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Items: 1 to 50 of 212

1.

Mucins as a New Frontier in Pulmonary Fibrosis.

Ballester B, Milara J, Cortijo J.

J Clin Med. 2019 Sep 11;8(9). pii: E1447. doi: 10.3390/jcm8091447. Review.

2.

Osimertinib in first-line treatment of advanced EGFR-mutated non-small-cell lung cancer: a cost-effectiveness analysis.

Aguilar-Serra J, Gimeno-Ballester V, Pastor-Clerigues A, Milara J, Marti-Bonmati E, Trigo-Vicente C, Alós-Almiñana M, Cortijo J.

J Comp Eff Res. 2019 Aug;8(11):853-863. doi: 10.2217/cer-2019-0029. Epub 2019 Sep 3.

PMID:
31478399
3.

Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonist/β 2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile.

Aparici M, Carcasona C, Ramos I, Montero JL, Otal R, Ortiz JL, Cortijo J, Puig C, Vilella D, De Alba J, Doe C, Gavaldà A, Miralpeix M.

J Pharmacol Exp Ther. 2019 Jul;370(1):127-136. doi: 10.1124/jpet.118.255620. Epub 2019 May 13.

PMID:
31085697
4.

Idiopathic Pulmonary Fibrosis and Lung Cancer: Mechanisms and Molecular Targets.

Ballester B, Milara J, Cortijo J.

Int J Mol Sci. 2019 Jan 30;20(3). pii: E593. doi: 10.3390/ijms20030593. Review.

5.

In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist /β2-adrenoceptor agonist (MABA) compound in neutrophils from COPD patients.

Milara J, Contreras S, de Diego A, Calbet M, Aparici M, Morcillo E, Miralpeix M, Cortijo J.

PLoS One. 2019 Jan 4;14(1):e0210188. doi: 10.1371/journal.pone.0210188. eCollection 2019.

6.

MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease.

Milara J, Díaz-Platas L, Contreras S, Ribera P, Roger I, Ballester B, Montero P, Cogolludo Á, Morcillo E, Cortijo J.

Respir Res. 2018 Nov 20;19(1):226. doi: 10.1186/s12931-018-0927-4.

7.

A Ciliary Motility Index for Activity Measurement in Cell Cultures With Respiratory Syncytial Virus.

Parrilla E, Armengot M, Mata M, Carda C, Cortijo J, Moratal D, Ginestar D, Hueso JL, Riera J.

Am J Rhinol Allergy. 2019 Mar;33(2):121-128. doi: 10.1177/1945892418811324. Epub 2018 Nov 20.

PMID:
30457015
8.

Deciphering function of the pulmonary arterial sphincters in loggerhead sea turtles (Caretta caretta).

García-Párraga D, Lorenzo T, Wang T, Ortiz JL, Ortega J, Crespo-Picazo JL, Cortijo J, Fahlman A.

J Exp Biol. 2018 Dec 4;221(Pt 23). pii: jeb179820. doi: 10.1242/jeb.179820.

9.

Mucin 1 deficiency mediates corticosteroid insensitivity in asthma.

Milara J, Morell A, de Diego A, Artigues E, Morcillo E, Cortijo J.

Allergy. 2019 Jan;74(1):111-121. doi: 10.1111/all.13546. Epub 2018 Oct 2.

PMID:
29978485
10.

JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study.

Milara J, Ballester B, Morell A, Ortiz JL, Escrivá J, Fernández E, Perez-Vizcaino F, Cogolludo A, Pastor E, Artigues E, Morcillo E, Cortijo J.

Thorax. 2018 Jun;73(6):519-529. doi: 10.1136/thoraxjnl-2017-210728. Epub 2018 Feb 10.

PMID:
29440315
11.

The JAK2 pathway is activated in idiopathic pulmonary fibrosis.

Milara J, Hernandez G, Ballester B, Morell A, Roger I, Montero P, Escrivá J, Lloris JM, Molina-Molina M, Morcillo E, Cortijo J.

Respir Res. 2018 Feb 6;19(1):24. doi: 10.1186/s12931-018-0728-9.

12.

Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching.

Chamorro V, Morales-Cano D, Milara J, Barreira B, Moreno L, Callejo M, Mondejar-Parreño G, Esquivel-Ruiz S, Cortijo J, Cogolludo Á, Barberá JA, Perez-Vizcaino F.

PLoS One. 2018 Jan 24;13(1):e0191239. doi: 10.1371/journal.pone.0191239. eCollection 2018.

13.

Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule.

Aparici M, Carcasona C, Ramos I, Montero JL, Ortiz JL, Cortijo J, Puig C, Vilella D, Doe C, Gavaldà A, Miralpeix M.

Pulm Pharmacol Ther. 2017 Oct;46:1-10. doi: 10.1016/j.pupt.2017.07.003. Epub 2017 Jul 17.

PMID:
28729041
14.

Selective Inhibition of Phosphodiesterases 4A, B, C and D Isoforms in Chronic Respiratory Diseases: Current and Future Evidences.

Contreras S, Milara J, Morcillo E, Cortijo J.

Curr Pharm Des. 2017;23(14):2073-2083. doi: 10.2174/1381612823666170214105651. Review.

PMID:
28201975
15.

Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients.

Milara J, Cervera A, de Diego A, Sanz C, Juan G, Gavaldà A, Miralpeix M, Morcillo E, Cortijo J.

Respir Res. 2016 Nov 8;17(1):145.

16.

Expression of aquaporins 1 and 5 in a model of ventilator-induced lung injury and its relation to tidal volume.

Fabregat G, García-de-la-Asunción J, Sarriá B, Mata M, Cortijo J, de Andrés J, Gallego L, Belda FJ.

Exp Physiol. 2016 Nov 1;101(11):1418-1431. doi: 10.1113/EP085729. Epub 2016 Sep 27.

17.

Evaluation of Mucociliary Clearance by Three Dimension Micro-CT-SPECT in Guinea Pig: Role of Bitter Taste Agonists.

Ortiz JL, Ortiz A, Milara J, Armengot M, Sanz C, Compañ D, Morcillo E, Cortijo J.

PLoS One. 2016 Oct 10;11(10):e0164399. doi: 10.1371/journal.pone.0164399. eCollection 2016.

18.

MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps.

Milara J, Morell A, Ballester B, Armengot M, Morcillo E, Cortijo J.

J Allergy Clin Immunol. 2017 Mar;139(3):855-862.e13. doi: 10.1016/j.jaci.2016.06.064. Epub 2016 Sep 14.

PMID:
27639937
19.

Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.

Morales-Cano D, Moreno L, Barreira B, Briones AM, Pandolfi R, Moral-Sanz J, Callejo M, Mondejar-Parreño G, Cortijo J, Salaices M, Duarte J, Perez-Vizcaino F, Cogolludo A.

Clin Sci (Lond). 2016 Oct 1;130(20):1823-36. doi: 10.1042/CS20160141. Epub 2016 Jul 13.

PMID:
27413020
20.

Cuttlefish Ink Melanin Encapsulated in Nanolipid Bubbles and Applied Through a Micro-Needling Procedure Easily Stains White Hair Facilitating Photoepilation.

Trelles MA, Almudever P, Alcolea JM, Cortijo J, Serrano G, Expósito I, Royo J, Leclère FM.

J Drugs Dermatol. 2016 May 1;15(5):615-25.

PMID:
27168270
21.

Vascular effects of sildenafil in patients with pulmonary fibrosis and pulmonary hypertension: an ex vivo/in vitro study.

Milara J, Escrivá J, Ortiz JL, Juan G, Artigues E, Morcillo E, Cortijo J.

Eur Respir J. 2016 Jun;47(6):1737-49. doi: 10.1183/13993003.01259-2015. Epub 2016 Mar 23.

22.

mRNA PGC-1α levels in blood samples reliably correlates with its myocardial expression: study in patients undergoing cardiac surgery.

Fabregat-Andres O, Paredes F, Monsalve M, Milara J, Ridocci-Soriano F, Gonzalez-Hervas S, Mena A, Facila L, Hornero F, Morell S, Martinez-Leon J, Cortijo J.

Anatol J Cardiol. 2016 Aug;16(8):622-629. doi: 10.5152/AnatolJCardiol.2015.6466. Epub 2015 Nov 26.

23.

Prognostic Value of Pulmonary Vascular Resistance by Magnetic Resonance in Systolic Heart Failure.

Fabregat-Andrés Ó, Estornell-Erill J, Ridocci-Soriano F, Pérez-Boscá JL, García-González P, Payá-Serrano R, Morell S, Cortijo J.

Arq Bras Cardiol. 2016 Mar;106(3):226-35. doi: 10.5935/abc.20160020. Epub 2016 Feb 2. English, Portuguese.

24.

ISG15 Is Upregulated in Respiratory Syncytial Virus Infection and Reduces Virus Growth through Protein ISGylation.

González-Sanz R, Mata M, Bermejo-Martín J, Álvarez A, Cortijo J, Melero JA, Martínez I.

J Virol. 2016 Jan 13;90(7):3428-38. doi: 10.1128/JVI.02695-15.

25.

Phosphatidylcholine liposomes as carriers to improve topical ascorbic acid treatment of skin disorders.

Serrano G, Almudéver P, Serrano JM, Milara J, Torrens A, Expósito I, Cortijo J.

Clin Cosmet Investig Dermatol. 2015 Dec 17;8:591-9. doi: 10.2147/CCID.S90781. eCollection 2015.

26.

Evaluation of the Ocular Tolerance of Three Tacrolimus Topical Pharmaceutical Preparations by Bovine Corneal Opacity and Permeability Test.

Pastor-Clerigues A, Serrano A, Milara J, Marti-Bonmati E, Lopez-Perez FJ, Garcia-Montanes S, Sanfeliu J, Saval-Victoria AC, Cortijo J.

Curr Eye Res. 2016 Jul;41(7):890-6. doi: 10.3109/02713683.2015.1082187. Epub 2015 Nov 10.

PMID:
26554729
27.

Roflumilast Prevents the Metabolic Effects of Bleomycin-Induced Fibrosis in a Murine Model.

Milara J, Morcillo E, Monleon D, Tenor H, Cortijo J.

PLoS One. 2015 Jul 20;10(7):e0133453. doi: 10.1371/journal.pone.0133453. eCollection 2015.

28.

Microneedling dilates the follicular infundibulum and increases transfollicular absorption of liposomal sepia melanin.

Serrano G, Almudéver P, Serrano JM, Cortijo J, Faus C, Reyes M, Expósito I, Torrens A, Millán F.

Clin Cosmet Investig Dermatol. 2015 Jun 26;8:313-8. doi: 10.2147/CCID.S77228. eCollection 2015.

29.

Lung inflammatory pattern and antibiotic treatment in pneumonia.

Lorenzo MJ, Moret I, Sarria B, Cases E, Cortijo J, Méndez R, Molina J, Gimeno A, Menéndez R.

Respir Res. 2015 Feb 7;16:15. doi: 10.1186/s12931-015-0165-y.

30.

PEG-Interferon-α ribavirin-induced HCV viral clearance: a pharmacogenetic multicenter Spanish study.

Milara J, Outeda-Macias M, Aumente-Rubio MD, Más-Serrano P, Aldaz A, Calvo MV, García-Simón MS, Martin-Barbero M, Padullés-Zamora N, Schoenenberger JA, Saavedra-Aldrich M, Tévar-Alfonso E, Saval A, Pastor-Clerigues A, García M, Margusino-Framiñan L, Montero-Alvarez JL, Merino E, Herrero JI, Beunza M, Conesa-Zamora P, Gimenez-Manzorro A, Comas-Sugrañes D, Cano-Marron M, Jiménez-Mutiloa E, Díaz-Ruíz P, Cortijo J.

Farm Hosp. 2015 Jan 1;39(1):29-43. doi: 10.7399/fh.2015.39.1.8547.

31.

Roflumilast improves corticosteroid resistance COPD bronchial epithelial cells stimulated with toll like receptor 3 agonist.

Milara J, Morell A, Ballester B, Sanz C, Freire J, Qian X, Alonso-Garcia M, Morcillo E, Cortijo J.

Respir Res. 2015 Feb 5;16:12. doi: 10.1186/s12931-015-0179-5.

32.

Anti-inflammatory and anti-fibrotic profile of fish oil emulsions used in parenteral nutrition-associated liver disease.

Pastor-Clerigues A, Marti-Bonmati E, Milara J, Almudever P, Cortijo J.

PLoS One. 2014 Dec 12;9(12):e115404. doi: 10.1371/journal.pone.0115404. eCollection 2014.

33.

Increased expression of AQP 1 and AQP 5 in rat lungs ventilated with low tidal volume is time dependent.

Fabregat G, García-de-la-Asunción J, Sarriá B, Cortijo J, De Andrés J, Mata M, Pastor E, Belda FJ.

PLoS One. 2014 Dec 9;9(12):e114247. doi: 10.1371/journal.pone.0114247. eCollection 2014.

34.

Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro.

Milara J, Peiró T, Serrano A, Artigues E, Aparicio J, Tenor H, Sanz C, Cortijo J.

COPD. 2015 Jun;12(3):320-31. doi: 10.3109/15412555.2014.948995. Epub 2014 Sep 10.

PMID:
25207459
35.

Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps.

Milara J, Peiró T, Armengot M, Frias S, Morell A, Serrano A, Cortijo J.

J Allergy Clin Immunol. 2015 Feb;135(2):470-6. doi: 10.1016/j.jaci.2014.07.011. Epub 2014 Aug 23.

PMID:
25159466
36.

Prognostic value of pulmonary vascular resistance estimated by cardiac magnetic resonance in patients with chronic heart failure.

Fabregat-Andrés Ó, Estornell-Erill J, Ridocci-Soriano F, García-González P, Bochard-Villanueva B, Cubillos-Arango A, Espriella-Juan Rde L, Fácila L, Morell S, Cortijo J.

Eur Heart J Cardiovasc Imaging. 2014 Dec;15(12):1391-9. doi: 10.1093/ehjci/jeu147. Epub 2014 Aug 7.

PMID:
25104808
37.

Reconstituted human upper airway epithelium as 3-d in vitro model for nasal polyposis.

de Borja Callejas F, Martínez-Antón A, Alobid I, Fuentes M, Cortijo J, Picado C, Roca-Ferrer J, Mullol J.

PLoS One. 2014 Jun 19;9(6):e100537. doi: 10.1371/journal.pone.0100537. eCollection 2014.

38.

Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease.

Milara J, Lluch J, Almudever P, Freire J, Xiaozhong Q, Cortijo J.

J Allergy Clin Immunol. 2014 Aug;134(2):314-22. doi: 10.1016/j.jaci.2014.02.001. Epub 2014 Mar 15.

PMID:
24636089
39.

Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD.

Milara J, Peiró T, Serrano A, Guijarro R, Zaragozá C, Tenor H, Cortijo J.

Pulm Pharmacol Ther. 2014 Aug;28(2):138-48. doi: 10.1016/j.pupt.2014.02.001. Epub 2014 Feb 11.

PMID:
24525294
40.

Primary ciliary dyskinesia assessment by means of optical flow analysis of phase-contrast microscopy images.

Parrilla E, Armengot M, Mata M, Sánchez-Vílchez JM, Cortijo J, Hueso JL, Riera J, Moratal D.

Comput Med Imaging Graph. 2014 Apr;38(3):163-70. doi: 10.1016/j.compmedimag.2013.12.010. Epub 2013 Dec 31.

PMID:
24438822
41.

Ciliary motility activity measurement using a dense optical flow algorithm.

Parrilla E, Armengot M, Mata M, Cortijo J, Riera J, Hueso JL, Moratal D.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:4446-9. doi: 10.1109/EMBC.2013.6610533.

PMID:
24110720
42.

Roflumilast inhibits respiratory syncytial virus infection in human differentiated bronchial epithelial cells.

Mata M, Martinez I, Melero JA, Tenor H, Cortijo J.

PLoS One. 2013 Jul 23;8(7):e69670. doi: 10.1371/journal.pone.0069670. Print 2013.

43.

Authors' response to: epithelial mesenchymal transition (EMT) in small airways of COPD patient.

Milara J, Peiró T, Serrano A, Cortijo J.

Thorax. 2013 Aug;68(8):784. doi: 10.1136/thoraxjnl-2013-203484. Epub 2013 Mar 26. No abstract available.

PMID:
23842820
44.

Bafetinib inhibits functional responses of human eosinophils in vitro.

Milara J, Martinez-Losa M, Sanz C, Almudéver P, Peiró T, Serrano A, Morcillo EJ, Zaragozá C, Cortijo J.

Eur J Pharmacol. 2013 Sep 5;715(1-3):172-80. doi: 10.1016/j.ejphar.2013.05.025. Epub 2013 Jun 6.

PMID:
23747655
45.

Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.

Almudéver P, Milara J, De Diego A, Serrano-Mollar A, Xaubet A, Perez-Vizcaino F, Cogolludo A, Cortijo J.

Thorax. 2013 Oct;68(10):938-48. doi: 10.1136/thoraxjnl-2013-203408. Epub 2013 Jun 5.

PMID:
23739137
46.

Ceramide mediates acute oxygen sensing in vascular tissues.

Moreno L, Moral-Sanz J, Morales-Cano D, Barreira B, Moreno E, Ferrarini A, Pandolfi R, Ruperez FJ, Cortijo J, Sanchez-Luna M, Villamor E, Perez-Vizcaino F, Cogolludo A.

Antioxid Redox Signal. 2014 Jan 1;20(1):1-14. doi: 10.1089/ars.2012.4752. Epub 2013 Aug 21.

47.

Effects of long-term azithromycin therapy on airway oxidative stress markers in non-cystic fibrosis bronchiectasis.

Diego AD, Milara J, Martinez-Moragón E, Palop M, León M, Cortijo J.

Respirology. 2013 Oct;18(7):1056-62. doi: 10.1111/resp.12130.

PMID:
23714268
48.

Study of USH1 splicing variants through minigenes and transcript analysis from nasal epithelial cells.

Aparisi MJ, García-García G, Aller E, Sequedo MD, Martínez-Fernández de la Cámara C, Rodrigo R, Armengot M, Cortijo J, Milara J, Díaz-LLopis M, Jaijo T, Millán JM.

PLoS One. 2013;8(2):e57506. doi: 10.1371/journal.pone.0057506. Epub 2013 Feb 25.

49.

Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke.

Milara J, Peiró T, Serrano A, Cortijo J.

Thorax. 2013 May;68(5):410-20. doi: 10.1136/thoraxjnl-2012-201761. Epub 2013 Jan 7.

PMID:
23299965
50.

Phosphodiesterase-4 inhibition improves corticosteroid insensitivity in pulmonary endothelial cells under oxidative stress.

Ortiz JL, Milara J, Lluch J, De Diego A, Sanz C, Cortijo J.

Allergy. 2013 Jan;68(1):64-73. doi: 10.1111/all.12055. Epub 2012 Nov 5.

PMID:
23121078

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