis: red propolis.

Alencar SM, Oldoni TL, Castro ML, Cabral IS, Costa-Neto CM, Cury JA, Rosalen PL, Ikegaki M.

J Ethnopharmacol. 2007 Sep 5;113(2):278-83. Epub 2007 Jun 23.


The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structure.

Oliveira L, Costa-Neto CM, Nakaie CR, Schreier S, Shimuta SI, Paiva AC.

Physiol Rev. 2007 Apr;87(2):565-92. Review.


Functional rescue of a defective angiotensin II AT1 receptor mutant by the Mas protooncogene.

Santos EL, Reis RI, Silva RG, Shimuta SI, Pecher C, Bascands JL, Schanstra JP, Oliveira L, Bader M, Paiva AC, Costa-Neto CM, Pesquero JB.

Regul Pept. 2007 Jun 7;141(1-3):159-67. Epub 2007 Jan 20.


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