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Clostridium difficile clade 3 (RT023) have a modified cell surface and contain a large transposable island with novel cargo.

Shaw HA, Khodadoost L, Preston MD, Corver J, Mullany P, Wren BW.

Sci Rep. 2019 Oct 25;9(1):15330. doi: 10.1038/s41598-019-51628-5.


The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics.

Shaw HA, Preston MD, Vendrik KEW, Cairns MD, Browne HP, Stabler RA, Crobach MJT, Corver J, Pituch H, Ingebretsen A, Pirmohamed M, Faulds-Pain A, Valiente E, Lawley TD, Fairweather NF, Kuijper EJ, Wren BW.

Clin Microbiol Infect. 2019 Sep 13. pii: S1198-743X(19)30489-6. doi: 10.1016/j.cmi.2019.09.004. [Epub ahead of print]


Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying.

De Meyer L, Lammens J, Vanbillemont B, Van Bockstal PJ, Corver J, Vervaet C, Friess W, De Beer T.

Int J Pharm. 2019 Oct 30;570:118631. doi: 10.1016/j.ijpharm.2019.118631. Epub 2019 Aug 20.


Identification and validation of two peptide markers for the recognition of Clostridioides difficile MLST-1 and MLST-11 by MALDI-MS.

Corver J, Sen J, Hornung BVH, Mertens BJ, Berssenbrugge EKL, Harmanus C, Sanders IMJG, Kumar N, Lawley TD, Kuijper EJ, Hensbergen PJ, Nicolardi S.

Clin Microbiol Infect. 2019 Jul;25(7):904.e1-904.e7. doi: 10.1016/j.cmi.2018.10.008. Epub 2018 Oct 26.


Thermal Imaging as a Noncontact Inline Process Analytical Tool for Product Temperature Monitoring during Continuous Freeze-Drying of Unit Doses.

Van Bockstal PJ, Corver J, De Meyer L, Vervaet C, De Beer T.

Anal Chem. 2018 Nov 20;90(22):13591-13599. doi: 10.1021/acs.analchem.8b03788. Epub 2018 Oct 30.


Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections.

Baktash A, Terveer EM, Zwittink RD, Hornung BVH, Corver J, Kuijper EJ, Smits WK.

Front Microbiol. 2018 Jun 12;9:1242. doi: 10.3389/fmicb.2018.01242. eCollection 2018. Review.


Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans.

Fleurbaaij F, Henneman AA, Corver J, Knetsch CW, Smits WK, Nauta ST, Giera M, Dragan I, Kumar N, Lawley TD, Verhoeven A, van Leeuwen HC, Kuijper EJ, Hensbergen PJ.

Sci Rep. 2018 May 25;8(1):8181. doi: 10.1038/s41598-018-26079-z.


Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family.

Klychnikov OI, Shamorkina TM, Weeks SD, van Leeuwen HC, Corver J, Drijfhout JW, van Veelen PA, Sluchanko NN, Strelkov SV, Hensbergen PJ.

J Biol Chem. 2018 Jul 13;293(28):11154-11165. doi: 10.1074/jbc.RA118.003244. Epub 2018 May 23.


Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying.

Brouckaert D, De Meyer L, Vanbillemont B, Van Bockstal PJ, Lammens J, Mortier S, Corver J, Vervaet C, Nopens I, De Beer T.

Anal Chem. 2018 Apr 3;90(7):4354-4362. doi: 10.1021/acs.analchem.7b03647. Epub 2018 Mar 16.


Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation.

Van Bockstal PJ, Corver J, Mortier STFC, De Meyer L, Nopens I, Gernaey KV, De Beer T.

Eur J Pharm Biopharm. 2018 Jun;127:159-170. doi: 10.1016/j.ejpb.2018.02.025. Epub 2018 Feb 21.


The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses.

Lammens J, Mortier STFC, De Meyer L, Vanbillemont B, Van Bockstal PJ, Van Herck S, Corver J, Nopens I, Vanhoorne V, De Geest BG, De Beer T, Vervaet C.

Int J Pharm. 2018 Mar 25;539(1-2):1-10. doi: 10.1016/j.ijpharm.2018.01.009. Epub 2018 Jan 31.


Global Sensitivity Analysis as Good Modelling Practices tool for the identification of the most influential process parameters of the primary drying step during freeze-drying.

Van Bockstal PJ, Mortier STFC, Corver J, Nopens I, Gernaey KV, De Beer T.

Eur J Pharm Biopharm. 2018 Feb;123:108-116. doi: 10.1016/j.ejpb.2017.12.006. Epub 2017 Dec 16.


Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans.

Knetsch CW, Kumar N, Forster SC, Connor TR, Browne HP, Harmanus C, Sanders IM, Harris SR, Turner L, Morris T, Perry M, Miyajima F, Roberts P, Pirmohamed M, Songer JG, Weese JS, Indra A, Corver J, Rupnik M, Wren BW, Riley TV, Kuijper EJ, Lawley TD.

J Clin Microbiol. 2018 Feb 22;56(3). pii: e01384-17. doi: 10.1128/JCM.01384-17. Print 2018 Mar.


Quantitative risk assessment via uncertainty analysis in combination with error propagation for the determination of the dynamic Design Space of the primary drying step during freeze-drying.

Van Bockstal PJ, Mortier STFC, Corver J, Nopens I, Gernaey KV, De Beer T.

Eur J Pharm Biopharm. 2017 Dec;121:32-41. doi: 10.1016/j.ejpb.2017.08.015. Epub 2017 Sep 18.


Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses.

De Meyer L, Lammens J, Mortier STFC, Vanbillemont B, Van Bockstal PJ, Corver J, Nopens I, Vervaet C, De Beer T.

Int J Pharm. 2017 Oct 30;532(1):185-193. doi: 10.1016/j.ijpharm.2017.09.004. Epub 2017 Sep 5.


Covalent attachment and Pro-Pro endopeptidase (PPEP-1)-mediated release of Clostridium difficile cell surface proteins involved in adhesion.

Corver J, Cordo' V, van Leeuwen HC, Klychnikov OI, Hensbergen PJ.

Mol Microbiol. 2017 Sep;105(5):663-673. doi: 10.1111/mmi.13736. Epub 2017 Jul 4. Review.


Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process.

Van Bockstal PJ, Mortier ST, De Meyer L, Corver J, Vervaet C, Nopens I, De Beer T.

Eur J Pharm Biopharm. 2017 May;114:11-21. doi: 10.1016/j.ejpb.2017.01.001. Epub 2017 Jan 12.


Noncontact Infrared-Mediated Heat Transfer During Continuous Freeze-Drying of Unit Doses.

Van Bockstal PJ, De Meyer L, Corver J, Vervaet C, De Beer T.

J Pharm Sci. 2017 Jan;106(1):71-82. doi: 10.1016/j.xphs.2016.05.003. Epub 2016 Jun 16.


A Novel Fic (Filamentation Induced by cAMP) Protein from Clostridium difficile Reveals an Inhibitory Motif-independent Adenylylation/AMPylation Mechanism.

Dedic E, Alsarraf H, Welner DH, Østergaard O, Klychnikov OI, Hensbergen PJ, Corver J, van Leeuwen HC, Jørgensen R.

J Biol Chem. 2016 Jun 17;291(25):13286-300. doi: 10.1074/jbc.M115.705491. Epub 2016 Apr 13.


Uncertainty analysis as essential step in the establishment of the dynamic Design Space of primary drying during freeze-drying.

Mortier STFC, Van Bockstal PJ, Corver J, Nopens I, Gernaey KV, De Beer T.

Eur J Pharm Biopharm. 2016 Jun;103:71-83. doi: 10.1016/j.ejpb.2016.03.015. Epub 2016 Mar 15.


Application of sepsis calculator in newborns with suspected infection.

Kerste M, Corver J, Sonnevelt MC, van Brakel M, van der Linden PD, M Braams-Lisman BA, Plötz FB.

J Matern Fetal Neonatal Med. 2016 Dec;29(23):3860-5. doi: 10.3109/14767058.2016.1149563. Epub 2016 Mar 7.


Clostridium difficile secreted Pro-Pro endopeptidase PPEP-1 (ZMP1/CD2830) modulates adhesion through cleavage of the collagen binding protein CD2831.

Hensbergen PJ, Klychnikov OI, Bakker D, Dragan I, Kelly ML, Minton NP, Corver J, Kuijper EJ, Drijfhout JW, van Leeuwen HC.

FEBS Lett. 2015 Dec 21;589(24 Pt B):3952-8. doi: 10.1016/j.febslet.2015.10.027. Epub 2015 Oct 29.


Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses.

De Meyer L, Van Bockstal PJ, Corver J, Vervaet C, Remon JP, De Beer T.

Int J Pharm. 2015 Dec 30;496(1):75-85. doi: 10.1016/j.ijpharm.2015.05.025. Epub 2015 May 14.


Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011.

Knetsch CW, Connor TR, Mutreja A, van Dorp SM, Sanders IM, Browne HP, Harris D, Lipman L, Keessen EC, Corver J, Kuijper EJ, Lawley TD.

Euro Surveill. 2014 Nov 13;19(45):20954.


The HtrA-like protease CD3284 modulates virulence of Clostridium difficile.

Bakker D, Buckley AM, de Jong A, van Winden VJ, Verhoeks JP, Kuipers OP, Douce GR, Kuijper EJ, Smits WK, Corver J.

Infect Immun. 2014 Oct;82(10):4222-32. doi: 10.1128/IAI.02336-14. Epub 2014 Jul 21.


A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.

Hensbergen PJ, Klychnikov OI, Bakker D, van Winden VJ, Ras N, Kemp AC, Cordfunke RA, Dragan I, Deelder AM, Kuijper EJ, Corver J, Drijfhout JW, van Leeuwen HC.

Mol Cell Proteomics. 2014 May;13(5):1231-44. doi: 10.1074/mcp.M113.034728. Epub 2014 Mar 12.


Current application and future perspectives of molecular typing methods to study Clostridium difficile infections.

Knetsch CW, Lawley TD, Hensgens MP, Corver J, Wilcox MW, Kuijper EJ.

Euro Surveill. 2013 Jan 24;18(4):20381. Review.


Clostridium difficile TcdC protein binds four-stranded G-quadruplex structures.

van Leeuwen HC, Bakker D, Steindel P, Kuijper EJ, Corver J.

Nucleic Acids Res. 2013 Feb 1;41(4):2382-93. doi: 10.1093/nar/gks1448. Epub 2013 Jan 8.


TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm.

Bakker D, Smits WK, Kuijper EJ, Corver J.

PLoS One. 2012;7(8):e43247. doi: 10.1371/journal.pone.0043247. Epub 2012 Aug 17.


Analysis of a Clostridium difficile PCR ribotype 078 100 kilobase island reveals the presence of a novel transposon, Tn6164.

Corver J, Bakker D, Brouwer MS, Harmanus C, Hensgens MP, Roberts AP, Lipman LJ, Kuijper EJ, van Leeuwen HC.

BMC Microbiol. 2012 Jul 2;12:130. doi: 10.1186/1471-2180-12-130.


Comparative analysis of an expanded Clostridium difficile reference strain collection reveals genetic diversity and evolution through six lineages.

Knetsch CW, Terveer EM, Lauber C, Gorbalenya AE, Harmanus C, Kuijper EJ, Corver J, van Leeuwen HC.

Infect Genet Evol. 2012 Oct;12(7):1577-85. doi: 10.1016/j.meegid.2012.06.003. Epub 2012 Jun 15.


Genetic markers for Clostridium difficile lineages linked to hypervirulence.

Knetsch CW, Hensgens MP, Harmanus C, van der Bijl MW, Savelkoul PH, Kuijper EJ, Corver J, van Leeuwen HC.

Microbiology. 2011 Nov;157(Pt 11):3113-23. doi: 10.1099/mic.0.051953-0. Epub 2011 Aug 26.


Comparison of real-time PCR techniques to cytotoxigenic culture methods for diagnosing Clostridium difficile infection.

Knetsch CW, Bakker D, de Boer RF, Sanders I, Hofs S, Kooistra-Smid AM, Corver J, Eastwood K, Wilcox MH, Kuijper EJ.

J Clin Microbiol. 2011 Jan;49(1):227-31. doi: 10.1128/JCM.01743-10. Epub 2010 Oct 27.


Relatedness of human and animal Clostridium difficile PCR ribotype 078 isolates determined on the basis of multilocus variable-number tandem-repeat analysis and tetracycline resistance.

Bakker D, Corver J, Harmanus C, Goorhuis A, Keessen EC, Fawley WN, Wilcox MH, Kuijper EJ.

J Clin Microbiol. 2010 Oct;48(10):3744-9. doi: 10.1128/JCM.01171-10. Epub 2010 Aug 4.


The changing epidemiology of Clostridium difficile infections.

Freeman J, Bauer MP, Baines SD, Corver J, Fawley WN, Goorhuis B, Kuijper EJ, Wilcox MH.

Clin Microbiol Rev. 2010 Jul;23(3):529-49. doi: 10.1128/CMR.00082-09. Review.


Terahertz spectroscopy to identify the polymorphs in freeze-dried Mannitol.

Chakkittakandy R, Corver JA, Planken PC.

J Pharm Sci. 2010 Feb;99(2):932-40. doi: 10.1002/jps.21870.


Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078.

Goorhuis A, Bakker D, Corver J, Debast SB, Harmanus C, Notermans DW, Bergwerff AA, Dekker FW, Kuijper EJ.

Clin Infect Dis. 2008 Nov 1;47(9):1162-70. doi: 10.1086/592257.


Quasi-near field terahertz generation and detection.

Chakkittakandy R, Corver JA, Planken PC.

Opt Express. 2008 Aug 18;16(17):12794-805.


Visualization of membrane protein domains by cryo-electron microscopy of dengue virus.

Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ.

Nat Struct Biol. 2003 Nov;10(11):907-12. Epub 2003 Oct 5.


Structures of immature flavivirus particles.

Zhang Y, Corver J, Chipman PR, Zhang W, Pletnev SV, Sedlak D, Baker TS, Strauss JH, Kuhn RJ, Rossmann MG.

EMBO J. 2003 Jun 2;22(11):2604-13.


Fine mapping of a cis-acting sequence element in yellow fever virus RNA that is required for RNA replication and cyclization.

Corver J, Lenches E, Smith K, Robison RA, Sando T, Strauss EG, Strauss JH.

J Virol. 2003 Feb;77(3):2265-70.


Fusion of alphaviruses with liposomes is a non-leaky process.

Smit JM, Li G, Schoen P, Corver J, Bittman R, Lin KC, Wilschut J.

FEBS Lett. 2002 Jun 19;521(1-3):62-6.


Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.

Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH.

Cell. 2002 Mar 8;108(5):717-25.


Membrane fusion activity of tick-borne encephalitis virus and recombinant subviral particles in a liposomal model system.

Corver J, Ortiz A, Allison SL, Schalich J, Heinz FX, Wilschut J.

Virology. 2000 Mar 30;269(1):37-46.


Mutagenesis of the RGD motif in the yellow fever virus 17D envelope protein.

van der Most RG, Corver J, Strauss JH.

Virology. 1999 Dec 5;265(1):83-95.


Membrane fusion activity of Semliki Forest virus in a liposomal model system: specific inhibition by Zn2+ ions.

Corver J, Bron R, Snippe H, Kraaijeveld C, Wilschut J.

Virology. 1997 Nov 10;238(1):14-21.


Inhibition of influenza virus fusion by polyanionic proteins.

Schoen P, Corver J, Meijer DK, Wilschut J, Swart PJ.

Biochem Pharmacol. 1997 Apr 4;53(7):995-1003.


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