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Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from Phania matricarioides (Spreng.) Griseb.

Gutiérrez YI, Scull R, Villa A, Satyal P, Cos P, Monzote L, Setzer WN.

Molecules. 2019 Apr 24;24(8). pii: E1615. doi: 10.3390/molecules24081615.


Characterization of the role of N-glycosylation sites in the respiratory syncytial virus fusion protein in virus replication, syncytium formation and antigenicity.

Leemans A, Boeren M, Van der Gucht W, Martinet W, Caljon G, Maes L, Cos P, Delputte P.

Virus Res. 2019 Jun;266:58-68. doi: 10.1016/j.virusres.2019.04.006. Epub 2019 Apr 17.


Non-Thermal Plasma as a Unique Delivery System of Short-Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells.

Lin A, Gorbanev Y, De Backer J, Van Loenhout J, Van Boxem W, Lemière F, Cos P, Dewilde S, Smits E, Bogaerts A.

Adv Sci (Weinh). 2019 Jan 28;6(6):1802062. doi: 10.1002/advs.201802062. eCollection 2019 Mar 20.


In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei.

Rojas Vargas JA, López AG, Pérez Y, Cos P, Froeyen M.

Parasitol Res. 2019 May;118(5):1533-1548. doi: 10.1007/s00436-019-06206-z. Epub 2019 Mar 23.


Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents.

Courtens C, Risseeuw M, Caljon G, Maes L, Cos P, Martin A, Van Calenbergh S.

Bioorg Med Chem Lett. 2019 May 15;29(10):1232-1235. doi: 10.1016/j.bmcl.2019.03.009. Epub 2019 Mar 7.


Phosphonodiamidate prodrugs of N-alkoxy analogs of a fosmidomycin surrogate as antimalarial and antitubercular agents.

Courtens C, Risseeuw M, Caljon G, Cos P, Martin A, Van Calenbergh S.

Bioorg Med Chem Lett. 2019 May 1;29(9):1051-1053. doi: 10.1016/j.bmcl.2019.03.008. Epub 2019 Mar 7.


Antimicrobial activity of leaf extracts and isolated constituents of Croton linearis.

García Díaz J, Tuenter E, Escalona Arranz JC, Llauradó Maury G, Cos P, Pieters L.

J Ethnopharmacol. 2019 May 23;236:250-257. doi: 10.1016/j.jep.2019.01.049. Epub 2019 Mar 5.


Optimization and Characterization of a Galleria mellonella Larval Infection Model for Virulence Studies and the Evaluation of Therapeutics Against Streptococcus pneumoniae.

Cools F, Torfs E, Aizawa J, Vanhoutte B, Maes L, Caljon G, Delputte P, Cappoen D, Cos P.

Front Microbiol. 2019 Feb 21;10:311. doi: 10.3389/fmicb.2019.00311. eCollection 2019.


Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG.

Allonsius CN, Vandenheuvel D, Oerlemans EFM, Petrova MI, Donders GGG, Cos P, Delputte P, Lebeer S.

Sci Rep. 2019 Feb 27;9(1):2900. doi: 10.1038/s41598-019-39625-0.


Synthesis and antitubercular activity of 1- and 3-substituted benzo[g]isoquinoline-5,10-diones.

Smets RJ, Torfs E, Lemière F, Cos P, Cappoen D, Abbaspour Tehrani K.

Org Biomol Chem. 2019 Mar 13;17(11):2923-2939. doi: 10.1039/c8ob02690d.


In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

Kanyanga RC, Lumpu SN, Ehata MT, Maya BM, Munduku CK, Bool-Miting FM, Cos P, Maes L, Vlietinck AJ, Exarchou V, Tuenter E, Pieters L.

J Ethnopharmacol. 2019 Feb 11. pii: S0378-8741(18)34998-5. doi: 10.1016/j.jep.2019.02.019. [Epub ahead of print]


HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.

Zarev Y, Foubert K, Cos P, Maes L, Elgorashi E, Apers S, Ionkova I, Pieters L.

Nat Prod Res. 2019 Jan 3:1-4. doi: 10.1080/14786419.2018.1539976. [Epub ahead of print]


Immunosuppression of Syrian golden hamsters accelerates relapse but not the emergence of resistance in Leishmania infantum following recurrent miltefosine pressure.

Hendrickx S, Bulté D, Van den Kerkhof M, Cos P, Delputte P, Maes L, Caljon G.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:1-7. doi: 10.1016/j.ijpddr.2018.12.001. Epub 2018 Dec 11.


Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain.

Eberhardt E, Bulté D, Van Bockstal L, Van den Kerkhof M, Cos P, Delputte P, Hendrickx S, Maes L, Caljon G.

J Antimicrob Chemother. 2019 Feb 1;74(2):395-406. doi: 10.1093/jac/dky450.


Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents.

Courtens C, Risseeuw M, Caljon G, Cos P, Van Calenbergh S.

ACS Med Chem Lett. 2018 Sep 11;9(10):986-989. doi: 10.1021/acsmedchemlett.8b00223. eCollection 2018 Oct 11.


Streptococcus pneumoniae galU gene mutation has a direct effect on biofilm growth, adherence and phagocytosis in vitro and pathogenicity in vivo.

Cools F, Torfs E, Vanhoutte B, de Macedo MB, Bonofiglio L, Mollerach M, Maes L, Caljon G, Delputte P, Cappoen D, Cos P.

Pathog Dis. 2018 Oct 1;76(7). doi: 10.1093/femspd/fty069.


Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function.

Mannaerts D, Faes E, Cos P, Briedé JJ, Gyselaers W, Cornette J, Gorbanev Y, Bogaerts A, Spaanderman M, Van Craenenbroeck E, Jacquemyn Y.

PLoS One. 2018 Sep 11;13(9):e0202919. doi: 10.1371/journal.pone.0202919. eCollection 2018.


Impact of primary mouse macrophage cell types on Leishmania infection and in vitro drug susceptibility.

Van den Kerkhof M, Van Bockstal L, Gielis JF, Delputte P, Cos P, Maes L, Caljon G, Hendrickx S.

Parasitol Res. 2018 Nov;117(11):3601-3612. doi: 10.1007/s00436-018-6059-4. Epub 2018 Aug 23.


Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization.

Leemans A, Boeren M, Van der Gucht W, Pintelon I, Roose K, Schepens B, Saelens X, Bailey D, Martinet W, Caljon G, Maes L, Cos P, Delputte P.

Viruses. 2018 Aug 14;10(8). pii: E426. doi: 10.3390/v10080426.


Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, Cantón E, Coenye T, Cos P, Cowen LE, Edgerton M, Espinel-Ingroff A, Filler SG, Ghannoum M, Gow NAR, Haas H, Jabra-Rizk MA, Johnson EM, Lockhart SR, Lopez-Ribot JL, Maertens J, Munro CA, Nett JE, Nobile CJ, Pfaller MA, Ramage G, Sanglard D, Sanguinetti M, Spriet I, Verweij PE, Warris A, Wauters J, Yeaman MR, Zaat SAJ, Thevissen K.

Microb Cell. 2018 Jun 14;5(7):300-326. doi: 10.15698/mic2018.07.638. Review.


Efficacy of Four Solanum spp. Extracts in an Animal Model of Cutaneous Leishmaniasis.

Cos P, Janssens J, Piñón A, Cuesta-Rubio O, Yglesias-Rivera A, Díaz-García A, Vilegas W, Monzote L.

Medicines (Basel). 2018 Jun 5;5(2). pii: E49. doi: 10.3390/medicines5020049.


UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes.

Saad M, Bijttebier S, Matheeussen A, Verbueken E, Pype C, Casteleyn C, Van Ginneken C, Maes L, Cos P, Van Cruchten S.

Data Brief. 2017 Dec 6;16:644-648. doi: 10.1016/j.dib.2017.11.079. eCollection 2018 Feb.


Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.

Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Aínsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S.

J Med Chem. 2018 Apr 12;61(7):2753-2775. doi: 10.1021/acs.jmedchem.7b01570. Epub 2018 Mar 15.


Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study.

Mannaerts D, Faes E, Gielis J, Van Craenenbroeck E, Cos P, Spaanderman M, Gyselaers W, Cornette J, Jacquemyn Y.

BMC Pregnancy Childbirth. 2018 Feb 27;18(1):60. doi: 10.1186/s12884-018-1685-5.


Microbial Community Dynamics during Rearing of Black Soldier Fly Larvae (Hermetia illucens) and Impact on Exploitation Potential.

De Smet J, Wynants E, Cos P, Van Campenhout L.

Appl Environ Microbiol. 2018 Apr 16;84(9). pii: e02722-17. doi: 10.1128/AEM.02722-17. Print 2018 May 1. Review.


Evaluation of a Pan-Leishmania Spliced-Leader RNA Detection Method in Human Blood and Experimentally Infected Syrian Golden Hamsters.

Eberhardt E, Van den Kerkhof M, Bulté D, Mabille D, Van Bockstal L, Monnerat S, Alves F, Mbui J, Delputte P, Cos P, Hendrickx S, Maes L, Caljon G.

J Mol Diagn. 2018 Mar;20(2):253-263. doi: 10.1016/j.jmoldx.2017.12.003. Epub 2018 Jan 31.


Combining experimental and modelling approaches to study the sources of reactive species induced in water by the COST RF plasma jet.

Gorbanev Y, Verlackt CCW, Tinck S, Tuenter E, Foubert K, Cos P, Bogaerts A.

Phys Chem Chem Phys. 2018 Jan 24;20(4):2797-2808. doi: 10.1039/c7cp07616a.


Bioassay-guided In vitro Study of the Antimicrobial and Cytotoxic Properties of the Leaves from Excoecaria Lucida Sw.

Ochoa-Pacheco A, Escalona Arranz JC, Beaven M, Peres-Roses R, Gámez YM, Camacho-Pozo MI, Maury GL, de Macedo MB, Cos P, Tavares JF, Da Silva MS.

Pharmacognosy Res. 2017 Oct-Dec;9(4):396-400. doi: 10.4103/pr.pr_124_16.


Biological Activities and Cytotoxicity of Eperua oleifera Ducke Oil-resin.

Alves Gomes FT, Boleti APA, Leandro LM, Squinello D, Aranha ESP, Vasconcelos MC, Cos P, Veiga-Junior VF, Lima ES.

Pharmacogn Mag. 2017 Oct-Dec;13(52):542-552. doi: 10.4103/pm.pm_552_16. Epub 2017 Nov 13.


Essential Oil from Piper aduncum: Chemical Analysis, Antimicrobial Assessment, and Literature Review.

Monzote L, Scull R, Cos P, Setzer WN.

Medicines (Basel). 2017 Jul 2;4(3). pii: E49. doi: 10.3390/medicines4030049.


Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds.

Torfs E, Vajs J, de Macedo MB, Cools F, Vanhoutte B, Gorbanev Y, Bogaerts A, Verschaeve L, Caljon G, Maes L, Delputte P, Cos P, Košmrlj J, Cappoen D.

Chem Biol Drug Des. 2018 Feb;91(2):631-640. doi: 10.1111/cbdd.13087. Epub 2017 Sep 14.


Chemical Composition and Antioxidant, Antinociceptive, and Anti-inflammatory Activities of Four Amazonian Byrsonima Species.

Guilhon-Simplicio F, Machado TM, do Nascimento LF, Souza RDS, Koolen HHF, da Silva FMA, Acho LDR, Dos Santos ARS, Cos P, Pereira MM, Lima ES.

Phytother Res. 2017 Nov;31(11):1686-1693. doi: 10.1002/ptr.5884. Epub 2017 Aug 25.


Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182].

Song L, Risseeuw MDP, Froeyen M, Karalic I, Goeman J, Cappoen D, Van der Eycken J, Cos P, Munier-Lehmann H, Van Calenbergh S.

Bioorg Med Chem. 2017 Oct 15;25(20):5889. doi: 10.1016/j.bmc.2017.08.023. Epub 2017 Aug 18. No abstract available.


Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection.

Van der Gucht W, Leemans A, De Schryver M, Heykers A, Caljon G, Maes L, Cos P, Delputte PL.

Virol J. 2017 Aug 17;14(1):157. doi: 10.1186/s12985-017-0824-3.


Interplay between Lactobacillus rhamnosus GG and Candida and the involvement of exopolysaccharides.

Allonsius CN, van den Broek MFL, De Boeck I, Kiekens S, Oerlemans EFM, Kiekens F, Foubert K, Vandenheuvel D, Cos P, Delputte P, Lebeer S.

Microb Biotechnol. 2017 Nov;10(6):1753-1763. doi: 10.1111/1751-7915.12799. Epub 2017 Aug 3.


Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones.

de Macedo MB, Kimmel R, Urankar D, Gazvoda M, Peixoto A, Cools F, Torfs E, Verschaeve L, Lima ES, Lyčka A, Milićević D, Klásek A, Cos P, Kafka S, Košmrlj J, Cappoen D.

Eur J Med Chem. 2017 Sep 29;138:491-500. doi: 10.1016/j.ejmech.2017.06.061. Epub 2017 Jun 29.


Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization.

Fontenete S, Leite M, Figueiredo C, Cos P, Azevedo NF.

Methods Mol Biol. 2017;1616:137-146. doi: 10.1007/978-1-4939-7037-7_8.


Optimization and characterization of a murine lung infection model for the evaluation of novel therapeutics against Burkholderia cenocepacia.

Vanhoutte B, Cappoen D, Maira BM, Cools F, Torfs E, Coenye T, Martinet W, Caljon G, Maes L, Delputte P, Cos P.

J Microbiol Methods. 2017 Aug;139:181-188. doi: 10.1016/j.mimet.2017.06.003. Epub 2017 Jun 3.


In Vitro and In Silico Antidiabetic and Antimicrobial Evaluation of Constituents from Kickxia ramosissima (Nanorrhinum ramosissimum).

Amin A, Tuenter E, Foubert K, Iqbal J, Cos P, Maes L, Exarchou V, Apers S, Pieters L.

Front Pharmacol. 2017 May 1;8:232. doi: 10.3389/fphar.2017.00232. eCollection 2017.


In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds.

Saad M, Matheeussen A, Bijttebier S, Verbueken E, Pype C, Casteleyn C, Van Ginneken C, Apers S, Maes L, Cos P, Van Cruchten S.

Toxicol In Vitro. 2017 Aug;42:329-336. doi: 10.1016/j.tiv.2017.05.009. Epub 2017 May 12.


Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum.

Hendrickx S, Van den Kerkhof M, Mabille D, Cos P, Delputte P, Maes L, Caljon G.

PLoS Negl Trop Dis. 2017 May 15;11(5):e0005620. doi: 10.1371/journal.pntd.0005620. eCollection 2017 May.


Pathogenetic role of endothelial nitric oxide synthase uncoupling during lung ischaemia-reperfusion injury.

Gielis JF, Quirynen L, Briedé JJ, Roelant E, Cos P, Van Schil PEY.

Eur J Cardiothorac Surg. 2017 Aug 1;52(2):256-263. doi: 10.1093/ejcts/ezx125.


Antibody-Induced Internalization of the Human Respiratory Syncytial Virus Fusion Protein.

Leemans A, De Schryver M, Van der Gucht W, Heykers A, Pintelon I, Hotard AL, Moore ML, Melero JA, McLellan JS, Graham BS, Broadbent L, Power UF, Caljon G, Cos P, Maes L, Delputte P.

J Virol. 2017 Jun 26;91(14). pii: e00184-17. doi: 10.1128/JVI.00184-17. Print 2017 Jul 15.


Oxidative and nitrosative stress during pulmonary ischemia-reperfusion injury: from the lab to the OR.

Gielis JF, Beckers PAJ, Briedé JJ, Cos P, Van Schil PE.

Ann Transl Med. 2017 Mar;5(6):131. doi: 10.21037/atm.2017.03.32. Review.


Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models.

Van den Driessche F, Vanhoutte B, Brackman G, Crabbé A, Rigole P, Vercruysse J, Verstraete G, Cappoen D, Vervaet C, Cos P, Coenye T.

PLoS One. 2017 Mar 1;12(3):e0172723. doi: 10.1371/journal.pone.0172723. eCollection 2017.


Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide Alkaloids.

Tuenter E, Segers K, Kang KB, Viaene J, Sung SH, Cos P, Maes L, Heyden YV, Pieters L.

Molecules. 2017 Feb 2;22(2). pii: E224. doi: 10.3390/molecules22020224.


Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach.

Vermote A, Brackman G, Risseeuw MD, Cappoen D, Cos P, Coenye T, Van Calenbergh S.

ACS Med Chem Lett. 2016 Nov 9;8(1):38-42. doi: 10.1021/acsmedchemlett.6b00315. eCollection 2017 Jan 12.


Monoclonal antibody binding to the macrophage-specific receptor sialoadhesin alters the phagocytic properties of human and mouse macrophages.

De Schryver M, Cappoen D, Elewaut D, Nauwynck HJ, Maes L, Caljon G, Cos P, Delputte PL.

Cell Immunol. 2017 Feb;312:51-60. doi: 10.1016/j.cellimm.2016.11.009. Epub 2016 Dec 9.


Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity.

Tuenter E, Ahmad R, Foubert K, Amin A, Orfanoudaki M, Cos P, Maes L, Apers S, Pieters L, Exarchou V.

J Nat Prod. 2016 Nov 23;79(11):2865-2872. Epub 2016 Nov 10.


Comparative analysis of the internalization of the macrophage receptor sialoadhesin in human and mouse primary macrophages and cell lines.

De Schryver M, Leemans A, Pintelon I, Cappoen D, Maes L, Caljon G, Cos P, Delputte PL.

Immunobiology. 2017 Jun;222(6):797-806. doi: 10.1016/j.imbio.2016.11.013. Epub 2016 Nov 21.


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