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Items: 1 to 50 of 160

1.

Therapeutic Administration of Broadly Neutralizing FI6 Antibody Reveals Lack of Interaction Between Human IgG1 and Pig Fc Receptors.

Morgan SB, Holzer B, Hemmink JD, Salguero FJ, Schwartz JC, Agatic G, Cameroni E, Guarino B, Porter E, Rijal P, Townsend A, Charleston B, Corti D, Tchilian E.

Front Immunol. 2018 Apr 24;9:865. doi: 10.3389/fimmu.2018.00865. eCollection 2018.

2.

Viral envelope-specific antibodies in chronic hepatitis B virus infection.

Corti D, Benigni F, Shouval D.

Curr Opin Virol. 2018 Jun;30:48-57. doi: 10.1016/j.coviro.2018.04.002. Epub 2018 May 5. Review.

PMID:
29738926
3.

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.

Pickett JE, Thompson JM, Sadowska A, Tkaczyk C, Sellman BR, Minola A, Corti D, Lanzavecchia A, Miller LS, Thorek DL.

Bone Res. 2018 Apr 25;6:13. doi: 10.1038/s41413-018-0014-y. eCollection 2018.

4.

Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion.

Lindesmith LC, Mallory ML, Debbink K, Donaldson EF, Brewer-Jensen PD, Swann EW, Sheahan TP, Graham RL, Beltramello M, Corti D, Lanzavecchia A, Baric RS.

mSphere. 2018 Feb 7;3(1). pii: e00518-17. doi: 10.1128/mSphere.00518-17. eCollection 2018 Jan-Feb.

5.

Non-contact AFM measurement of the Hamaker constants of solids: Calibrating cantilever geometries.

Fronczak SG, Browne CA, Krenek EC, Beaudoin SP, Corti DS.

J Colloid Interface Sci. 2018 May 1;517:213-220. doi: 10.1016/j.jcis.2018.01.108. Epub 2018 Feb 1.

PMID:
29427887
6.

Comparison of Four Serological Methods and Two Reverse Transcription-PCR Assays for Diagnosis and Surveillance of Zika Virus Infection.

Balmaseda A, Zambrana JV, Collado D, García N, Saborío S, Elizondo D, Mercado JC, Gonzalez K, Cerpas C, Nuñez A, Corti D, Waggoner JJ, Kuan G, Burger-Calderon R, Harris E.

J Clin Microbiol. 2018 Feb 22;56(3). pii: e01785-17. doi: 10.1128/JCM.01785-17. Print 2018 Mar.

PMID:
29305550
7.

Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae.

Pennini ME, De Marco A, Pelletier M, Bonnell J, Cvitkovic R, Beltramello M, Cameroni E, Bianchi S, Zatta F, Zhao W, Xiao X, Camara MM, DiGiandomenico A, Semenova E, Lanzavecchia A, Warrener P, Suzich J, Wang Q, Corti D, Stover CK.

Nat Commun. 2017 Dec 8;8(1):1991. doi: 10.1038/s41467-017-02223-7.

8.

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus.

Sastry M, Zhang B, Chen M, Joyce MG, Kong WP, Chuang GY, Ko K, Kumar A, Silacci C, Thom M, Salazar AM, Corti D, Lanzavecchia A, Taylor G, Mascola JR, Graham BS, Kwong PD.

PLoS One. 2017 Oct 26;12(10):e0186854. doi: 10.1371/journal.pone.0186854. eCollection 2017.

9.

Protection of calves by a prefusion-stabilized bovine RSV F vaccine.

Zhang B, Chen L, Silacci C, Thom M, Boyington JC, Druz A, Joyce MG, Guzman E, Kong WP, Lai YT, Stewart-Jones GBE, Tsybovsky Y, Yang Y, Zhou T, Baxa U, Mascola JR, Corti D, Lanzavecchia A, Taylor G, Kwong PD.

NPJ Vaccines. 2017 Mar 8;2:7. doi: 10.1038/s41541-017-0005-9.

10.

A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential.

Wang J, Bardelli M, Espinosa DA, Pedotti M, Ng TS, Bianchi S, Simonelli L, Lim EXY, Foglierini M, Zatta F, Jaconi S, Beltramello M, Cameroni E, Fibriansah G, Shi J, Barca T, Pagani I, Rubio A, Broccoli V, Vicenzi E, Graham V, Pullan S, Dowall S, Hewson R, Jurt S, Zerbe O, Stettler K, Lanzavecchia A, Sallusto F, Cavalli A, Harris E, Lok SM, Varani L, Corti D.

Cell. 2017 Sep 21;171(1):229-241.e15. doi: 10.1016/j.cell.2017.09.002.

PMID:
28938115
11.

Correction to "A New "Quasi-Dynamic" Method for Determining the Hamaker Constant of Solids using an Atomic Force Microscope".

Fronczak SG, Dong J, Franses EI, Browne CA, Krenek EC, Beaudoin SP, Corti DS.

Langmuir. 2017 Aug 8;33(31):7826-7827. doi: 10.1021/acs.langmuir.7b02203. Epub 2017 Jul 30. No abstract available.

PMID:
28756674
12.

Antibody-based assay discriminates Zika virus infection from other flaviviruses.

Balmaseda A, Stettler K, Medialdea-Carrera R, Collado D, Jin X, Zambrana JV, Jaconi S, Cameroni E, Saborio S, Rovida F, Percivalle E, Ijaz S, Dicks S, Ushiro-Lumb I, Barzon L, Siqueira P, Brown DWG, Baldanti F, Tedder R, Zambon M, de Filippis AMB, Harris E, Corti D.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8384-8389. doi: 10.1073/pnas.1704984114. Epub 2017 Jul 17.

13.

Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.

Tkaczyk C, Kasturirangan S, Minola A, Jones-Nelson O, Gunter V, Shi YY, Rosenthal K, Aleti V, Semenova E, Warrener P, Tabor D, Stover CK, Corti D, Rainey G, Sellman BR.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00629-17. doi: 10.1128/AAC.00629-17. Print 2017 Aug.

14.

Tackling influenza with broadly neutralizing antibodies.

Corti D, Cameroni E, Guarino B, Kallewaard NL, Zhu Q, Lanzavecchia A.

Curr Opin Virol. 2017 Jun;24:60-69. doi: 10.1016/j.coviro.2017.03.002. Epub 2017 May 18. Review.

PMID:
28527859
15.

Anti-LPS antibodies protect against Klebsiella pneumoniae by empowering neutrophil-mediated clearance without neutralizing TLR4.

Cohen TS, Pelletier M, Cheng L, Pennini ME, Bonnell J, Cvitkovic R, Chang CS, Xiao X, Cameroni E, Corti D, Semenova E, Warrener P, Sellman BR, Suzich J, Wang Q, Stover CK.

JCI Insight. 2017 May 4;2(9). pii: 92774. doi: 10.1172/jci.insight.92774. [Epub ahead of print]

16.

Professional attitudes toward incident reporting: can we measure and compare improvements in patient safety culture?

Tricarico P, Castriotta L, Battistella C, Bellomo F, Cattani G, Grillone L, Degan S, De Corti D, Brusaferro S.

Int J Qual Health Care. 2017 Apr 1;29(2):243-249. doi: 10.1093/intqhc/mzx004.

PMID:
28453824
17.

High-avidity IgA protects the intestine by enchaining growing bacteria.

Moor K, Diard M, Sellin ME, Felmy B, Wotzka SY, Toska A, Bakkeren E, Arnoldini M, Bansept F, Co AD, Völler T, Minola A, Fernandez-Rodriguez B, Agatic G, Barbieri S, Piccoli L, Casiraghi C, Corti D, Lanzavecchia A, Regoes RR, Loverdo C, Stocker R, Brumley DR, Hardt WD, Slack E.

Nature. 2017 Apr 27;544(7651):498-502. doi: 10.1038/nature22058. Epub 2017 Apr 12.

PMID:
28405025
18.

Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node.

Chatziandreou N, Farsakoglu Y, Palomino-Segura M, D'Antuono R, Pizzagalli DU, Sallusto F, Lukacs-Kornek V, Uguccioni M, Corti D, Turley SJ, Lanzavecchia A, Carroll MC, Gonzalez SF.

Cell Rep. 2017 Mar 7;18(10):2427-2440. doi: 10.1016/j.celrep.2017.02.026.

19.

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Sgambato A, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L.

Nature. 2017 Feb 16;542(7641):362-366. doi: 10.1038/nature21064. Epub 2017 Feb 8.

PMID:
28178232
20.

A New "Quasi-Dynamic" Method for Determining the Hamaker Constant of Solids Using an Atomic Force Microscope.

Fronczak SG, Dong J, Browne CA, Krenek EC, Franses EI, Beaudoin SP, Corti DS.

Langmuir. 2017 Jan 24;33(3):714-725. doi: 10.1021/acs.langmuir.6b04063. Epub 2017 Jan 12. Erratum in: Langmuir. 2017 Aug 8;33(31):7826-7827.

PMID:
28036189
21.

Correction to "Effect of Interparticle Interactions on Agglomeration and Sedimentation Rates of Colloidal Silica Microspheres".

Yang YJ, Kelkar AV, Corti DS, Franses EI.

Langmuir. 2016 Nov 15;32(45):11993-11995. Epub 2016 Nov 2. No abstract available.

PMID:
27934064
22.

A case-crossover study of sleep, fatigue, and other transient exposures at workplace and the risk of non-fatal occupational injuries among the employees of an Italian academic hospital.

Valent F, Mariuz M, Liva G, Bellomo F, De Corti D, Degan S, Ferrazzano A, Brusaferro S.

Int J Occup Med Environ Health. 2016 Nov 18;29(6):1001-1009. doi: 10.13075/ijomeh.1896.00695. Epub 2016 Oct 14.

23.

Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.

Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, Kwong PD, Corti D, Lanzavecchia A, Perez L.

Nat Microbiol. 2016 Jun 6;1(8):16082. doi: 10.1038/nmicrobiol.2016.82.

24.

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.

Kallewaard NL, Corti D, Collins PJ, Neu U, McAuliffe JM, Benjamin E, Wachter-Rosati L, Palmer-Hill FJ, Yuan AQ, Walker PA, Vorlaender MK, Bianchi S, Guarino B, De Marco A, Vanzetta F, Agatic G, Foglierini M, Pinna D, Fernandez-Rodriguez B, Fruehwirth A, Silacci C, Ogrodowicz RW, Martin SR, Sallusto F, Suzich JA, Lanzavecchia A, Zhu Q, Gamblin SJ, Skehel JJ.

Cell. 2016 Jul 28;166(3):596-608. doi: 10.1016/j.cell.2016.05.073. Epub 2016 Jul 21.

25.

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection.

Stettler K, Beltramello M, Espinosa DA, Graham V, Cassotta A, Bianchi S, Vanzetta F, Minola A, Jaconi S, Mele F, Foglierini M, Pedotti M, Simonelli L, Dowall S, Atkinson B, Percivalle E, Simmons CP, Varani L, Blum J, Baldanti F, Cameroni E, Hewson R, Harris E, Lanzavecchia A, Sallusto F, Corti D.

Science. 2016 Aug 19;353(6301):823-6. doi: 10.1126/science.aaf8505. Epub 2016 Jul 14.

26.

Antibody-guided vaccine design: identification of protective epitopes.

Lanzavecchia A, Frühwirth A, Perez L, Corti D.

Curr Opin Immunol. 2016 Aug;41:62-67. doi: 10.1016/j.coi.2016.06.001. Epub 2016 Jun 22. Review.

27.

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF.

Cell Rep. 2016 Jun 28;16(1):133-147. doi: 10.1016/j.celrep.2016.05.063. Epub 2016 Jun 16.

28.

Intrinsic positive end-expiratory pressure during ventilation through small endotracheal tubes during general anesthesia: incidence, mechanism, and predictive factors.

Gemma M, Nicelli E, Corti D, De Vitis A, Patroniti N, Foti G, Calvi MR, Beretta L.

J Clin Anesth. 2016 Jun;31:124-30. doi: 10.1016/j.jclinane.2016.01.029. Epub 2016 Apr 16.

PMID:
27185694
29.

GSH-targeted nanosponges increase doxorubicin-induced toxicity "in vitro" and "in vivo" in cancer cells with high antioxidant defenses.

Daga M, Ullio C, Argenziano M, Dianzani C, Cavalli R, Trotta F, Ferretti C, Zara GP, Gigliotti CL, Ciamporcero ES, Pettazzoni P, Corti D, Pizzimenti S, Barrera G.

Free Radic Biol Med. 2016 Aug;97:24-37. doi: 10.1016/j.freeradbiomed.2016.05.009. Epub 2016 May 14.

30.

Effect of Interparticle Interactions on Agglomeration and Sedimentation Rates of Colloidal Silica Microspheres.

Yang YJ, Kelkar AV, Corti DS, Franses EI.

Langmuir. 2016 May 24;32(20):5111-23. doi: 10.1021/acs.langmuir.6b00925. Epub 2016 May 10. No abstract available. Erratum in: Langmuir. 2016 Nov 15;32(45):11993-11995.

PMID:
27120677
31.

Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome.

Corti D, Passini N, Lanzavecchia A, Zambon M.

J Infect Public Health. 2016 May-Jun;9(3):231-5. doi: 10.1016/j.jiph.2016.04.003. Epub 2016 Apr 19. Review.

32.

Promises and pitfalls for recombinant oligoclonal antibodies-based therapeutics in cancer and infectious disease.

Corti D, Kearns JD.

Curr Opin Immunol. 2016 Jun;40:51-61. doi: 10.1016/j.coi.2016.03.001. Epub 2016 Mar 23. Review.

PMID:
26995095
33.

Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis.

De Benedictis P, Minola A, Rota Nodari E, Aiello R, Zecchin B, Salomoni A, Foglierini M, Agatic G, Vanzetta F, Lavenir R, Lepelletier A, Bentley E, Weiss R, Cattoli G, Capua I, Sallusto F, Wright E, Lanzavecchia A, Bourhy H, Corti D.

EMBO Mol Med. 2016 Apr 1;8(4):407-21. doi: 10.15252/emmm.201505986.

34.

SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.

35.

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody.

Corti D, Misasi J, Mulangu S, Stanley DA, Kanekiyo M, Wollen S, Ploquin A, Doria-Rose NA, Staupe RP, Bailey M, Shi W, Choe M, Marcus H, Thompson EA, Cagigi A, Silacci C, Fernandez-Rodriguez B, Perez L, Sallusto F, Vanzetta F, Agatic G, Cameroni E, Kisalu N, Gordon I, Ledgerwood JE, Mascola JR, Graham BS, Muyembe-Tamfun JJ, Trefry JC, Lanzavecchia A, Sullivan NJ.

Science. 2016 Mar 18;351(6279):1339-42. doi: 10.1126/science.aad5224. Epub 2016 Feb 25.

36.

Structural and molecular basis for Ebola virus neutralization by protective human antibodies.

Misasi J, Gilman MS, Kanekiyo M, Gui M, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS, Xiang Y, Sullivan NJ, McLellan JS.

Science. 2016 Mar 18;351(6279):1343-6. doi: 10.1126/science.aad6117. Epub 2016 Feb 25.

37.

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.

Tan J, Pieper K, Piccoli L, Abdi A, Perez MF, Geiger R, Tully CM, Jarrossay D, Maina Ndungu F, Wambua J, Bejon P, Fregni CS, Fernandez-Rodriguez B, Barbieri S, Bianchi S, Marsh K, Thathy V, Corti D, Sallusto F, Bull P, Lanzavecchia A.

Nature. 2016 Jan 7;529(7584):105-109. doi: 10.1038/nature16450. Epub 2015 Dec 23.

38.

An ecological study on the association between characteristics of hospital units and the risk of occupational injuries and adverse events on the example of an Italian teaching hospital.

Valent F, Liva G, Bellomo F, De Corti D, Degan S, Cattani G, Rosa I, Mizza A, Brusaferro S.

Int J Occup Med Environ Health. 2016;29(1):149-59. doi: 10.13075/ijomeh.1896.00580.

39.

Tumors and mitochondrial respiration: a neglected connection.

Viale A, Corti D, Draetta GF.

Cancer Res. 2015 Sep 15;75(18):3685-6. Review.

40.

Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells.

Preite S, Baumjohann D, Foglierini M, Basso C, Ronchi F, Fernandez Rodriguez BM, Corti D, Lanzavecchia A, Sallusto F.

Eur J Immunol. 2015 Nov;45(11):3010-21. doi: 10.1002/eji.201545920. Epub 2015 Oct 1.

41.

The plasticizer dibutyl phthalate (DBP) potentiates chemical allergen-induced THP-1 activation.

Lourenço AC, Galbiati V, Corti D, Papale A, Martino-Andrade AJ, Corsini E.

Toxicol In Vitro. 2015 Dec;29(8):2001-8. doi: 10.1016/j.tiv.2015.08.011. Epub 2015 Aug 28.

PMID:
26319029
42.
43.

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus.

Corti D, Zhao J, Pedotti M, Simonelli L, Agnihothram S, Fett C, Fernandez-Rodriguez B, Foglierini M, Agatic G, Vanzetta F, Gopal R, Langrish CJ, Barrett NA, Sallusto F, Baric RS, Varani L, Zambon M, Perlman S, Lanzavecchia A.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10473-8. doi: 10.1073/pnas.1510199112. Epub 2015 Jul 27.

44.

Use of Close-Packed Vesicular Dispersions to Stabilize Colloidal Particle Dispersions against Sedimentation.

Yang YJ, Corti DS, Franses EI.

Langmuir. 2015 Aug 18;31(32):8802-8. doi: 10.1021/acs.langmuir.5b02133. Epub 2015 Aug 4.

PMID:
26203879
45.

Serum Immunoglobulin A Cross-Strain Blockade of Human Noroviruses.

Lindesmith LC, Beltramello M, Swanstrom J, Jones TA, Corti D, Lanzavecchia A, Baric RS.

Open Forum Infect Dis. 2015 Jul 1;2(3):ofv084. doi: 10.1093/ofid/ofv084. eCollection 2015 Sep.

46.

Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody.

Xiong X, Corti D, Liu J, Pinna D, Foglierini M, Calder LJ, Martin SR, Lin YP, Walker PA, Collins PJ, Monne I, Suguitan AL Jr, Santos C, Temperton NJ, Subbarao K, Lanzavecchia A, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9430-5. doi: 10.1073/pnas.1510816112. Epub 2015 Jul 13.

47.

Efficient Methods To Isolate Human Monoclonal Antibodies from Memory B Cells and Plasma Cells.

Corti D, Lanzavecchia A.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.AID-0018-2014. Review.

PMID:
26104354
48.

Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis.

Piccoli L, Campo I, Fregni CS, Rodriguez BM, Minola A, Sallusto F, Luisetti M, Corti D, Lanzavecchia A.

Nat Commun. 2015 Jun 16;6:7375. doi: 10.1038/ncomms8375.

49.

Optimization of the THP-1 activation assay to detect pharmaceuticals with potential to cause immune mediated drug reactions.

Corti D, Galbiati V, Gatti N, Marinovich M, Galli CL, Corsini E.

Toxicol In Vitro. 2015 Oct;29(7):1339-49. doi: 10.1016/j.tiv.2015.04.012. Epub 2015 May 28.

PMID:
26028146
50.

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.

Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS; NISC Comparative Sequencing Program, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP Jr, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD.

Cell. 2015 Jun 4;161(6):1280-92. doi: 10.1016/j.cell.2015.05.007. Epub 2015 May 21.

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