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Items: 1 to 50 of 91

1.

Sarco/Endoplasmic Reticulum Ca2+-ATPase is a more effective calcium remover than Sodium-Calcium Exchanger in human embryonic stem cell-derived cardiomyocytes.

Li S, Chopra A, Keung W, Chan C, Costa KD, Kong CW, Hajjar RJ, Chen C, Li R.

Am J Physiol Heart Circ Physiol. 2019 Jul 26. doi: 10.1152/ajpheart.00540.2018. [Epub ahead of print]

PMID:
31347915
2.

Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells.

Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA.

Stem Cell Res Ther. 2019 Jul 8;10(1):203. doi: 10.1186/s13287-019-1305-y.

3.

3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer.

Borrello J, Nasser P, Iatridis J, Costa KD.

Addit Manuf. 2018 Oct;23:374-380. doi: 10.1016/j.addma.2018.08.019. Epub 2018 Aug 18.

PMID:
31106119
4.

Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues.

Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA.

Sci Rep. 2019 May 16;9(1):7502. doi: 10.1038/s41598-019-42953-w.

5.

Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses.

Keung W, Chan PKW, Backeris PC, Lee EK, Wong N, Wong AOT, Wong GKY, Chan CWY, Fermini B, Costa KD, Li RA.

Clin Pharmacol Ther. 2019 Aug;106(2):402-414. doi: 10.1002/cpt.1385. Epub 2019 Mar 28.

PMID:
30723889
6.

An In Silico Study of the Antioxidant Ability for Two Caffeine Analogs Using Molecular Docking and Quantum Chemical Methods.

Costa JDS, Ramos RDS, Costa KDSL, Brasil DDSB, Silva CHTPD, Ferreira EFB, Borges RDS, Campos JM, Macêdo WJDC, Santos CBRD.

Molecules. 2018 Oct 29;23(11). pii: E2801. doi: 10.3390/molecules23112801.

7.

Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies.

Turnbull IC, Mayourian J, Murphy JF, Stillitano F, Ceholski DK, Costa KD.

Methods Mol Biol. 2018;1816:145-159. doi: 10.1007/978-1-4939-8597-5_11.

8.

An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity.

Mayourian J, Sobie EA, Costa KD.

Methods Mol Biol. 2018;1816:17-35. doi: 10.1007/978-1-4939-8597-5_2.

9.

Dehomogenized Elastic Properties of Heterogeneous Layered Materials in AFM Indentation Experiments.

Lee JJ, Rao S, Kaushik G, Azeloglu EU, Costa KD.

Biophys J. 2018 Jun 5;114(11):2717-2731. doi: 10.1016/j.bpj.2018.04.036.

10.

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes.

Ceholski DK, Turnbull IC, Kong CW, Koplev S, Mayourian J, Gorski PA, Stillitano F, Skodras AA, Nonnenmacher M, Cohen N, Björkegren JLM, Stroik DR, Cornea RL, Thomas DD, Li RA, Costa KD, Hajjar RJ.

J Mol Cell Cardiol. 2018 Jun;119:147-154. doi: 10.1016/j.yjmcc.2018.05.007. Epub 2018 May 9.

11.

Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

Li RA, Keung W, Cashman TJ, Backeris PC, Johnson BV, Bardot ES, Wong AOT, Chan PKW, Chan CWY, Costa KD.

Biomaterials. 2018 May;163:116-127. doi: 10.1016/j.biomaterials.2018.02.024. Epub 2018 Feb 10.

12.

Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility.

Mayourian J, Ceholski DK, Gorski PA, Mathiyalagan P, Murphy JF, Salazar SI, Stillitano F, Hare JM, Sahoo S, Hajjar RJ, Costa KD.

Circ Res. 2018 Mar 30;122(7):933-944. doi: 10.1161/CIRCRESAHA.118.312420. Epub 2018 Feb 15.

13.

Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling.

Mayourian J, Ceholski DK, Gonzalez DM, Cashman TJ, Sahoo S, Hajjar RJ, Costa KD.

Circ Res. 2018 Jan 5;122(1):167-183. doi: 10.1161/CIRCRESAHA.117.311589. Review.

14.

Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension.

Zhou N, Lee JJ, Stoll S, Ma B, Costa KD, Qiu H.

Cell Physiol Biochem. 2017;44(2):701-715. doi: 10.1159/000485284. Epub 2017 Nov 23.

15.

Coronary capillary blood flow in a rat model of congestive heart failure.

Kagan HJ, Belekdanian VD, Chen J, Backeris P, Hammoudi N, Turnbull IC, Costa KD, Hajjar RJ.

J Appl Physiol (1985). 2018 Mar 1;124(3):632-640. doi: 10.1152/japplphysiol.00741.2017. Epub 2017 Oct 19.

16.

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.

Lee EK, Tran DD, Keung W, Chan P, Wong G, Chan CW, Costa KD, Li RA, Khine M.

Stem Cell Reports. 2017 Nov 14;9(5):1560-1572. doi: 10.1016/j.stemcr.2017.09.008. Epub 2017 Oct 12.

17.

CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response.

Ceholski DK, Turnbull IC, Pothula V, Lecce L, Jarrah AA, Kho C, Lee A, Hadri L, Costa KD, Hajjar RJ, Tarzami ST.

Stem Cell Res. 2017 Aug;23:77-86. doi: 10.1016/j.scr.2017.06.015. Epub 2017 Jul 8.

18.

Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.

Mayourian J, Cashman TJ, Ceholski DK, Johnson BV, Sachs D, Kaji DA, Sahoo S, Hare JM, Hajjar RJ, Sobie EA, Costa KD.

Circ Res. 2017 Aug 4;121(4):411-423. doi: 10.1161/CIRCRESAHA.117.310796. Epub 2017 Jun 22.

19.

Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension.

Zhou N, Lee JJ, Stoll S, Ma B, Wiener R, Wang C, Costa KD, Qiu H.

Cardiovasc Res. 2017 Feb;113(2):171-182. doi: 10.1093/cvr/cvw222. Epub 2016 Oct 23.

20.

Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents.

Turnbull IC, Eltoukhy AA, Anderson DG, Costa KD.

Methods Mol Biol. 2017;1521:153-166.

21.

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.

Mayourian J, Savizky RM, Sobie EA, Costa KD.

PLoS Comput Biol. 2016 Jul 25;12(7):e1005014. doi: 10.1371/journal.pcbi.1005014. eCollection 2016 Jul.

22.

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues.

Stillitano F, Turnbull IC, Karakikes I, Nonnenmacher M, Backeris P, Hulot JS, Kranias EG, Hajjar RJ, Costa KD.

Eur Heart J. 2016 Nov 14;37(43):3282-3284. Epub 2016 Jul 22.

23.

Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome.

Lee JJ, Galatioto J, Rao S, Ramirez F, Costa KD.

Ann Biomed Eng. 2016 Oct;44(10):2994-3006. doi: 10.1007/s10439-016-1616-4. Epub 2016 Apr 18.

24.

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy.

Cashman TJ, Josowitz R, Gelb BD, Li RA, Dubois NC, Costa KD.

J Vis Exp. 2016 Mar 1;(109):e53447. doi: 10.3791/53447.

25.

Decellularized Scaffold Hydrogel Materials for MI Treatment: Could "The Matrix" Really Be the Future?

Costa KD.

J Am Coll Cardiol. 2016 Mar 8;67(9):1087-90. doi: 10.1016/j.jacc.2016.01.006. No abstract available.

26.

Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues.

Kerscher P, Turnbull IC, Hodge AJ, Kim J, Seliktar D, Easley CJ, Costa KD, Lipke EA.

Biomaterials. 2016 Mar;83:383-95. doi: 10.1016/j.biomaterials.2015.12.011. Epub 2015 Dec 18.

27.

Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes.

Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, Casaccia P.

J Neurosci. 2016 Jan 20;36(3):806-13. doi: 10.1523/JNEUROSCI.2873-15.2016.

28.

Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy.

Cashman TJ, Josowitz R, Johnson BV, Gelb BD, Costa KD.

PLoS One. 2016 Jan 19;11(1):e0146697. doi: 10.1371/journal.pone.0146697. eCollection 2016.

29.

Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression.

Turnbull IC, Eltoukhy AA, Fish KM, Nonnenmacher M, Ishikawa K, Chen J, Hajjar RJ, Anderson DG, Costa KD.

Mol Ther. 2016 Feb;24(1):66-75. doi: 10.1038/mt.2015.193. Epub 2015 Oct 16.

30.

An update on the etiology of abdominal aortic aneurysms: implications for future diagnostic testing.

Miner GH, Faries PL, Costa KD, Hanss BG, Marin ML.

Expert Rev Cardiovasc Ther. 2015 Oct;13(10):1079-90. doi: 10.1586/14779072.2015.1082906. Epub 2015 Sep 7. Review.

PMID:
26401919
31.

An Evolving Understanding of the Genetic Causes of Abdominal Aortic Aneurysm Disease.

Miner GH, Costa KD, Hanss BG, Marin ML.

Surg Technol Int. 2015 May;26:197-205.

PMID:
26055010
32.

Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes.

Zhu R, Blazeski A, Poon E, Costa KD, Tung L, Boheler KR.

Stem Cell Res Ther. 2014 Oct 20;5(5):117. doi: 10.1186/scrt507. Review.

33.

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.

Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA.

Circ Arrhythm Electrophysiol. 2015 Feb;8(1):193-202. doi: 10.1161/CIRCEP.114.002049. Epub 2014 Dec 10.

34.

Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine.

Ishikawa K, Fish K, Aguero J, Yaniz-Galende E, Jeong D, Kho C, Tilemann L, Fish L, Liang L, Eltoukhy AA, Anderson DG, Zsebo K, Costa KD, Hajjar RJ.

Circ Heart Fail. 2015 Jan;8(1):167-74. doi: 10.1161/CIRCHEARTFAILURE.114.001711. Epub 2014 Oct 23.

35.

Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.

Cook JR, Carta L, Bénard L, Chemaly ER, Chiu E, Rao SK, Hampton TG, Yurchenco P; GenTAC Registry Consortium, Costa KD, Hajjar RJ, Ramirez F.

J Clin Invest. 2014 Mar;124(3):1329-39. doi: 10.1172/JCI71059. Epub 2014 Feb 17.

36.

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.

Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee JJ, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot JS, Costa KD.

FASEB J. 2014 Feb;28(2):644-54. doi: 10.1096/fj.13-228007. Epub 2013 Oct 30.

37.

Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes.

Boycott HE, Barbier CS, Eichel CA, Costa KD, Martins RP, Louault F, Dilanian G, Coulombe A, Hatem SN, Balse E.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3955-64. doi: 10.1073/pnas.1309896110. Epub 2013 Sep 24.

38.

Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias.

Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA.

Biomaterials. 2013 Nov;34(35):8878-86. doi: 10.1016/j.biomaterials.2013.07.039. Epub 2013 Aug 12.

PMID:
23942210
39.

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform.

Gianella A, Mieszawska AJ, Hoeben FJ, Janssen HM, Jarzyna PA, Cormode DP, Costa KD, Rao S, Farokhzad OC, Langer R, Fayad ZA, Mulder WJ.

Chem Commun (Camb). 2013 Oct 21;49(82):9392-4. doi: 10.1039/c3cc43618g.

40.

Impact of matrix metalloproteinases on inhibition of mineralization by fetuin.

Schure R, Costa KD, Rezaei R, Lee W, Laschinger C, Tenenbaum HC, McCulloch CA.

J Periodontal Res. 2013 Jun;48(3):357-66. doi: 10.1111/jre.12015. Epub 2012 Oct 12.

PMID:
23058002
41.

Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms.

Cashman TJ, Gouon-Evans V, Costa KD.

Stem Cell Rev Rep. 2013 Jun;9(3):254-65. doi: 10.1007/s12015-012-9375-6. Review.

42.

Myocyte-depleted engineered cardiac tissues support therapeutic potential of mesenchymal stem cells.

Serrao GW, Turnbull IC, Ancukiewicz D, Kim DE, Kao E, Cashman TJ, Hadri L, Hajjar RJ, Costa KD.

Tissue Eng Part A. 2012 Jul;18(13-14):1322-33. doi: 10.1089/ten.TEA.2011.0278. Epub 2012 Jun 25.

43.

Engineered human pluripotent stem cell-derived cardiac cells and tissues for electrophysiological studies.

Lieu DK, Turnbull IC, Costa KD, Li RA.

Drug Discov Today Dis Models. 2012 Winter;9(4):e209-e217. doi: 10.1016/j.ddmod.2012.06.002.

44.

Biomedical model fitting and error analysis.

Costa KD, Kleinstein SH, Hershberg U.

Sci Signal. 2011 Sep 20;4(192):tr9. doi: 10.1126/scisignal.2001983.

45.

Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies.

Wang X, Chen S, Kong M, Wang Z, Costa KD, Li RA, Sun D.

Lab Chip. 2011 Nov 7;11(21):3656-62. doi: 10.1039/c1lc20653b. Epub 2011 Sep 14.

PMID:
21918752
46.

Aortic implantation of mesenchymal stem cells after aneurysm injury in a porcine model.

Turnbull IC, Hadri L, Rapti K, Sadek M, Liang L, Shin HJ, Costa KD, Marin ML, Hajjar RJ, Faries PL.

J Surg Res. 2011 Sep;170(1):e179-88. doi: 10.1016/j.jss.2011.05.042. Epub 2011 Jul 13.

47.

Atomic force microscopy in mechanobiology: measuring microelastic heterogeneity of living cells.

Azeloglu EU, Costa KD.

Methods Mol Biol. 2011;736:303-29. doi: 10.1007/978-1-61779-105-5_19. Review.

PMID:
21660735
48.

Delivery of gelfoam-enabled cells and vectors into the pericardial space using a percutaneous approach in a porcine model.

Ladage D, Turnbull IC, Ishikawa K, Takewa Y, Rapti K, Morel C, Karakikes I, Hadri L, Müller-Ehmsen J, Costa KD, Hajjar RJ, Kawase Y.

Gene Ther. 2011 Oct;18(10):979-85. doi: 10.1038/gt.2011.52. Epub 2011 Apr 21.

49.

An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation.

Huo B, Lu XL, Costa KD, Xu Q, Guo XE.

Cell Calcium. 2010 Mar;47(3):234-41. doi: 10.1016/j.ceca.2009.12.005. Epub 2010 Jan 8.

50.

Cross-bridge cycling gives rise to spatiotemporal heterogeneity of dynamic subcellular mechanics in cardiac myocytes probed with atomic force microscopy.

Azeloglu EU, Costa KD.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H853-60. doi: 10.1152/ajpheart.00427.2009. Epub 2009 Dec 18.

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