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Items: 35

1.

Structure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ion-bound configuration.

Tilegenova C, Cortes DM, Jahovic N, Hardy E, Hariharan P, Guan L, Cuello LG.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16829-16834. doi: 10.1073/pnas.1901888116. Epub 2019 Aug 6.

PMID:
31387976
2.

Inverted allosteric coupling between activation and inactivation gates in K+ channels.

Labro AJ, Cortes DM, Tilegenova C, Cuello LG.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5426-5431. doi: 10.1073/pnas.1800559115. Epub 2018 May 7.

3.

Structural Dynamics of the MscL C-terminal Domain.

Bavi N, Martinac AD, Cortes DM, Bavi O, Ridone P, Nomura T, Hill AP, Martinac B, Perozo E.

Sci Rep. 2017 Dec 8;7(1):17229. doi: 10.1038/s41598-017-17396-w.

4.

The gating cycle of a K+ channel at atomic resolution.

Cuello LG, Cortes DM, Perozo E.

Elife. 2017 Nov 22;6. pii: e28032. doi: 10.7554/eLife.28032.

5.

A cost-effective protocol for the over-expression and purification of fully-functional and more stable Erwinia chrysanthemi ligand-gated ion channel.

Elberson BW, Whisenant TE, Cortes DM, Cuello LG.

Protein Expr Purif. 2017 May;133:177-186. doi: 10.1016/j.pep.2017.03.006. Epub 2017 Mar 7.

6.

Hysteresis of KcsA potassium channel's activation- deactivation gating is caused by structural changes at the channel's selectivity filter.

Tilegenova C, Cortes DM, Cuello LG.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3234-3239. doi: 10.1073/pnas.1618101114. Epub 2017 Mar 6.

7.

An Escherichia coli-Based Assay to Assess the Function of Recombinant Human Hemichannels.

Krishnan S, Fiori MC, Whisenant TE, Cortes DM, Altenberg GA, Cuello LG.

SLAS Discov. 2017 Feb;22(2):135-143. doi: 10.1177/1087057116675321. Epub 2016 Oct 28.

PMID:
27789753
8.

An improved method for the cost-effective expression and purification of large quantities of KcsA.

Tilegenova C, Vemulapally S, Cortes DM, Cuello LG.

Protein Expr Purif. 2016 Nov;127:53-60. doi: 10.1016/j.pep.2016.07.002. Epub 2016 Jul 5.

9.

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels.

Bavi N, Cortes DM, Cox CD, Rohde PR, Liu W, Deitmer JW, Bavi O, Strop P, Hill AP, Rees D, Corry B, Perozo E, Martinac B.

Nat Commun. 2016 Jun 22;7:11984. doi: 10.1038/ncomms11984.

10.

Functional hemichannels formed by human connexin 26 expressed in bacteria.

Fiori MC, Krishnan S, Cortes DM, Retamal MA, Reuss L, Altenberg GA, Cuello LG.

Biosci Rep. 2015 Mar 18;35(2). pii: e00177. doi: 10.1042/BSR20140089.

11.

Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP.

Li Q, Jogini V, Wanderling S, Cortes DM, Perozo E.

Biochemistry. 2012 Oct 16;51(41):8132-42. doi: 10.1021/bi300980q. Epub 2012 Oct 5.

12.

Mechanism of activation gating in the full-length KcsA K+ channel.

Uysal S, Cuello LG, Cortes DM, Koide S, Kossiakoff AA, Perozo E.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11896-9. doi: 10.1073/pnas.1105112108. Epub 2011 Jul 5.

13.

On the structural basis of modal gating behavior in K(+) channels.

Chakrapani S, Cordero-Morales JF, Jogini V, Pan AC, Cortes DM, Roux B, Perozo E.

Nat Struct Mol Biol. 2011 Jan;18(1):67-74. doi: 10.1038/nsmb.1968. Epub 2010 Dec 26.

14.

Structural dynamics of the magnesium-bound conformation of CorA in a lipid bilayer.

Dalmas O, Cuello LG, Jogini V, Cortes DM, Roux B, Perozo E.

Structure. 2010 Jul 14;18(7):868-78. doi: 10.1016/j.str.2010.04.009.

15.

Structural basis for the coupling between activation and inactivation gates in K(+) channels.

Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E.

Nature. 2010 Jul 8;466(7303):272-5. doi: 10.1038/nature09136.

16.

Structural mechanism of C-type inactivation in K(+) channels.

Cuello LG, Jogini V, Cortes DM, Perozo E.

Nature. 2010 Jul 8;466(7303):203-8. doi: 10.1038/nature09153.

17.

Design and characterization of a constitutively open KcsA.

Cuello LG, Jogini V, Cortes DM, Sompornpisut A, Purdy MD, Wiener MC, Perozo E.

FEBS Lett. 2010 Mar 19;584(6):1133-8. doi: 10.1016/j.febslet.2010.02.015. Epub 2010 Feb 12.

18.

A molecular mechanism for proton-dependent gating in KcsA.

Cuello LG, Cortes DM, Jogini V, Sompornpisut A, Perozo E.

FEBS Lett. 2010 Mar 19;584(6):1126-32. doi: 10.1016/j.febslet.2010.02.003. Epub 2010 Feb 6.

19.

Three-dimensional architecture of membrane-embedded MscS in the closed conformation.

Vásquez V, Sotomayor M, Cortes DM, Roux B, Schulten K, Perozo E.

J Mol Biol. 2008 Apr 18;378(1):55-70. doi: 10.1016/j.jmb.2007.10.086. Epub 2007 Nov 9.

20.

Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer.

Chakrapani S, Cuello LG, Cortes DM, Perozo E.

Structure. 2008 Mar;16(3):398-409. doi: 10.1016/j.str.2007.12.015.

21.

Molecular driving forces determining potassium channel slow inactivation.

Cordero-Morales JF, Jogini V, Lewis A, Vásquez V, Cortes DM, Roux B, Perozo E.

Nat Struct Mol Biol. 2007 Nov;14(11):1062-9. Epub 2007 Oct 7.

PMID:
17922012
22.

An optimized purification and reconstitution method for the MscS channel: strategies for spectroscopical analysis.

Vásquez V, Cortes DM, Furukawa H, Perozo E.

Biochemistry. 2007 Jun 12;46(23):6766-73. Epub 2007 May 15.

PMID:
17500538
23.

Molecular determinants of gating at the potassium-channel selectivity filter.

Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, Roux B, Perozo E.

Nat Struct Mol Biol. 2006 Apr;13(4):311-8. Epub 2006 Mar 12.

PMID:
16532009
24.

Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer.

Cuello LG, Cortes DM, Perozo E.

Science. 2004 Oct 15;306(5695):491-5.

25.

Open channel structure of MscL and the gating mechanism of mechanosensitive channels.

Perozo E, Cortes DM, Sompornpisut P, Kloda A, Martinac B.

Nature. 2002 Aug 29;418(6901):942-8.

PMID:
12198539
26.

Reactions of cysteines substituted in the amphipathic N-terminal tail of a bacterial potassium channel with hydrophilic and hydrophobic maleimides.

Li J, Xu Q, Cortes DM, Perozo E, Laskey A, Karlin A.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11605-10. Epub 2002 Aug 20.

27.

Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating.

Perozo E, Kloda A, Cortes DM, Martinac B.

Nat Struct Biol. 2002 Sep;9(9):696-703.

PMID:
12172537
28.

EPR approaches to ion channel structure and function.

Perozo E, Cuello LG, Cortes DM, Liu YS, Sompornpisut P.

Novartis Found Symp. 2002;245:146-58; discussion 158-64, 165-8. Review.

PMID:
12027005
29.

Site-directed spin-labeling analysis of reconstituted Mscl in the closed state.

Perozo E, Kloda A, Cortes DM, Martinac B.

J Gen Physiol. 2001 Aug;118(2):193-206.

30.
31.

Structural rearrangements underlying K+-channel activation gating.

Perozo E, Cortes DM, Cuello LG.

Science. 1999 Jul 2;285(5424):73-8.

32.

Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy.

Perozo E, Cortes DM, Cuello LG.

Nat Struct Biol. 1998 Jun;5(6):459-69.

PMID:
9628484
33.

pH-dependent gating in the Streptomyces lividans K+ channel.

Cuello LG, Romero JG, Cortes DM, Perozo E.

Biochemistry. 1998 Mar 10;37(10):3229-36.

PMID:
9536962
34.
35.

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