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Items: 36


Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs.

Montag J, Petersen B, Flögel AK, Becker E, Lucas-Hahn A, Cost GJ, Mühlfeld C, Kraft T, Niemann H, Brenner B.

Sci Rep. 2018 Mar 19;8(1):4786. doi: 10.1038/s41598-018-22936-z.


Delivery of Genome Editing Reagents to Hematopoietic Stem/Progenitor Cells.

Hoban MD, Romero Z, Cost GJ, Mendel M, Holmes M, Kohn DB.

Curr Protoc Stem Cell Biol. 2016 Feb 3;36:5B.4.1-10. doi: 10.1002/9780470151808.sc05b04s36. Review.


Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.

Hoban MD, Cost GJ, Mendel MC, Romero Z, Kaufman ML, Joglekar AV, Ho M, Lumaquin D, Gray D, Lill GR, Cooper AR, Urbinati F, Senadheera S, Zhu A, Liu PQ, Paschon DE, Zhang L, Rebar EJ, Wilber A, Wang X, Gregory PD, Holmes MC, Reik A, Hollis RP, Kohn DB.

Blood. 2015 Apr 23;125(17):2597-604. doi: 10.1182/blood-2014-12-615948. Epub 2015 Mar 2.


Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease.

Inglese J, Dranchak P, Moran JJ, Jang SW, Srinivasan R, Santiago Y, Zhang L, Guha R, Martinez N, MacArthur R, Cost GJ, Svaren J.

ACS Chem Biol. 2014 Nov 21;9(11):2594-602. doi: 10.1021/cb5005492. Epub 2014 Sep 16.


Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.

Sexton AN, Regalado SG, Lai CS, Cost GJ, O'Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D.

Genes Dev. 2014 Sep 1;28(17):1885-99. doi: 10.1101/gad.246819.114. Epub 2014 Aug 15.


Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.

Remy S, Tesson L, Menoret S, Usal C, De Cian A, Thepenier V, Thinard R, Baron D, Charpentier M, Renaud JB, Buelow R, Cost GJ, Giovannangeli C, Fraichard A, Concordet JP, Anegon I.

Genome Res. 2014 Aug;24(8):1371-83. doi: 10.1101/gr.171538.113. Epub 2014 Jul 2.


Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.

Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D.

Stem Cell Reports. 2014 Jun 3;2(6):838-52. doi: 10.1016/j.stemcr.2014.05.001. eCollection 2014 Jun 3. Erratum in: Stem Cell Reports. 2014 Jul 8;3(1):215.


Translating dosage compensation to trisomy 21.

Jiang J, Jing Y, Cost GJ, Chiang JC, Kolpa HJ, Cotton AM, Carone DM, Carone BR, Shivak DA, Guschin DY, Pearl JR, Rebar EJ, Byron M, Gregory PD, Brown CJ, Urnov FD, Hall LL, Lawrence JB.

Nature. 2013 Aug 15;500(7462):296-300. doi: 10.1038/nature12394. Epub 2013 Jul 17.


Gene knockout and knockin by zinc-finger nucleases: current status and perspectives.

Hauschild-Quintern J, Petersen B, Cost GJ, Niemann H.

Cell Mol Life Sci. 2013 Aug;70(16):2969-83. doi: 10.1007/s00018-012-1204-1. Epub 2012 Nov 17. Review.


In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration.

Cristea S, Freyvert Y, Santiago Y, Holmes MC, Urnov FD, Gregory PD, Cost GJ.

Biotechnol Bioeng. 2013 Mar;110(3):871-80. doi: 10.1002/bit.24733. Epub 2012 Oct 23.


Knockout rats generated by embryo microinjection of TALENs.

Tesson L, Usal C, Ménoret S, Leung E, Niles BJ, Remy S, Santiago Y, Vincent AI, Meng X, Zhang L, Gregory PD, Anegon I, Cost GJ.

Nat Biotechnol. 2011 Aug 5;29(8):695-6. doi: 10.1038/nbt.1940. No abstract available.


Genetic engineering of human pluripotent cells using TALE nucleases.

Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R.

Nat Biotechnol. 2011 Jul 7;29(8):731-4. doi: 10.1038/nbt.1927.


Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases.

Hauschild J, Petersen B, Santiago Y, Queisser AL, Carnwath JW, Lucas-Hahn A, Zhang L, Meng X, Gregory PD, Schwinzer R, Cost GJ, Niemann H.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12013-7. doi: 10.1073/pnas.1106422108. Epub 2011 Jul 5. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):15010.


Dissection of splicing regulation at an endogenous locus by zinc-finger nuclease-mediated gene editing.

Cristea S, Gregory PD, Urnov FD, Cost GJ.

PLoS One. 2011 Feb 8;6(2):e16961. doi: 10.1371/journal.pone.0016961.


A TALE nuclease architecture for efficient genome editing.

Miller JC, Tan S, Qiao G, Barlow KA, Wang J, Xia DF, Meng X, Paschon DE, Leung E, Hinkley SJ, Dulay GP, Hua KL, Ankoudinova I, Cost GJ, Urnov FD, Zhang HS, Holmes MC, Zhang L, Gregory PD, Rebar EJ.

Nat Biotechnol. 2011 Feb;29(2):143-8. doi: 10.1038/nbt.1755. Epub 2010 Dec 22.


Characterization of immunoglobulin heavy chain knockout rats.

Ménoret S, Iscache AL, Tesson L, Rémy S, Usal C, Osborn MJ, Cost GJ, Brüggemann M, Buelow R, Anegon I.

Eur J Immunol. 2010 Oct;40(10):2932-41. doi: 10.1002/eji.201040939.


Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies.

Malphettes L, Freyvert Y, Chang J, Liu PQ, Chan E, Miller JC, Zhou Z, Nguyen T, Tsai C, Snowden AW, Collingwood TN, Gregory PD, Cost GJ.

Biotechnol Bioeng. 2010 Aug 1;106(5):774-83. doi: 10.1002/bit.22751.


Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology.

Orlando SJ, Santiago Y, DeKelver RC, Freyvert Y, Boydston EA, Moehle EA, Choi VM, Gopalan SM, Lou JF, Li J, Miller JC, Holmes MC, Gregory PD, Urnov FD, Cost GJ.

Nucleic Acids Res. 2010 Aug;38(15):e152. doi: 10.1093/nar/gkq512. Epub 2010 Jun 8.


Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases.

Liu PQ, Chan EM, Cost GJ, Zhang L, Wang J, Miller JC, Guschin DY, Reik A, Holmes MC, Mott JE, Collingwood TN, Gregory PD.

Biotechnol Bioeng. 2010 May 1;106(1):97-105. doi: 10.1002/bit.22654.


Generation of gene-specific mutated rats using zinc-finger nucleases.

Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I, Buelow R.

Methods Mol Biol. 2010;597:211-25. doi: 10.1007/978-1-60327-389-3_15.


BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells.

Cost GJ, Freyvert Y, Vafiadis A, Santiago Y, Miller JC, Rebar E, Collingwood TN, Snowden A, Gregory PD.

Biotechnol Bioeng. 2010 Feb 1;105(2):330-40. doi: 10.1002/bit.22541.


Retrotransposon overdose and genome integrity.

Scheifele LZ, Cost GJ, Zupancic ML, Caputo EM, Boeke JD.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13927-32. doi: 10.1073/pnas.0906552106. Epub 2009 Aug 4.


Knockout rats via embryo microinjection of zinc-finger nucleases.

Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R.

Science. 2009 Jul 24;325(5939):433. doi: 10.1126/science.1172447.


Directed assembly of DNA molecules via simultaneous ligation and digestion.

Cost GJ, Cozzarelli NR.

Biotechniques. 2007 Jan;42(1):84, 86-9.


Giant proteins that move DNA: bullies of the genomic playground.

Cozzarelli NR, Cost GJ, Nöllmann M, Viard T, Stray JE.

Nat Rev Mol Cell Biol. 2006 Aug;7(8):580-8. Review.


Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae.

Cost GJ, Cozzarelli NR.

Genetics. 2006 Apr;172(4):2185-200. Epub 2006 Feb 1.


Sequence-directed DNA translocation by purified FtsK.

Pease PJ, Levy O, Cost GJ, Gore J, Ptacin JL, Sherratt D, Bustamante C, Cozzarelli NR.

Science. 2005 Jan 28;307(5709):586-90.


Human L1 element target-primed reverse transcription in vitro.

Cost GJ, Feng Q, Jacquier A, Boeke JD.

EMBO J. 2002 Nov 1;21(21):5899-910.


Human l1 retrotransposition is associated with genetic instability in vivo.

Symer DE, Connelly C, Szak ST, Caputo EM, Cost GJ, Parmigiani G, Boeke JD.

Cell. 2002 Aug 9;110(3):327-38.


Target DNA chromatinization modulates nicking by L1 endonuclease.

Cost GJ, Golding A, Schlissel MS, Boeke JD.

Nucleic Acids Res. 2001 Jan 15;29(2):573-7.


Lack of imprinting of three human cyclin-dependent kinase inhibitor genes.

Cost GJ, Thompson JS, Reichard BA, Lee JY, Feinberg AP.

Cancer Res. 1997 Mar 1;57(5):926-9.


A central role for a single c-Myb binding site in a thymic locus control region.

Ess KC, Whitaker TL, Cost GJ, Witte DP, Hutton JJ, Aronow BJ.

Mol Cell Biol. 1995 Oct;15(10):5707-15.

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